{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:28:16Z","timestamp":1789770496101,"version":"4.0.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jprasurg.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.bjps.2022.08.069","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T19:54:46Z","timestamp":1661630086000},"page":"151-163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Vasopressors improve outcomes in autologous free tissue transfer: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"81","author":[{"given":"Omar","family":"Noori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despoina","family":"Stamou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Ch'ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7665-8015","authenticated-orcid":false,"given":"Alexander HR","family":"Varey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjps.2022.08.069_bib0001","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/00006534-197203000-00005","article-title":"Autotransplant of omentum to a large scalp defect, with microsurgical revascularization","volume":"49","author":"McLean","year":"1972","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0002","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/micr.22097","article-title":"Safety of intra-operative vasopressor in free jejunal flap reconstruction","volume":"33","author":"Chan","year":"2013","journal-title":"Microsurgery"},{"key":"10.1016\/j.bjps.2022.08.069_bib0003","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1001\/archotol.125.3.295","article-title":"Unsurpassed reliability of free flaps for head and neck reconstruction","volume":"125","author":"Blackwell","year":"1999","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0004","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/00006534-199009000-00019","article-title":"The role of emergent exploration in free-tissue transfer: a review of 150 consecutive cases","volume":"86","author":"Hidalgo","year":"1990","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0005","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/00006534-199809010-00015","article-title":"A prospective study of microvascular free-flap surgery and outcome","volume":"102","author":"Khouri","year":"1998","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0006","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/00006534-199609000-00015","article-title":"Choice of flap and incidence of free flap success","volume":"98","author":"Kroll","year":"1996","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0007","first-page":"S71","article-title":"Effect of intraoperative dopamine on free flap survival in a rat model: a double-blind, randomized, controlled trial","volume":"41","author":"Singh","year":"2012","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0008","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.otohns.2007.04.011","article-title":"Utilization of free tissue transfer in head and neck surgery","volume":"137","author":"Smith","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0009","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.3389\/fphar.2020.01248","article-title":"The use of vasopressor agents in free tissue transfer for head and neck reconstruction: current trends and review of the literature","volume":"11","author":"Naik","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bjps.2022.08.069_bib0010","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1002\/hed.25190","article-title":"Intraoperative hypotension and flap loss in free tissue transfer surgery of the head and neck","volume":"40","author":"Kass","year":"2018","journal-title":"Head Neck"},{"key":"10.1016\/j.bjps.2022.08.069_bib0011","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/SAP.0b013e3181bda312","article-title":"Effects of vasopressor administration on the outcomes of microsurgical breast reconstruction","volume":"65","author":"Chen","year":"2010","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0012","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/bjacepd\/mkg009","article-title":"Anaesthesia for microvascular free tissue transfer","volume":"3","author":"Adams","year":"2003","journal-title":"BJA CEPD Reviews"},{"key":"10.1016\/j.bjps.2022.08.069_bib0013","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/00000637-199711000-00013","article-title":"Effects of vasoactive medications on the blood flow of island musculocutaneous flaps in swine","volume":"39","author":"Cordeiro","year":"1997","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0014","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1097\/01.prs.0000279371.63439.8d","article-title":"The effects of systemic phenylephrine and epinephrine on pedicle artery and microvascular perfusion in a pig model of myoadipocutaneous rotational flaps","volume":"120","author":"Massey","year":"2007","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0015","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.otohns.2009.11.001","article-title":"Vasopressor use in free tissue transfer surgery","volume":"142","author":"Monroe","year":"2010","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0016","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/SAP.0b013e31828d70b3","article-title":"Vasopressors and reconstructive flap perfusion: a review of the literature comparing the effects of various pharmacologic agents","volume":"73","author":"Ibrahim","year":"2014","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0017","unstructured":"Australian Medicines Handbook 2017 (online): sympathomimetics., Adelaide: australian Medicines Handbook Pty Ltd, 2017."},{"key":"10.1016\/j.bjps.2022.08.069_bib0018","first-page":"512","volume":"1","author":"Neligan","year":"2012"},{"key":"10.1016\/j.bjps.2022.08.069_bib0019","unstructured":"Veritas Health Innovation: Covidence systematic Review Software. Melbourne, Australia."},{"key":"10.1016\/j.bjps.2022.08.069_bib0020","series-title":"The Nordic Cochrane Centre TCC: Review Manager (RevMan) (ed 5.3). Copenhagen","year":"2014"},{"key":"10.1016\/j.bjps.2022.08.069_bib0021","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1055\/s-0035-1563381","article-title":"Intraoperative Use of Vasopressors Is Safe in Head and Neck Free Tissue Transfer","volume":"32","author":"Swanson","year":"2016","journal-title":"J Reconstr Microsurg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0022","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1055\/s-0035-1546422","article-title":"Perioperative management for microsurgical free tissue transfer: survey of current practices with a comparison to the literature","volume":"31","author":"Motakef","year":"2015","journal-title":"J Reconstr Microsurg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0023","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1055\/s-0039-1687914","article-title":"Perioperative vasopressor use in free flap surgery: a systematic review and meta-analysis","volume":"35","author":"Goh","year":"2019","journal-title":"J Reconstr Microsurg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0024","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1097\/01.prs.0000260598.24376.e1","article-title":"Free flap reexploration: indications, treatment, and outcomes in 1193 free flaps","volume":"119","author":"Bui","year":"2007","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0025","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1055\/s-2003-42630","article-title":"Analytic review of 2372 free flap transfers for head and neck reconstruction following cancer resection","volume":"19","author":"Nakatsuka","year":"2003","journal-title":"J Reconstr Microsurg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0026","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1161\/CIRCULATIONAHA.107.728840","article-title":"Inotropes and vasopressors: review of physiology and clinical use in cardiovascular disease","volume":"118","author":"Overgaard","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.bjps.2022.08.069_bib0027","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/micr.22072","article-title":"Power spectral analysis of the effects of epinephrine, norepinephrine, dobutamine and dopexamine on microcirculation following free tissue transfer","volume":"33","author":"Eley","year":"2013","journal-title":"Microsurgery"},{"key":"10.1016\/j.bjps.2022.08.069_bib0028","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1111\/j.1365-2044.2009.06055.x","article-title":"The effect of dobutamine on blood flow of free tissue transfer flaps during head and neck reconstructive surgery*","volume":"64","author":"Scholz","year":"2009","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bjps.2022.08.069_bib0029","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/01.sap.0000137133.08105.73","article-title":"The effect of intravenous dopamine and dobutamine on blood circulation during a microvascular TRAM flap operation","volume":"53","author":"Suominen","year":"2004","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0030","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/micr.20961","article-title":"Impact of vasopressors on outcomes in head and neck free tissue transfer","volume":"32","author":"Harris","year":"2012","journal-title":"Microsurgery"},{"key":"10.1016\/j.bjps.2022.08.069_bib0031","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/2000656X.2016.1269777","article-title":"Intraoperative vasopressors and thrombotic complications in free flap breast reconstruction","volume":"51","author":"Nelson","year":"2017","journal-title":"J Plast Surg Hand Surg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0032","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00238-016-1223-5","article-title":"Influence of postoperative vasoactive agent administration on free flap outcomes","volume":"39","author":"Kotsougiani","year":"2016","journal-title":"Eur J Plast Surg"},{"key":"10.1016\/j.bjps.2022.08.069_bib0033","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1001\/jamaoto.2016.2981","article-title":"Optimal perioperative care in major head and neck cancer surgery with free flap reconstruction: a consensus review and recommendations from the enhanced recovery after surgery society","volume":"143","author":"Dort","year":"2017","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"2","key":"10.1016\/j.bjps.2022.08.069_bib0034","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/SLA.0000000000002295","article-title":"Intraoperative use of vasopressors does not increase the risk of free flap compromise and failure in cancer patients","volume":"268","author":"Fang","year":"2018","journal-title":"Ann Surg"},{"issue":"6","key":"10.1016\/j.bjps.2022.08.069_bib0035","doi-asserted-by":"crossref","first-page":"1016e","DOI":"10.1097\/PRS.0000000000002176","article-title":"The effect of norepinephrine and dopamine on radial forearm flap partial tissue oxygen pressure and microdialysate metabolite measurements: a randomized controlled trial","volume":"137","author":"Raittinen","year":"2016","journal-title":"Plast Reconstr Surg"},{"issue":"1_suppl","key":"10.1016\/j.bjps.2022.08.069_bib0036","article-title":"Postoperative use of vasopressors in head and neck microvascular reconstruction","volume":"151","author":"Roche","year":"2014","journal-title":"J Otolaryngol \u2013 Head Neck Surgery"},{"issue":"6","key":"10.1016\/j.bjps.2022.08.069_bib0037","doi-asserted-by":"crossref","first-page":"S135","DOI":"10.1097\/SAP.0000000000000076","article-title":"Impact of intraoperative vasopressor use in free tissue transfer for head, neck, and extremity reconstruction","volume":"72","author":"Kelly","year":"2014","journal-title":"Ann Plast Surg"},{"issue":"2_suppl","key":"10.1016\/j.bjps.2022.08.069_bib0038","first-page":"P70","article-title":"Microvascular free flaps and intraoperative vasopressors","volume":"145","author":"Wilson","year":"2011","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"10.1016\/j.bjps.2022.08.069_bib0039","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/j.bjoms.2011.04.050","article-title":"Effect of intraoperative use of vasopressors on the outcome of microvascular tissue transfer in head and neck surgery","volume":"49","author":"Eberle","year":"2011","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"6","key":"10.1016\/j.bjps.2022.08.069_bib0040","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1177\/0194599811401313","article-title":"Safety of vasopressor use in head and neck microvascular reconstruction: a prospective observational study","volume":"144","author":"Monroe","year":"2011","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"2","key":"10.1016\/j.bjps.2022.08.069_bib0041","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3233\/CH-189411","article-title":"Impact of intraoperative use of vasopressors in lower extremity reconstruction: single centre analysis of 437 free gracilis muscle and fasciocutaneous anterolateral thigh flaps","volume":"71","author":"Heine-Geldern","year":"2019","journal-title":"Clin Hemorheol Microcirc"},{"issue":"2","key":"10.1016\/j.bjps.2022.08.069_bib0042","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1245\/s10434-019-07758-1","article-title":"Assessment of DIEP flap perfusion with intraoperative indocyanine green fluorescence imaging in vasopressor- dominated hemodynamic support versus liberal fluid administration: a randomized controlled trial with breast cancer patients","volume":"27","author":"Anker","year":"2020","journal-title":"Ann Surg Oncol"},{"issue":"9","key":"10.1016\/j.bjps.2022.08.069_bib0043","first-page":"327","article-title":"Vasoactive agents do not adversely influence the success of maxillo-facial microvascular free-flap surgery: a retrospective analysis","volume":"4","author":"Rose","year":"2016","journal-title":"Int J Anesthesiol Res"}],"container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681522005125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681522005125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:50:54Z","timestamp":1761684654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681522005125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":43,"alternative-id":["S1748681522005125"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2022.08.069","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vasopressors improve outcomes in autologous free tissue transfer: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Plastic, Reconstructive & Aesthetic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjps.2022.08.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}