{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:27:05Z","timestamp":1787315225146,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","jprasurg.com","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.bjps.2024.04.001","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T12:08:27Z","timestamp":1712750907000},"page":"386-401","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["EMLA cream in burns: A systematic review of safety, analgesic efficacy, and effects on burn pathophysiology"],"prefix":"10.1016","volume":"95","author":[{"given":"Filip","family":"Rangatchew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7567-2109","authenticated-orcid":false,"given":"Lars","family":"Schoelzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof T.","family":"Drzewiecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke","family":"Holmgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bjps.2024.04.001_bib1","first-page":"135","article-title":"Analgesia, sedation and arousal status in burn patients: The gap between recommendations and current practices","volume":"30","author":"Lavrentieva","year":"2017","journal-title":"Ann Burns Fire Disasters"},{"issue":"7","key":"10.1016\/j.bjps.2024.04.001_bib2","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.burns.2009.03.003","article-title":"The management of pain in the burns unit","volume":"35","author":"Richardson","year":"2009","journal-title":"Burns"},{"key":"10.1016\/j.bjps.2024.04.001_bib3","unstructured":"European Commission, European Medicines Agency\/Committee for Medicinal Products for Human Use (CHMP). https:\/\/ec.europa.eu\/health\/documents\/community-register\/html\/ho25383.htm. Accessed September 26, 2022."},{"key":"10.1016\/j.bjps.2024.04.001_bib4","unstructured":"Astra-Pharmaceuticals, Cream EMLA. 5% label. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2000\/19941s11lbl.pdf. Accessed September 22, 2022."},{"issue":"3","key":"10.1016\/j.bjps.2024.04.001_bib5","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1097\/00006534-200103000-00015","article-title":"Split-skin grafting with lidocaine-prilocaine cream: a meta-analysis of efficacy and safety in geriatric versus nongeriatric patients","volume":"107","author":"Wahlgren","year":"2001","journal-title":"Plast Reconstr Surg"},{"issue":"4","key":"10.1016\/j.bjps.2024.04.001_bib6","doi-asserted-by":"crossref","first-page":"450","DOI":"10.4103\/0970-9185.169049","article-title":"Topical anesthesia","volume":"31","author":"Kumar","year":"2015","journal-title":"J Anaesthesiol Clin Pharm"},{"issue":"10","key":"10.1016\/j.bjps.2024.04.001_bib7","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1093\/bja\/44.10.1040","article-title":"Factors affecting plasma levels of lignocaine and prilocaine","volume":"44","author":"Scott","year":"1972","journal-title":"Br J Anaesth"},{"issue":"3","key":"10.1016\/j.bjps.2024.04.001_bib8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00063110-200309000-00014","article-title":"Sharp wound debridement in local anaesthesia using EMLA cream: 6 years\u2019 experience in 1084 patients","volume":"10","author":"Blanke","year":"2003","journal-title":"Eur J Emerg Med"},{"issue":"7","key":"10.1016\/j.bjps.2024.04.001_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred Reporting Items for Systematic Reviews and Meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLOS Med"},{"key":"10.1016\/j.bjps.2024.04.001_bib10","unstructured":"Cochrane Community. https:\/\/community.cochrane.org\/help\/tools-and-software\/covidence. Accessed September 26, 2022."},{"issue":"6","key":"10.1016\/j.bjps.2024.04.001_bib11","first-page":"88","article-title":"EMLA anaesthetic cream for debridement of burns: a study of plasma concentrations of lidocaine and prilocaine and a review of the literature","volume":"7","author":"Lillieborg","year":"2017","journal-title":"Int J Burns Trauma"},{"issue":"3","key":"10.1016\/j.bjps.2024.04.001_bib12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0305-4179(97)00118-6","article-title":"Skin grafting of full thickness burns under local anaesthesia with EMLA\u00ae cream","volume":"24","author":"Janezic","year":"1998","journal-title":"Burns"},{"issue":"3","key":"10.1016\/j.bjps.2024.04.001_bib13","first-page":"229","article-title":"Usage of lidocaine-prilocaine cream in the treatment of postburn pain in pediatric patients","volume":"16","author":"Kargi","year":"2010","journal-title":"Ulus Travma Acids Cerrah Derg"},{"issue":"4","key":"10.1016\/j.bjps.2024.04.001_bib14","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s00101-009-1512-5","article-title":"Meth\u00e4moglobinintoxikation durch prilocaine in EMLA\u00ae: Akzidentelle Intoxikation bei einem Kleinkind mit Verbr\u00fchungen","volume":"58","author":"Book","year":"2009","journal-title":"Anaesth"},{"key":"10.1016\/j.bjps.2024.04.001_bib15","first-page":"2503","article-title":"Avoid Emla cream in burn injuries: Undvik Emla-kr\u00e4m vid br\u00e4nnskada (Case report from the Swedish Medical Products Agency)","volume":"92","author":"Anonymous","year":"1995","journal-title":"L\u00e4kartidningen (Swed Med J)"},{"issue":"6","key":"10.1016\/j.bjps.2024.04.001_bib16","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/bja\/76.6.806","article-title":"Analgesic and anti-inflammatory effects of lignocaine-prilocaine (EMLA) cream in human burn injury","volume":"76","author":"Pedersen","year":"1996","journal-title":"Br J Anaesth"},{"issue":"5","key":"10.1016\/j.bjps.2024.04.001_bib17","first-page":"300","article-title":"No antiinflammatory effect of short-term topical and subcutaneous administration of local anesthetics on postburn inflammation","volume":"18","author":"M\u00f8iniche","year":"1993","journal-title":"Reg Anesth"},{"issue":"1 Pt 1","key":"10.1016\/j.bjps.2024.04.001_bib18","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/00004630-199801000-00011","article-title":"Local anesthetics improve dermal perfusion after burn injury","volume":"19","author":"J\u00f6nsson","year":"1998","journal-title":"J Burn Care Rehabil"},{"issue":"5","key":"10.1016\/j.bjps.2024.04.001_bib19","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1213\/00000539-199905000-00031","article-title":"Digital image analysis of erythema development after experimental thermal injury to human skin: Effect of postburn topical local anesthetics (EML\u00a0A\u00ae)","volume":"88","author":"Mattsson","year":"1999","journal-title":"Anesth Analg"},{"issue":"4","key":"10.1016\/j.bjps.2024.04.001_bib20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0305-4179(03)00006-8","article-title":"Influence of local anaesthetics on inflammatory activity postburn","volume":"29","author":"Yreg\u00e5rd","year":"2003","journal-title":"Burns"},{"issue":"6","key":"10.1016\/j.bjps.2024.04.001_bib21","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1034\/j.1399-6576.1999.430605.x","article-title":"Effects of amide local anaesthetics on eicosanoid formation in burned skin","volume":"43","author":"J\u00f6nsson","year":"1999","journal-title":"Acta Anaesthesiol Scand"},{"issue":"2","key":"10.1016\/j.bjps.2024.04.001_bib22","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/00000542-199002000-00016","article-title":"Amide local anesthetics reduce albumin extravasation in burn injuries","volume":"72","author":"Cassuto","year":"1990","journal-title":"Anesthesiology"},{"issue":"4","key":"10.1016\/j.bjps.2024.04.001_bib23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0305-4179(98)00011-4","article-title":"Topical local anaesthetics (EMLA\u00ae) inhibit burn-induced plasma extravasation as measured by digital image colour analysis","volume":"24","author":"J\u00f6nsson","year":"1998","journal-title":"Burns"},{"issue":"2","key":"10.1016\/j.bjps.2024.04.001_bib24","first-page":"134","article-title":"Topical use of Rectogesic(R) and Emla(R) to improve cutaneous blood perfusion following thermal injury. A comparative experimental study","volume":"28","author":"Tagkalakis","year":"2015","journal-title":"Ann Burns Fire Disasters"},{"issue":"6","key":"10.1016\/j.bjps.2024.04.001_bib25","first-page":"564","article-title":"Maximum recommended doses of local anesthetics: a multifactorial concept","volume":"29","author":"Rosenberg","year":"2004","journal-title":"Reg Anesth Pain Med"},{"issue":"6","key":"10.1016\/j.bjps.2024.04.001_bib26","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1097\/ALN.0b013e3181fcef48","article-title":"Lidocaine: the origin of a modern local anesthetic. 1949","volume":"113","author":"Gordh","year":"2010","journal-title":"Anesthesiology"},{"issue":"3","key":"10.1016\/j.bjps.2024.04.001_bib27","first-page":"1059","article-title":"Dental anesthesia in the presence of inflammation: pharmacological mechanisms for the reduced efficacy of local anesthetics","volume":"4","author":"Tsuchiya","year":"2016","journal-title":"Int J Clin Anesth"},{"issue":"2","key":"10.1016\/j.bjps.2024.04.001_bib28","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2344\/0003-3006-59.2.90","article-title":"Local anesthetics: review of pharmacological considerations","volume":"59","author":"Becker","year":"2012","journal-title":"Anesth Prog"},{"key":"10.1016\/j.bjps.2024.04.001_bib29","unstructured":"Danish Medicines Agency. Emla cream 5% product summary. https:\/\/produktresume.dk\/AppBuilder\/search?q=Emla. Published 2018. Accessed January 2, 2023."},{"issue":"4","key":"10.1016\/j.bjps.2024.04.001_bib30","first-page":"155","article-title":"Prilocaine\u2014an underutilized local anesthetic.","volume":"10","author":"Wildsmith","year":"1985","journal-title":"Reg Anesth J Neural Block Obstet Surg Pain Control"},{"issue":"72","key":"10.1016\/j.bjps.2024.04.001_bib31","article-title":"Hyperspectral imaging and classification for grading skin erythema","volume":"6","author":"Abdlaty","year":"2018","journal-title":"Front Phys"},{"issue":"6","key":"10.1016\/j.bjps.2024.04.001_bib32","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/bja\/63.6.655","article-title":"Vascular response of human skin after analgesia with emla cream","volume":"63","author":"Bjerring","year":"1989","journal-title":"Br J Anaesth"},{"issue":"5","key":"10.1016\/j.bjps.2024.04.001_bib33","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2340\/0001555564439440","article-title":"Vascular effects of a local anesthetic mixture in atopic dermatitis","volume":"64","author":"Juhlin","year":"1984","journal-title":"Acta Derm Venereol"},{"issue":"3","key":"10.1016\/j.bjps.2024.04.001_bib34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1089\/wound.2014.0536","article-title":"The burn wound microenvironment","volume":"5","author":"Rose","year":"2016","journal-title":"Adv Wound Care"},{"key":"10.1016\/j.bjps.2024.04.001_bib35","first-page":"66","article-title":"Pathophysiology of burn shock and burn edema","author":"Wurzer","year":"2017","journal-title":"Total Burn Care Fifth Ed"},{"issue":"4","key":"10.1016\/j.bjps.2024.04.001_bib36","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/pm\/pnx228","article-title":"Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment","volume":"19","author":"Morgan","year":"2018","journal-title":"Pain Med"},{"issue":"6","key":"10.1016\/j.bjps.2024.04.001_bib37","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/0305-4179(95)00022-4","article-title":"Plasma concentrations of type II phospholipase A2, cytokines and eicosanoids in patients with burns","volume":"21","author":"Nakae","year":"1995","journal-title":"Burns"}],"container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681524001852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681524001852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:11:28Z","timestamp":1722384688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681524001852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":37,"alternative-id":["S1748681524001852"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2024.04.001","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EMLA cream in burns: A systematic review of safety, analgesic efficacy, and effects on burn pathophysiology","name":"articletitle","label":"Article Title"},{"value":"Journal of Plastic, Reconstructive & Aesthetic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjps.2024.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.","name":"copyright","label":"Copyright"}]}}