{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:59:02Z","timestamp":1787626742788,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272276"],"award-info":[{"award-number":["82272276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jprasurg.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bjps.2025.12.005","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T01:44:50Z","timestamp":1765417490000},"page":"592-600","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Lipase A as a lipid metabolism-related biomarker and therapeutic target in hypertrophic scars"],"prefix":"10.1016","volume":"113","author":[{"given":"Xuehua","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuxin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlian","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9685-7003","authenticated-orcid":false,"given":"Ronghua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bjps.2025.12.005_bib1","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0140-6736(16)31406-4","article-title":"Hypertrophic scarring: the greatest unmet challenge after burn injury","volume":"388","author":"Finnerty","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.bjps.2025.12.005_bib2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature07039","article-title":"Wound repair and regeneration","volume":"453","author":"Gurtner","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bjps.2025.12.005_bib3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12951-023-01861-y","article-title":"Extracellular vesicles from Lactobacillus druckerii inhibit hypertrophic scar fibrosis","volume":"21","author":"Han","year":"2023","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.bjps.2025.12.005_bib4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fmed.2017.00083","article-title":"Current therapeutic approach to hypertrophic scars","volume":"4","author":"Mokos","year":"2017","journal-title":"Front Med"},{"key":"10.1016\/j.bjps.2025.12.005_bib5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/BCR.0B013E318093E482","article-title":"Hypertrophic scar, wound contraction and hyper-hypopigmentation","volume":"28","author":"Engrav","year":"2007","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.bjps.2025.12.005_bib6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0305-4179(03)00067-6","article-title":"What is the prevalence of hypertrophic scarring following burns?","volume":"29","author":"Bombaro","year":"2003","journal-title":"Burns"},{"key":"10.1016\/j.bjps.2025.12.005_bib7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s12079-013-0195-5","article-title":"The molecular mechanism of hypertrophic scar","volume":"7","author":"Zhu","year":"2013","journal-title":"J Cell Commun Signal"},{"key":"10.1016\/j.bjps.2025.12.005_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkad047","article-title":"Metabolic reprogramming in skin wound healing","volume":"12","author":"Wang","year":"2024","journal-title":"Burns Trauma"},{"key":"10.1016\/j.bjps.2025.12.005_bib9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41573-019-0040-5","article-title":"Targeting metabolic dysregulation for fibrosis therapy","volume":"19","author":"Zhao","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bjps.2025.12.005_bib10","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/j.jid.2023.02.039","article-title":"Metabolic reprogramming and reliance in human skin wound healing","volume":"143","author":"Manchanda","year":"2023","journal-title":"J Investig Dermatol"},{"key":"10.1016\/j.bjps.2025.12.005_bib11","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.tcb.2020.09.006","article-title":"Lipid metabolism in regulation of macrophage functions","volume":"30","author":"Yan","year":"2020","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.bjps.2025.12.005_bib12","doi-asserted-by":"crossref","first-page":"7052","DOI":"10.3390\/molecules27207052","article-title":"Important hormones regulating lipid metabolism","volume":"27","author":"Zhang","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bjps.2025.12.005_bib13","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/nrc.2016.89","article-title":"The multifaceted roles of fatty acid synthesis in cancer","volume":"16","author":"R\u00f6hrig","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bjps.2025.12.005_bib14","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.cmet.2019.06.014","article-title":"Oncogene amplification in growth factor signaling pathways renders cancers dependent on membrane lipid remodeling","volume":"30","author":"Bi","year":"2019","journal-title":"Cell Metab"},{"key":"10.1016\/j.bjps.2025.12.005_bib15","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1158\/2159-8290.CD-19-0061","article-title":"Glioma stem cell\u2013specific superenhancer promotes polyunsaturated fatty-acid synthesis to support EGFR signaling","volume":"9","author":"Gimple","year":"2019","journal-title":"Cancer Discov"},{"key":"10.1016\/j.bjps.2025.12.005_bib16","doi-asserted-by":"crossref","first-page":"12445","DOI":"10.1039\/D2SC04307F","article-title":"Linoleic acid metabolism activation in macrophages promotes the clearing of intracellular Staphylococcus aureus","volume":"13","author":"Yan","year":"2022","journal-title":"Chem Sci"},{"key":"10.1016\/j.bjps.2025.12.005_bib17","doi-asserted-by":"crossref","first-page":"120153","DOI":"10.1016\/j.jep.2025.120153","article-title":"Sanleng Wan inhibits endometriosis progression by regulating sphingolipid metabolism via the S1P\/S1PR1-Akt axis based on serum metabolomics and network pharmacology","volume":"352","author":"Fu","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bjps.2025.12.005_bib18","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cmet.2023.02.013","article-title":"Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity","volume":"35","author":"Lauson","year":"2023","journal-title":"Cell Metab"},{"key":"10.1016\/j.bjps.2025.12.005_bib19","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/s41419-021-04213-6","article-title":"ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation","volume":"12","author":"Li","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.bjps.2025.12.005_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.177108","article-title":"The involvement and possible targeting of cardiolipins degradation and disturbed linoleic acid metabolism in cardiac atrophy under cancer cachexia","volume":"985","author":"Wang","year":"2024","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bjps.2025.12.005_bib21","doi-asserted-by":"crossref","DOI":"10.1080\/15384047.2024.2325130","article-title":"Linoleic acid exhibits anti-proliferative and anti-invasive activities in endometrial cancer cells and a transgenic model of endometrial cancer","volume":"25","author":"Qiu","year":"2024","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.bjps.2025.12.005_bib22","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3390\/ijms23010225","article-title":"Linoleic acid upregulates microRNA-494 to induce quiescence in colorectal cancer","volume":"23","author":"Ogata","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bjps.2025.12.005_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217903","article-title":"Metabolic gatekeeper ACAD9 coordinates linoleic acid metabolism and redox homeostasis via mitochondrial complex I to drive ovarian cancer progression","volume":"630","author":"Li","year":"2025","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bjps.2025.12.005_bib24","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cmet.2024.10.016","article-title":"Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis","volume":"37","author":"Gengatharan","year":"2025","journal-title":"Cell Metab"},{"key":"10.1016\/j.bjps.2025.12.005_bib25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.pccm.2025.05.002","article-title":"Sphingolipid metabolism dysregulation: a cause for lung cancer development, progression, and resistance to therapies","volume":"3","author":"Cungui","year":"2025","journal-title":"Chin Med J Pulm Crit Care Med"},{"key":"10.1016\/j.bjps.2025.12.005_bib26","doi-asserted-by":"crossref","first-page":"678","DOI":"10.3390\/cells12050678","article-title":"An updated review of hypertrophic scarring","volume":"12","author":"Mony","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.bjps.2025.12.005_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/science.adm9805","article-title":"Direct sensing of dietary \u03c9-6 linoleic acid through FABP5-mTORC1 signaling","volume":"387","author":"Koundouros","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.bjps.2025.12.005_bib28","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41586-024-07098-5","article-title":"IL-10 constrains sphingolipid metabolism to limit inflammation","volume":"627","author":"York","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bjps.2025.12.005_bib29","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1136\/gutjnl-2023-330009","article-title":"Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis","volume":"73","author":"Ma","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.bjps.2025.12.005_bib30","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1161\/CIRCRESAHA.123.323826","article-title":"Rewiring endothelial sphingolipid metabolism to favor S1P over ceramide protects from coronary atherosclerosis","volume":"134","author":"Manzo","year":"2024","journal-title":"Circ Res"},{"key":"10.1016\/j.bjps.2025.12.005_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2025.156237","article-title":"Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver","volume":"168","author":"Gruevska","year":"2025","journal-title":"Metabolism"},{"key":"10.1016\/j.bjps.2025.12.005_bib32","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/DSS.0000000000001678","article-title":"Treatment of hypertrophic scars using laser-assisted corticosteroid versus laser-assisted 5-fluorouracil delivery","volume":"45","author":"Waibel","year":"2019","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.bjps.2025.12.005_bib33","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1111\/jocd.16304","article-title":"Betamethasone transdermal administration combined with fractional Er: YAG lasers or microplasma radiofrequency technology improved hypertrophic scars: a retrospective study","volume":"23","author":"Liu","year":"2024","journal-title":"J Cosmet Dermatol"},{"key":"10.1016\/j.bjps.2025.12.005_bib34","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S2707-3688(23)00015-8","article-title":"Imiquimod liposome gel preparations and their ability to inhibit hypertrophic scars","volume":"2","author":"Yujian","year":"2021","journal-title":"J Holist Integr Pharm"},{"key":"10.1016\/j.bjps.2025.12.005_bib35","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.burns.2021.02.013","article-title":"The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: a systematic review and meta-analysis","volume":"47","author":"Zhuang","year":"2021","journal-title":"Burns"},{"key":"10.1016\/j.bjps.2025.12.005_bib36","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00266-022-03229-3","article-title":"Efficacy and safety of verapamil versus triamcinolone acetonide in treating keloids and hypertrophic scars: a systematic review and meta-analysis","volume":"47","author":"Zhang","year":"2023","journal-title":"Aesthet Plast Surg"},{"key":"10.1016\/j.bjps.2025.12.005_bib37","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1210\/me.2008-0464","article-title":"Direct effect of glucocorticoids on lipolysis in adipocytes","volume":"23","author":"Xu","year":"2009","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.bjps.2025.12.005_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167045","article-title":"Exercise ameliorates lipid droplet metabolism disorder by the PLIN2\u2013LIPA axis-mediated lipophagy in mouse model of non-alcoholic fatty liver disease","volume":"1870","author":"Fang","year":"2024","journal-title":"Biochim Biophys Acta (BBA) Mol Basis Dis"},{"key":"10.1016\/j.bjps.2025.12.005_bib39","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1161\/ATVBAHA.119.312136","article-title":"Lysosomal acid lipase in lipid metabolism and beyond","volume":"39","author":"Li","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.bjps.2025.12.005_bib40","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2022.2085432","article-title":"Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression","volume":"11","author":"Liu","year":"2022","journal-title":"Oncoimmunology"}],"container-title":["Journal of Plastic, Reconstructive & Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681525007260?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681525007260?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T01:38:35Z","timestamp":1774057115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681525007260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":40,"alternative-id":["S1748681525007260"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2025.12.005","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipase A as a lipid metabolism-related biomarker and therapeutic target in hypertrophic scars","name":"articletitle","label":"Article Title"},{"value":"Journal of Plastic, Reconstructive & Aesthetic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjps.2025.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.","name":"copyright","label":"Copyright"}]}}