{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:20:29Z","timestamp":1782400829923,"version":"3.54.5"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG 3H0441"],"award-info":[{"award-number":["CMRPG 3H0441"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jprasurg.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.bjps.2019.07.010","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T02:04:06Z","timestamp":1565229846000},"page":"516-527","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Combination of mesenchymal stem cell-conditioned medium and botulinum toxin type A for treating human hypertrophic scars"],"prefix":"10.1016","volume":"73","author":[{"given":"Ching-Hsuan","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Wen","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6679-0020","authenticated-orcid":false,"given":"Chien-Wei","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Yung","family":"Chiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiow-Shuh","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jui-Yung","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5232-5374","authenticated-orcid":false,"given":"Oscar K.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjps.2019.07.010_bib0001","first-page":"27","article-title":"Recent advances in hypertrophic scar","volume":"33","author":"Zhang","year":"2018","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.bjps.2019.07.010_bib0002","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1097\/00006534-199910000-00031","article-title":"On the nature of hypertrophic scars and keloids: a review","volume":"104","author":"Niessen","year":"1999","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2019.07.010_bib0003","doi-asserted-by":"crossref","first-page":"e8353","DOI":"10.1097\/MD.0000000000008353","article-title":"Topical cryoanesthesia for the relief of pain caused by steroid injections used to treat hypertrophic scars and keloids","volume":"96","author":"Wang","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.bjps.2019.07.010_bib0004","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/j.1478-3231.2010.02364.x","article-title":"Transplantation of bone marrow cells reduces CCl4 -induced liver fibrosis in mice","volume":"31","author":"Cho","year":"2011","journal-title":"Liver Int"},{"key":"10.1016\/j.bjps.2019.07.010_bib0005","doi-asserted-by":"crossref","first-page":"666","DOI":"10.5999\/aps.2013.40.6.666","article-title":"Stem cells in plastic surgery: a review of current clinical and translational applications","volume":"40","author":"Salibian","year":"2013","journal-title":"Arch Plast Surg"},{"key":"10.1016\/j.bjps.2019.07.010_bib0006","first-page":"77","article-title":"Relaxin, cardiac stem cells and heart regeneration","volume":"118","author":"Formigli","year":"2013","journal-title":"Ital J Anat Embryol"},{"key":"10.1016\/j.bjps.2019.07.010_bib0007","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1159\/000492558","article-title":"Treatment efficiency of different routes of bone marrow-derived mesenchymal stem cell injection in rat liver fibrosis model","volume":"48","author":"Idriss","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.bjps.2019.07.010_bib0008","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s11033-008-9235-2","article-title":"Paracrine action mediate the antifibrotic effect of transplanted mesenchymal stem cells in a rat model of global heart failure","volume":"36","author":"Li","year":"2009","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.bjps.2019.07.010_bib0009","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s12967-014-0260-8","article-title":"A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods","volume":"12","author":"Madrigal","year":"2014","journal-title":"J Transl Med"},{"key":"10.1016\/j.bjps.2019.07.010_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2019.04.002","article-title":"The mesenchymal stem cell secretome: a new paradigm towards cell-free therapeutic mode in regenerative medicine","volume":"46","author":"PK","year":"2019","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.bjps.2019.07.010_bib0011","doi-asserted-by":"crossref","first-page":"e369","DOI":"10.11607\/jomi.te17","article-title":"Acceleration of wound healing with stem cell-derived growth factors","volume":"28","author":"Tamari","year":"2013","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.bjps.2019.07.010_bib0012","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13287-016-0356-6","article-title":"Adipose tissue-derived stem cells suppress hypertrophic scar fibrosis via the p38\/MAPK signaling pathway","volume":"7","author":"Li","year":"2016","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bjps.2019.07.010_bib0013","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/PRS.0000000000000504","article-title":"Adipose tissue-derived stromal cells inhibit TGF-beta1-induced differentiation of human dermal fibroblasts and keloid scar-derived fibroblasts in a paracrine fashion","volume":"134","author":"Spiekman","year":"2014","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2019.07.010_bib0014","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jdermsci.2016.03.003","article-title":"Bone marrow derived mesenchymal stem cells inhibit the proliferative and profibrotic phenotype of hypertrophic scar fibroblasts and keloid fibroblasts through paracrine signaling","volume":"83","author":"Fang","year":"2016","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.bjps.2019.07.010_bib0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13287-015-0133-y","article-title":"Intralesional injection of adipose-derived stem cells reduces hypertrophic scarring in a rabbit ear model","volume":"6","author":"Zhang","year":"2015","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bjps.2019.07.010_bib0016","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0031-6997(25)06852-8","article-title":"The origin, structure, and pharmacological activity of botulinum toxin","volume":"33","author":"Simpson","year":"1981","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.bjps.2019.07.010_bib0017","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/PRS.0000000000000416","article-title":"Botulinum toxin to improve results in cleft lip repair","volume":"134","author":"Chang","year":"2014","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2019.07.010_bib0018","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00266-009-9334-z","article-title":"Treatment of hypertrophic scars with intralesional botulinum toxin type A injections: a preliminary report","volume":"33","author":"Xiao","year":"2009","journal-title":"Aesthet Plast Surg"},{"key":"10.1016\/j.bjps.2019.07.010_bib0019","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.bjps.2008.05.003","article-title":"Botulinum toxin type A affects cell cycle distribution of fibroblasts derived from hypertrophic scar","volume":"61","author":"Zhibo","year":"2008","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"10.1016\/j.bjps.2019.07.010_bib0020","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s00266-009-9423-z","article-title":"Effect of botulinum toxin type A on transforming growth factor beta1 in fibroblasts derived from hypertrophic scar: a preliminary report","volume":"34","author":"Xiao","year":"2010","journal-title":"Aesthet Plast Surg"},{"issue":"Suppl 2","key":"10.1016\/j.bjps.2019.07.010_bib0021","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.1097\/SAP.0000000000000470","article-title":"Comparison of combination therapy (steroid, calcium channel blocker, and interferon) with steroid monotherapy for treating human hypertrophic scars in an animal model","volume":"74","author":"Yang","year":"2015","journal-title":"Ann Plast Surg"},{"issue":"Suppl 1","key":"10.1016\/j.bjps.2019.07.010_bib0022","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1097\/DSS.0000000000000990","article-title":"A comparison of gene expression of decorin and MMP13 in hypertrophic scars treated with calcium channel blocker, steroid, and interferon: a human-scar-carrying animal model study","volume":"43","author":"Yang","year":"2017","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.bjps.2019.07.010_bib0023","doi-asserted-by":"crossref","first-page":"43e","DOI":"10.1097\/PRS.0000000000003426","article-title":"Comparison of steroid and botulinum toxin type a monotherapy with combination therapy for treating human hypertrophic scars in an animal model","volume":"140","author":"Chen","year":"2017","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2019.07.010_bib0024","first-page":"1642","article-title":"Fibronectin is overproduced by keloid fibroblasts during abnormal wound healing","volume":"9","author":"Babu","year":"1989","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.bjps.2019.07.010_bib0025","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13287-017-0560-z","article-title":"Exosomes from mesenchymal stem cells induce the conversion of hepatocytes into progenitor oval cells","volume":"8","author":"Wu","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bjps.2019.07.010_bib0026","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1242\/jcs.02921","article-title":"Interactions of primary fibroblasts and keratinocytes with extracellular matrix proteins: contribution of alpha2beta1 integrin","volume":"119","author":"Zhang","year":"2006","journal-title":"J Cell Sci"},{"key":"10.1016\/j.bjps.2019.07.010_bib0027","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1479-5876-11-39","article-title":"Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and ERK1\/2","volume":"11","author":"Przybyt","year":"2013","journal-title":"J Transl Med"},{"key":"10.1016\/j.bjps.2019.07.010_bib0028","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.immunol.021908.132532","article-title":"Alternative activation of macrophages: an immunologic functional perspective","volume":"27","author":"Martinez","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.bjps.2019.07.010_bib0029","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1089\/wound.2012.0406","article-title":"Critical role of transforming growth factor beta in different phases of wound healing","volume":"2","author":"Pakyari","year":"2013","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"10.1016\/j.bjps.2019.07.010_bib0030","doi-asserted-by":"crossref","first-page":"12384","DOI":"10.1074\/jbc.M208544200","article-title":"Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase","volume":"278","author":"Thannickal","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bjps.2019.07.010_bib0031","doi-asserted-by":"crossref","DOI":"10.1002\/sctm.18-0126","article-title":"Cell therapy for heart regeneration: learning from the past to build a brighter future","author":"Gnecchi","year":"2018","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.bjps.2019.07.010_bib0032","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.3390\/ijms19102917","article-title":"Contribution of resident stem cells to liver and biliary tree regeneration in human diseases","author":"Overi","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bjps.2019.07.010_bib0033","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.21037\/jtd.2018.01.46","article-title":"Stem cell therapies for chronic obstructive pulmonary disease: current status of pre-clinical studies and clinical trials","volume":"10","author":"Sun","year":"2018","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.bjps.2019.07.010_bib0034","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/scrt526","article-title":"Mesenchymal stem cell-mediated suppression of hypertrophic scarring is p53 dependent in a rabbit ear model","volume":"5","author":"Liu","year":"2014","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bjps.2019.07.010_bib0035","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.scr.2011.01.004","article-title":"Serum-deprived human multipotent mesenchymal stromal cells (MSCs) are highly angiogenic","volume":"6","author":"Oskowitz","year":"2011","journal-title":"Stem Cell Res"},{"key":"10.1016\/j.bjps.2019.07.010_bib0036","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1089\/wound.2017.0775","article-title":"Human adipose-derived stem cell conditioned media and exosomes containing MALAT1 promote human dermal fibroblast migration and ischemic wound healing","volume":"7","author":"Cooper","year":"2018","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"10.1016\/j.bjps.2019.07.010_bib0037","doi-asserted-by":"crossref","first-page":"18019","DOI":"10.1038\/s41598-017-18144-w","article-title":"Mesenchymal stem cell-conditioned medium reduces disease severity and immune responses in inflammatory arthritis","volume":"7","author":"Kay","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.bjps.2019.07.010_bib0038","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115690","article-title":"Botulinum toxin to improve results in cleft lip repair: a double-blinded, randomized, vehicle-controlled clinical trial","volume":"9","author":"Chang","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bjps.2019.07.010_bib0039","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00266-017-0803-5","article-title":"Effect of BTXA on inhibiting hypertrophic scar formation in a rabbit ear model","volume":"41","author":"Liu","year":"2017","journal-title":"Aesthet Plast Surg"},{"key":"10.1016\/j.bjps.2019.07.010_bib0040","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.3390\/molecules17022169","article-title":"Effects of botulinum toxin type a on collagen deposition in hypertrophic scars","volume":"17","author":"Xiao","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.bjps.2019.07.010_bib0041","first-page":"1603","article-title":"Intralesional treatments for hypertrophic scars: comparison among corticosteroid, 5-fluorouracil and botulinum toxin in rabbit ear hypertrophic scar model","volume":"20","author":"Caliskan","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.bjps.2019.07.010_bib0042","article-title":"Botulinum neurotoxin type A induces TLR2-mediated inflammatory responses in macrophages","volume":"10","author":"Kim","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bjps.2019.07.010_bib0043","doi-asserted-by":"crossref","first-page":"S133","DOI":"10.1097\/00002508-200211001-00004","article-title":"Considering the immune response to botulinum toxin","volume":"18","author":"Critchfield","year":"2002","journal-title":"Clin J Pain"},{"key":"10.1016\/j.bjps.2019.07.010_bib0044","first-page":"11","article-title":"Neutralizing antibodies to botulinum neurotoxin type A in aesthetic medicine: five case reports","volume":"7","author":"Torres","year":"2014","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"10.1016\/j.bjps.2019.07.010_bib0045","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/1534734608320786","article-title":"The use of corticosteroids to treat keloids: a review","volume":"7","author":"Roques","year":"2008","journal-title":"Int J Low Extrem Wounds"}],"container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681519303444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681519303444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:41:13Z","timestamp":1761684073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681519303444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S1748681519303444"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2019.07.010","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combination of mesenchymal stem cell-conditioned medium and botulinum toxin type A for treating human hypertrophic scars","name":"articletitle","label":"Article Title"},{"value":"Journal of Plastic, Reconstructive & Aesthetic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjps.2019.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}