{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:16:52Z","timestamp":1783426612973,"version":"3.54.6"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006389","name":"Universit\u00e9 de Gen\u00e8ve","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006389","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020971","name":"University of Geneva Faculty of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jprasurg.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bjps.2025.09.033","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T02:56:14Z","timestamp":1759546574000},"page":"116-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dose-dependent effects of hyperbaric oxygen on PC12 cell viability and neurite outgrowth with and without NGF stimulation"],"prefix":"10.1016","volume":"111","author":[{"given":"Dominik","family":"Andr\u00e9-L\u00e9vigne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot","family":"Maytain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigue","family":"Pignel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Boet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Felix","family":"Kalbermatten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Madduri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bjps.2025.09.033_bib1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.aanat.2011.04.008","article-title":"Outcome measures of peripheral nerve regeneration","volume":"193","author":"Wood","year":"2011","journal-title":"Ann Anat"},{"issue":"2","key":"10.1016\/j.bjps.2025.09.033_bib2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1750-3639.1999.tb00231.x","article-title":"Mechanisms of immune regulation in the peripheral nervous system","volume":"9","author":"Gold","year":"1999","journal-title":"Brain Pathol"},{"issue":"4","key":"10.1016\/j.bjps.2025.09.033_bib3","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0002-9610(69)90174-3","article-title":"Oxygen and healing","volume":"118","author":"Hunt","year":"1969","journal-title":"Am J Surg"},{"issue":"3","key":"10.1016\/j.bjps.2025.09.033_bib4","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s00268-003-7400-2","article-title":"Oxygen in wound healing--more than a nutrient","volume":"28","author":"Tandara","year":"2004","journal-title":"World J Surg"},{"issue":"11","key":"10.1016\/j.bjps.2025.09.033_bib5","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.bbagen.2008.01.006","article-title":"Redox signals in wound healing","volume":"1780","author":"Sen","year":"2008","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"10.1016\/j.bjps.2025.09.033_bib6","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/ana.410290308","article-title":"Peripheral neuropathy after chronic endoneurial ischemia","volume":"29","author":"Sladky","year":"1991","journal-title":"Ann Neurol"},{"issue":"1","key":"10.1016\/j.bjps.2025.09.033_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1524-475X.2008.00436.x","article-title":"Wound healing essentials: let there be oxygen","volume":"17","author":"Sen","year":"2009","journal-title":"Wound Repair Regen"},{"issue":"2","key":"10.1016\/j.bjps.2025.09.033_bib8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1179\/016164107X181824","article-title":"Hyperbaric oxygenation in peripheral nerve repair and regeneration","volume":"29","author":"Sanchez","year":"2007","journal-title":"Neurol Res"},{"issue":"6","key":"10.1016\/j.bjps.2025.09.033_bib9","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/wrr.12480","article-title":"Hyperbaric oxygen therapy promotes wound repair in ischemic and hyperglycemic conditions, increasing tissue perfusion and collagen deposition","volume":"24","author":"Andre-Levigne","year":"2016","journal-title":"Wound Repair Regen"},{"issue":"5","key":"10.1016\/j.bjps.2025.09.033_bib10","first-page":"345","article-title":"Hyperbaric oxygen therapy and promoting neurological recovery following nerve trauma","volume":"38","author":"Nazario","year":"2011","journal-title":"Undersea Hyperb Med"},{"issue":"2","key":"10.1016\/j.bjps.2025.09.033_bib11","first-page":"203","article-title":"Hyperbaric oxygen in the treatment of life-threatening soft-tissue infections","volume":"5","author":"Clark","year":"1999","journal-title":"Respir Care Clin N Am"},{"issue":"6","key":"10.1016\/j.bjps.2025.09.033_bib12","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/infdis\/142.6.915","article-title":"A mechanism for the amelioration by hyperbaric oxygen of experimental staphylococcal osteomyelitis in rabbits","volume":"142","author":"Mader","year":"1980","journal-title":"J Infect Dis"},{"issue":"7","key":"10.1016\/j.bjps.2025.09.033_bib13","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/micr.30023","article-title":"The effect of different application timings of hyperbaric oxygen treatment on nerve regeneration in rats","volume":"36","author":"Ince","year":"2016","journal-title":"Microsurgery"},{"issue":"5","key":"10.1016\/j.bjps.2025.09.033_bib14","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.amjoto.2013.06.006","article-title":"Hyperbaric oxygen versus steroid in facial nerve injury: an experimental animal study","volume":"34","author":"Toros","year":"2013","journal-title":"Am J Otolaryngol"},{"issue":"2","key":"10.1016\/j.bjps.2025.09.033_bib15","first-page":"107","article-title":"Effect of hyperbaric oxygenation on peripheral nerve regeneration in adult male rabbits","volume":"23","author":"Bradshaw","year":"1996","journal-title":"Undersea Hyperb Med"},{"issue":"2","key":"10.1016\/j.bjps.2025.09.033_bib16","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1006\/exnr.1997.6745","article-title":"Hyperbaric oxygen treatment enhances regeneration of the rat sciatic nerve","volume":"149","author":"Haapaniemi","year":"1998","journal-title":"Exp Neurol"},{"issue":"1","key":"10.1016\/j.bjps.2025.09.033_bib17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/02844310151032439","article-title":"Effects of hyperbaric oxygen treatment on axonal outgrowth in sciatic nerve grafts in rats","volume":"35","author":"Haapaniemi","year":"2001","journal-title":"Scand J Plast Reconstr Surg Hand Surg"},{"issue":"3","key":"10.1016\/j.bjps.2025.09.033_bib18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1529-8027.2002.02021.x","article-title":"Functional evaluation after rat sciatic nerve injury followed by hyperbaric oxygen treatment","volume":"7","author":"Haapaniemi","year":"2002","journal-title":"J Peripher Nerv Syst"},{"issue":"3","key":"10.1016\/j.bjps.2025.09.033_bib19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1590\/S0041-87811999000300003","article-title":"Effect of hyperbaric oxygen on the regeneration of experimental crush injuries of nerves","volume":"54","author":"Tuma Junior","year":"1999","journal-title":"Rev Hosp Clin Fac Med Sao Paulo"},{"issue":"2","key":"10.1016\/j.bjps.2025.09.033_bib20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1529-8027.2001.01014.x","article-title":"Hyperbaric oxygen treatment has different effects on nerve regeneration in acellular nerve and muscle grafts","volume":"6","author":"Nishiura","year":"2001","journal-title":"J Peripher Nerv Syst"},{"issue":"9","key":"10.1016\/j.bjps.2025.09.033_bib21","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/rapm-2022-104113","article-title":"The role of hyperbaric oxygen therapy in the management of perioperative peripheral nerve injury: a scoping review of the literature","volume":"48","author":"Brenna","year":"2023","journal-title":"Reg Anesth Pain Med"},{"issue":"15","key":"10.1016\/j.bjps.2025.09.033_bib22","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.3390\/nu15153454","article-title":"Polyphenols and their impact on the prevention of neurodegenerative diseases and development","volume":"15","author":"Grabska-Kobylecka","year":"2023","journal-title":"Nutrients"},{"issue":"16","key":"10.1016\/j.bjps.2025.09.033_bib23","doi-asserted-by":"crossref","first-page":"13898","DOI":"10.1074\/jbc.M209164200","article-title":"Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner","volume":"278","author":"Salinas","year":"2003","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.bjps.2025.09.033_bib24","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1021\/acsinfecdis.0c00107","article-title":"Nerve growth factor confers neuroprotection against colistin-induced peripheral neurotoxicity","volume":"6","author":"Dai","year":"2020","journal-title":"ACS Infect Dis"},{"issue":"10","key":"10.1016\/j.bjps.2025.09.033_bib25","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1002\/jbm.a.35078","article-title":"PDLLA\/PRGD\/beta-TCP conduits build the neurotrophin-rich microenvironment suppressing the oxidative stress and promoting the sciatic nerve regeneration","volume":"102","author":"Qiu","year":"2014","journal-title":"J Biomed Mater Res A"},{"issue":"4","key":"10.1016\/j.bjps.2025.09.033_bib26","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/jnr.22778","article-title":"Expression of antioxidant molecules after peripheral nerve injury and regeneration","volume":"90","author":"Lanza","year":"2012","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.bjps.2025.09.033_bib27","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.2147\/JIR.S422790","article-title":"Effect of hyperbaric oxygen intervention on oxidative stress and expression of nerve growth factor in patients with craniocerebral injury","volume":"16","author":"Ren","year":"2023","journal-title":"J Inflamm Res"},{"issue":"1","key":"10.1016\/j.bjps.2025.09.033_bib28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s12883-017-1004-1","article-title":"Neuroprotective effects of hyperbaric oxygen (HBO) therapy on neuronal death induced by sciatic nerve transection in rat","volume":"17","author":"Shams","year":"2017","journal-title":"BMC Neurol"},{"issue":"7","key":"10.1016\/j.bjps.2025.09.033_bib29","doi-asserted-by":"crossref","first-page":"7513","DOI":"10.18632\/oncotarget.23867","article-title":"Early hyperbaric oxygen effects on neuropathic pain and nitric oxide synthase isoforms in CCI rats","volume":"9","author":"Ding","year":"2018","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.bjps.2025.09.033_bib30","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3390\/biom10060958","article-title":"The hyperoxic-hypoxic paradox","volume":"10","author":"Hadanny","year":"2020","journal-title":"Biomolecules"},{"issue":"8","key":"10.1016\/j.bjps.2025.09.033_bib31","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.3390\/biom11081210","article-title":"The effects of hyperbaric oxygenation on oxidative stress, inflammation and angiogenesis","volume":"11","author":"De Wolde","year":"2021","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.bjps.2025.09.033_bib32","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ymthe.2005.07.684","article-title":"Dermal wound healing is subject to redox control","volume":"13","author":"Roy","year":"2006","journal-title":"Mol Ther"},{"issue":"6","key":"10.1016\/j.bjps.2025.09.033_bib33","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1046\/j.1524-475X.2003.11607.x","article-title":"The general case for redox control of wound repair","volume":"11","author":"Sen","year":"2003","journal-title":"Wound Repair Regen"},{"issue":"3","key":"10.1016\/j.bjps.2025.09.033_bib34","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41556-018-0039-x","article-title":"Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons","volume":"20","author":"Hervera","year":"2018","journal-title":"Nat Cell Biol"}],"container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681525005820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681525005820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:33:59Z","timestamp":1783424039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681525005820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":34,"alternative-id":["S1748681525005820"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2025.09.033","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dose-dependent effects of hyperbaric oxygen on PC12 cell viability and neurite outgrowth with and without NGF stimulation","name":"articletitle","label":"Article Title"},{"value":"Journal of Plastic, Reconstructive & Aesthetic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjps.2025.09.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.","name":"copyright","label":"Copyright"}]}}