{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:29:17Z","timestamp":1779316157544,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jprasurg.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bjps.2025.08.024","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T07:04:07Z","timestamp":1756451047000},"page":"130-143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Impact of topical analgesia on injection pain perception in facial botulinum toxin injections: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"110","author":[{"given":"Galathea","family":"Van Hout","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4159-8067","authenticated-orcid":false,"given":"Gino","family":"Vissers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Tondu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Thiessen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3708-6501","authenticated-orcid":false,"given":"Veronique","family":"Verhoeven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bjps.2025.08.024_bib1","first-page":"e416","article-title":"Efficacy of botulinum toxin in the treatment of bruxism: systematic review","volume":"24","author":"Fern\u00e1ndez-N\u00fa\u00f1ez","year":"2019","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"6","key":"10.1016\/j.bjps.2025.08.024_bib2","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.bjps.2017.01.009","article-title":"Botulinum toxin treatment for facial palsy: a systematic review","volume":"70","author":"Cooper","year":"2017","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"2","key":"10.1016\/j.bjps.2025.08.024_bib3","first-page":"Cd006499","article-title":"Botulinum toxin for the treatment of strabismus","author":"Rowe","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"9","key":"10.1016\/j.bjps.2025.08.024_bib4","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1097\/DCR.0000000000000612","article-title":"Optimal dosing of botulinum toxin for treatment of chronic anal fissure: a systematic review and meta-analysis","volume":"59","author":"Lin","year":"2016","journal-title":"Dis Colon Rectum"},{"issue":"6","key":"10.1016\/j.bjps.2025.08.024_bib5","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.parkreldis.2012.04.005","article-title":"Muscle selection for treatment of cervical dystonia with botulinum toxin\u2014a systematic review","volume":"18","author":"Nijmeijer","year":"2012","journal-title":"Parkinsonism Relat Disord"},{"issue":"2","key":"10.1016\/j.bjps.2025.08.024_bib6","doi-asserted-by":"crossref","first-page":"256","DOI":"10.23736\/S1973-9087.16.04329-X","article-title":"Efficacy and safety of botulinum toxin type A for upper limb spasticity after stroke or traumatic brain injury: a systematic review with meta-analysis and trial sequential analysis","volume":"53","author":"Dong","year":"2017","journal-title":"Eur J Phys Rehabil Med"},{"issue":"1","key":"10.1016\/j.bjps.2025.08.024_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/toxins14010025","article-title":"Botulinum toxin\u2014A injection in chronic pelvic pain syndrome treatment: a systematic review and pooled meta-analysis","volume":"14","author":"Panunzio","year":"2022","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.bjps.2025.08.024_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3284446","article-title":"Botox (OnabotulinumtoxinA) for treatment of migraine symptoms: a systematic review","volume":"2022","author":"Shaterian","year":"2022","journal-title":"Pain Res Manag"},{"issue":"2","key":"10.1016\/j.bjps.2025.08.024_bib9","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/IOP.0b013e318030459c","article-title":"Efficacy of skin cooling and EMLA cream application for pain relief of periocular botulinum toxin injection","volume":"23","author":"Elibol","year":"2007","journal-title":"Ophthalmic Plast Reconstr Surg"},{"issue":"5","key":"10.1016\/j.bjps.2025.08.024_bib10","doi-asserted-by":"crossref","first-page":"Np327","DOI":"10.1093\/asj\/sjac036","article-title":"Complications of cosmetic botulinum toxin A injections to the upper face: a systematic review and meta-analysis","volume":"42","author":"Zargaran","year":"2022","journal-title":"Aesthet Surg J"},{"issue":"3","key":"10.1016\/j.bjps.2025.08.024_bib11","doi-asserted-by":"crossref","first-page":"518e","DOI":"10.1097\/01.prs.0000475758.63709.23","article-title":"Global aesthetics consensus: botulinum toxin type A\u2014evidence-based review, emerging concepts, and consensus recommendations for aesthetic use, including updates on complications","volume":"137","author":"Sundaram","year":"2016","journal-title":"Plast Reconstr Surg"},{"issue":"7","key":"10.1016\/j.bjps.2025.08.024_bib12","first-page":"886","article-title":"Pain sensation during intradermal injections of three different botulinum toxin preparations in different doses and dilutions","volume":"32","author":"Kranz","year":"2006","journal-title":"Dermatol Surg"},{"issue":"6","key":"10.1016\/j.bjps.2025.08.024_bib13","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1067\/mjd.2003.487","article-title":"Reduction in injection pain with botulinum toxin type B further diluted using saline with preservative: a double-blind, randomized controlled trial","volume":"48","author":"van Laborde","year":"2003","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.bjps.2025.08.024_bib14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2165\/11530110-000000000-00000","article-title":"Botulinum toxin: examining duration of effect in facial aesthetic applications","volume":"11","author":"Flynn","year":"2010","journal-title":"Am J Clin Dermatol"},{"issue":"4","key":"10.1016\/j.bjps.2025.08.024_bib15","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/SAP.0b013e31812f6e0f","article-title":"EMLA cream application without occlusive dressing before upper facial botulinum toxin injection: a randomized, double-blind, placebo-controlled trial","volume":"60","author":"Kashkouli","year":"2008","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.bjps.2025.08.024_bib16","unstructured":"Sch\u00fcnemann H BJ, Guyatt G, Oxman A, editors. GRADE handbook for grading quality of evidence and strength of recommendations. The GRADE Working Group; 2013."},{"issue":"12","key":"10.1016\/j.bjps.2025.08.024_bib17","first-page":"1655","article-title":"Single-center, double-blind, randomized study to evaluate the efficacy of 4% lidocaine cream versus vehicle cream during botulinum toxin type A treatments","volume":"31","author":"Carruthers","year":"2005","journal-title":"Dermatol Surg"},{"issue":"6","key":"10.1016\/j.bjps.2025.08.024_bib18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1177\/0145561319839839","article-title":"Vibration versus ice to reduce cosmetic botulinum toxin injection pain\u2014a\u00a0randomized controlled trial","volume":"98","author":"Chorney","year":"2019","journal-title":"Ear Nose Throat J"},{"issue":"9","key":"10.1016\/j.bjps.2025.08.024_bib19","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.bjps.2009.07.045","article-title":"Botulinum toxin injection pain relief using a topical anesthetic skin refrigerant","volume":"63","author":"Engel","year":"2010","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"1","key":"10.1016\/j.bjps.2025.08.024_bib20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.asj.2003.10.002","article-title":"Easing Botox administration with EMLA cream","volume":"24","author":"Eppley","year":"2004","journal-title":"Aesthet Surg J"},{"issue":"3","key":"10.1016\/j.bjps.2025.08.024_bib21","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/SAP.0000000000000121","article-title":"A clinical comparison of EMLA cream and ethyl chloride spray application for pain relief of forehead Botulinum toxin injection","volume":"75","author":"Irkoren","year":"2015","journal-title":"Ann Plast Surg"},{"issue":"6","key":"10.1016\/j.bjps.2025.08.024_bib22","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/00002341-200211000-00010","article-title":"Skin cooling before periocular botulinum toxin A injection","volume":"18","author":"Linder","year":"2002","journal-title":"Ophthalmic Plast Reconstr Surg"},{"issue":"6","key":"10.1016\/j.bjps.2025.08.024_bib23","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/01.iop.0000248989.33572.3c","article-title":"Efficacy of botulinum toxin type a after topical anesthesia","volume":"22","author":"Sami","year":"2006","journal-title":"Ophthalmic Plast Reconstr Surg"},{"issue":"6","key":"10.1016\/j.bjps.2025.08.024_bib24","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/01.sap.0000139563.51598.75","article-title":"Evaluating the effects of ice application on the pain felt during botulinum toxin type-a injections: a prospective, randomized, single-blind controlled trial","volume":"53","author":"Sarifakioglu","year":"2004","journal-title":"Ann Plast Surg"},{"issue":"8","key":"10.1016\/j.bjps.2025.08.024_bib25","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1177\/1090820X11422809","article-title":"Investigating the efficacy of vibration anesthesia to reduce pain from cosmetic botulinum toxin injections","volume":"31","author":"Sharma","year":"2011","journal-title":"Aesthet Surg J"},{"issue":"3","key":"10.1016\/j.bjps.2025.08.024_bib26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/IOP.0b013e3181a145ca","article-title":"Reduction of pain and anxiety prior to botulinum toxin injections with a new topical anesthetic method","volume":"25","author":"Weiss","year":"2009","journal-title":"Ophthalmic Plast Reconstr Surg"},{"issue":"5","key":"10.1016\/j.bjps.2025.08.024_bib27","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1159\/000066186","article-title":"Anesthesia with EMLA cream for botulinum A toxin injection into eyelids","volume":"216","author":"Soylev","year":"2002","journal-title":"Ophthalmologica"},{"issue":"10","key":"10.1016\/j.bjps.2025.08.024_bib28","first-page":"1200","article-title":"Evaluating the effects of ice application on patient comfort before and after botulinum toxin type A injections","volume":"93","author":"Saeliw","year":"2010","journal-title":"J Med Assoc Thai"},{"issue":"3","key":"10.1016\/j.bjps.2025.08.024_bib29","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/01.sap.0000238338.61631.e0","article-title":"Skin cooling for botulinum toxin A injection in patients with focal axillary hyperhidrosis \u2013\u00a0a\u00a0prospective, randomized, controlled study","volume":"58","author":"Bechara","year":"2007","journal-title":"Ann Plast Surg"},{"issue":"3","key":"10.1016\/j.bjps.2025.08.024_bib30","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1136\/bjo.78.3.209","article-title":"Percutaneous anaesthesia with a lignocaine-prilocaine cream (Emla) for eyelid skin surgery","volume":"78","author":"Gotsis","year":"1994","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"10.1016\/j.bjps.2025.08.024_bib31","first-page":"495","article-title":"Emla versus ice as a topical anesthetic","volume":"27","author":"Kuwahara","year":"2001","journal-title":"Dermatol Surg"},{"issue":"2","key":"10.1016\/j.bjps.2025.08.024_bib32","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/bja\/64.2.173","article-title":"Depth and duration of skin analgesia to needle insertion after topical application of EMLA cream","volume":"64","author":"Bjerring","year":"1990","journal-title":"Br J Anaesth"}],"container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681525005157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681525005157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T16:32:49Z","timestamp":1760805169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681525005157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":32,"alternative-id":["S1748681525005157"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2025.08.024","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of topical analgesia on injection pain perception in facial botulinum toxin injections: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Plastic, Reconstructive & Aesthetic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjps.2025.08.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}