{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:40:54Z","timestamp":1791996054160,"version":"4.4.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jprasurg.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.bjps.2025.02.050","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T03:23:15Z","timestamp":1741058595000},"page":"328-333","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A nationwide analysis of the association between parental age and incidence of cleft lip\/palate"],"prefix":"10.1016","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7208-1215","authenticated-orcid":false,"given":"Bhavana","family":"Thota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustine W.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7701-6460","authenticated-orcid":false,"given":"Kelsi","family":"Krakauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6764-9874","authenticated-orcid":false,"given":"Hoang-Viet","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4457-1442","authenticated-orcid":false,"given":"Payton","family":"Grande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3346-1930","authenticated-orcid":false,"given":"Jennifer","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1579-2787","authenticated-orcid":false,"given":"Rahim S.","family":"Nazerali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjps.2025.02.050_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mrrev.2021.108373","article-title":"Orofacial clefts embryology, classification, epidemiology, and genetics","volume":"787","author":"Nasreddine","year":"2021","journal-title":"Mutat Res Rev Mutat Res"},{"issue":"4","key":"10.1016\/j.bjps.2025.02.050_bib2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1055\/s-0041-1722951","article-title":"Genetic factors in nonsyndromic orofacial clefts","volume":"7","author":"Khan","year":"2020","journal-title":"Glob Med Genet"},{"issue":"3","key":"10.1016\/j.bjps.2025.02.050_bib3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1037\/a0028961","article-title":"It's a privilege to smile: Impact of cleft lip palate on families","volume":"30","author":"Zeytinoglu","year":"2012","journal-title":"Fam Syst Health"},{"issue":"2","key":"10.1016\/j.bjps.2025.02.050_bib4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0094-1298(03)00134-2","article-title":"Psychological issues in cleft lip and palate","volume":"31","author":"Kapp-Simon","year":"2004","journal-title":"Clin Plast Surg"},{"issue":"3","key":"10.1016\/j.bjps.2025.02.050_bib5","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1177\/003335490912400315","article-title":"Children with orofacial clefts: Health-care use and costs among a privately insured population","volume":"124","author":"Boulet","year":"2009","journal-title":"Public Health Rep"},{"issue":"3","key":"10.1016\/j.bjps.2025.02.050_bib6","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1055\/s-0039-3402353","article-title":"Burden of care: Management of cleft lip and palate","volume":"52","author":"Murthy","year":"2019","journal-title":"Indian J Plast Surg"},{"issue":"1","key":"10.1016\/j.bjps.2025.02.050_bib7","first-page":"21","article-title":"Environment and genetics in the etiology of cleft lip and cleft palate with reference to the role of folic acid [Ambiente e genetica nell'eziologia delle labioschisi e palatoschisi con particolare riferimento al ruolo dell'acido folico]","volume":"24","author":"Bianchi","year":"2000","journal-title":"Epidemiol Prev"},{"issue":"1","key":"10.1016\/j.bjps.2025.02.050_bib8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/(SICI)1096-9926(199607)54:1<27::AID-TERA4>3.0.CO;2-0","article-title":"Maternal alcohol use and risk of orofacial cleft birth defects","volume":"54","author":"Munger","year":"1996","journal-title":"Teratology"},{"key":"10.1016\/j.bjps.2025.02.050_bib9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.18332\/tid\/163177","article-title":"Environmental tobacco smoke exposure and non-syndromic orofacial cleft: Systematic review and meta-analysis","volume":"21","author":"Sabbagh","year":"2023","journal-title":"Tob Induc Dis"},{"key":"10.1016\/j.bjps.2025.02.050_bib10","article-title":"Smoking in adolescents with cleft lip and\/or palate: Prevalence and associated factors","volume":"41","author":"Villela","year":"2023","journal-title":"Rev Paul Pedia"},{"issue":"3","key":"10.1016\/j.bjps.2025.02.050_bib11","first-page":"578","article-title":"Analysis of environmental exposures for nonsyndromic cleft lip and\/or palate: A case-control study","volume":"51","author":"Ahmed Sakran","year":"2022","journal-title":"Iran J Public Health"},{"issue":"9","key":"10.1016\/j.bjps.2025.02.050_bib12","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1007\/s10815-022-02533-w","article-title":"Effect of advanced parental age on pregnancy outcome and offspring health","volume":"39","author":"Zhang","year":"2022","journal-title":"J Assist Reprod Genet"},{"issue":"12","key":"10.1016\/j.bjps.2025.02.050_bib13","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/bdra.23049","article-title":"Association between maternal age and birth defects of unknown etiology: United States, 1997-2007","volume":"94","author":"Gill","year":"2012","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"9","key":"10.1016\/j.bjps.2025.02.050_bib14","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1093\/humrep\/deaa105","article-title":"Association between advanced paternal age and congenital heart defects: A systematic review and meta-analysis","volume":"35","author":"Joinau-Zoulovits","year":"2020","journal-title":"Hum Reprod"},{"issue":"188","key":"10.1016\/j.bjps.2025.02.050_bib15","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1136\/adc.36.188.420","article-title":"Cleft lip and palate: Seasonal incidence, birth weight, birth rank, sex, site, associated malformations and parental age. A statistical survey","volume":"36","author":"Fraser","year":"1961","journal-title":"Arch Dis Child"},{"issue":"3-4","key":"10.1016\/j.bjps.2025.02.050_bib16","first-page":"231","article-title":"Parental age and incidence of cleft lip and cleft palate anomalies","volume":"8","author":"Balgir","year":"1984","journal-title":"Acta Anthropog"},{"issue":"2","key":"10.1016\/j.bjps.2025.02.050_bib17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00006534-195208000-00003","article-title":"Cleft lip and palate and parental age: A statistical study of etiology","volume":"10","author":"McEvitt","year":"1952","journal-title":"Plast Reconstr Surg (1946)"},{"issue":"12","key":"10.1016\/j.bjps.2025.02.050_bib18","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.annepidem.2015.05.003","article-title":"Parental age and the risk of isolated cleft lip: A registry-based study","volume":"25","author":"Berg","year":"2015","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.bjps.2025.02.050_bib19","unstructured":"Morse A. Stable fertility rates 1990\u20132019 mask distinct variations by age; 2022. Accessed from: https:\/\/www.census.gov\/library\/stories\/2022\/04\/fertility-rates-declined-for-younger-women-increased-for-older-women.html. [Accessed 8 January 2023]."},{"key":"10.1016\/j.bjps.2025.02.050_bib20","unstructured":"Bui Q, Miller CC. The age that women have babies: How a gap divides America; 2018. Available from: https:\/\/www.nytimes.com\/interactive\/2018\/08\/04\/upshot\/up-birth-age-gap.html#:\u223c:text=New%20parents%20tend%20to%20be,of%20first%20birth%20is%2031. [Accessed 8 January 2023]."},{"key":"10.1016\/j.bjps.2025.02.050_bib21","unstructured":"CDC. Vital Statistics Wonder Database; 2023. Available from: https:\/\/wonder.cdc.gov\/. [Accessed 17 Feburary 2023]."},{"issue":"5","key":"10.1016\/j.bjps.2025.02.050_bib22","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1597\/1545-1569_2003_040_0481_ssaoci_2.0.co_2","article-title":"Socioeconomic status and orofacial clefts in Scotland, 1989 to 1998","volume":"40","author":"Clark","year":"2003","journal-title":"Cleft Palate Craniofac J"},{"issue":"1","key":"10.1016\/j.bjps.2025.02.050_bib23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1597\/1545-1569_1997_034_0011_msaoc_2.3.co_2","article-title":"Maternal smoking and orofacial clefts","volume":"34","author":"Kallen","year":"1997","journal-title":"Cleft Palate Craniofac J"},{"issue":"3","key":"10.1016\/j.bjps.2025.02.050_bib24","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/ppe.12727","article-title":"Risk of non-syndromic orofacial clefts by maternal rural-urban residence and race\/ethnicity: A population-based case-control study in Washington State 1989-2014","volume":"35","author":"Kapos","year":"2021","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.bjps.2025.02.050_bib25","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.bjps.2023.11.012","article-title":"US air pollution is associated with increased incidence of non-syndromic cleft lip\/palate","volume":"88","author":"Krakauer","year":"2024","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"1","key":"10.1016\/j.bjps.2025.02.050_bib26","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/(SICI)1096-8628(19980827)79:1<42::AID-AJMG11>3.0.CO;2-M","article-title":"Racial and ethnic variations in the prevalence of orofacial clefts in California, 1983-1992","volume":"79","author":"Croen","year":"1998","journal-title":"Am J Med Genet"},{"issue":"1","key":"10.1016\/j.bjps.2025.02.050_bib27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/humupd\/dmr040","article-title":"Demographic and medical consequences of the postponement of parenthood","volume":"18","author":"Schmidt","year":"2012","journal-title":"Hum Reprod Update"},{"issue":"7","key":"10.1016\/j.bjps.2025.02.050_bib28","first-page":"819","article-title":"Orofacial clefts and maternal risk factors: A population-based case-control study","volume":"11","author":"Santoro","year":"2024","journal-title":"Child (Basel)"},{"issue":"1","key":"10.1016\/j.bjps.2025.02.050_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jdent.2011.10.002","article-title":"Parental age as a risk factor for non-syndromic oral clefts: A meta-analysis","volume":"40","author":"Herkrath","year":"2012","journal-title":"J Dent"}],"container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S174868152500155X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S174868152500155X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T19:38:46Z","timestamp":1760643526000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S174868152500155X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":29,"alternative-id":["S174868152500155X"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2025.02.050","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A nationwide analysis of the association between parental age and incidence of cleft lip\/palate","name":"articletitle","label":"Article Title"},{"value":"Journal of Plastic, Reconstructive & Aesthetic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjps.2025.02.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.","name":"copyright","label":"Copyright"}]}}