{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:41:46Z","timestamp":1787316106543,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"am","delay-in-days":338,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 NS102360"],"award-info":[{"award-number":["RO1 NS102360"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jprasurg.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.bjps.2023.10.054","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T11:18:19Z","timestamp":1697282299000},"page":"329-338","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Functional outcomes of nerve allografts augmented with mesenchymal stem cells and surgical angiogenesis in a rat sciatic nerve defect model"],"prefix":"10.1016","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1747-6665","authenticated-orcid":false,"given":"Meiwand","family":"Bedar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiam M.","family":"Saffari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke","family":"Mathot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Y.","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjps.2023.10.054_bib1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/micr.30574","article-title":"Peripheral nerve repair throughout the body with processed nerve allografts: results from a large multicenter study","volume":"40","author":"Safa","year":"2020","journal-title":"Microsurgery"},{"key":"10.1016\/j.bjps.2023.10.054_bib2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/SAP.0000000000001252","article-title":"The surgical management of nerve gaps: present and future","volume":"80","author":"Bassilios Habre","year":"2018","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/micr.22371","article-title":"The influence of vascularization of transplanted processed allograft nerve on return of motor function in rats","volume":"36","author":"Giusti","year":"2016","journal-title":"Microsurgery"},{"key":"10.1016\/j.bjps.2023.10.054_bib4","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.4103\/1673-5374.276327","article-title":"The role of vascularization in nerve regeneration of nerve graft","volume":"15","author":"Saffari","year":"2020","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.bjps.2023.10.054_bib5","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.bjps.2019.11.048","article-title":"Revascularization patterns of nerve allografts in a rat sciatic nerve defect model","volume":"73","author":"Saffari","year":"2020","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib6","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/PRS.0000000000008291","article-title":"Surgical angiogenesis of decellularized nerve allografts improves early functional recovery in a rat sciatic nerve defect model","volume":"148","author":"Saffari","year":"2021","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib7","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1016\/j.bjps.2022.02.076","article-title":"The effect of mesenchymal stem cells and surgical angiogenesis on immune response and revascularization of acellular nerve allografts in a rat sciatic defect model","volume":"75","author":"Bedar","year":"2022","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib8","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.bjps.2020.12.039","article-title":"Microcomputed analysis of nerve angioarchitecture after combined stem cell delivery and surgical angiogenesis to nerve allograft","volume":"74","author":"Saffari","year":"2021","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib9","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/micr.30579","article-title":"Adipose derived mesenchymal stem cells seeded onto a decellularized nerve allograft enhances angiogenesis in a rat sciatic nerve defect model","volume":"40","author":"Mathot","year":"2020","journal-title":"Microsurgery"},{"key":"10.1016\/j.bjps.2023.10.054_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2019.144151","article-title":"Gene expression profiles of differentiated and undifferentiated adipose derived mesenchymal stem cells dynamically seeded onto a processed nerve allograft","volume":"724","author":"Mathot","year":"2020","journal-title":"Gene"},{"key":"10.1016\/j.bjps.2023.10.054_bib11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.gene.2019.02.078","article-title":"Targeted stimulation of MSCs in peripheral nerve repair","volume":"710","author":"Mathot","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.bjps.2023.10.054_bib12","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/MOT.0000000000000569","article-title":"Stem cell-based approaches to enhance nerve regeneration and improve functional outcomes in vascularized composite allotransplantation","volume":"23","author":"Tung","year":"2018","journal-title":"Curr Opin Organ Transpl"},{"key":"10.1016\/j.bjps.2023.10.054_bib13","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/PRS.0000000000008191","article-title":"Functional outcomes of nerve allografts seeded with undifferentiated and differentiated mesenchymal stem cells in a rat sciatic nerve defect model","volume":"148","author":"Mathot","year":"2021","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib14","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.expneurol.2007.06.029","article-title":"Adipose-derived stem cells differentiate into a Schwann cell phenotype and promote neurite outgrowth in vitro","volume":"207","author":"Kingham","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bjps.2023.10.054_bib15","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.bjps.2021.05.066","article-title":"Nerve gaps repaired with acellular nerve allografts recellularized with Schwann-like cells: preclinical trial","volume":"75","author":"Tamez-Mata","year":"2022","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib16","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.neulet.2012.02.066","article-title":"Recellularized nerve allografts with differentiated mesenchymal stem cells promote peripheral nerve regeneration","volume":"514","author":"Wang","year":"2012","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.bjps.2023.10.054_bib17","doi-asserted-by":"crossref","DOI":"10.3171\/2017.1.FOCUS16462","article-title":"Optimizing decellularization techniques to create a new nerve allograft: an in vitro study using rodent nerve segments","volume":"42","author":"Hundepool","year":"2017","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.bjps.2023.10.054_bib18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bjps.2019.05.030","article-title":"Adhesion, distribution, and migration of differentiated and undifferentiated mesenchymal stem cells (MSCs) seeded on nerve allografts","volume":"73","author":"Mathot","year":"2020","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib19","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/PRS.0000000000004614","article-title":"A simple dynamic strategy to deliver stem cells to decellularized nerve allografts","volume":"142","author":"Rbia","year":"2018","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib20","doi-asserted-by":"crossref","first-page":"633e","DOI":"10.1097\/PRS.0000000000001681","article-title":"Noninvasive ultrasound of the tibial muscle for longitudinal analysis of nerve regeneration in rats","volume":"136","author":"Hundepool","year":"2015","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib21","doi-asserted-by":"crossref","first-page":"410","DOI":"10.2106\/JBJS.K.00253","article-title":"Return of motor function after segmental nerve loss in a rat model: comparison of autogenous nerve graft, collagen conduit, and processed allograft (AxoGen)","volume":"94","author":"Giusti","year":"2012","journal-title":"J Bone Jt Surg Am"},{"key":"10.1016\/j.bjps.2023.10.054_bib22","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/micr.20520","article-title":"Isometric tetanic force measurement method of the tibialis anterior in the rat","volume":"28","author":"Shin","year":"2008","journal-title":"Microsurgery"},{"key":"10.1016\/j.bjps.2023.10.054_bib23","doi-asserted-by":"crossref","DOI":"10.3791\/61926","article-title":"Maximum isometric tetanic force measurement of the tibialis anterior muscle in the rat","author":"Bedar","year":"2021","journal-title":"J Vis Exp"},{"key":"10.1016\/j.bjps.2023.10.054_bib24","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.3171\/JNS-07\/12\/1168","article-title":"The role of evaluation methods in the assessment of peripheral nerve regeneration through synthetic conduits: a systematic review.\u00a0Laboratory investigation","volume":"107","author":"Vleggeert-Lankamp","year":"2007","journal-title":"J Neurosurg"},{"key":"10.1016\/j.bjps.2023.10.054_bib25","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cell.2015.07.021","article-title":"Macrophage-induced blood vessels guide Schwann cell-mediated regeneration of peripheral nerves","volume":"162","author":"Cattin","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bjps.2023.10.054_bib26","doi-asserted-by":"crossref","DOI":"10.1097\/GOX.0000000000000652","article-title":"Effect of artificial nerve conduit vascularization on peripheral nerve in a necrotic bed","volume":"4","author":"Iijima","year":"2016","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"10.1016\/j.bjps.2023.10.054_bib27","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1080\/2000656X.2021.1933994","article-title":"Treatment of painful median nerve neuroma using pedicled vascularized lateral antebrachial cutaneous nerve with adipofascial flap: a cadaveric study and exploration of clinical application","volume":"56","author":"Kawamura","year":"2022","journal-title":"J Plast Surg Hand Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib28","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1097\/00006534-199205000-00024","article-title":"Functional results of vascularized versus nonvascularized nerve grafting","volume":"89","author":"Kanaya","year":"1992","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib29","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1080\/01616412.2016.1198527","article-title":"Vascularized nerve grafts: an experimental study","volume":"38","author":"Donzelli","year":"2016","journal-title":"Neurol Res"},{"key":"10.1016\/j.bjps.2023.10.054_bib30","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1097\/PRS.0b013e3182a3bfeb","article-title":"Functional evaluation in the rat sciatic nerve defect model: a comparison of the sciatic functional index, ankle angles, and isometric tetanic force","volume":"132","author":"Lee","year":"2013","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib31","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.bjps.2009.09.012","article-title":"Adipose-derived stem cells enhance peripheral nerve regeneration","volume":"63","author":"di Summa","year":"2010","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib32","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.expneurol.2011.01.013","article-title":"Differentiation of mesenchymal stem cells to support peripheral nerve regeneration in a rat model","volume":"228","author":"Ladak","year":"2011","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bjps.2023.10.054_bib33","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.bjps.2011.11.035","article-title":"Differentiated and undifferentiated adipose-derived stem cells improve function in rats with peripheral nerve gaps","volume":"65","author":"Orbay","year":"2012","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib34","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/term.1919","article-title":"Undifferentiated and differentiated adipose-derived stem cells improve nerve regeneration in a rat model of facial nerve defect","volume":"11","author":"Watanabe","year":"2017","journal-title":"J Tissue Eng Regen Med"},{"key":"10.1016\/j.bjps.2023.10.054_bib35","article-title":"Gene expression and growth factor analysis in early nerve regeneration following segmental nerve defect reconstruction with a mesenchymal stromal cell-enhanced decellularized nerve allograft","volume":"8","author":"Rbia","year":"2020","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"10.1016\/j.bjps.2023.10.054_bib36","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.bjps.2019.04.014","article-title":"Seeding decellularized nerve allografts with adipose-derived mesenchymal stromal cells: an in vitro analysis of the gene expression and growth factors produced","volume":"72","author":"Rbia","year":"2019","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib37","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.expneurol.2014.08.002","article-title":"A comparative morphological, electrophysiological and functional analysis of axon regeneration through peripheral nerve autografts genetically modified to overexpress BDNF, CNTF, GDNF, NGF, NT3 or VEGF","volume":"261","author":"Hoyng","year":"2014","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bjps.2023.10.054_bib38","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3109\/08941939.2015.1093046","article-title":"Nonexpanded adipose stromal vascular fraction local therapy on peripheral nerve regeneration using allografts","volume":"29","author":"Mohammadi","year":"2016","journal-title":"J Invest Surg"},{"key":"10.1016\/j.bjps.2023.10.054_bib39","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/micr.30713","article-title":"A meta-analysis of functional outcomes in rat sciatic nerve injury models","volume":"41","author":"DeLeonibus","year":"2021","journal-title":"Microsurgery"}],"container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681523006095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681523006095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:51:54Z","timestamp":1761684714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681523006095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":39,"alternative-id":["S1748681523006095"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2023.10.054","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional outcomes of nerve allografts augmented with mesenchymal stem cells and surgical angiogenesis in a rat sciatic nerve defect model","name":"articletitle","label":"Article Title"},{"value":"Journal of Plastic, Reconstructive & Aesthetic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjps.2023.10.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}