{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:42:37Z","timestamp":1787755357393,"version":"build-2784847793"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/4255\/2020"],"award-info":[{"award-number":["UIDB\/4255\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jprasurg.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.bjps.2026.01.020","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T07:52:23Z","timestamp":1768981943000},"page":"212-224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Meta-analysis of platelet-rich plasma for venous ulcers: Clinical efficacy and complications"],"prefix":"10.1016","volume":"114","author":[{"given":"Tiago","family":"Rodrigues-Guimar\u00e3es","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Horta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9908-9003","authenticated-orcid":false,"given":"M\u00e1rio","family":"Marques-Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2656-8935","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Rocha-Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bjps.2026.01.020_bib1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.mcna.2021.04.006","article-title":"Lower extremity ulcers","volume":"105","author":"Schneider","year":"2021","journal-title":"Med Clin N Am"},{"issue":"3","key":"10.1016\/j.bjps.2026.01.020_bib2","doi-asserted-by":"crossref","first-page":"ITC17","DOI":"10.7326\/AITC201608020","article-title":"Venous leg ulcers","volume":"165","author":"Vivas","year":"2016","journal-title":"Ann Intern Med"},{"issue":"2","key":"10.1016\/j.bjps.2026.01.020_bib3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jvn.2015.01.003","article-title":"Chronic venous disease and venous leg ulcers: an evidence-based update","volume":"33","author":"Kelechi","year":"2015","journal-title":"J Vasc Nurs"},{"issue":"2","key":"10.1016\/j.bjps.2026.01.020_bib4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ejvs.2021.12.024","article-title":"Editor's Choice - European Society for Vascular Surgery (ESVS) 2022 clinical practice guidelines on the management of chronic venous disease of the lower limbs","volume":"63","author":"De Maeseneer","year":"2022","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"1","key":"10.1016\/j.bjps.2026.01.020_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1177\/1358863X211028298","article-title":"An estimate of the economic burden of venous leg ulcers associated with deep venous disease","volume":"27","author":"Kolluri","year":"2022","journal-title":"Vasc Med"},{"issue":"4","key":"10.1016\/j.bjps.2026.01.020_bib6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1177\/15347346211046203","article-title":"Clinical study of platelet-rich plasma (PRP) for lower extremity venous ulcers: a meta-analysis and systematic review","volume":"22","author":"Fang","year":"2023","journal-title":"Int J Low Extrem Wounds"},{"issue":"3","key":"10.1016\/j.bjps.2026.01.020_bib7","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jaad.2019.04.037","article-title":"Platelet-rich plasma and its utility in medical dermatology: a systematic review","volume":"81","author":"Hesseler","year":"2019","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.bjps.2026.01.020_bib8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/scrt218","article-title":"Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors","volume":"4","author":"Amable","year":"2013","journal-title":"Stem Cell Res Ther"},{"issue":"5","key":"10.1016\/j.bjps.2026.01.020_bib9","article-title":"Autologous platelet-rich plasma for treating chronic wounds","volume":"2016","author":"Martinez-Zapata","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"20","key":"10.1016\/j.bjps.2026.01.020_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21207794","article-title":"Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020","volume":"21","author":"Everts","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.bjps.2026.01.020_bib11","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/wrr.12702","article-title":"Application of standardized platelet-rich plasma in elderly patients with complex wounds","volume":"27","author":"Tian","year":"2019","journal-title":"Wound Repair Regen"},{"issue":"3","key":"10.1016\/j.bjps.2026.01.020_bib12","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/jocd.14662","article-title":"Platelet-rich plasma in hair loss-mechanism, preparation, and classification","volume":"21","author":"Alexander","year":"2022","journal-title":"J Cosmet Dermatol"},{"issue":"1","key":"10.1016\/j.bjps.2026.01.020_bib13","doi-asserted-by":"crossref","DOI":"10.1111\/dth.14343","article-title":"Platelet-rich plasma-where do we stand today? A critical narrative review and analysis","volume":"34","author":"Arora","year":"2021","journal-title":"Dermatol Ther"},{"issue":"1","key":"10.1016\/j.bjps.2026.01.020_bib14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/iwj.13029","article-title":"The use of fat grafting and platelet-rich plasma for wound healing: a review of the current evidence","volume":"16","author":"Smith","year":"2019","journal-title":"Int Wound J"},{"issue":"1","key":"10.1016\/j.bjps.2026.01.020_bib15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/17474086.2021.1860002","article-title":"Evidence-based indications of platelet-rich plasma therapy","volume":"14","author":"Gupta","year":"2021","journal-title":"Expert Rev Hematol"},{"key":"10.1016\/j.bjps.2026.01.020_bib16","doi-asserted-by":"crossref","first-page":"j4008","DOI":"10.1136\/bmj.j4008","article-title":"AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.bjps.2026.01.020_bib17","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1001\/jama.2017.19163","article-title":"Preferred reporting items for a systematic review and meta-analysis of diagnostic test accuracy studies: the PRISMA-DTA Statement","volume":"319","author":"McInnes","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.bjps.2026.01.020_bib18","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"issue":"10","key":"10.1016\/j.bjps.2026.01.020_bib19","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1111\/jocd.14138","article-title":"Objective assessment of platelet-rich plasma (PRP) potentiality in the treatment of chronic leg ulcer: RCT on 80 patients with Venous ulcer","volume":"20","author":"Helmy","year":"2021","journal-title":"J Cosmet Dermatol"},{"issue":"6","key":"10.1016\/j.bjps.2026.01.020_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/dth.13897","article-title":"Evaluation of safety and efficacy of autologous topical platelet gel vs platelet rich plasma injection in the treatment of venous leg ulcers: a randomized case control study","volume":"33","author":"Elgarhy","year":"2020","journal-title":"Dermatol Ther"},{"issue":"4","key":"10.1016\/j.bjps.2026.01.020_bib21","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1111\/iwj.13361","article-title":"Autologous platelet-rich plasma injection enhances healing of chronic venous leg ulcer: a prospective randomised study","volume":"17","author":"Elbarbary","year":"2020","journal-title":"Int Wound J"},{"issue":"1","key":"10.1016\/j.bjps.2026.01.020_bib22","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4103\/idoj.IDOJ_119_19","article-title":"Comparison of efficacy of autologous platelet-rich fibrin versus Unna's paste dressing in chronic venous leg ulcers: a comparative study","volume":"11","author":"Yuvasri","year":"2020","journal-title":"Indian Dermatol Online J"},{"issue":"Sup6","key":"10.1016\/j.bjps.2026.01.020_bib23","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.12968\/jowc.2018.27.Sup6.S20","article-title":"Autologous platelet-rich plasma in the treatment of venous leg ulcers in primary care: a randomised controlled, pilot study","volume":"27","author":"Burgos-Alonso","year":"2018","journal-title":"J Wound Care"},{"issue":"3","key":"10.1016\/j.bjps.2026.01.020_bib24","doi-asserted-by":"crossref","first-page":"316","DOI":"10.4103\/1110-1121.239205","article-title":"Autogenous leucocyte-rich and platelet-rich fibrin for the treatment of leg venous ulcer: a randomized control study","volume":"37","author":"Goda","year":"2018","journal-title":"Egypt J Surg"},{"issue":"2","key":"10.1016\/j.bjps.2026.01.020_bib25","first-page":"2258","article-title":"The study of the effectiveness of the drug combination of collagen and platelet-rich plasma for the regional treatment of venous ulcers","volume":"8","author":"Glukhov","year":"2017","journal-title":"Res J Pharm Biol Chem Sci"},{"issue":"4","key":"10.1016\/j.bjps.2026.01.020_bib26","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1590\/abd1806-4841.20175496","article-title":"Pilot study of homologous platelet gel in venous ulcers","volume":"92","author":"Oliveira","year":"2017","journal-title":"An Bras Dermatol"},{"issue":"2","key":"10.1016\/j.bjps.2026.01.020_bib27","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jtv.2016.11.003","article-title":"Efficacy and safety of the use of platelet-rich plasma to manage venous ulcers","volume":"26","author":"Escamilla Cardenosa","year":"2017","journal-title":"J Tissue Viability"},{"issue":"1","key":"10.1016\/j.bjps.2026.01.020_bib28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/JCAS.JCAS_137_16","article-title":"Comparison of efficacy of autologous platelet-rich fibrin versus saline dressing in chronic venous leg ulcers: a randomised controlled trial","volume":"10","author":"Somani","year":"2017","journal-title":"J Cutan Aesthet Surg"},{"issue":"1","key":"10.1016\/j.bjps.2026.01.020_bib29","first-page":"13","article-title":"Efficacy and safety of plasma rich in growth factors in the treatment of venous ulcers: a randomized clinical trial controlled with conventional treatment","volume":"3","author":"Aguirre","year":"2015","journal-title":"Clin Dermatol"},{"issue":"3","key":"10.1016\/j.bjps.2026.01.020_bib30","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/jocd.12401","article-title":"Autologous platelet-rich plasma versus conventional therapy for the treatment of chronic venous leg ulcers: a comparative study","volume":"17","author":"Moneib","year":"2018","journal-title":"J Cosmet Dermatol"},{"issue":"3","key":"10.1016\/j.bjps.2026.01.020_bib31","first-page":"593","article-title":"Autologous platelet-rich plasma for treatment of venous leg ulcers: a prospective controlled study","volume":"32","author":"Etugov","year":"2018","journal-title":"J Biol Regul Homeost Agents"},{"issue":"6","key":"10.1016\/j.bjps.2026.01.020_bib32","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1177\/1708538114563824","article-title":"Autologous platelet-rich plasma in treatment of chronic venous leg ulcers: a prospective case series","volume":"23","author":"Yilmaz","year":"2015","journal-title":"Vascular"},{"issue":"2","key":"10.1016\/j.bjps.2026.01.020_bib33","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4103\/0974-2077.112671","article-title":"Autologous platelet rich plasma in chronic venous ulcers: study of 17 cases","volume":"6","author":"Sarvajnamurthy","year":"2013","journal-title":"J Cutan Aesthet Surg"},{"key":"10.1016\/j.bjps.2026.01.020_bib34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/5584_2019_388","article-title":"Autologous platelet-rich plasma reduces healing time of chronic venous leg ulcers: a prospective observational study","volume":"1176","author":"Milek","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.bjps.2026.01.020_bib35","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkaa028","article-title":"Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization","volume":"8","author":"Xu","year":"2020","journal-title":"Burns Trauma"},{"issue":"10","key":"10.1016\/j.bjps.2026.01.020_bib36","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.3390\/medicina57101072","article-title":"Diabetic wound-healing science","volume":"57","author":"Burgess","year":"2021","journal-title":"Medicina"},{"issue":"8","key":"10.1016\/j.bjps.2026.01.020_bib37","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s12325-014-0140-x","article-title":"Pathogenesis and treatment of impaired wound healing in diabetes mellitus: new insights","volume":"31","author":"Baltzis","year":"2014","journal-title":"Adv Ther"},{"issue":"1","key":"10.1016\/j.bjps.2026.01.020_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/wrr.12245","article-title":"Chronic wound repair and healing in older adults: current status and future research","volume":"23","author":"Gould","year":"2015","journal-title":"Wound Repair Regen"},{"issue":"9","key":"10.1016\/j.bjps.2026.01.020_bib39","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat Rev Cardiol"},{"issue":"4","key":"10.1016\/j.bjps.2026.01.020_bib40","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1080\/09537104.2019.1665641","article-title":"Modulators of platelet function in aging","volume":"31","author":"Iyer","year":"2020","journal-title":"Platelets"},{"issue":"1","key":"10.1016\/j.bjps.2026.01.020_bib41","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/01.ASW.0000363487.01977.a9","article-title":"Older adults and ulcers: chronic wounds in the geriatric population","volume":"23","author":"Cheung","year":"2010","journal-title":"Adv Skin Wound Care"}],"container-title":["Journal of Plastic, Reconstructive &amp; Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681526000343?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1748681526000343?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T15:16:33Z","timestamp":1778080593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1748681526000343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":41,"alternative-id":["S1748681526000343"],"URL":"https:\/\/doi.org\/10.1016\/j.bjps.2026.01.020","relation":{},"ISSN":["1748-6815"],"issn-type":[{"value":"1748-6815","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Meta-analysis of platelet-rich plasma for venous ulcers: Clinical efficacy and complications","name":"articletitle","label":"Article Title"},{"value":"Journal of Plastic, Reconstructive & Aesthetic Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjps.2026.01.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.","name":"copyright","label":"Copyright"}]}}