{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:54:46Z","timestamp":1779310486663,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jprasurg.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.bjps.2021.11.074","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T11:45:44Z","timestamp":1638272744000},"page":"1360-1371","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Impact of Metabolic Syndrome on Microvascular Head and Neck Reconstruction: An ACS-NSQIP data analysis"],"prefix":"10.1016","volume":"75","author":[{"given":"Adriana C.","family":"Panayi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin","family":"Haug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Kauke-Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannick F.","family":"Diehm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bohdan","family":"Pomahac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjps.2021.11.074_bib0001","article-title":"Overview of the metabolic syndrome; an emerging pandemic of public health significance","author":"Oladejo","year":"2011","journal-title":"Ann. Ibadan Postgrad. Med."},{"key":"10.1016\/j.bjps.2021.11.074_bib0002","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2015.4260","article-title":"Prevalence of the metabolic syndrome in the United States, 2003-2012","author":"Aguilar","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.bjps.2021.11.074_bib0003","doi-asserted-by":"crossref","DOI":"10.1093\/bja\/aev199","article-title":"Impact of metabolic syndrome in surgical patients: Should we bother?","author":"Tzimas","year":"2015","journal-title":"British Journal of Anaesthesia"},{"key":"10.1016\/j.bjps.2021.11.074_bib0004","doi-asserted-by":"crossref","DOI":"10.2174\/15701611113116660171","article-title":"Hemostatic Factors and the Metabolic Syndrome","author":"Kostapanos","year":"2014","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.bjps.2021.11.074_bib0005","doi-asserted-by":"crossref","DOI":"10.1007\/s12630-012-9760-2","article-title":"Perioperative management of the severely obese patient: A selective pathophysiological review","author":"Cullen","year":"2012","journal-title":"Can. J. Anesth."},{"key":"10.1016\/j.bjps.2021.11.074_bib0006","article-title":"Effect of metabolic syndrome on perioperative outcomes after liver surgery: A National Surgical Quality Improvement Program (NSQIP) analysis","author":"Bhayani","year":"2012","journal-title":"Surg. (United States)"},{"key":"10.1016\/j.bjps.2021.11.074_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjsurg.2019.12.021","article-title":"Association of metabolic syndrome with morbidity and mortality in emergency general surgery","author":"Elsamna","year":"2020","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.bjps.2021.11.074_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.arth.2011.06.027","article-title":"Quantifying Cardiovascular Risks in Patients With Metabolic Syndrome Undergoing Total Joint Arthroplasty","author":"Gandhi","year":"2012","journal-title":"J. Arthroplasty"},{"key":"10.1016\/j.bjps.2021.11.074_bib0009","doi-asserted-by":"crossref","DOI":"10.3325\/cmj.2013.54.355","article-title":"Metabolic syndrome increases risk for pulmonary embolism after hip and knee arthroplasty","author":"Mraovic","year":"2013","journal-title":"Croat. Med. J."},{"key":"10.1016\/j.bjps.2021.11.074_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.arth.2012.04.011","article-title":"The Metabolic Syndrome in Patients Undergoing Knee and Hip Arthroplasty. Trends and In-Hospital Outcomes in the United States","author":"Gonzalez Della Valle","year":"2012","journal-title":"J. Arthroplasty"},{"key":"10.1016\/j.bjps.2021.11.074_bib0011","doi-asserted-by":"crossref","DOI":"10.1097\/BRS.0b013e31823a3a13","article-title":"Metabolic syndrome and lumbar spine fusion surgery: Epidemiology and perioperative outcomes","author":"Memtsoudis","year":"2012","journal-title":"Spine (Phila. Pa. 1976)"},{"key":"10.1016\/j.bjps.2021.11.074_bib0012","doi-asserted-by":"crossref","DOI":"10.1001\/jamafacial.2018.1176","article-title":"Association of Smoking Tobacco with Complications in Head and Neck Microvascular Reconstructive Surgery","volume":"21","author":"Crippen","year":"2019","journal-title":"JAMA Facial Plast. Surg."},{"key":"10.1016\/j.bjps.2021.11.074_bib0013","doi-asserted-by":"crossref","DOI":"10.1002\/lary.26813","article-title":"Tobacco exposure and wound healing in head and neck surgical wounds","volume":"128","author":"Lassig","year":"2018","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bjps.2021.11.074_bib0014","doi-asserted-by":"crossref","DOI":"10.1097\/SLA.0b013e31824f632d","article-title":"Wound healing and infection in surgery: The pathophysiological impact of smoking, smoking cessation, and nicotine replacement therapy: A systematic review","volume":"255","author":"S\u00f8rensen","year":"2012","journal-title":"Annals of Surgery"},{"key":"10.1016\/j.bjps.2021.11.074_bib0015","doi-asserted-by":"crossref","DOI":"10.1002\/hed.10291","article-title":"Comorbid condition as a prognostic factor for complications in major surgery of the oral cavity and oropharynx with microvascular soft tissue reconstruction","author":"Borggreven","year":"2003","journal-title":"Head Neck"},{"key":"10.1016\/j.bjps.2021.11.074_bib0016","doi-asserted-by":"crossref","DOI":"10.1097\/00005537-200002010-00005","article-title":"Length of stay after free flap reconstruction of the head and neck","author":"Ryan","year":"2000","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bjps.2021.11.074_bib0017","doi-asserted-by":"crossref","DOI":"10.1097\/00006534-199902000-00007","article-title":"Factors associated with complications in microvascular reconstruction of head and neck defects","author":"Singh","year":"1999","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.bjps.2021.11.074_bib0018","doi-asserted-by":"crossref","DOI":"10.1001\/archotol.130.8.962","article-title":"Analysis of outcome and complications in 400 cases of microvascular head and neck reconstruction","author":"Suh","year":"2004","journal-title":"Arch. Otolaryngol. - Head Neck Surg."},{"key":"10.1016\/j.bjps.2021.11.074_bib0019","doi-asserted-by":"crossref","DOI":"10.1111\/coa.12730","article-title":"A national analysis of trends, outcomes and volume\u2013outcome relationships in thyroid surgery","volume":"42","author":"Nouraei","year":"2017","journal-title":"Clin. Otolaryngol."},{"key":"10.1016\/j.bjps.2021.11.074_bib0020","article-title":"Evaluating the impact of metabolic syndrome on postoperative thyroidectomy outcomes","author":"Elsamna","year":"2020","journal-title":"Head Neck"},{"key":"10.1016\/j.bjps.2021.11.074_bib0021","article-title":"Metabolic syndrome is associated with increased postoperative complications and use of hospital resources in patients undergoing laparoscopic adrenalectomy","author":"Shariq","year":"2018","journal-title":"Surg. (United States)"},{"key":"10.1016\/j.bjps.2021.11.074_bib0022","doi-asserted-by":"crossref","DOI":"10.1007\/s11605-015-3007-9","article-title":"Metabolic Syndrome is Associated with Increased Postoperative Morbidity and Hospital Resource Utilization in Patients Undergoing Elective Pancreatectomy","author":"Tee","year":"2016","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.bjps.2021.11.074_bib0023","doi-asserted-by":"crossref","DOI":"10.1080\/2000656X.2019.1626738","article-title":"Risk factors associated with the development of sepsis after reconstructive flap surgery*","volume":"53","author":"Sparenberg","year":"2019","journal-title":"Journal of Plastic Surgery and Hand Surgery"},{"key":"10.1016\/j.bjps.2021.11.074_bib0024","doi-asserted-by":"crossref","DOI":"10.1097\/BRS.0000000000002397","article-title":"Metabolic Syndrome and 30-Day Outcomes in Elective Lumbar Spinal Fusion","author":"Chung","year":"2018","journal-title":"Spine (Phila. Pa. 1976)"},{"key":"10.1016\/j.bjps.2021.11.074_bib0025","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2018.00189","article-title":"Molecular regulatory pathways link sepsis with metabolic syndrome: Non-coding RNA elements underlying the sepsis\/metabolic cross-talk","author":"Meydan","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bjps.2021.11.074_bib0026","doi-asserted-by":"crossref","DOI":"10.1530\/JOE-14-0283","article-title":"The role of adipose tissue immune cells in obesity and low-grade inflammation","author":"Mraz","year":"2014","journal-title":"Journal of Endocrinology"},{"key":"10.1016\/j.bjps.2021.11.074_bib0027","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1007\/s11695-019-04360-y","article-title":"The Impact of Metabolic Syndrome on Patients Undergoing Breast Reduction Surgery","volume":"30","author":"Riddle","year":"2020","journal-title":"Obes Surg"},{"key":"10.1016\/j.bjps.2021.11.074_bib0028","doi-asserted-by":"crossref","DOI":"10.1055\/s-0038-1627449","article-title":"Impact of Obesity on Outcomes in Breast Reconstruction: A Systematic Review and Meta-Analysis","volume":"34","author":"Panayi","year":"2018","journal-title":"J. Reconstr. Microsurg."},{"key":"10.1016\/j.bjps.2021.11.074_bib0029","article-title":"Factors affecting wound complications in head and neck surgery: A prospective study","volume":"34","author":"Chaukar","year":"2013","journal-title":"Indian J. Med. Paediatr. Oncol."},{"key":"10.1016\/j.bjps.2021.11.074_bib0030","doi-asserted-by":"crossref","DOI":"10.1177\/019459988709600209","article-title":"A predictive model for wound sepsis in oncologic surgery of the head and neck","volume":"96","author":"Cole","year":"1987","journal-title":"Otolaryngol. - Head Neck Surg."},{"key":"10.1016\/j.bjps.2021.11.074_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjsurg.2018.11.020","article-title":"Impact of frailty on outcomes in surgical patients: A systematic review and meta-analysis","volume":"218","author":"Panayi","year":"2019","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.bjps.2021.11.074_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.cger.2016.01.004","article-title":"Assessing Risks and Benefits of Invasive Cardiac Procedures in Patients with Advanced Multimorbidity","author":"Orkaby","year":"2016","journal-title":"Clinics in Geriatric Medicine"},{"key":"10.1016\/j.bjps.2021.11.074_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjoto.2021.103121","article-title":"The modified 5-item frailty index is a predictor of perioperative risk in head and neck microvascular reconstruction: An analysis of 3795 cases","volume":"42","author":"Panayi","year":"2021","journal-title":"Am. J. Otolaryngol."},{"key":"10.1016\/j.bjps.2021.11.074_bib0034","article-title":"Combined (endo-)vascular intervention and microsurgical lower extremity free flap reconstruction\u2013 A propensity score matching analysis in 5386 ACS-NSQIP patients","author":"Haug","year":"2020","journal-title":"J. Plast. Reconstr. Aesthetic Surg."},{"key":"10.1016\/j.bjps.2021.11.074_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jamcollsurg.2009.09.031","article-title":"Toward Robust Information: Data Quality and Inter-Rater Reliability in the American College of Surgeons National Surgical Quality Improvement Program","author":"Shiloach","year":"2010","journal-title":"J. Am. Coll. Surg."}],"container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681521006185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681521006185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:46:10Z","timestamp":1761684370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681521006185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S1748681521006185"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2021.11.074","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Impact of Metabolic Syndrome on Microvascular Head and Neck Reconstruction: An ACS-NSQIP data analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Plastic, Reconstructive & Aesthetic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjps.2021.11.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.","name":"copyright","label":"Copyright"}]}}