{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:26:13Z","timestamp":1771658773626,"version":"3.50.1"},"reference-count":57,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.bjps.2007.05.017","type":"journal-article","created":{"date-parts":[[2007,7,17]],"date-time":"2007-07-17T11:22:42Z","timestamp":1184671362000},"page":"939-948","source":"Crossref","is-referenced-by-count":34,"title":["Impact of gradual blood flow increase on ischaemia\u2013reperfusion injury in the rat cremaster microcirculation model"],"prefix":"10.1016","volume":"61","author":[{"given":"Selahattin","family":"Ozmen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhan","family":"Ayhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yavuz","family":"Demir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Siemionow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenan","family":"Atabay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjps.2007.05.017_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/bmb\/ldh025","article-title":"Vascular ischaemia and reperfusion injury","volume":"70","author":"Eltzschig","year":"2004","journal-title":"Br Med Bull"},{"key":"10.1016\/j.bjps.2007.05.017_bib2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0009-9120(99)00041-7","article-title":"Effects of pentoxifylline and coenzyme Q10 in hepatic ischemia\/reperfusion injury","volume":"32","author":"Portakal","year":"1999","journal-title":"Clin Biochem"},{"key":"10.1016\/j.bjps.2007.05.017_bib3","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/00024382-200014020-00026","article-title":"Prostaglandin E1 reduces ischemia\/reperfusion injury by normalizing nitric oxide and superoxide release","volume":"14","author":"Huk","year":"2000","journal-title":"Shock"},{"key":"10.1016\/j.bjps.2007.05.017_bib4","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0014-2999(00)00466-0","article-title":"Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation","volume":"401","author":"Calapai","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bjps.2007.05.017_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0009-8981(97)00089-2","article-title":"Effects of cyclosporine A and ibuprofen on liver ischemia-reperfusion injury in the rat","volume":"275","author":"Konukoglu","year":"1998","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.bjps.2007.05.017_bib6","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1476-5381.1992.tb14267.x","article-title":"Effects of systemic non-steroidal anti-inflammatory drugs on nociception during tail ischaemia and on reperfusion hyperalgesia in rats","volume":"105","author":"Gelgor","year":"1992","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bjps.2007.05.017_bib7","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0022-5223(19)36512-2","article-title":"Reperfusion conditions: importance of ensuring gentle versus sudden reperfusion during relief of coronary occlusion","volume":"92","author":"Okamoto","year":"1986","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.bjps.2007.05.017_bib8","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1161\/01.CIR.84.5.2135","article-title":"Staged reperfusion attenuates myocardial stunning in dogs. Role of transient acidosis during early reperfusion","volume":"84","author":"Hori","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.bjps.2007.05.017_bib9","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0003-4975(97)00734-0","article-title":"Gradual reperfusion reduces infarct size and endothelial injury but augments neutrophil accumulation","volume":"64","author":"Sato","year":"1997","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.bjps.2007.05.017_bib10","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1177\/096721099300100619","article-title":"Effect of gradual reperfusion on ventricular function after 6-h preservation","volume":"1","author":"Ueno","year":"1993","journal-title":"Cardiovasc Surg"},{"key":"10.1016\/j.bjps.2007.05.017_bib11","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1161\/01.CIR.88.5.2370","article-title":"Short-term synchronized retroperfusion before reperfusion reduces infarct size after prolonged ischemia in dogs","volume":"88","author":"Wakida","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.bjps.2007.05.017_bib12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/bmmb.1993.1054","article-title":"Effects of gradual reperfusion on postischemic metabolism and functional recovery of isolated guinea pig heart","volume":"50","author":"Pisarenko","year":"1993","journal-title":"Biochem Med Metab Biol"},{"key":"10.1016\/j.bjps.2007.05.017_bib13","first-page":"G366","article-title":"Gradual reintroduction of oxygen reduces reperfusion injury in cat stomach","volume":"254","author":"Perry","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1016\/j.bjps.2007.05.017_bib14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0967-2109(95)94158-S","article-title":"Ischemia-reperfusion injury of the spinal cord: the influence of normovolemic hemodilution and gradual reperfusion","volume":"3","author":"Wisselink","year":"1995","journal-title":"Cardiovasc Surg"},{"key":"10.1016\/j.bjps.2007.05.017_bib15","unstructured":"Atabay K, Hong C, Bentz ML, et\u00a0al. Is controlled gradual reperfusion of blood to post-ischemic tissue beneficial for minimizing reperfusion injury? Presented at the 39th annual meeting of the Plastic Surgery Research Council. Ann Arbor, MI, June 4\u20137, 1994."},{"key":"10.1016\/j.bjps.2007.05.017_bib16","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/00000637-200110000-00009","article-title":"The effect of gradually increased blood flow on ischemia-reperfusion injury","volume":"47","author":"Unal","year":"2001","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.bjps.2007.05.017_bib17","first-page":"183","article-title":"Leukocyte-endothelial interaction and capillary perfusion in ischemia\/reperfusion of the rat cremaster muscle","volume":"7","author":"Siemionow","year":"1991","journal-title":"Microcirc Endothelium Lymphatics"},{"key":"10.1016\/j.bjps.2007.05.017_bib18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0026-2862(88)90038-6","article-title":"Vascular isolation of the rat cremaster muscle","volume":"36","author":"Anderson","year":"1988","journal-title":"Microvasc Res"},{"key":"10.1016\/j.bjps.2007.05.017_bib19","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1016\/S0041-1345(98)01397-9","article-title":"The nature of ischemia\/reperfusion injury","volume":"30","author":"Massberg","year":"1998","journal-title":"Transplant Proc"},{"key":"10.1016\/j.bjps.2007.05.017_bib20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-4684-8935-4_11","article-title":"White cell-endothelium interaction during postischemic reperfusion of skin and skeletal muscle","volume":"242","author":"Messmer","year":"1988","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.bjps.2007.05.017_bib21","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1172\/JCI109031","article-title":"Oxygen radicals mediate endothelial cell damage by complement stimulated granulocytes","volume":"61","author":"Sacks","year":"1978","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bjps.2007.05.017_bib22","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1172\/JCI110390","article-title":"Neutrophilmediated endothelial injury in vitro","volume":"68","author":"Harlan","year":"1981","journal-title":"J Clin Invest"},{"key":"10.1016\/j.bjps.2007.05.017_bib23","first-page":"H93","article-title":"Accumulation of polymorphonuclear leukocytes during 3-h experimental myocardial ischemia","volume":"251","author":"Engler","year":"1986","journal-title":"Am J Physiol"},{"key":"10.1016\/j.bjps.2007.05.017_bib24","first-page":"437","article-title":"Cerebral ischemia II: the no re-flow phenomenon","volume":"52","author":"Ames","year":"1968","journal-title":"Am J Pathol"},{"key":"10.1016\/j.bjps.2007.05.017_bib25","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/00006534-197802000-00017","article-title":"The no-reflow phenomenon in experimental free flaps","volume":"61","author":"May","year":"1978","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2007.05.017_bib26","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1097\/00006534-199705000-00001","article-title":"Ischemia-reperfusion injury in myocutaneous flaps: role of leukocytes and leukotrienes","volume":"99","author":"Kirschner","year":"1997","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2007.05.017_bib27","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1054\/bjps.1998.0080","article-title":"Dexamethasone treatment prior to reperfusion improves the survival of skin flaps subjected to secondary venous ischaemia","volume":"51","author":"Willemart","year":"1998","journal-title":"Br J Plast Surg"},{"key":"10.1016\/j.bjps.2007.05.017_bib28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/cvr\/14.3.137","article-title":"Beneficial effect of dexamethasone on the \u201cno reflow\u201d phenomenon in canine myocardium","volume":"14","author":"Nellis","year":"1980","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.bjps.2007.05.017_bib29","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/sj.bjp.0702328","article-title":"Leukocyte\u2013endothelial cell adhesion: avenues for therapeutic intervention","volume":"126","author":"Panes","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bjps.2007.05.017_bib30","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0161-5890(99)00116-9","article-title":"Complement activation following oxidative stress","volume":"36","author":"Collard","year":"1999","journal-title":"Mol Immunol"},{"key":"10.1016\/j.bjps.2007.05.017_bib31","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1126\/science.2371562","article-title":"Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis","volume":"249","author":"Weisman","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.bjps.2007.05.017_bib32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0007-1226(94)90045-0","article-title":"The effect of allopurinol on experimental Island skin flap survival under prolonged periods of arterial ischaemia","volume":"47","author":"Tamir","year":"1994","journal-title":"Br J Plast Surg"},{"key":"10.1016\/j.bjps.2007.05.017_bib33","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/sj.bjp.0702789","article-title":"The influence of allopurinol on kidney haemodynamic and excretory responses to renal ischaemia in anaesthetized rats","volume":"128","author":"Hestin","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bjps.2007.05.017_bib34","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0300-483X(00)00201-8","article-title":"Apoptotic cell death during ischemia\/reperfusion and its attenuation by antioxidant therapy","volume":"148","author":"Galang","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.bjps.2007.05.017_bib35","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0008-6363(00)00078-X","article-title":"Status of myocardial antioxidants in ischemia-reperfusion injury","volume":"47","author":"Dhalla","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.bjps.2007.05.017_bib36","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1203\/00006450-200010000-00023","article-title":"Effects of deferoxamine, a chelator of free iron, on NA(+), K(+)-ATPase activity of cortical brain cell membrane during early reperfusion after hypoxia-ischemia in newborn lambs","volume":"48","author":"Groenendaal","year":"2000","journal-title":"Pediatr Res"},{"key":"10.1016\/j.bjps.2007.05.017_bib37","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0041-1345(00)00848-4","article-title":"Ischemia-reperfusion injury of rabbit kidney: comparative effects of desferrioxamine and N-acetylcysteine as antioxidants","volume":"32","author":"Pincemail","year":"2000","journal-title":"Transplant Proc"},{"key":"10.1016\/j.bjps.2007.05.017_bib38","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/S0003-4975(96)01386-0","article-title":"Effect of desferrioxamine cardioplegia on ischemia-reperfusion injury in isolated rat heart","volume":"63","author":"Nicholson","year":"1997","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.bjps.2007.05.017_bib39","doi-asserted-by":"crossref","first-page":"36","DOI":"10.12968\/jowc.2000.9.1.25939","article-title":"Pressure-induced skin lesions in pigs: reperfusion injury and the effects of vitamin E","volume":"9","author":"Houwing","year":"2000","journal-title":"J Wound Care"},{"key":"10.1016\/j.bjps.2007.05.017_bib40","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0009-8981(99)00071-6","article-title":"Alpha-tocopherol acetate significantly suppressed the increase in heart interstitial 8-hydroxydeoxyguanosine following myocardial ischemia and reperfusion in anesthetized rats","volume":"285","author":"Yang","year":"1999","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.bjps.2007.05.017_bib41","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1523\/JNEUROSCI.20-08-02817.2000","article-title":"The cytosolic antioxidant copper\/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice","volume":"20","author":"Fujimura","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.bjps.2007.05.017_bib42","doi-asserted-by":"crossref","first-page":"9369","DOI":"10.1074\/jbc.275.13.9369","article-title":"Regulation of xanthine oxidase by nitric oxide and peroxynitrite","volume":"275","author":"Lee","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bjps.2007.05.017_bib43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0167-5273(96)02854-9","article-title":"Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options","volume":"58","author":"Maxwell","year":"1997","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.bjps.2007.05.017_bib44","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"key":"10.1016\/j.bjps.2007.05.017_bib45","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1046\/j.1464-410X.1997.00209.x","article-title":"Ischemia-reperfusion injury in rat kidney: the effect of preconditioning","volume":"79","author":"Islam","year":"1997","journal-title":"Br J Urol"},{"key":"10.1016\/j.bjps.2007.05.017_bib46","first-page":"3303","article-title":"Preconditioning: effect upon lesion modulation in warm liver ischemia","volume":"25","author":"Lloris-Carsi","year":"1993","journal-title":"Transplant Proc"},{"key":"10.1016\/j.bjps.2007.05.017_bib47","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0022-5223(19)36512-2","article-title":"Studies of controlled reperfusion after ischemia. XIV. Reperfusion conditions: importance of ensuring gentle versus sudden reperfusion during relief of coronary occlusion","volume":"92","author":"Okamoto","year":"1986","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.bjps.2007.05.017_bib48","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0002-8703(89)90723-0","article-title":"Controlled versus hyperemic flow during reperfusion of jeopardized ischemic myocardium","volume":"117","author":"Peng","year":"1989","journal-title":"Am Heart J"},{"key":"10.1016\/j.bjps.2007.05.017_bib49","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1161\/01.RES.50.2.287","article-title":"Effects of pH on Na\u2013K exchange in canine cardiac sarcolemmal vesicles","volume":"50","author":"Philipson","year":"1982","journal-title":"Circ Res"},{"key":"10.1016\/j.bjps.2007.05.017_bib50","first-page":"H1703","article-title":"Beneficial actions of superoxide dismutase and catalase in stunned myocardium in dogs","volume":"263","author":"Gross","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.bjps.2007.05.017_bib51","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1073\/pnas.84.5.1404","article-title":"Direct measurement of free radical generation following reperfusion of ischemic myocardium","volume":"84","author":"Zweier","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bjps.2007.05.017_bib52","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1182\/blood.V53.6.1133.1133","article-title":"Effects of oxygen tension and pH on the respiratory burst of human neutrophils","volume":"53","author":"Gabig","year":"1979","journal-title":"Blood"},{"key":"10.1016\/j.bjps.2007.05.017_bib53","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1161\/01.CIR.67.5.1016","article-title":"Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog","volume":"67","author":"Romson","year":"1983","journal-title":"Circulation"},{"key":"10.1016\/j.bjps.2007.05.017_bib54","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0022-3565(24)36369-4","article-title":"Adenosine A2 activation attenuates reperfusion injury by inhibiting neutrophil accumulation, superoxide generation and coronary endothelial adherence","volume":"280","author":"Jordan","year":"1997","journal-title":"J Pharmacol Exp Therapeutics"},{"key":"10.1016\/j.bjps.2007.05.017_bib55","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1083\/jcb.11.3.571","article-title":"Studies on inflammation. I. the effect of histamine and serotonin on vascular permeability: an electron microscopic study","volume":"11","author":"Majno","year":"1961","journal-title":"J Biophy Biochem Cytol"},{"key":"10.1016\/j.bjps.2007.05.017_bib56","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0026-2862(73)90054-X","article-title":"An open cremaster muscle preparation for the study of blood vessels by in vitro microscopy","volume":"5","author":"Baez","year":"1973","journal-title":"Microvasc Res"},{"key":"10.1016\/j.bjps.2007.05.017_bib57","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0014-2999(79)90493-X","article-title":"Modification of \u03b1-adrenergic responses of small arteries by altered PCO2 and pH","volume":"57","author":"Wiegman","year":"1979","journal-title":"Eur J Pharmacol"}],"container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681507002963?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681507002963?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T15:08:48Z","timestamp":1737299328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681507002963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":57,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S1748681507002963"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2007.05.017","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}