{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:44:52Z","timestamp":1790178292600,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.bjps.2008.03.023","type":"journal-article","created":{"date-parts":[[2008,7,11]],"date-time":"2008-07-11T11:29:32Z","timestamp":1215775772000},"page":"1024-1028","source":"Crossref","is-referenced-by-count":29,"title":["Botulinum toxin for treatment of glandular hypersecretory disorders"],"prefix":"10.1016","volume":"61","author":[{"given":"T.A.","family":"Laing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.E.","family":"Laing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.T.","family":"O'Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjps.2008.03.023_bib1","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1002\/mds.20003","article-title":"Historical notes on botulism, Clostridium botulinum, botulinum toxin, and the idea of the therapeutic use of the toxin","volume":"19","author":"Erbguth","year":"2004","journal-title":"Mov Disord"},{"key":"10.1016\/j.bjps.2008.03.023_bib2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/bmj.320.7228.161","article-title":"Uses of botulinum toxin injection in medicine today","volume":"320","author":"Munchau","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.bjps.2008.03.023_bib3","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/ana.410420619","article-title":"Treatment of gustatory sweating with botulinum toxin","volume":"42","author":"Naumann","year":"1997","journal-title":"Ann Neurol"},{"key":"10.1016\/j.bjps.2008.03.023_bib4","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/sj.eye.6700230","article-title":"Treatment of gustatory hyperlacrimation (crocodile tears) with injection of botulinum toxin into the lacrimal gland","volume":"16","author":"Montoya","year":"2002","journal-title":"Eye"},{"key":"10.1016\/j.bjps.2008.03.023_bib5","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0190-9622(98)70242-7","article-title":"Botulinum toxin therapy for palmar hyperhidrosis","volume":"38","author":"Shelley","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.bjps.2008.03.023_bib6","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1212\/WNL.57.11.2095","article-title":"Botulinum toxin type A in primary palmar hyperhidrosis: randomized, single-blind, two-dose study","volume":"57","author":"Saadia","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.bjps.2008.03.023_bib7","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1056\/NEJM200102153440704","article-title":"Botulinum toxin A for axillary hyperhidrosis (excessive sweating)","volume":"344","author":"Heckmann","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bjps.2008.03.023_bib8","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1001\/archderm.141.10.1255","article-title":"Low-dose efficacy of botulinum toxin A for axillary hyperhidrosis: a randomized, side-by-side, open-label study","volume":"141","author":"Heckmann","year":"2005","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.bjps.2008.03.023_bib9","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1365-4632.2004.02531.x","article-title":"Pilot study of the safety and efficacy of Myobloc (botulinum toxin type B) for treatment of axillary hyperhidrosis","volume":"44","author":"Baumann","year":"2005","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.bjps.2008.03.023_bib10","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1111\/j.1524-4725.2006.32335.x","article-title":"Topically applied botulinum toxin type A for the treatment of primary axillary hyperhidrosis: results of a randomized, blinded, vehicle-controlled study","volume":"33","author":"Glogau","year":"2007","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.bjps.2008.03.023_bib11","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1111\/j.1524-4725.2006.32331.x","article-title":"A double-blind, randomized, comparative study of two type A botulinum toxins in the treatment of primary axillary hyperhidrosis","volume":"33","author":"Talarico-Filho","year":"2007","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.bjps.2008.03.023_bib12","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1001\/archderm.134.3.301","article-title":"Focal hyperhidrosis. Effective treatment with intracutaneous botulinum toxin","volume":"134","author":"Naumann","year":"1998","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.bjps.2008.03.023_bib13","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1017\/S0022215106003835","article-title":"The bullet that hit a nerve: the history of Lucja Frey and her syndrome","volume":"120","author":"Dulguerov","year":"2006","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.bjps.2008.03.023_bib14","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3109\/00016485709124377","article-title":"Gustatory sweating and flushing after conservative parotidectomy","volume":"48","author":"Laage-Hellman","year":"1957","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.bjps.2008.03.023_bib15","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0002-9610(70)80010-1","article-title":"Jacobson's neurectomy for Frey's syndrome","volume":"120","author":"Smith","year":"1970","journal-title":"Am J Surg"},{"key":"10.1016\/j.bjps.2008.03.023_bib16","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/bjs.1800791116","article-title":"Parotidectomy for parotid tumours: 19-year experience from the Netherlands","volume":"79","author":"Debets","year":"1992","journal-title":"Br J Surg"},{"key":"10.1016\/j.bjps.2008.03.023_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1001\/archfaci.5.1.109","article-title":"Use of AlloDerm implant to prevent Frey syndrome after parotidectomy","volume":"5","author":"Sinha","year":"2003","journal-title":"Arch Facial Plast Surg"},{"key":"10.1016\/j.bjps.2008.03.023_bib18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1001\/archotol.1967.00760050004002","article-title":"Intratympanic surgical treatment of Frey's syndrome","volume":"86","author":"Blumenfeld","year":"1967","journal-title":"Arch Otolaryngol"},{"key":"10.1016\/j.bjps.2008.03.023_bib19","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/hed.10262","article-title":"Treatment of gustatory sweating (Frey's syndrome) with botulinum toxin A","volume":"25","author":"Eckardt","year":"2003","journal-title":"Head Neck"},{"key":"10.1016\/j.bjps.2008.03.023_bib20","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s10286-002-0026-x","article-title":"The role of gustatory flushing in Frey's syndrome and its treatment with botulinum toxin type A","volume":"12","author":"Tugnoli","year":"2002","journal-title":"Clin Auton Res"},{"key":"10.1016\/j.bjps.2008.03.023_bib21","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1097\/00005537-200204000-00027","article-title":"Increased botulinum toxin type A dosage is more effective in patients with Frey's syndrome","volume":"112","author":"Guntinas-Lichius","year":"2002","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bjps.2008.03.023_bib22","first-page":"E79","article-title":"Control of Frey's syndrome in patients treated with botulinum toxin type A","volume":"12","author":"Luna Ortiz","year":"2007","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.bjps.2008.03.023_bib23","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1726-4901(09)70075-9","article-title":"Preliminary experience with botulinum toxin type A intracutaneous injection for Frey's syndrome","volume":"68","author":"Wang","year":"2005","journal-title":"J Chin Med Assoc"},{"key":"10.1016\/j.bjps.2008.03.023_bib24","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1017\/S0012162206001939","article-title":"Parotid and submandibular botulinum toxin A injections for sialorrhoea in children with cerebral palsy","volume":"48","author":"Banerjee","year":"2006","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.bjps.2008.03.023_bib25","first-page":"170","article-title":"Botulinum toxin type A treatment for Parkinsonian patients with moderate to severe sialorrhea","volume":"15","author":"Su","year":"2006","journal-title":"Acta Neurol Taiwan"},{"key":"10.1016\/j.bjps.2008.03.023_bib26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/mus.20545","article-title":"Botulinum toxin improves sialorrhea and quality of living in bulbar amyotrophic lateral sclerosis","volume":"34","author":"Verma","year":"2006","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.bjps.2008.03.023_bib27","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/01.iop.0000244515.07925.99","article-title":"Duration of botulinum toxin effect in the treatment of crocodile tears","volume":"22","author":"Nava-Castaneda","year":"2006","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2008.03.023_bib28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1076\/orbi.22.3.193.15622","article-title":"The use of botulinum toxin A in the treatment of functional epiphora","volume":"22","author":"Whittaker","year":"2003","journal-title":"Orbit"},{"key":"10.1016\/j.bjps.2008.03.023_bib29","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1177\/000348940111001110","article-title":"Botulinum toxin type A induces apoptosis in nasal glands of guinea pigs","volume":"110","author":"Rohrbach","year":"2001","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.bjps.2008.03.023_bib30","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.amjoto.2006.01.008","article-title":"The effect of intranasal injection of botulinum toxin A on the symptoms of vasomotor rhinitis","volume":"27","author":"Ozcan","year":"2006","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.bjps.2008.03.023_bib31","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1080\/00016489.2003.11720744","article-title":"Effect of botulinum toxin type A on nasal symptoms in patients with allergic rhinitis: a double-blind, placebo-controlled clinical trial","volume":"123","author":"Unal","year":"2003","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.bjps.2008.03.023_bib32","first-page":"566","article-title":"Rhinorrhea is decreased in dogs after nasal application of botulinum toxin","volume":"112","author":"Shaari","year":"1995","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.bjps.2008.03.023_bib33","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1159\/000055778","article-title":"Minimally invasive application of botulinum toxin type A in nasal hypersecretion","volume":"63","author":"Rohrbach","year":"2001","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"10.1016\/j.bjps.2008.03.023_bib34","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1097\/00005537-200410000-00033","article-title":"Reduction of salivary flow with botulinum toxin: extended report on 33 patients with drooling, salivary fistulas, and sialadenitis","volume":"114","author":"Ellies","year":"2004","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bjps.2008.03.023_bib35","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/00005537-200203000-00033","article-title":"Treatment of chronic parotid sialectasis with botulinum toxin A","volume":"112","author":"Guntinas-Lichius","year":"2002","journal-title":"Laryngoscope"}],"container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681508004658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681508004658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T16:31:13Z","timestamp":1557678673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681508004658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S1748681508004658"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2008.03.023","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}