{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:19:21Z","timestamp":1780463961443,"version":"3.54.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","jprasurg.com","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bjps.2025.01.043","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T22:14:14Z","timestamp":1738275254000},"page":"128-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Novel method for preparation of autologous leucocyte rich platelet-rich plasma (L-PRP) under closed system and assessment of its clinical efficacy in androgenetic alopecia\u2014A retrospective cohort study"],"prefix":"10.1016","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6297-5126","authenticated-orcid":false,"given":"Kriti","family":"Batni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1807-2390","authenticated-orcid":false,"given":"Dheeraj","family":"Khetan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8051-7891","authenticated-orcid":false,"given":"Ankur","family":"Bhatnagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0866-068X","authenticated-orcid":false,"given":"Rajendra Kumar","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anviti","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bjps.2025.01.043_bib1","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1365-2133.2010.09640.x","article-title":"Prevalence of androgenetic alopecia in China: a community-based study in six cities","volume":"162","author":"Wang","year":"2010","journal-title":"Br J Dermatol"},{"issue":"2","key":"10.1016\/j.bjps.2025.01.043_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4103\/0974-7753.58556","article-title":"Male androgenetic alopecia: population-based study in 1,005 subjects","volume":"1","author":"Krupa Shankar","year":"2009","journal-title":"Int J Trichol"},{"key":"10.1016\/j.bjps.2025.01.043_bib3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.21037\/sci.2017.06.07","article-title":"Platelet-rich plasma-an 'Elixir' for treatment of alopecia: personal experience on 117 patients with review of literature","volume":"4","author":"Garg","year":"2017","journal-title":"Stem Cell Investig"},{"issue":"4","key":"10.1016\/j.bjps.2025.01.043_bib4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4103\/0974-2077.150743","article-title":"Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period","volume":"7","author":"Gkini","year":"2014","journal-title":"J Cutan Aesthet Surg"},{"issue":"11","key":"10.1016\/j.bjps.2025.01.043_bib5","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.5966\/sctm.2015-0107","article-title":"The effect of platelet-rich plasma in hair regrowth: a randomized placebo-controlled trial","volume":"4","author":"Gentile","year":"2015","journal-title":"Stem Cells Transl Med"},{"issue":"4","key":"10.1016\/j.bjps.2025.01.043_bib6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00008505-200110000-00002","article-title":"Platelet-rich plasma (PRP): what is PRP and what is not PRP?","volume":"10","author":"Marx","year":"2001","journal-title":"Implant Dent"},{"issue":"2","key":"10.1016\/j.bjps.2025.01.043_bib7","first-page":"e2145","article-title":"Efficacy of homologous, platelet-rich plasma dressing in chronic non-healing Ulcers: an observational study","volume":"10","author":"Prabhu","year":"2018","journal-title":"Cureus"},{"issue":"7","key":"10.1016\/j.bjps.2025.01.043_bib8","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.2174\/138920112800624445","article-title":"Applications of leukocyte- and platelet-rich plasma (L-PRP) in trauma surgery","volume":"13","author":"Yuan","year":"2012","journal-title":"Curr Pharm Biotechnol"},{"issue":"1","key":"10.1016\/j.bjps.2025.01.043_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1742-4933-10-23","article-title":"Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration","volume":"10","author":"Albanese","year":"2013","journal-title":"Immun Ageing"},{"issue":"12","key":"10.1016\/j.bjps.2025.01.043_bib10","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1017\/S0022215116009403","article-title":"Platelet-rich plasma in otolaryngology","volume":"130","author":"Stavrakas","year":"2016","journal-title":"J Laryngol Otol"},{"issue":"1","key":"10.1016\/j.bjps.2025.01.043_bib11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13019-016-0452-9","article-title":"Evaluation of autologous platelet rich plasma for cardiac surgery: outcome analysis of 2000 patients","volume":"11","author":"Patel","year":"2016","journal-title":"J Cardiothorac Surg"},{"issue":"1","key":"10.1016\/j.bjps.2025.01.043_bib12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ijwd.2018.08.004","article-title":"Platelet-rich plasma for androgenetic alopecia: A review of the literature and proposed treatment protocol","volume":"5","author":"Stevens","year":"2018","journal-title":"Int J Womens Dermatol"},{"issue":"2","key":"10.1016\/j.bjps.2025.01.043_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4103\/0974-2077.138352","article-title":"Platelet-rich plasma in androgenic alopecia: myth or an effective tool","volume":"7","author":"Khatu","year":"2014","journal-title":"J Cutan Aesthet Surg"},{"issue":"1","key":"10.1016\/j.bjps.2025.01.043_bib14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.32098\/mltj.01.2014.02","article-title":"Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives","volume":"4","author":"Dohan Ehrenfest","year":"2014","journal-title":"Muscles Ligaments Tendons J"},{"key":"10.1016\/j.bjps.2025.01.043_bib15","unstructured":"Section 12: Autologous blood transfusion. Transfusion Medicine Technical Manual. Third Edition 2023. Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India. pg no: 230\u2013231. Available from: \u3008https:\/\/www.google.com\/url?sa=t&source=web&rct=j&opi=89978449&url=https:\/\/dghs.gov.in\/Uploaddata\/Transfusion%2520Medicine%2520Technical%2520Manual%25202023.pdf&ved=2ahUKEwinoNGSm42IAxUpV2wGHfJ5MLkQFnoECBgQAQ&usg=AOvVaw0lZhStJ3hNbZ3qCGs0RVEV\u3009. Accessed on 24\/08\/2024."},{"issue":"5","key":"10.1016\/j.bjps.2025.01.043_bib16","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1177\/0363546519827294","article-title":"Effects of aspirin on growth factor release from freshly isolated leukocyte-rich platelet-rich plasma in healthy men: a prospective fixed-sequence controlled laboratory study","volume":"47","author":"Jayaram","year":"2019","journal-title":"Am J Sports Med"},{"issue":"1","key":"10.1016\/j.bjps.2025.01.043_bib17","first-page":"6","article-title":"Platlet rich plasma (PRP) improves fat grafting outcomes","volume":"2","author":"Modarressi","year":"2013","journal-title":"World J Plast Surg"},{"issue":"4","key":"10.1016\/j.bjps.2025.01.043_bib18","first-page":"559","article-title":"Hair evaluation method: pull test and wash test","volume":"33","author":"Guarrera","year":"2015","journal-title":"Dermatol Clin"},{"issue":"4","key":"10.1016\/j.bjps.2025.01.043_bib19","first-page":"189","article-title":"Cicatricial alopecia. An approach to diagnosis and management","volume":"30","author":"Price","year":"2011","journal-title":"Semin Cutan Med Surg"},{"issue":"2","key":"10.1016\/j.bjps.2025.01.043_bib20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000341542","article-title":"The adapted classification of male pattern hair loss improves reliability","volume":"225","author":"Khumalo","year":"2012","journal-title":"Dermatology"},{"issue":"3","key":"10.1016\/j.bjps.2025.01.043_bib21","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-2133.1977.tb15179.x","article-title":"Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex","volume":"97","author":"Ludwig","year":"1977","journal-title":"Br J Dermatol"},{"issue":"2","key":"10.1016\/j.bjps.2025.01.043_bib22","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4103\/ijdvl.IJDVL_589_18","article-title":"Comparison of efficacy of platelet-rich plasma therapy with or without topical 5% minoxidil in male-type baldness: A randomized, double-blind placebo control trial","volume":"86","author":"Singh","year":"2020","journal-title":"Indian J Dermatol Venereol Leprol"},{"issue":"4","key":"10.1016\/j.bjps.2025.01.043_bib23","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/DSS.0000000000000665","article-title":"Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia","volume":"42","author":"Alves","year":"2016","journal-title":"Dermatol Surg"},{"issue":"2","key":"10.1016\/j.bjps.2025.01.043_bib24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4103\/0973-6247.162713","article-title":"Efficacy of platelet-rich plasma in treatment of androgenic alopecia","volume":"9","author":"Singhal","year":"2015","journal-title":"Asian J Transfus Sci"},{"issue":"10","key":"10.1016\/j.bjps.2025.01.043_bib25","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1111\/jocd.14963","article-title":"Combination of platelet-rich plasma and platelet gel in treatment of resistance androgenic alopecia: A case series study","volume":"21","author":"Lotfi","year":"2022","journal-title":"J Cosmet Dermatol"},{"issue":"5","key":"10.1016\/j.bjps.2025.01.043_bib26","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.jaad.2020.06.1021","article-title":"The effect of platelet-rich plasma on female androgenetic alopecia: A randomized controlled trial","volume":"83","author":"Dubin","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.bjps.2025.01.043_bib27","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/760709","article-title":"The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation","volume":"2014","author":"Cervelli","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.bjps.2025.01.043_bib28","first-page":"292","article-title":"Autologous platelet rich plasma as a treatment of male androgenetic alopecia: study of 14 cases","volume":"6","author":"Borhan","year":"2015","journal-title":"J Clin Exp Dermatol Res"},{"key":"10.1016\/j.bjps.2025.01.043_bib29","article-title":"Blood collection, storage and component preparation methods","volume":"13","author":"Sweeny","year":"2002","journal-title":"Tech Man Am Assoc Blood Banks AABB"},{"key":"10.1016\/j.bjps.2025.01.043_bib30","doi-asserted-by":"crossref","first-page":"e1132","DOI":"10.6061\/clinics\/2019\/e1132","article-title":"Turn down - turn up: a simple and low-cost protocol for preparing platelet-rich plasma","volume":"74","author":"Machado","year":"2019","journal-title":"Clinics"},{"issue":"5","key":"10.1016\/j.bjps.2025.01.043_bib31","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/DSS.0000000000001049","article-title":"The effect of plasma rich in growth factors on pattern hair loss: a pilot study","volume":"43","author":"Anitua","year":"2017","journal-title":"Dermatol Surg"},{"issue":"2","key":"10.1016\/j.bjps.2025.01.043_bib32","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3390\/ijms18020408","article-title":"Evaluation of not-activated and activated PRP in hair loss treatment: role of growth factor and cytokine concentrations obtained by different collection systems","volume":"18","author":"Gentile","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"131","key":"10.1016\/j.bjps.2025.01.043_bib33","first-page":"56406","article-title":"Mechanical and controlled PRP injections in patients affected by androgenetic alopecia","author":"Gentile","year":"2018","journal-title":"J Vis Exp"},{"issue":"14","key":"10.1016\/j.bjps.2025.01.043_bib34","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.3390\/ijms20143446","article-title":"Autologous cellular method using micrografts of human adipose tissue derived follicle stem cells in androgenic alopecia","volume":"20","author":"Gentile","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.bjps.2025.01.043_bib35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/biomedicines7020027","article-title":"Platelet-rich plasma and micrografts enriched with autologous human follicle mesenchymal stem cells improve hair re-growth in androgenetic alopecia. biomolecular pathway analysis and clinical evaluation","volume":"7","author":"Gentile","year":"2019","journal-title":"Biomedicines"},{"key":"10.1016\/j.bjps.2025.01.043_bib36","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7397162","article-title":"Autologous micrografts from scalp tissue: trichoscopic and long-term clinical evaluation in male and female androgenetic alopecia","author":"Gentile","year":"2020","journal-title":"Biomed Res Int"},{"issue":"9","key":"10.1016\/j.bjps.2025.01.043_bib37","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1080\/14712598.2020.1797676","article-title":"A randomized blinded retrospective study: the combined use of micro-needling technique, low-level laser therapy and autologous non-activated platelet-rich plasma improves hair re-growth in patients with androgenic alopecia","volume":"20","author":"Gentile","year":"2020","journal-title":"Expert Opin Biol Ther"},{"issue":"3","key":"10.1016\/j.bjps.2025.01.043_bib38","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2165\/00044011-200929050-00001","article-title":"HairMax LaserComb laser phototherapy device in the treatment of male androgenetic alopecia: A randomized, double-blind, sham device-controlled, multicentre trial","volume":"29","author":"Leavitt","year":"2009","journal-title":"Clin Drug Investig"},{"issue":"8","key":"10.1016\/j.bjps.2025.01.043_bib39","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1111\/dsu.12200","article-title":"Low-level light therapy for androgenetic alopecia: a 24-week, randomized, double-blind, sham device-controlled multicenter trial","volume":"39","author":"Kim","year":"2013","journal-title":"Dermatol Surg"},{"issue":"7","key":"10.1016\/j.bjps.2025.01.043_bib40","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/1346-8138.12890","article-title":"Five-year efficacy of finasteride in 801 Japanese men with androgenetic alopecia","volume":"42","author":"Yoshitake","year":"2015","journal-title":"J Dermatol"},{"issue":"3","key":"10.1016\/j.bjps.2025.01.043_bib41","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1365-2133.2005.06218.x","article-title":"Treatment of female pattern hair loss with oral antiandrogens","volume":"152","author":"Sinclair","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.bjps.2025.01.043_bib42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11934-018-0814-z","article-title":"The Impact of 5\u03b1-Reductase Inhibitor Use for Male Pattern Hair Loss on Men\u2019s Health","volume":"19","author":"Said","year":"2018","journal-title":"Curr Urol Rep"},{"issue":"1","key":"10.1016\/j.bjps.2025.01.043_bib43","first-page":"e12510","article-title":"A case of contact allergic dermatitis to topical minoxidil","volume":"13","author":"BinJadeed","year":"2021","journal-title":"Cureus"}],"container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681525000440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681525000440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T22:15:05Z","timestamp":1744496105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681525000440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":43,"alternative-id":["S1748681525000440"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2025.01.043","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel method for preparation of autologous leucocyte rich platelet-rich plasma (L-PRP) under closed system and assessment of its clinical efficacy in androgenetic alopecia\u2014A retrospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Journal of Plastic, Reconstructive & Aesthetic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjps.2025.01.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}