{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:04:08Z","timestamp":1774926248042,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministerstwo Nauki i Szkolnictwa Wy\u017cszego","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004166","name":"Warszawski Uniwersytet Medyczny","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jprasurg.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.bjps.2019.10.011","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T12:04:33Z","timestamp":1570795473000},"page":"222-230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Neuroregenerative effects of polyethylene glycol and FK-506 in a rat model of sciatic nerve injury"],"prefix":"10.1016","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0557-1588","authenticated-orcid":false,"given":"Adriana M.","family":"Paskal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiktor","family":"Paskal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7161-163X","authenticated-orcid":false,"given":"Piotr","family":"Pietruski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zofia","family":"Kusmierczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Jankowska-Steifer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslaw","family":"Andrychowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawel K.","family":"Wlodarski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjps.2019.10.011_bib0001","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1136\/bmj.2.4260.237","article-title":"A classification of nerve injuries","volume":"2","author":"Seddon","year":"1942","journal-title":"Br Med J"},{"key":"10.1016\/j.bjps.2019.10.011_bib0002","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1113\/jphysiol.1943.sp004027","article-title":"Rate of regeneration of peripheral nerves in man","volume":"102","author":"Seddon","year":"1943","journal-title":"J Physiol"},{"key":"10.1016\/j.bjps.2019.10.011_bib0003","doi-asserted-by":"crossref","first-page":"5325","DOI":"10.1523\/JNEUROSCI.6156-10.2011","article-title":"The basis for diminished functional recovery after delayed peripheral nerve repair","volume":"31","author":"Gordon","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.bjps.2019.10.011_bib0004","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s13311-015-0415-1","article-title":"Electrical stimulation to enhance axon regeneration after peripheral nerve injuries in animal models and humans","volume":"13","author":"Gordon","year":"2016","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bjps.2019.10.011_bib0005","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/01.prs.0000227628.43867.5b","article-title":"Neuroregenerative effects of preinjury fk-506 administration","volume":"118","author":"Snyder","year":"2006","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2019.10.011_bib0006","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.expneurol.2014.09.006","article-title":"Improving peripheral nerve regeneration: from molecular mechanisms to potential therapeutic targets","volume":"261","author":"Chan","year":"2014","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bjps.2019.10.011_bib0007","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1097\/PRS.0000000000000226","article-title":"Nerve conduits for peripheral nerve surgery","volume":"133","author":"Pabari","year":"2014","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2019.10.011_bib0008","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.hcl.2013.04.012","article-title":"Evidence and techniques in rehabilitation following nerve injuries","volume":"29","author":"Novak","year":"2013","journal-title":"Hand Clin"},{"key":"10.1016\/j.bjps.2019.10.011_bib0009","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/bmb\/ldr005","article-title":"Non-surgical therapies for peripheral nerve injury","volume":"100","author":"Martinez de Albornoz","year":"2011","journal-title":"Br Med Bull"},{"key":"10.1016\/j.bjps.2019.10.011_bib0010","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1152\/jn.01051.2009","article-title":"Polyethylene glycol rapidly restores axonal integrity and improves the rate of motor behavior recovery after sciatic nerve crush injury","volume":"104","author":"Britt","year":"2010","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.bjps.2019.10.011_bib0011","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/jnr.23514","article-title":"Polyethylene glycol-fused allografts produce rapid behavioral recovery after ablation of sciatic nerve segments","volume":"93","author":"Riley","year":"2015","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.bjps.2019.10.011_bib0012","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/jnr.23023","article-title":"Rapid, effective, and long-lasting behavioral recovery produced by microsutures, methylene blue, and polyethylene glycol after completely cutting rat sciatic nerves","volume":"90","author":"Bittner","year":"2012","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.bjps.2019.10.011_bib0013","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20061478","article-title":"Polyethylene glycol: the future of posttraumatic nerve repair? Systemic review","volume":"20","author":"Paskal","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bjps.2019.10.011_bib0014","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.4103\/1673-5374.187019","article-title":"Repair of traumatic plasmalemmal damage to neurons and other eukaryotic cells","volume":"11","author":"Bittner","year":"2016","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.bjps.2019.10.011_bib0015","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/cns.12713","article-title":"Polyethylene glycol-induced motor recovery after total spinal transection in rats","volume":"23","author":"Ren","year":"2017","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.bjps.2019.10.011_bib0016","first-page":"16","article-title":"Preliminary investigation of a polyethylene glycol hydrogel \"nerve glue\"","volume":"4","author":"Isaacs","year":"2009","journal-title":"J Brachial Plex Peripher Nerve Inj"},{"key":"10.1016\/j.bjps.2019.10.011_bib0017","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1055\/s-0032-1333316","article-title":"Fk506 and nerve regeneration: past, present, and future","volume":"29","author":"Konofaos","year":"2013","journal-title":"J Reconstr Microsurg"},{"key":"10.1016\/j.bjps.2019.10.011_bib0018","doi-asserted-by":"crossref","first-page":"7509","DOI":"10.1523\/JNEUROSCI.15-11-07509.1995","article-title":"The immunosuppressant fk506 increases the rate of axonal regeneration in rat sciatic nerve","volume":"15","author":"Gold","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.bjps.2019.10.011_bib0019","doi-asserted-by":"crossref","first-page":"A105","DOI":"10.1227\/01.NEU.0000358537.30354.63","article-title":"Role of chronic schwann cell denervation in poor functional recovery after nerve injuries and experimental strategies to combat it","volume":"65","author":"Sulaiman","year":"2009","journal-title":"Neurosurgery"},{"key":"10.1016\/j.bjps.2019.10.011_bib0020","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1177\/1545968311431965","article-title":"Efficacy of short-term fk506 administration on accelerating nerve regeneration","volume":"26","author":"Yan","year":"2012","journal-title":"Neurorehabil Neural Repair"},{"key":"10.1016\/j.bjps.2019.10.011_bib0021","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1097\/00006534-199906000-00018","article-title":"Fk506 accelerates functional recovery following nerve grafting in a rat model","volume":"103","author":"Doolabh","year":"1999","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2019.10.011_bib0022","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1097\/01.PRS.0000091167.27303.18","article-title":"Dose-dependent effects of fk506 on neuroregeneration in a rat model","volume":"112","author":"Yang","year":"2003","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2019.10.011_bib0023","first-page":"287","article-title":"The immunosuppressant fk506 increases functional recovery and nerve regeneration following peripheral nerve injury","volume":"6","author":"Gold","year":"1994","journal-title":"Restor Neurol Neurosci"},{"key":"10.1016\/j.bjps.2019.10.011_bib0024","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1016\/j.bjps.2013.09.024","article-title":"Effects of fk-506 and ctla4-ig on nerve allografts in mice","volume":"67","author":"Kim","year":"2014","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"10.1016\/j.bjps.2019.10.011_bib0025","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000076565","article-title":"Fk506 requires stimulation of the extracellular signal-regulated kinase 1\/2 and the steroid receptor chaperone protein p23 for neurite elongation","volume":"13","author":"Gold","year":"2004","journal-title":"Neurosignals"},{"key":"10.1016\/j.bjps.2019.10.011_bib0026","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00006534-198901000-00024","article-title":"Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat","volume":"83","author":"Bain","year":"1989","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2019.10.011_bib0027","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1097\/PRS.0000000000001822","article-title":"The effect of autologous fat graft with different surgical repair methods on nerve regeneration in a rat sciatic nerve defect model","volume":"136","author":"Tuncel","year":"2015","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2019.10.011_bib0028","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jss.2012.03.049","article-title":"Hydrophilic polymers enhance early functional outcomes after nerve autografting","volume":"177","author":"Sexton","year":"2012","journal-title":"J Surg Res"},{"key":"10.1016\/j.bjps.2019.10.011_bib0029","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1038\/nprot.2010.128","article-title":"A semiautomated targeted sampling method to assess optic nerve axonal loss in a rat model of glaucoma","volume":"5","author":"Marina","year":"2010","journal-title":"Nat Protoc"},{"key":"10.1016\/j.bjps.2019.10.011_bib0030","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.bjps.2019.10.011_bib0031","series-title":"Contrast limited adaptive histograph equalization. Graphic gems IV","first-page":"474","author":"Zuiderveld","year":"1994"},{"key":"10.1016\/j.bjps.2019.10.011_bib0032","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2144\/000112257","article-title":"Cellprofiler: free, versatile software for automated biological image analysis","volume":"42","author":"Lamprecht","year":"2007","journal-title":"BioTechniques"},{"key":"10.1016\/j.bjps.2019.10.011_bib0033","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/micr.1920140507","article-title":"Autotomy and the sciatic functional index","volume":"14","author":"Weber","year":"1993","journal-title":"Microsurgery"},{"key":"10.1016\/j.bjps.2019.10.011_bib0034","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00005072-198501000-00006","article-title":"A new approach toward analyzing peripheral nerve fiber populations. II. Foreshortening of regenerated internodes corresponds to reduced sheath thickness","volume":"44","author":"Beuche","year":"1985","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.bjps.2019.10.011_bib0035","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/jnr.23734","article-title":"Polyethylene glycol fusion repair prevents reinnervation accuracy in rat peripheral nerve","volume":"94","author":"Robinson","year":"2016","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.bjps.2019.10.011_bib0036","first-page":"1244","article-title":"Complications of immunosuppressive agents therapy in transplant patients","volume":"81","author":"Reske","year":"2015","journal-title":"Minerva Anestesiol"},{"key":"10.1016\/j.bjps.2019.10.011_bib0037","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/229255030301100110","article-title":"The effects of cold preservation and subimmunosuppressive doses of fk506 on axonal regeneration in murine peripheral nerve isografts","volume":"11","author":"Myckatyn","year":"2003","journal-title":"Can J Plast Surg"},{"key":"10.1016\/j.bjps.2019.10.011_bib0038","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1055\/s-2006-956239","article-title":"Effects of intrathecal administration of fk506 after sciatic nerve crush injury","volume":"22","author":"Sarikcioglu","year":"2006","journal-title":"J Reconstr Microsurg"},{"key":"10.1016\/j.bjps.2019.10.011_bib0039","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s10571-007-9221-6","article-title":"Fk506 protects neurons following peripheral nerve injury via immunosuppression","volume":"27","author":"Saxena","year":"2007","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.bjps.2019.10.011_bib0040","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/SHK.0000000000000628","article-title":"Controlled delivery of fk506 to improve nerve regeneration","volume":"46","author":"Labroo","year":"2016","journal-title":"Shock"}],"container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681519304723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681519304723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:39:27Z","timestamp":1761683967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681519304723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S1748681519304723"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2019.10.011","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroregenerative effects of polyethylene glycol and FK-506 in a rat model of sciatic nerve injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Plastic, Reconstructive & Aesthetic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjps.2019.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}