{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:39:55Z","timestamp":1779316795507,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["CA12587-01"],"award-info":[{"award-number":["CA12587-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["CA12587-06"],"award-info":[{"award-number":["CA12587-06"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["T32-GM008616"],"award-info":[{"award-number":["T32-GM008616"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","jprasurg.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.bjps.2014.08.054","type":"journal-article","created":{"date-parts":[[2014,8,30]],"date-time":"2014-08-30T16:34:40Z","timestamp":1409416480000},"page":"98-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prophylactic administration of Amifostine protects vessel thickness in the setting of irradiated bone"],"prefix":"10.1016","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-0063","authenticated-orcid":false,"given":"Erin E.","family":"Page","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6130-613X","authenticated-orcid":false,"given":"Sagar S.","family":"Deshpande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah S.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Felice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Donneys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose J.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir S.","family":"Deshpande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R.","family":"Buchman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjps.2014.08.054_bib1","series-title":"Cancer facts and figures 2013","author":"American Cancer Society","year":"2013"},{"key":"10.1016\/j.bjps.2014.08.054_bib2","doi-asserted-by":"crossref","first-page":"8126","DOI":"10.1158\/0008-5472.CAN-04-2445","article-title":"Head and neck cancer","volume":"64","author":"Grandis","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.bjps.2014.08.054_bib3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/jnci\/85.2.95","article-title":"Overview of combined modality therapies for head and neck cancer","volume":"85","author":"Dimery","year":"1993","journal-title":"JNCI J Natl Cancer Inst"},{"key":"10.1016\/j.bjps.2014.08.054_bib4","doi-asserted-by":"crossref","first-page":"402","DOI":"10.2307\/3573324","article-title":"Long-term effects of radiation on the vascularity of rat bone: quantitative measurements with a new technique","volume":"48","author":"Cutright","year":"1971","journal-title":"Radiat Res"},{"key":"10.1016\/j.bjps.2014.08.054_bib5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3109\/02841868309134038","article-title":"Functional changes in the vascularity of the irradiated rat femur. Implications for late effects","volume":"22","author":"Pitaknen","year":"1983","journal-title":"Acta Radiol Oncol"},{"key":"10.1016\/j.bjps.2014.08.054_bib6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/01.prs.0000371787.08042.d3","article-title":"Quantification and characterization of radiation-induced changes to mandibular vascularity using micro-computed tomography","volume":"125","author":"Deshpande","year":"2010","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2014.08.054_bib7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0278-2391(83)90294-X","article-title":"Osteoradionecrosis: a new concept of its pathophysiology","volume":"41","author":"Marx","year":"1983","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjps.2014.08.054_bib8","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0030-4220(87)90136-8","article-title":"Studies in the radiobiology of osteoradionecrosis and their clinical significance","volume":"64","author":"Marx","year":"1987","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.bjps.2014.08.054_bib9","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1200\/JCO.2000.18.19.3339","article-title":"Phase III randomized trial of Amifostine as a radioprotector in head and neck cancer","volume":"18","author":"Brizel","year":"2000","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.bjps.2014.08.054_bib10","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1053\/srao.2003.50006","article-title":"Chemical radioprotection: a critical review of Amifostine as a cytoprotector in radiotherapy","volume":"13","author":"Andreassen","year":"2003","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.bjps.2014.08.054_bib11","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.ijrobp.2005.07.966","article-title":"Influence of intravenous Amifostine on xerostomia, tumor control, and survival after radiotherapy for head-and-neck cancer: 2-year follow-up of a prospective, randomized, phase III trial","volume":"63","author":"Wasserman","year":"2005","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.bjps.2014.08.054_bib12","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1097\/PRS.0b013e31826d2201","article-title":"Quantitative histologic evidence of Amifostine-induced cytoprotection in an irradiated murine model of mandibular distraction osteogenesis","volume":"130","author":"Tchanque-Fossuo","year":"2012","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2014.08.054_bib13","doi-asserted-by":"crossref","first-page":"646e","DOI":"10.1097\/PRS.0b013e3182454352","article-title":"Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible","volume":"129","author":"Tchanque-Fossuo","year":"2012","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2014.08.054_bib14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bone.2013.07.005","article-title":"The effect of Amifostine prophylaxis on bone densitometry, biomechanical strength and union in mandibular pathologic fracture repair","volume":"57","author":"Tchanque-Fossuo","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bjps.2014.08.054_bib15","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.bone.2012.07.029","article-title":"Raman spectroscopy demonstrates Amifostine induced preservation of bone mineralization patterns in the irradiated murine mandible","volume":"52","author":"Tchanque-Fossuo","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bjps.2014.08.054_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/01.prs.0000421721.94954.6b","article-title":"Amifostine therapeutic enhancement of vascularity in an irradiated model of mandibular fracture repair model","volume":"130","author":"Tchanque-Fossuo","year":"2012","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2014.08.054_bib17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/01.prs.0000430028.59323.5d","article-title":"Amifostine offers protection of osteocyte viability during fracture healing after radiotherapy","volume":"131","author":"Spiegel","year":"2013","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2014.08.054_bib18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/01.prs.0000371789.15666.dd","article-title":"Distraction osteogenesis in the rat mandible following radiation and treatment with Amifostine","volume":"125","author":"Monson","year":"2010","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2014.08.054_bib19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/01.prs.0000396808.36234.b6","article-title":"Amifostine demonstrates significant cytoprotection in an irradiated murine model of mandibular distraction osteogenesis","volume":"127","author":"Razdolsky","year":"2011","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2014.08.054_bib20","doi-asserted-by":"crossref","first-page":"480e","DOI":"10.1097\/PRS.0b013e31822b67ae","article-title":"Dose-response effect of human equivalent radiation in the murine mandible","volume":"128","author":"Tchanque-Fossuo","year":"2011","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2014.08.054_bib21","first-page":"2","article-title":"Human equivalent radiation dose response in the rat mandible","volume":"124","author":"Monson","year":"2009","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2014.08.054_bib22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/(SICI)1097-0215(20000420)90:2<73::AID-IJC3>3.0.CO;2-E","article-title":"Dose response of Amifostine in protection of growth plate function from irradiation effects","volume":"90","author":"Damron","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1016\/j.bjps.2014.08.054_bib23","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0360-3016(01)01532-2","article-title":"Amifostine before fractionated irradiation protects bone growth in rats better than fractionation alone","volume":"50","author":"Damron","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.bjps.2014.08.054_bib24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1200\/JCO.2010.31.5051","article-title":"Amifostine in the treatment of head and neck cancer: intravenous administration, subcutaneous administration, or none of the above","volume":"29","author":"Eisbruch","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bjps.2014.08.054_bib25","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1124\/jpet.102.042838","article-title":"Amifostine inhibits angiogenesis in\u00a0vivo","volume":"304","author":"Giannopoulou","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bjps.2014.08.054_bib26","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1080\/10715760310001612559","article-title":"Amifostine has antiangiogenic properties in\u00a0vitro by changing the redox status of human endothelial cells","volume":"37","author":"Giannopoulou","year":"2003","journal-title":"Free Radic Res"},{"key":"10.1016\/j.bjps.2014.08.054_bib27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/ijc.1592","article-title":"Inhibition of spontaneous metastases formation by Amifostine","volume":"97","author":"Grdina","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1016\/j.bjps.2014.08.054_bib28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1053\/sonc.2002.37357","article-title":"Antimetastatic effectiveness of Amifostine therapy following surgical removal of Sa-NH tumors in mice","volume":"29","author":"Grdina","year":"2002","journal-title":"Semin Oncol"},{"key":"10.1016\/j.bjps.2014.08.054_bib29","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/00000637-200211000-00012","article-title":"Unique rodent model of distraction osteogenesis of the mandible","volume":"49","author":"Buchman","year":"2002","journal-title":"Ann Plast Surg"}],"container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681514004756?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681514004756?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T10:04:31Z","timestamp":1565777071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681514004756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S1748681514004756"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2014.08.054","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prophylactic administration of Amifostine protects vessel thickness in the setting of irradiated bone","name":"articletitle","label":"Article Title"},{"value":"Journal of Plastic, Reconstructive & Aesthetic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjps.2014.08.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}