{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:40:34Z","timestamp":1780105234638,"version":"3.54.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British Journal of Plastic Surgery"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.bjps.2005.04.012","type":"journal-article","created":{"date-parts":[[2005,7,23]],"date-time":"2005-07-23T12:05:55Z","timestamp":1122120355000},"page":"765-773","source":"Crossref","is-referenced-by-count":41,"title":["Motorneuron protection by N-acetyl-cysteine after ventral root avulsion and ventral rhizotomy"],"prefix":"10.1016","volume":"58","author":[{"given":"C.-G.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Welin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Novikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-O.","family":"Kellerth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wiberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bjps.2005.04.012_bib1","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1097\/00006534-199910000-00001","article-title":"Outcomes of brachial plexus reconstruction in 204 patients with devastating paralysis","volume":"104","author":"Terzis","year":"1999","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2005.04.012_bib2","series-title":"Operative hand surgery","first-page":"630","article-title":"Repair and grafting of the peripheral nerve","author":"Terzis","year":"1998"},{"issue":"5 Pt 2","key":"10.1016\/j.bjps.2005.04.012_bib3","doi-asserted-by":"crossref","first-page":"3886","DOI":"10.1523\/JNEUROSCI.15-05-03886.1995","article-title":"Contributing factors to poor functional recovery after delayed nerve repair: prolonged denervation","volume":"15","author":"Fu","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.bjps.2005.04.012_bib4","series-title":"The peripheral nerve: structure, function and reconstruction","author":"Terzis","year":"1990"},{"key":"10.1016\/j.bjps.2005.04.012_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1939.19.1.1","article-title":"The reaction of muscle to denervation","volume":"19","author":"Tower","year":"1939","journal-title":"Physiol Rev"},{"issue":"2","key":"10.1016\/j.bjps.2005.04.012_bib6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0030-5898(20)31389-4","article-title":"The anatomic foundation of peripheral nerve repair techniques","volume":"12","author":"Sunderland","year":"1981","journal-title":"Orthop Clin North Am"},{"issue":"5","key":"10.1016\/j.bjps.2005.04.012_bib7","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1055\/s-2007-1006604","article-title":"Trophism, tropism, and specificity in nerve regeneration","volume":"10","author":"Lundborg","year":"1994","journal-title":"J Reconstr Microsurg"},{"issue":"21","key":"10.1016\/j.bjps.2005.04.012_bib8","doi-asserted-by":"crossref","first-page":"8674","DOI":"10.1523\/JNEUROSCI.18-21-08674.1998","article-title":"Contributions of pathway and neuron to preferential motor reinnervation","volume":"18","author":"Brushart","year":"1998","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.bjps.2005.04.012_bib9","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s00221-001-0929-0","article-title":"Primary sensory neurons and satellite cells after peripheral axotomy in the adult rat\u2014timecourse of cell death and elimination","volume":"142","author":"Hart","year":"2002","journal-title":"Exp Brain Res"},{"issue":"2","key":"10.1016\/j.bjps.2005.04.012_bib10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s002210100769","article-title":"Delayed loss of spinal motorneurons after peripheral nerve injury in adult rats: a quantitative morphological study","volume":"139","author":"Ma","year":"2001","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.bjps.2005.04.012_bib11","series-title":"Cell death and diseases of the nervous system","first-page":"181","article-title":"Axotomy-induced motor neuron death","author":"Elliott","year":"1999"},{"issue":"1\u20132","key":"10.1016\/j.bjps.2005.04.012_bib12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF02740621","article-title":"The cellular and molecular basis of peripheral nerve regeneration","volume":"14","author":"Fu","year":"1997","journal-title":"Mol Neurobiol"},{"issue":"3","key":"10.1016\/j.bjps.2005.04.012_bib13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000111214","article-title":"The effects of remaining axons on motoneuron survival and NOS expression following axotomy in the adult rat","volume":"19","author":"Gu","year":"1997","journal-title":"Dev Neurosci"},{"issue":"1","key":"10.1016\/j.bjps.2005.04.012_bib14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/cne.903420105","article-title":"Ventral root avulsion: an experimental model of death of adult motor neurons","volume":"342","author":"Koliatsos","year":"1994","journal-title":"J Comp Neurol"},{"issue":"3","key":"10.1016\/j.bjps.2005.04.012_bib15","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0306-4522(96)00665-3","article-title":"Brain-derived neurotrophic factor promotes axonal regeneration and long-term survival of adult rat spinal motoneurons in vivo","volume":"79","author":"Novikov","year":"1997","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.bjps.2005.04.012_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/alp.37.1.1.9","article-title":"Early nerve repair after injury to the postganglionic plexus: an experimental study of sensory and motor neuronal survival in adult rats","volume":"37","author":"Ma","year":"2003","journal-title":"Scand J Plast Reconstr Surg Hand Surg"},{"issue":"1","key":"10.1016\/j.bjps.2005.04.012_bib17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF02740752","article-title":"Priming events and retrograde injury signals. A new perspective on the cellular and molecular biology of nerve regeneration","volume":"13","author":"Ambron","year":"1996","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.bjps.2005.04.012_bib18","series-title":"Cell death and diseases of nervous system","author":"Koliatsos","year":"1999"},{"issue":"1","key":"10.1016\/j.bjps.2005.04.012_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuroscience.2003.12.040","article-title":"Sensory neuroprotection, mitochondrial preservation, and therapeutic potential of N-acetyl-cysteine after nerve injury","volume":"125","author":"Hart","year":"2004","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.bjps.2005.04.012_bib20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/(SICI)1096-9861(19980629)396:2<158::AID-CNE2>3.0.CO;2-#","article-title":"Characterization of spinal motoneuron degeneration following different types of peripheral nerve injury in neonatal and adult mice","volume":"396","author":"Li","year":"1998","journal-title":"J Comp Neurol"},{"issue":"1","key":"10.1016\/j.bjps.2005.04.012_bib21","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0014-4886(86)90161-5","article-title":"Motoneurons of the rat sciatic nerve","volume":"93","author":"Swett","year":"1986","journal-title":"Exp Neurol"},{"issue":"1","key":"10.1016\/j.bjps.2005.04.012_bib22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0165-0270(97)02227-9","article-title":"Persistent neuronal labeling by retrograde fluorescent tracers: a comparison between fast blue, fluoro-gold and various dextran conjugates","volume":"74","author":"Novikova","year":"1997","journal-title":"J Neurosci Methods"},{"issue":"1","key":"10.1016\/j.bjps.2005.04.012_bib23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0306-4522(00)00256-6","article-title":"Exogenous brain-derived neurotrophic factor regulates the synaptic composition of axonally lesioned and normal adult rat motoneurons","volume":"100","author":"Novikov","year":"2000","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.bjps.2005.04.012_bib24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0304-3940(95)12078-I","article-title":"Brain-derived neurotrophic factor promotes survival and blocks nitric oxide synthase expression in adult rat spinal motoneurons after ventral root avulsion","volume":"200","author":"Novikov","year":"1995","journal-title":"Neurosci Lett"},{"issue":"3","key":"10.1016\/j.bjps.2005.04.012_bib25","first-page":"709","article-title":"Peripheral nerve injury and regeneration","volume":"10","author":"Terenghi","year":"1995","journal-title":"Histol Histopathol"},{"issue":"21","key":"10.1016\/j.bjps.2005.04.012_bib26","doi-asserted-by":"crossref","first-page":"9771","DOI":"10.1073\/pnas.92.21.9771","article-title":"Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor","volume":"92","author":"Li","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5 Pt 2","key":"10.1016\/j.bjps.2005.04.012_bib27","first-page":"R1422","article-title":"Cachectic effect of ciliary neurotrophic factor on innervated skeletal muscle","volume":"271","author":"Martin","year":"1996","journal-title":"Am J Physiol"},{"issue":"5","key":"10.1016\/j.bjps.2005.04.012_bib28","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1212\/WNL.54.5.1080","article-title":"A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291","volume":"54","author":"McArthur","year":"2000","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.bjps.2005.04.012_bib29","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1046\/j.1460-9568.2000.00978.x","article-title":"Survival effects of BDNF and NT-3 on axotomized rubrospinal neurons depend on the temporal pattern of neurotrophin administration","volume":"12","author":"Novikova","year":"2000","journal-title":"Eur J Neurosci"},{"issue":"4","key":"10.1016\/j.bjps.2005.04.012_bib30","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/1096-9861(20001225)428:4<671::AID-CNE7>3.0.CO;2-H","article-title":"BDNF abolishes the survival effect of NT-3 in axotomized Clarke neurons of adult rats","volume":"428","author":"Novikova","year":"2000","journal-title":"J Comp Neurol"},{"issue":"5","key":"10.1016\/j.bjps.2005.04.012_bib31","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0959-4388(98)80089-5","article-title":"Linking extracellular survival signals and the apoptotic machinery","volume":"8","author":"Nunez","year":"1998","journal-title":"Curr Opin Neurobiol"},{"issue":"1\u20132","key":"10.1016\/j.bjps.2005.04.012_bib32","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0006-8993(96)00829-3","article-title":"Expression pattern of candidate cell death effector proteins Bax, Bcl-2, Bcl-X, and c-Jun in sensory and motor neurons following sciatic nerve transection in the rat","volume":"739","author":"Gillardon","year":"1996","journal-title":"Brain Res"},{"key":"10.1016\/j.bjps.2005.04.012_bib33","series-title":"Cell death and diseases of the nervous system","first-page":"103","article-title":"The cell cycle and neuronal death","author":"Freeman","year":"1999"},{"issue":"2","key":"10.1016\/j.bjps.2005.04.012_bib34","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0002-9440(10)65588-5","article-title":"Apoptosis of retrogradely degenerating neurons occurs in association with the accumulation of perikaryal mitochondria and oxidative damage to the nucleus","volume":"153","author":"Al Abdulla","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.bjps.2005.04.012_bib35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1042\/bse0330043","article-title":"Mitochondria in the life and death of neurons","volume":"33","author":"Budd","year":"1998","journal-title":"Essays Biochem"},{"issue":"2","key":"10.1016\/j.bjps.2005.04.012_bib36","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0005-2728(98)00168-6","article-title":"Nitric oxide, mitochondria and neurological disease","volume":"1410","author":"Heales","year":"1999","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"10.1016\/j.bjps.2005.04.012_bib37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0006-8993(99)01228-7","article-title":"Glutathione depletion and neuronal cell death: the role of reactive oxygen intermediates and mitochondrial function","volume":"826","author":"Wullner","year":"1999","journal-title":"Brain Res"},{"issue":"8","key":"10.1016\/j.bjps.2005.04.012_bib38","first-page":"793","article-title":"Multiple roles of glutathione in the central nervous system","volume":"378","author":"Cooper","year":"1997","journal-title":"Biol Chem"},{"issue":"1\u20132","key":"10.1016\/j.bjps.2005.04.012_bib39","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0006-8993(96)00844-X","article-title":"Increased uptake of l-cysteine and l-cystine by nerve growth factor in rat pheochromocytoma cells","volume":"740","author":"Pan","year":"1996","journal-title":"Brain Res"},{"issue":"4","key":"10.1016\/j.bjps.2005.04.012_bib40","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1046\/j.1471-4159.2000.0741434.x","article-title":"Astrocytes provide cysteine to neurons by releasing glutathione","volume":"74","author":"Wang","year":"2000","journal-title":"J Neurochem"},{"issue":"2","key":"10.1016\/j.bjps.2005.04.012_bib41","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1523\/JNEUROSCI.19-02-00562.1999","article-title":"Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione","volume":"19","author":"Dringen","year":"1999","journal-title":"J Neurosci"},{"issue":"2","key":"10.1016\/j.bjps.2005.04.012_bib42","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0304-3940(98)00894-5","article-title":"N-acetylcysteine, but not methionine or 2-oxothiazolidine-4-carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain","volume":"259","author":"Dringen","year":"1999","journal-title":"Neurosci Lett"},{"issue":"2","key":"10.1016\/j.bjps.2005.04.012_bib43","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0304-3959(98)00091-8","article-title":"Wallerian degeneration and hyperalgesia after peripheral nerve injury are glutathione-dependent","volume":"77","author":"Wagner","year":"1998","journal-title":"Pain"},{"issue":"51","key":"10.1016\/j.bjps.2005.04.012_bib44","doi-asserted-by":"crossref","first-page":"33018","DOI":"10.1074\/jbc.271.51.33018","article-title":"Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N-acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade","volume":"271","author":"Kamata","year":"1996","journal-title":"J Biol Chem"},{"issue":"45","key":"10.1016\/j.bjps.2005.04.012_bib45","doi-asserted-by":"crossref","first-page":"26827","DOI":"10.1074\/jbc.270.45.26827","article-title":"N-acetylcysteine-promoted survival of PC12 cells is glutathione-independent but transcription-dependent","volume":"270","author":"Yan","year":"1995","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.bjps.2005.04.012_bib46","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1534-5807(02)00132-6","article-title":"Oxidants painting the cysteine chapel: redox regulation of PTPs","volume":"2","author":"Xu","year":"2002","journal-title":"Dev Cell"},{"issue":"1","key":"10.1016\/j.bjps.2005.04.012_bib47","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","author":"Droge","year":"2002","journal-title":"Physiol Rev"},{"issue":"4","key":"10.1016\/j.bjps.2005.04.012_bib48","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1523\/JNEUROSCI.15-04-02857.1995","article-title":"N-acetylcysteine (d- and l-stereoisomers) prevents apoptotic death of neuronal cells","volume":"15","author":"Ferrari","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.bjps.2005.04.012_bib49","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0306-4522(99)00359-0","article-title":"Survival of chronically-injured neurons can be prolonged by treatment with neurotrophic factors","volume":"94","author":"Houle","year":"1999","journal-title":"Neuroscience"}],"container-title":["British Journal of Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007122605001220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007122605001220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T22:52:58Z","timestamp":1626216778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007122605001220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0007122605001220"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2005.04.012","relation":{},"ISSN":["0007-1226"],"issn-type":[{"value":"0007-1226","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}