{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:27:33Z","timestamp":1780414053135,"version":"3.54.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jprasurg.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.bjps.2022.06.104","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T02:22:09Z","timestamp":1656469329000},"page":"4221-4232","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["In search of the optimal pain management strategy for children undergoing cleft lip and palate repair: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4306-0014","authenticated-orcid":false,"given":"Alexander","family":"Morzycki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4002-4598","authenticated-orcid":false,"given":"Kevin","family":"Nickel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Cho","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0117-3478","authenticated-orcid":false,"given":"Regan","family":"Guilfoyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bjps.2022.06.104_bib0001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/ejo\/26.1.7","article-title":"The complex genetics of cleft lip and palate","volume":"26","author":"Cobourne","year":"2004","journal-title":"Eur J Orthod"},{"issue":"9","key":"10.1016\/j.bjps.2022.06.104_bib0002","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1177\/1055665618764516","article-title":"Opioid sparing in cleft palate surgery","volume":"55","author":"Carr","year":"2018","journal-title":"Cleft Palate-Craniofacial J"},{"key":"10.1016\/j.bjps.2022.06.104_bib0003","doi-asserted-by":"crossref","DOI":"10.1097\/00000539-200204000-00015","article-title":"Postoperative pain relief in children undergoing tympanomastoid surgery: is a regional block better than opioids?","author":"Suresh","year":"2002","journal-title":"Anesth Analg"},{"issue":"1","key":"10.1016\/j.bjps.2022.06.104_bib0004","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0022-3468(85)80390-0","article-title":"Can the human neonate mount an endocrine and metabolic response to surgery?","volume":"20","author":"Anand","year":"1985","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.bjps.2022.06.104_bib0005","doi-asserted-by":"crossref","DOI":"10.1111\/j.1460-9592.1992.tb00189.x","article-title":"Anaesthesia for primary repair of cleft lip and cleft palate: a review of 244 procedures","author":"Doyle","year":"1992","journal-title":"Pediatr Anesth"},{"issue":"2","key":"10.1016\/j.bjps.2022.06.104_bib0006","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/028443101300165318","article-title":"Identification of children at high anaesthetic risk at the time of primary palatoplasty","volume":"35","author":"Henriksson","year":"2001","journal-title":"Scand J Plast Reconstr Surg Hand Surg"},{"issue":"2","key":"10.1016\/j.bjps.2022.06.104_bib0007","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1597\/1545-1569_2002_039_0145_aofpao_2.0.co_2","article-title":"Airway obstruction following palatoplasty: analysis of consecutive operations","volume":"39","author":"Antony","year":"2002","journal-title":"Cleft Palate-Craniofacial J"},{"issue":"3","key":"10.1016\/j.bjps.2022.06.104_bib0008","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/028443101750523186","article-title":"Risk factors in children having palatoplasty","volume":"35","author":"Henriksson","year":"2001","journal-title":"Scand J Plast Reconstr Surg Hand Surg"},{"issue":"6","key":"10.1016\/j.bjps.2022.06.104_bib0009","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1097\/ALN.0000000000000171","article-title":"Bilateral suprazygomatic maxillary nerve block for cleft palate repair in children","volume":"120","author":"Chiono","year":"2014","journal-title":"Anesthesiology"},{"issue":"6","key":"10.1016\/j.bjps.2022.06.104_bib0010","first-page":"654","article-title":"Comparative study of greater palatine nerve block and intravenous pethidine for postoperative analgesia in children undergoing palatoplasty","volume":"53","author":"Kamath","year":"2009","journal-title":"Indian J Anaesth"},{"issue":"1","key":"10.1016\/j.bjps.2022.06.104_bib0011","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/02844319950159668","article-title":"Bilateral infraobital nerve block is superior to peri-incisional infiltration for analgesia after repair of cleft lip","volume":"33","author":"Prabhu","year":"1999","journal-title":"Scand J Plast Reconstr Surg Hand Surg"},{"key":"10.1016\/j.bjps.2022.06.104_bib0012","doi-asserted-by":"crossref","first-page":"276","DOI":"10.11613\/BM.2012.031","article-title":"Interrater reliability: the kappa statistic","author":"McHugh","year":"2012","journal-title":"Biochem Medica"},{"issue":"8","key":"10.1016\/j.bjps.2022.06.104_bib0013","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1460-9592.2010.03347.x","article-title":"Efficacy of palatal block for analgesia following palatoplasty in children with cleft palate","volume":"20","author":"Jonnavithula","year":"2010","journal-title":"Pediatr Anesth"},{"issue":"3","key":"10.1016\/j.bjps.2022.06.104_bib0014","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.egja.2018.05.003","article-title":"Bilateral suprazygomatic maxillary nerve block versus palatal block for cleft palate repair in children: a randomized controlled trial","volume":"34","author":"Abu Elyazed","year":"2018","journal-title":"Egypt J Anaesth"},{"issue":"9","key":"10.1016\/j.bjps.2022.06.104_bib0015","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.joms.2018.03.037","article-title":"Does sphenopalatine ganglion block improve pain control and intraoperative hemodynamics in children undergoing palatoplasty? A randomized controlled trial","volume":"76","author":"Parameswaran","year":"2018","journal-title":"J Oral Maxillofac Surg"},{"issue":"9","key":"10.1016\/j.bjps.2022.06.104_bib0016","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1460-9592.2012.03861.x","article-title":"Ultrasound guidance characteristics and efficiency of suprazygomatic maxillary nerve blocks in infants: a descriptive prospective study","volume":"22","author":"Sola","year":"2012","journal-title":"Pediatr Anesth"},{"issue":"3","key":"10.1016\/j.bjps.2022.06.104_bib0017","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/EJA.0b013e3283347c15","article-title":"Addition of dexmedetomidine to bupivacaine for greater palatine nerve block prolongs postoperative analgesia after cleft palate repair","volume":"27","author":"Obayah","year":"2010","journal-title":"Eur J Anaesthesiol"},{"issue":"5","key":"10.1016\/j.bjps.2022.06.104_bib0018","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1097\/SCS.0b013e31822ea7fd","article-title":"Effect of rectal diclofenac and acetaminophen alone and in combination on postoperative pain after cleft palate repair in children","volume":"22","author":"Mireskandari","year":"2011","journal-title":"J Craniofac Surg"},{"issue":"5","key":"10.1016\/j.bjps.2022.06.104_bib0019","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1597\/06-206.1","article-title":"Comparison of codeine phosphate and morphine sulphate in infants undergoing cleft palate repair","volume":"44","author":"Fenlon","year":"2007","journal-title":"Cleft Palate-Craniofac J"},{"issue":"5","key":"10.1016\/j.bjps.2022.06.104_bib0020","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1097\/SCS.0b013e31848432e4","article-title":"Effects of preoperative local ropivacaine infiltration on postoperative pain scores in infants and small children undergoing elective cleft palate repair","volume":"19","author":"Coban","year":"2008","journal-title":"J Craniofac Surg"},{"issue":"2","key":"10.1016\/j.bjps.2022.06.104_bib0021","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4097\/kjae.2018.71.2.135","article-title":"Comparative study of levobupivacaine and bupivacaine for bilateral maxillary nerve block during pediatric primary cleft palate surgery: a randomized double-blind controlled study","volume":"71","author":"Mostafa","year":"2018","journal-title":"Korean J Anesthesiol"},{"issue":"4","key":"10.1016\/j.bjps.2022.06.104_bib0022","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1097\/00000539-200104000-00020","article-title":"Prophylactically-administered rectal acetaminophen does not reduce postoperative opioid requirements in infants and small children undergoing elective cleft palate repair","volume":"92","author":"Bremerich","year":"2001","journal-title":"Anesth Analg"},{"issue":"6","key":"10.1016\/j.bjps.2022.06.104_bib0023","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/pan.12393","article-title":"Analgesic effectiveness of acetaminophen for primary cleft palate repair in young children: a randomized placebo controlled trial","volume":"24","author":"Nour","year":"2014","journal-title":"Pediatr Anesth"},{"issue":"2","key":"10.1016\/j.bjps.2022.06.104_bib0025","first-page":"111","article-title":"Role of bilateral suprazygomatic maxillary nerve block in primary surgery for soft palate cleft and soft-hard palate cleft","volume":"3","author":"Binet","year":"2015","journal-title":"Pediatr Anesth Crit Care J"},{"issue":"4","key":"10.1016\/j.bjps.2022.06.104_bib0026","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1460-9592.2010.03262.x","article-title":"A new approach for peri-operative analgesia of cleft palate repair in infants: the bilateral suprazygomatic maxillary nerve block","volume":"20","author":"Mesnil","year":"2010","journal-title":"Pediatr Anesth"},{"issue":"5","key":"10.1016\/j.bjps.2022.06.104_bib0027","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/pan.12124","article-title":"A randomized study of surgical site infiltration with bupivacaine or ketamine for pain relief in children following cleft palate repair","volume":"23","author":"Jha","year":"2013","journal-title":"Pediatr Anesth"},{"issue":"3","key":"10.1016\/j.bjps.2022.06.104_bib0028","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3109\/02844319109020629","article-title":"Bilateral infraorbital block with 0.5% bupivacaine as post-operative analgesia following cheiloplasty in children","volume":"25","author":"Nicodemus","year":"1991","journal-title":"Scand J Plast Reconstr Surg Hand Surg"},{"issue":"1","key":"10.1016\/j.bjps.2022.06.104_bib0029","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/SAP.0b013e3181851b8e","article-title":"Bilateral extraoral, infraorbital nerve block for postoperative pain relief after cleft lip repair in pediatric patients","volume":"63","author":"Takmaz","year":"2009","journal-title":"Ann Plast Surg"},{"issue":"2","key":"10.1016\/j.bjps.2022.06.104_bib0030","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1055\/s-0039-1697220","article-title":"Comparison of preoperative infraorbital block and peri-incisional infiltration for postoperative pain relief in cleft lip surgeries","volume":"37","author":"Gaonkar","year":"2004","journal-title":"Indian J Plast Surg"},{"issue":"2","key":"10.1016\/j.bjps.2022.06.104_bib0031","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1460-9592.2006.02032.x","article-title":"A comparison of bilateral infraorbital nerve block with intravenous fentanyl for analgesia following cleft lip repair in children","volume":"17","author":"Rajamani","year":"2007","journal-title":"Pediatr Anesth"},{"issue":"11","key":"10.1016\/j.bjps.2022.06.104_bib0032","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1111\/j.1460-9592.2008.02721.x","article-title":"Postoperative pain control for primary cleft lip repair in infants: is there an advantage in performing peripheral nerve blocks?","volume":"18","author":"Simion","year":"2008","journal-title":"Pediatr Anesth"},{"issue":"5","key":"10.1016\/j.bjps.2022.06.104_bib0033","first-page":"UC04","article-title":"Bilateral infraorbital nerve block versus intravenous pentazocine: a comparative study on post-operative pain relief following cleft lip surgery","volume":"9","author":"Grewal","year":"2015","journal-title":"J Clin Diagnostic Res"},{"issue":"4","key":"10.1016\/j.bjps.2022.06.104_bib0034","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4103\/2356-9115.247404","article-title":"Bilateral greater palatine nerve block for perioperative analgesia in children undergoing palatoplasty","volume":"5","author":"Mady","year":"2018","journal-title":"Res Opin Anesth Intensive Care"},{"issue":"2","key":"10.1016\/j.bjps.2022.06.104_bib0035","first-page":"44","article-title":"Intraoral maxillary nerve block: an anatomical and clinical study","volume":"30","author":"Malamed","year":"1983","journal-title":"Anesth Prog"},{"issue":"5","key":"10.1016\/j.bjps.2022.06.104_bib0036","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/bja\/74.5.506","article-title":"Infraorbital nerve block in neonates for cleft lip repair: anatomical study and clinical application","volume":"74","author":"Bosenberg","year":"1995","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.bjps.2022.06.104_bib0037","doi-asserted-by":"crossref","DOI":"10.4103\/0970-9185.175649","article-title":"Postoperative analgesia for cleft lip and palate repair in children","author":"Reena","year":"2016","journal-title":"J Anaesthesiol Clin Pharmacol"},{"issue":"7","key":"10.1016\/j.bjps.2022.06.104_bib0038","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1046\/j.1460-9592.2002.00906.x","article-title":"Correlation of cleft type with incidence of perioperative respiratory complications in infants with cleft lip and palate","volume":"12","author":"Takemura","year":"2002","journal-title":"Pediatr Anesth"},{"key":"10.1016\/j.bjps.2022.06.104_bib0039","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ajem.2021.02.007","article-title":"Sphenopalatine ganglion block for the treatment of acute headache: an old treatment revisited","volume":"49","author":"Busman","year":"2021","journal-title":"Am J Emerg Med"},{"issue":"3","key":"10.1016\/j.bjps.2022.06.104_bib0040","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1213\/01.ane.0000492662.35217.8c","article-title":"Comparative study of bilateral suprazygomatic maxillary and bilateral greater palatine nerve block for perioperative analgesia in children undergoing palatoplasty","volume":"123","author":"Selim","year":"2016","journal-title":"Anesth Analg"},{"issue":"9","key":"10.1016\/j.bjps.2022.06.104_bib0041","first-page":"422","article-title":"Effect on postoperative pain after local application of Bupivacaine in the Tonsillar Fossa; a prospective single blind controlled trial","volume":"59","author":"Kadar","year":"2003","journal-title":"J Pak Med Assoc"},{"issue":"5","key":"10.1016\/j.bjps.2022.06.104_bib0042","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00003643-200405000-00005","article-title":"Unplanned hospital admission in children undergoing day-case surgery","volume":"21","author":"Awad","year":"2004","journal-title":"Eur J Anaesthesiol"},{"issue":"5","key":"10.1016\/j.bjps.2022.06.104_bib0043","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1365-2044.1996.tb07788.x","article-title":"Postanaesthetic shivering in children","volume":"51","author":"Lyons","year":"1996","journal-title":"Anaesthesia"},{"issue":"8","key":"10.1016\/j.bjps.2022.06.104_bib0044","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.jhsa.2015.03.034","article-title":"Effect of time interval between tumescent local anesthesia infiltration and start of surgery on operative field visibility in hand surgery without tourniquet","volume":"40","author":"Bashir","year":"2015","journal-title":"J Hand Surg Am"},{"issue":"3","key":"10.1016\/j.bjps.2022.06.104_bib0045","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/01.sap.0000221468.54751.09","article-title":"Short-stay cleft palate surgery with intraoperative dexamethasone and marcaine","volume":"57","author":"Bateman","year":"2006","journal-title":"Ann Plast Surg"},{"issue":"14","key":"10.1016\/j.bjps.2022.06.104_bib0046","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1056\/NEJMra012626","article-title":"Analgesics for the treatment of pain in children","volume":"347","author":"Berde","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bjps.2022.06.104_bib0047","series-title":"Cochrane Database of Systematic Reviews","article-title":"Infraorbital nerve block for postoperative pain following cleft lip repair in children","author":"Feriani","year":"2014"},{"issue":"1","key":"10.1016\/j.bjps.2022.06.104_bib0049","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/SAP.0b013e3181851b8e","article-title":"Bilateral extraoral, infraorbital nerve block for postoperative pain relief after cleft lip repair in pediatric patients","volume":"63","author":"Takmaz","year":"2009","journal-title":"Ann Plast Surg"},{"issue":"1","key":"10.1016\/j.bjps.2022.06.104_bib0050","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1155\/2009\/348184","article-title":"Behavioural assessment of pediatric pain","volume":"14","author":"Blount","year":"2009","journal-title":"Pain Res Manag"},{"issue":"1","key":"10.1016\/j.bjps.2022.06.104_bib0051","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1597\/09-226","article-title":"A modified surgical schedule for primary management of cleft lip and palate in developing countries","volume":"48","author":"Agrawal","year":"2011","journal-title":"Cleft Palate-Craniofacial J"},{"issue":"1","key":"10.1016\/j.bjps.2022.06.104_bib0052","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/1055665617739564","article-title":"Parameters for evaluation and treatment of patients with cleft lip\/palate or other craniofacial differences","volume":"55","year":"2018","journal-title":"Cleft Palate Craniofac J"}],"container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681522004296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681522004296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:50:05Z","timestamp":1761684605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681522004296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S1748681522004296"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2022.06.104","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In search of the optimal pain management strategy for children undergoing cleft lip and palate repair: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Plastic, Reconstructive & Aesthetic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjps.2022.06.104","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}