{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:50:04Z","timestamp":1786985404695,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jprasurg.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.bjps.2015.09.004","type":"journal-article","created":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T01:26:58Z","timestamp":1443230818000},"page":"101-107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["The clinical application of rhBMP-7 for the reconstruction of\u00a0alveolar cleft"],"prefix":"10.1016","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2760-6008","authenticated-orcid":false,"given":"Ashraf","family":"Ayoub","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherian P.","family":"Roshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Gillgrass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Naudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arup","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjps.2015.09.004_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg2933","article-title":"Cleft lip and palate: understanding genetic and environmental influences","volume":"12","author":"Dixon","year":"2011","journal-title":"Nat Rev Gen"},{"key":"10.1016\/j.bjps.2015.09.004_bib2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1597\/1545-1569_1998_035_0077_rnfabg_2.3.co_2","article-title":"Reduced need for alveolar bone grafting by presurgical orthopedics and primary gingivoperiosteoplasty","volume":"35","author":"Santiago","year":"1998","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.bjps.2015.09.004_bib3","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/0007-1226(83)90124-8","article-title":"An 11-year follow-up of the effects of early bone grafting in infants born with complete clefts of the lip and palate","volume":"36","author":"Robertson","year":"1983","journal-title":"Br J Plast Surg"},{"key":"10.1016\/j.bjps.2015.09.004_bib4","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1597\/1545-1569_1999_036_0284_sotaio_2.3.co_2","article-title":"State of the art in oral and maxillofacial surgery: treatment of maxillary hypoplasia and anterior palatal and alveolar clefts","volume":"36","author":"Steinberg","year":"1999","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.bjps.2015.09.004_bib5","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1097\/00001665-200311000-00005","article-title":"Management of alveolar clefts","volume":"14","author":"Bajaj","year":"2003","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.bjps.2015.09.004_bib6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0002-9416(76)90258-X","article-title":"Combined orthodontic-surgical management of residual palato-alveolar cleft defects","volume":"70","author":"Boyne","year":"1976","journal-title":"Am J Orthod"},{"key":"10.1016\/j.bjps.2015.09.004_bib7","first-page":"87","article-title":"Secondary bone grafting of residual alveolar and palatal clefts","volume":"30","author":"Boyne","year":"1972","journal-title":"J Oral Surg"},{"key":"10.1016\/j.bjps.2015.09.004_bib8","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1597\/1545-1569_1997_034_0455_eoabgi_2.3.co_2","article-title":"Effect of alveolar bone grafting in the mixed dentition on maxillary growth in complete unilateral cleft lip and palate patients","volume":"34","author":"Daskalogiannakis","year":"1997","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.bjps.2015.09.004_bib9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1597\/1545-1569_2002_039_0018_abgipw_2.0.co_2","article-title":"Alveolar bone grafting in patients with complete clefts: a comparative study between secondary and tertiary bone grafting","volume":"39","author":"Dempf","year":"2002","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.bjps.2015.09.004_bib10","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/0278-2391(90)90005-M","article-title":"Allogeneic bone for secondary alveolar cleft osteoplasty","volume":"48","author":"Maxson","year":"1990","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjps.2015.09.004_bib11","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.bjoms.2008.07.184","article-title":"Secondary alveolar bone grafting: the dilemma of donor site selection and morbidity","volume":"46","author":"Rawashdeh","year":"2008","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjps.2015.09.004_bib12","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1597\/1545-1569_1999_036_0144_sabgum_2.3.co_2","article-title":"Secondary alveolar bone grafting using milled cranial bone graft: a retrospective study of a consecutive series of 100 patients","volume":"36","author":"Denny","year":"1999","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.bjps.2015.09.004_bib13","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/00006534-199509001-00004","article-title":"A comparison of iliac and cranial bone in secondary grafting of alveolar clefts","volume":"96","author":"LaRossa","year":"1995","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2015.09.004_bib14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1010-5182(05)80102-7","article-title":"Timing and transplant materials for closure of alveolar clefts. A clinical comparison of 296 cases","volume":"21","author":"Freihofer","year":"1993","journal-title":"J Cranio Maxillofac Surg"},{"key":"10.1016\/j.bjps.2015.09.004_bib15","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1597\/03-158.1","article-title":"Morbidity of chin bone transplants used for reconstructing alveolar defects in cleft patients","volume":"42","author":"Booij","year":"2005","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.bjps.2015.09.004_bib16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bjoms.2008.05.014","article-title":"Retrospective review of donor site complications after harvest of cancellous bone from the anteriomedial tibia","volume":"47","author":"Walker","year":"2009","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjps.2015.09.004_bib17","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/hed.20452","article-title":"Donor site morbidity after harvesting of proximal tibia bone","volume":"28","author":"Chen","year":"2006","journal-title":"Head Neck"},{"key":"10.1016\/j.bjps.2015.09.004_bib18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/SCS.0b013e3181cf6084","article-title":"Secondary alveolar bone grafting: our experience with olecranon bone graft","volume":"21","author":"Nadal","year":"2010","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.bjps.2015.09.004_bib19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00784-011-0547-6","article-title":"Reconstruction of the alveolar cleft: can growth factor-aided tissue engineering replace autologous bone grafting? A literature review and systematic review of results obtained with bone morphogenetic protein-2","volume":"15","author":"van Hout","year":"2011","journal-title":"Clin Oral Invest"},{"key":"10.1016\/j.bjps.2015.09.004_bib20","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1089\/ten.tec.2009.0824","article-title":"Evaluation of maxillary alveolar reconstruction using a resorbable collagen sponge with recombinant human bone morphogenetic protein-2 in cleft lip and palate patients","volume":"16","author":"Alonso","year":"2010","journal-title":"Tissue Eng Method"},{"key":"10.1016\/j.bjps.2015.09.004_bib21","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0278-2391(03)00722-5","article-title":"Analysis of bone resorption after secondary alveolar cleft bone grafts before and after canine eruption in connection with orthodontic gap closure or prosthodontic treatment","volume":"61","author":"Schultze-Mosgau","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjps.2015.09.004_bib22","first-page":"9","article-title":"Canine eruption into grafted bone in maxillary alveolar cleft defects","volume":"19","author":"El Deeb","year":"1982","journal-title":"Cleft Palate J"},{"key":"10.1016\/j.bjps.2015.09.004_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1597\/1545-1569_1997_034_0195_raosaa_2.3.co_2","article-title":"Radiographic assessment of secondary autogenous alveolar bone grafting in cleft lip and palate patients","volume":"34","author":"Kindelan","year":"1997","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.bjps.2015.09.004_bib24","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.bjoms.2011.10.007","article-title":"Reliability of the Kindelan scoring system for alveolar bone grafting with and without a pre-graft occlusal radiograph in patients with cleft lip and palate","volume":"50","author":"Dobbyn","year":"2012","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjps.2015.09.004_bib25","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/0002-9416(84)90376-2","article-title":"Delayed bone grafting in the cleft maxilla and palate: a retrospective multidisciplinary analysis","volume":"86","author":"Turvey","year":"1984","journal-title":"Am J Orthod"},{"key":"10.1016\/j.bjps.2015.09.004_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bjoms.2005.04.015","article-title":"Morbidity at the iliac crest donor site following bone grafting of the cleft alveolus","volume":"44","author":"Swan","year":"2006","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.bjps.2015.09.004_bib27","first-page":"175","article-title":"Elimination of the residual alveolar cleft by secondary bone grafting and subsequent orthodontic treatment","volume":"23","author":"Bergland","year":"1986","journal-title":"Cleft Palate J"},{"key":"10.1016\/j.bjps.2015.09.004_bib28","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/oxfordjournals.ejo.a036006","article-title":"The influence of bone grafting age on dental abnormalities and alveolar bone height in patients with unilateral cleft lip and palate","volume":"11","author":"Brattstrom","year":"1989","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.bjps.2015.09.004_bib29","first-page":"513","article-title":"Secondary alveolar bone grafting\u2013five-year periodontal and radiographic evaluation in 100 consecutive cases","volume":"33","author":"Tan","year":"1996","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.bjps.2015.09.004_bib30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000337666","article-title":"Alveolar bone grafting","volume":"16","author":"Semb","year":"2012","journal-title":"Front Oral Biol"},{"key":"10.1016\/j.bjps.2015.09.004_bib31","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1597\/1545-1569_1997_034_0199_codcfp_2.3.co_2","article-title":"Comparison of 2-D calculations from periapical and occlusal radiographs versus 3-D calculations from CAT scans in determining bone support for cleft-adjacent teeth following early alveolar bone grafts","volume":"34","author":"Rosenstein","year":"1997","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.bjps.2015.09.004_bib32","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1097\/01.prs.0000293870.64781.12","article-title":"Reduced morbidity and improved healing with bone morphogenic protein-2 in older patients with alveolar cleft defects","volume":"121","author":"Dickinson","year":"2008","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2015.09.004_bib33","unstructured":"FDA public health notification: life threatening complications assocaited with recombinant human bone morphogenetic protein in cervical spine fusion (www.fda.gov\/cdrh\/safety\/070108-rhbmp.html)."},{"key":"10.1016\/j.bjps.2015.09.004_bib34","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1097\/00003086-199910001-00010","article-title":"Carrier system for bone morphogenetic proteins","volume":"367","author":"Winn","year":"1999","journal-title":"Clin Orthop"},{"key":"10.1016\/j.bjps.2015.09.004_bib35","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/(SICI)1097-4636(199908)46:2<193::AID-JBM8>3.0.CO;2-1","article-title":"Characterisation of rhBMP-2 pharmacokinetics implanted with bimaterial carriers in the rat ectopic model","volume":"46","author":"Uludag","year":"1999","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.bjps.2015.09.004_bib36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bjps.2012.08.015","article-title":"Alveolar bone healing accompanied by severe swelling in clfet children treated with bone morphogenetic protein-2 delivered by hydrogel","volume":"66","author":"Neovius","year":"2013","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"10.1016\/j.bjps.2015.09.004_bib37","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/BCO.0b013e32810c00f6","article-title":"The safety and utility of bone morphogenetic protein in anterrior and posterior cervical-spine fusions","volume":"18","author":"Lee","year":"2007","journal-title":"Curr Opin Orthop"}],"container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681515004374?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681515004374?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:37:55Z","timestamp":1761683875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681515004374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S1748681515004374"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2015.09.004","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The clinical application of rhBMP-7 for the reconstruction of\u00a0alveolar cleft","name":"articletitle","label":"Article Title"},{"value":"Journal of Plastic, Reconstructive & Aesthetic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjps.2015.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}