{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:14:41Z","timestamp":1790723681074,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jprasurg.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.bjps.2023.06.012","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T02:15:16Z","timestamp":1687140916000},"page":"368-376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Carbon dioxide laser treatment of burn-related scarring: Results of the ELIPSE (Early Laser Intervention Promotes Scar Evolution) prospective randomized controlled trial"],"prefix":"10.1016","volume":"84","author":[{"given":"Christopher J.","family":"Lewis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8947-834X","authenticated-orcid":false,"given":"Lisa","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9696-2201","authenticated-orcid":false,"given":"Zhenjun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4026-2964","authenticated-orcid":false,"given":"Phillip","family":"Melton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Fear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona M.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Rea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjps.2023.06.012_bib1","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.burns.2017.03.017","article-title":"Identification of factors predicting scar outcome after burn in adults: a prospective case-control study","volume":"43","author":"Wallace","year":"2017","journal-title":"Burns"},{"issue":"7","key":"10.1016\/j.bjps.2023.06.012_bib2","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1080\/09546634.2019.1704679","article-title":"Efficacy of fractional carbon dioxide laser therapy for burn scars: a meta-analysis","volume":"32","author":"Zhang","year":"2021","journal-title":"J Dermatol Treat"},{"key":"10.1016\/j.bjps.2023.06.012_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.burns.2019.01.004","article-title":"Ablative fractional resurfacing for burn scar management affects the number and type of elective surgical reconstructive procedures, hospital admission patterns as well as length of stay","volume":"46","author":"Issler-Fisher","year":"2020","journal-title":"Burns"},{"key":"10.1016\/j.bjps.2023.06.012_bib4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/lsm.23166","article-title":"Ablative fractional resurfacing with laser-facilitated steroid delivery for burn scar management: does the depth of laser penetration matter?","volume":"52","author":"Issler-Fisher","year":"2020","journal-title":"Lasers Surg Med"},{"key":"10.1016\/j.bjps.2023.06.012_bib5","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/jbcr\/irz046","article-title":"Fractional CO2 laser treatment outcomes for pediatric hypertrophic burn scars","volume":"40","author":"Patel","year":"2019","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.bjps.2023.06.012_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/243651","article-title":"Shine on: review of laser- and light-based therapies for the treatment of burn scars","volume":"2012","author":"Hultman","year":"2012","journal-title":"Dermatol Res Pract"},{"key":"10.1016\/j.bjps.2023.06.012_bib7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.bjps.2019.01.027","article-title":"Carbon dioxide laser treatment in burn-related scarring: a prospective randomised controlled trial","volume":"72","author":"Douglas","year":"2019","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"10.1016\/j.bjps.2023.06.012_bib8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1001\/2013.jamadermatol.668","article-title":"Evaluation of clinical results, histological architecture, and collagen expression following treatment of mature burn scars with a fractional carbon dioxide laser","volume":"149","author":"Ozog","year":"2013","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.bjps.2023.06.012_bib9","first-page":"22","article-title":"Fractional laser resurfacing treats photoaging by promoting neocollegenesis and cutaneous edema","volume":"13","author":"Borges","year":"2020","journal-title":"J Clin Aesthet Dermatol"},{"key":"10.1016\/j.bjps.2023.06.012_bib10","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s10103-013-1383-5","article-title":"The role of transforming growth factor beta1 in fractional laser resurfacing with a carbon dioxide laser","volume":"29","author":"Jiang","year":"2014","journal-title":"Lasers Med Sci"},{"key":"10.1016\/j.bjps.2023.06.012_bib11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/jocd.12099","article-title":"Evaluation of the effect of fractional CO2 laser on histopathological picture and TGF-beta1 expression in hypertrophic scar","volume":"13","author":"Makboul","year":"2014","journal-title":"J Cosmet Dermatol"},{"key":"10.1016\/j.bjps.2023.06.012_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110395","article-title":"Standardising and assessing digital images for use in clinical trials: a practical, reproducible method that blinds the assessor to treatment allocation","volume":"9","author":"Bowen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bjps.2023.06.012_bib13","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.burns.2015.04.018","article-title":"What score on the Vancouver Scar Scale constitutes a hypertrophic scar? Results from a survey of North American burn-care providers","volume":"41","author":"Thompson","year":"2015","journal-title":"Burns"},{"key":"10.1016\/j.bjps.2023.06.012_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11136-011-9924-5","article-title":"Rasch analysis of the Patient and Observer Scar Assessment Scale (POSAS) in burn scars","volume":"21","author":"van der Wal","year":"2012","journal-title":"Qual Life Res"},{"key":"10.1016\/j.bjps.2023.06.012_bib15","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/MRR.0000000000000134","article-title":"Clinimetric properties and clinical utility in rehabilitation of postsurgical scar rating scales: a systematic review","volume":"38","author":"Vercelli","year":"2015","journal-title":"Int J Rehabil Res"},{"key":"10.1016\/j.bjps.2023.06.012_bib16","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1016\/j.jss.2010.05.056","article-title":"Burn scar assessment: a systematic review of different scar scales","volume":"164","author":"Brusselaers","year":"2010","journal-title":"J Surg Res"},{"key":"10.1016\/j.bjps.2023.06.012_bib17","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.burns.2014.01.025","article-title":"Reliability of scar assessments performed with an integrated skin testing device - the DermaLab Combo((R))","volume":"40","author":"Gankande","year":"2014","journal-title":"Burns"},{"key":"10.1016\/j.bjps.2023.06.012_bib18","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.burns.2015.01.012","article-title":"Interpretation of the DermaLab Combo(R) pigmentation and vascularity measurements in burn scar assessment: an exploratory analysis","volume":"41","author":"Gankande","year":"2015","journal-title":"Burns"},{"key":"10.1016\/j.bjps.2023.06.012_bib19","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/lsm.22055","article-title":"Clinical and molecular effects on mature burn scars after treatment with a fractional CO(2) laser","volume":"44","author":"Qu","year":"2012","journal-title":"Lasers Surg Med"},{"key":"10.1016\/j.bjps.2023.06.012_bib20","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.burns.2019.07.012","article-title":"The Brisbane Burn Scar Impact Profile (child and young person version) for measuring health-related quality of life in children with burn scars: a longitudinal cohort study of reliability, validity and responsiveness","volume":"45","author":"Simons","year":"2019","journal-title":"Burns"},{"key":"10.1016\/j.bjps.2023.06.012_bib21","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.burns.2019.04.015","article-title":"The longitudinal validity, reproducibility and responsiveness of the Brisbane Burn Scar Impact Profile (caregiver report for young children version) for measuring health-related quality of life in children with burn scars","volume":"45","author":"Simons","year":"2019","journal-title":"Burns"},{"key":"10.1016\/j.bjps.2023.06.012_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184452","article-title":"Psychometric properties of the Brisbane Burn Scar Impact Profile in adults with burn scars","volume":"12","author":"Tyack","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bjps.2023.06.012_bib23","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.burns.2015.05.021","article-title":"Measuring the impact of burn scarring on health-related quality of life: development and preliminary content validation of the Brisbane Burn Scar Impact Profile (BBSIP) for children and adults","volume":"41","author":"Tyack","year":"2015","journal-title":"Burns"},{"issue":"Suppl 1","key":"10.1016\/j.bjps.2023.06.012_bib24","first-page":"s32","article-title":"Recommendations on clinical proof of efficacy for potential scar prevention and reduction therapies","volume":"19","author":"Bush","year":"2011","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.bjps.2023.06.012_bib25","doi-asserted-by":"crossref","first-page":"1073e","DOI":"10.1097\/PRS.0000000000006265","article-title":"Rasch analysis of the patient and observer scar assessment scale in linear scars: suggestions for a Patient and Observer Scar Assessment Scale v2.1","volume":"144","author":"Franchignoni","year":"2019","journal-title":"Plast Reconstr Surg"},{"issue":"2","key":"10.1016\/j.bjps.2023.06.012_bib26","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s11136-022-03244-6","article-title":"Development of the patient scale of the Patient and Observer Scar Assessment Scale (POSAS) 3.0: a qualitative study","volume":"32","author":"Carriere","year":"2023","journal-title":"Qual Life Res"},{"key":"10.1016\/j.bjps.2023.06.012_bib27","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.burns.2017.01.019","article-title":"The official update of the POSAS: an invitation to share experiences to improve the POSAS in 'Project POSAS 3.0\u2032","volume":"43","author":"van Zuijlen","year":"2017","journal-title":"Burns"},{"key":"10.1016\/j.bjps.2023.06.012_bib28","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bjps.2020.08.108","article-title":"Laser treatment of specific scar characteristics in hypertrophic scars and keloid: a systematic review","volume":"74","author":"Oosterhoff","year":"2021","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"6","key":"10.1016\/j.bjps.2023.06.012_bib29","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3390\/cells8060607","article-title":"Regeneration of dermis: scarring and cells involved","volume":"8","author":"Rippa","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bjps.2023.06.012_bib30","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/lsm.22610","article-title":"Fractional laser-assisted drug uptake: impact of time-related topical application to achieve enhanced delivery","volume":"49","author":"Banzhaf","year":"2017","journal-title":"Lasers Surg Med"}],"container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681523003212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681523003212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:52:13Z","timestamp":1761684733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681523003212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":30,"alternative-id":["S1748681523003212"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2023.06.012","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbon dioxide laser treatment of burn-related scarring: Results of the ELIPSE (Early Laser Intervention Promotes Scar Evolution) prospective randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Plastic, Reconstructive & Aesthetic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjps.2023.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2023 Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons. All rights reserved.","name":"copyright","label":"Copyright"}]}}