{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T09:37:48Z","timestamp":1783762668189,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brazilian Journal of Physical Therapy"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.bjpt.2020.03.002","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T03:09:30Z","timestamp":1583982570000},"page":"147-155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Resistance training decreases matrix metalloproteinase-2 activity in quadriceps tendon in a rat model of osteoarthritis"],"prefix":"10.1016","volume":"25","author":[{"given":"Fernando Augusto","family":"Vasilceac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita de C\u00e1ssia","family":"Marqueti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo Vieira de Sousa","family":"Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahan da Cunha","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Carvalho de","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Luiz Quaglioti","family":"Durigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stela M\u00e1rcia","family":"Mattiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bjpt.2020.03.002_bib0165","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/acel.12562","article-title":"Cellular senescence in osteoarthritis pathology","volume":"16","author":"McCulloch","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.bjpt.2020.03.002_bib0170","doi-asserted-by":"crossref","first-page":"16","DOI":"10.7812\/TPP\/16-183","article-title":"Knee osteoarthritis: a primer","volume":"21","author":"Lespasio","year":"2017","journal-title":"Perm J"},{"issue":"11","key":"10.1016\/j.bjpt.2020.03.002_bib0175","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1016\/j.ajpath.2015.07.003","article-title":"Attenuation of the progression of articular cartilage degeneration by inhibition of TGF-beta1 signaling in a mouse model of osteoarthritis","volume":"185","author":"Chen","year":"2015","journal-title":"Am J Pathol"},{"issue":"3","key":"10.1016\/j.bjpt.2020.03.002_bib0180","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1053\/joca.2001.0505","article-title":"Development and regulation of osteophyte formation during experimental osteoarthritis","volume":"10","author":"Hashimoto","year":"2002","journal-title":"Osteoarthrit Cartil"},{"issue":"11","key":"10.1016\/j.bjpt.2020.03.002_bib0185","doi-asserted-by":"crossref","first-page":"763","DOI":"10.5435\/JAAOS-D-16-00548","article-title":"The diagnostic utility of synovial fluid markers in periprosthetic joint infection: a systematic review and meta-analysis","volume":"25","author":"Saleh","year":"2017","journal-title":"J Am Acad Orthop Surg"},{"issue":"5","key":"10.1016\/j.bjpt.2020.03.002_bib0190","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1002\/art.21812","article-title":"Cellular events leading to chondrocyte death after cartilage impact injury","volume":"54","author":"Green","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.bjpt.2020.03.002_bib0195","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/bs.pmbts.2017.03.003","article-title":"Matrix metalloproteinases and synovial joint pathology","volume":"148","author":"Malemud","year":"2017","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"10","key":"10.1016\/j.bjpt.2020.03.002_bib0200","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1369\/0022155417729154","article-title":"Extracellular distribution of collagen II and perifibrillar adapter proteins in healthy and osteoarthritic human knee joint cartilage","volume":"65","author":"Firner","year":"2017","journal-title":"J Histochem Cytochem"},{"issue":"4","key":"10.1016\/j.bjpt.2020.03.002_bib0205","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1055\/s-0042-123192","article-title":"Effects of resistance training volume on MMPs in circulation, muscle and adipose tissue","volume":"38","author":"de Sousa Neto","year":"2017","journal-title":"Int J Sports Med"},{"issue":"5","key":"10.1016\/j.bjpt.2020.03.002_bib0210","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/2040622312454157","article-title":"Prospects for treating osteoarthritis: enzyme\u2013protein interactions regulating matrix metalloproteinase activity","volume":"3","author":"Meszaros","year":"2012","journal-title":"Ther Adv Chronic Dis"},{"issue":"10","key":"10.1016\/j.bjpt.2020.03.002_bib0215","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1177\/0269215515610039","article-title":"The effects of resistance exercise in patients with knee osteoarthritis: a systematic review and meta-analysis","volume":"30","author":"Li","year":"2016","journal-title":"Clin Rehabil"},{"issue":"1","key":"10.1016\/j.bjpt.2020.03.002_bib0220","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3892\/mmr.2012.1168","article-title":"Effects of exercise therapy on knee joint function and synovial fluid cytokine levels in patients with knee osteoarthritis","volume":"7","author":"Zhang","year":"2013","journal-title":"Mol Med Rep"},{"issue":"11","key":"10.1016\/j.bjpt.2020.03.002_bib0225","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1002\/art.21415","article-title":"Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: a four-month, randomized, controlled trial in patients at risk of osteoarthritis","volume":"52","author":"Roos","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.bjpt.2020.03.002_bib0230","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/03008207.2016.1193174","article-title":"Effectiveness of an aquatic exercise program and low-level laser therapy on articular cartilage in an experimental model of osteoarthritis in rats","volume":"57","author":"Milares","year":"2016","journal-title":"Connect Tissue Res"},{"issue":"5","key":"10.1016\/j.bjpt.2020.03.002_bib0235","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/ar2791","article-title":"Osteoarthritis associated with estrogen deficiency","volume":"11","author":"Roman-Blas","year":"2009","journal-title":"Arthritis Res Ther"},{"issue":"24","key":"10.1016\/j.bjpt.2020.03.002_bib0240","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1242\/dev.114777","article-title":"Tendon development and musculoskeletal assembly: emerging roles for the extracellular matrix","volume":"142","author":"Subramanian","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.bjpt.2020.03.002_bib0245","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0074-7696(00)96003-0","article-title":"The cell and developmental biology of tendons and ligaments","volume":"196","author":"Benjamin","year":"2000","journal-title":"Int Rev Cytol"},{"issue":"10","key":"10.1016\/j.bjpt.2020.03.002_bib0250","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.joca.2004.06.008","article-title":"Dose-response relationship for exercise on severity of experimental osteoarthritis in rats: a pilot study","volume":"12","author":"Galois","year":"2004","journal-title":"Osteoarthrit Cartil"},{"issue":"1","key":"10.1016\/j.bjpt.2020.03.002_bib0255","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1139\/h04-002","article-title":"Physiological hypertrophy of the FHL muscle following 8 weeks of progressive resistance exercise in the rat","volume":"29","author":"Hornberger","year":"2004","journal-title":"Can J Appl Physiol"},{"issue":"2","key":"10.1016\/j.bjpt.2020.03.002_bib0260","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1055\/s-0031-1291224","article-title":"MMP(-2) expression in skeletal muscle after strength training","volume":"33","author":"Deus","year":"2012","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.bjpt.2020.03.002_bib0265","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3389\/fphys.2018.00190","article-title":"Effects of resistance training on matrix metalloproteinase activity in skeletal muscles and blood circulation during aging","volume":"9","author":"de Sousa Neto","year":"2018","journal-title":"Front Physiol"},{"issue":"6","key":"10.1016\/j.bjpt.2020.03.002_bib0270","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s00421-008-0867-7","article-title":"Matrix metallopeptidase 2 activity in tendon regions: effects of mechanical loading exercise associated to anabolic-androgenic steroids","volume":"104","author":"Marqueti","year":"2008","journal-title":"Eur J Appl Physiol"},{"issue":"1","key":"10.1016\/j.bjpt.2020.03.002_bib0275","doi-asserted-by":"crossref","first-page":"e550","DOI":"10.1002\/term.2325","article-title":"Modulation of MMP-2 and MMP-9 through connected pathways and growth factors is critical for extracellular matrix balance of intra-articular ligaments","volume":"12","author":"Xie","year":"2018","journal-title":"J Tissue Eng Regen Med"},{"issue":"3","key":"10.1016\/j.bjpt.2020.03.002_bib0280","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/bdrc.21041","article-title":"Tendon and ligament regeneration and repair: clinical relevance and developmental paradigm","volume":"99","author":"Yang","year":"2013","journal-title":"Birth Defects Res C: Embryo Today"},{"issue":"1","key":"10.1016\/j.bjpt.2020.03.002_bib0285","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.joca.2015.07.020","article-title":"Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats","volume":"24","author":"Assis","year":"2016","journal-title":"Osteoarthrit Cartil"},{"issue":"suppl 3","key":"10.1016\/j.bjpt.2020.03.002_bib0290","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1186\/ar572","article-title":"Matrix metalloproteinases in arthritic disease","volume":"4","author":"Murphy","year":"2002","journal-title":"Arthritis Res"},{"issue":"3","key":"10.1016\/j.bjpt.2020.03.002_bib0295","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/art.22417","article-title":"Regulation of matrix metalloproteinase gene expression by a retinoid X receptor-specific ligand","volume":"56","author":"Burrage","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.bjpt.2020.03.002_bib0300","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2174\/138945007779940098","article-title":"Molecular targets in osteoarthritis: metalloproteinases and their inhibitors","volume":"8","author":"Burrage","year":"2007","journal-title":"Curr Drug Targets"},{"issue":"8","key":"10.1016\/j.bjpt.2020.03.002_bib0305","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.joca.2017.02.800","article-title":"Effects of high intensity resistance aquatic training on body composition and walking speed in women with mild knee osteoarthritis: a 4-month RCT with 12-month follow-up","volume":"25","author":"Waller","year":"2017","journal-title":"Osteoarthrit Cartil"},{"issue":"4","key":"10.1016\/j.bjpt.2020.03.002_bib0310","doi-asserted-by":"crossref","first-page":"R1552","DOI":"10.1152\/ajpregu.00423.2007","article-title":"Temporal extracellular matrix adaptations in ligament during wound healing and hindlimb unloading","volume":"293","author":"Martinez","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"10.1016\/j.bjpt.2020.03.002_bib0315","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1186\/s12891-017-1795-7","article-title":"Analysis of medical service use of knee osteoarthritis and knee meniscal and ligament injuries in Korea: a cross-sectional study of national patient sample data","volume":"18","author":"Suh","year":"2017","journal-title":"BMC Musculoskelet Disord"},{"issue":"1","key":"10.1016\/j.bjpt.2020.03.002_bib0320","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1055\/s-0037-1601409","article-title":"Knee osteoarthritis after reconstruction of isolated anterior cruciate ligament injuries: a systematic literature review","volume":"5","author":"Riccardo","year":"2017","journal-title":"Joints"}],"container-title":["Brazilian Journal of Physical Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1413355519303090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1413355519303090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T15:51:49Z","timestamp":1761407509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1413355519303090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S1413355519303090"],"URL":"https:\/\/doi.org\/10.1016\/j.bjpt.2020.03.002","relation":{},"ISSN":["1413-3555"],"issn-type":[{"value":"1413-3555","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resistance training decreases matrix metalloproteinase-2 activity in quadriceps tendon in a rat model of osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Brazilian Journal of Physical Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bjpt.2020.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Associa\u00e7\u00e3o Brasileira de Pesquisa e P\u00f3s-Gradua\u00e7\u00e3o em Fisioterapia. Published by Elsevier Editora Ltda. All rights reserved.","name":"copyright","label":"Copyright"}]}}