{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:57:45Z","timestamp":1769579865307,"version":"3.49.0"},"reference-count":117,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T00:00:00Z","timestamp":1382486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["bloodreviews.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Reviews"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.blre.2013.10.001","type":"journal-article","created":{"date-parts":[[2013,10,10]],"date-time":"2013-10-10T01:42:54Z","timestamp":1381369374000},"page":"289-295","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Iron and transfusion medicine"],"prefix":"10.1016","volume":"27","author":[{"given":"Sophie","family":"Waldvogel-Abramovski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rard","family":"Waeber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Gassner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Buser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat M.","family":"Frey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Favrat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Daniel","family":"Tissot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.blre.2013.10.001_bb0005","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1111\/j.1537-2995.2012.03584.x","article-title":"Switching iron-deficient whole blood donors to plateletpheresis","volume":"52","author":"O'Meara","year":"2012","journal-title":"Transfusion"},{"key":"10.1016\/j.blre.2013.10.001_bb0010","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00277-011-1371-4","article-title":"Prognostic value of red blood cell parameters and ferritin in predicting deferral due to low hemoglobin in whole blood donors","volume":"91","author":"Stern","year":"2012","journal-title":"Ann Hematol"},{"key":"10.1016\/j.blre.2013.10.001_bb0015","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1111\/j.1537-2995.2011.03148.x","article-title":"The value of routine ferritin measurement in blood donors","volume":"51","author":"O'Meara","year":"2011","journal-title":"Transfusion"},{"key":"10.1016\/j.blre.2013.10.001_bb0020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1741-7015-10-8","article-title":"Clinical evaluation of iron treatment efficiency among non-anemic but iron-deficient female blood donors: a randomized controlled trial","volume":"10","author":"Waldvogel","year":"2012","journal-title":"BMC Med"},{"key":"10.1016\/j.blre.2013.10.001_bb0025","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1111\/j.1537-2995.2011.03173.x","article-title":"Hemoglobin and iron indices in nonanemic premenopausal blood donors predict future deferral from whole blood donation","volume":"51","author":"Pasricha","year":"2011","journal-title":"Transfusion"},{"key":"10.1016\/j.blre.2013.10.001_bb0030","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/j.1537-2995.2011.03401.x","article-title":"Iron deficiency in blood donors: the REDS-II Donor Iron Status Evaluation (RISE) study","volume":"52","author":"Cable","year":"2012","journal-title":"Transfusion"},{"key":"10.1016\/j.blre.2013.10.001_bb0035","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.transci.2009.09.017","article-title":"The effect of blood donation frequency on iron status","volume":"41","author":"Rosvik","year":"2009","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.blre.2013.10.001_bb0040","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.transci.2004.01.011","article-title":"Transferrin receptor in serum. A new tool in the diagnosis and prevention of iron deficiency in blood donors","volume":"31","author":"Flesland","year":"2004","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.blre.2013.10.001_bb0045","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3324\/haematol.2010.037960","article-title":"Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors","volume":"96","author":"Pasricha","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.blre.2013.10.001_bb0050","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1136\/bmj.326.7399.1124","article-title":"Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial","volume":"326","author":"Verdon","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.blre.2013.10.001_bb0055","first-page":"2277","article-title":"Iron deficiency without anemia: where are we in 2012?","volume":"8","author":"Favrat","year":"2012","journal-title":"Rev Med Suisse"},{"key":"10.1016\/j.blre.2013.10.001_bb0060","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1503\/cmaj.110950","article-title":"Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trial","volume":"184","author":"Vaucher","year":"2012","journal-title":"CMAJ"},{"key":"10.1016\/j.blre.2013.10.001_bb0065","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1136\/gut.2010.228874","article-title":"Guidelines for the management of iron deficiency anaemia","volume":"60","author":"Goddard","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.blre.2013.10.001_bb0070","series-title":"Global burden of disease and risk factors","article-title":"Measuring the global burden of disease and risk factors, 1990\u20132001","author":"Lopez","year":"2006"},{"key":"10.1016\/j.blre.2013.10.001_bb0075","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1182\/blood-2011-07-366120","article-title":"Ironing out fatigue","volume":"118","author":"von Drygalski","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.blre.2013.10.001_bb0080","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1475-2891-9-4","article-title":"The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis","volume":"9","author":"Falkingham","year":"2010","journal-title":"Nutr J"},{"key":"10.1016\/j.blre.2013.10.001_bb0085","first-page":"173","article-title":"The SUVIMAX (France) study: the role of antioxidants in the prevention of cancer and cardiovascular disorders","volume":"72","author":"Vazquez Martinez","year":"1998","journal-title":"Rev Esp Salud Publica"},{"key":"10.1016\/j.blre.2013.10.001_bb0090","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.3945\/ajcn.2008.27151","article-title":"Assessment of iron deficiency in US preschool children and nonpregnant females of childbearing age: National Health and Nutrition Examination Survey 2003\u20132006","volume":"89","author":"Cogswell","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.blre.2013.10.001_bb0095","doi-asserted-by":"crossref","first-page":"378","DOI":"10.7326\/0003-4819-52-2-378","article-title":"Iron therapy in chronically fatigued, nonanemic women: a double-blind study","volume":"52","author":"Beutler","year":"1960","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.blre.2013.10.001_bb0100","first-page":"232","article-title":"One 1000mg iron dose of ferric carboxymaltose improved fatigue in iron-deficient, non-anaemic women in the randomised placebo-controlled study PREFER","volume":"119","author":"Favrat","year":"2012","journal-title":"BJOG"},{"key":"10.1016\/j.blre.2013.10.001_bb0105","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/ajcn\/79.3.437","article-title":"Tissue iron deficiency without anemia impairs adaptation in endurance capacity after aerobic training in previously untrained women","volume":"79","author":"Brownlie","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.blre.2013.10.001_bb0110","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1097\/00005768-200105000-00010","article-title":"Effects of iron repletion on blood volume and performance capacity in young athletes","volume":"33","author":"Friedmann","year":"2001","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.blre.2013.10.001_bb0115","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S1474-4422(05)70139-3","article-title":"The restless legs syndrome","volume":"4","author":"Trenkwalder","year":"2005","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.blre.2013.10.001_bb0120","doi-asserted-by":"crossref","first-page":"590S","DOI":"10.1093\/jn\/131.2.590S","article-title":"Is there a causal relationship between iron deficiency or iron-deficiency anemia and weight at birth, length of gestation and perinatal mortality?","volume":"131","author":"Rasmussen","year":"2001","journal-title":"J Nutr"},{"key":"10.1016\/j.blre.2013.10.001_bb0125","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1056\/NEJMoa0908355","article-title":"Ferric carboxymaltose in patients with heart failure and iron deficiency","volume":"361","author":"Anker","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.blre.2013.10.001_bb0130","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1111\/j.1537-2995.2006.00969.x","article-title":"Iron depletion by whole-blood donation harms menstruating females: the current whole-blood-collection paradigm needs to be changed","volume":"46","author":"Newman","year":"2006","journal-title":"Transfusion"},{"key":"10.1016\/j.blre.2013.10.001_bb0135","doi-asserted-by":"crossref","first-page":"330","DOI":"10.5581\/1516-8484.20120086","article-title":"Blood donation, blood supply, iron deficiency and anemia\u2014it is time to shift attention back to donor health","volume":"34","author":"Cancado","year":"2012","journal-title":"Rev Bras Hematol Hemoter"},{"key":"10.1016\/j.blre.2013.10.001_bb0140","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1034\/j.1600-0609.2002.01668.x","article-title":"Iron status in Danish men 1984\u201394: a cohort comparison of changes in iron stores and the prevalence of iron deficiency and iron overload","volume":"68","author":"Milman","year":"2002","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.blre.2013.10.001_bb0145","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/ajcn\/66.2.347","article-title":"Iron absorption from the whole diet in men: how effective is the regulation of iron absorption?","volume":"66","author":"Hallberg","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.blre.2013.10.001_bb0150","first-page":"1537","article-title":"High prevalence of subclinical iron deficiency in whole blood donors not deferred for low hemoglobin","volume":"2012","author":"Baart","year":"2012","journal-title":"Transfusion"},{"key":"10.1016\/j.blre.2013.10.001_bb0155","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1111\/j.1537-2995.2008.01823.x","article-title":"Behavioral, biochemical, and genetic analysis of iron metabolism in high-intensity blood donors","volume":"48","author":"Mast","year":"2008","journal-title":"Transfusion"},{"key":"10.1016\/j.blre.2013.10.001_bb0160","first-page":"78 S","article-title":"Iron balance remains stable in life-long blood donors","volume":"7","author":"Frey","year":"2007","journal-title":"Forum Med Suisse"},{"key":"10.1016\/j.blre.2013.10.001_bb0165","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1093\/ajcn\/78.6.1225","article-title":"High serum ferritin is not identical to high iron stores","volume":"78","author":"Hallberg","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.blre.2013.10.001_bb0170","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.nutr.26.061505.111303","article-title":"Regulation of iron metabolism by hepcidin","volume":"26","author":"Nemeth","year":"2006","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.blre.2013.10.001_bb0175","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1182\/blood-2011-01-258467","article-title":"Hepcidin and iron regulation, 10years later","volume":"117","author":"Ganz","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.blre.2013.10.001_bb0180","first-page":"10","article-title":"Hepcidin: the link to understanding iron regulation","volume":"42","author":"Robens","year":"2010","journal-title":"MLO Med Lab Obs"},{"key":"10.1016\/j.blre.2013.10.001_bb0185","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s00109-008-0346-y","article-title":"Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression","volume":"86","author":"Theurl","year":"2008","journal-title":"J Mol Med"},{"key":"10.1016\/j.blre.2013.10.001_bb0190","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1172\/JCI0215686","article-title":"The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation","volume":"110","author":"Nicolas","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.blre.2013.10.001_bb0195","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bcmd.2007.02.004","article-title":"Effect of phlebotomy on hepcidin expression in hemojuvelin-mutant mice","volume":"39","author":"Krijt","year":"2007","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.blre.2013.10.001_bb0200","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1182\/asheducation-2008.1.151","article-title":"The regulation of hepcidin and its effects on systemic and cellular iron metabolism","author":"Fleming","year":"2008","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.blre.2013.10.001_bb0205","first-page":"3.05","article-title":"Iron balance in repeat blood donors\u2014the role of hepcidin","volume":"36","author":"Schorer","year":"2009","journal-title":"Transfus Med Hemother"},{"key":"10.1016\/j.blre.2013.10.001_bb0210","first-page":"26","article-title":"Hepcidin predicts hemoglobin in individuals experiencing repeated phlebotomy","volume":"2013","author":"Mast","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.blre.2013.10.001_bb0215","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.4155\/bio.13.225","article-title":"Validation of hepcidin quantification in plasma using LC-HRMS and discovery of a new hepcidin isoform","volume":"5","author":"Rochat","year":"2013","journal-title":"Bioanalysis"},{"key":"10.1016\/j.blre.2013.10.001_bb0220","first-page":"471","article-title":"Haematocrit is invalid for estimating red cell volume: a prospective study in male volunteers","volume":"10","author":"Jacob","year":"2012","journal-title":"Blood Transfus"},{"key":"10.1016\/j.blre.2013.10.001_bb0225","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/j.1537-2995.2011.03389.x","article-title":"The difference between fingerstick and venous hemoglobin and hematocrit varies by sex and iron stores","volume":"52","author":"Cable","year":"2012","journal-title":"Transfusion"},{"key":"10.1016\/j.blre.2013.10.001_bb0230","doi-asserted-by":"crossref","first-page":"e30065","DOI":"10.1371\/journal.pone.0030065","article-title":"Non-invasive measurement of hemoglobin: assessment of two different point-of-care technologies","volume":"7","author":"Gayat","year":"2012","journal-title":"PloS one"},{"key":"10.1016\/j.blre.2013.10.001_bb0235","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3810\/pgm.2012.07.2584","article-title":"Accuracy of noninvasive and invasive point-of-care total blood hemoglobin measurement in an outpatient setting","volume":"124","author":"Raikhel","year":"2012","journal-title":"Postgrad Med"},{"key":"10.1016\/j.blre.2013.10.001_bb0240","doi-asserted-by":"crossref","first-page":"356","DOI":"10.5581\/1516-8484.20120092","article-title":"Etiology of anemia of blood donor candidates deferred by hematologic screening","volume":"34","author":"da Silva","year":"2012","journal-title":"Rev Bras Hematol Hemoter"},{"key":"10.1016\/j.blre.2013.10.001_bb0245","article-title":"Iron status and dietary iron intake of female blood donors","author":"Booth","year":"2013","journal-title":"Transfusion"},{"key":"10.1016\/j.blre.2013.10.001_bb0250","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1111\/trf.12260","article-title":"Restless legs syndrome, pica, and iron status in blood donors","volume":"53","author":"Spencer","year":"2013","journal-title":"Transfusion"},{"key":"10.1016\/j.blre.2013.10.001_bb0255","series-title":"Use and quality assurance of blood components","article-title":"Guide to the preparation","author":"EDQM","year":"2011"},{"key":"10.1016\/j.blre.2013.10.001_bb0260","doi-asserted-by":"crossref","DOI":"10.1111\/trf.12209","article-title":"Laboratory variables for assessing iron deficiency in REDS-II Iron Status Evaluation (RISE) blood donors","author":"Kiss","year":"2013","journal-title":"Transfusion"},{"key":"10.1016\/j.blre.2013.10.001_bb0265","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1111\/trf.12061","article-title":"Ascertainment of iron deficiency and depletion in blood donors through screening questions for pica and restless legs syndrome","volume":"53","author":"Bryant","year":"2013","journal-title":"Transfusion"},{"key":"10.1016\/j.blre.2013.10.001_bb0270","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1111\/j.1537-2995.2012.03957.x","article-title":"Zinc protoporphyrin levels have added value in the prediction of low hemoglobin deferral in whole blood donors","volume":"53","author":"Baart","year":"2013","journal-title":"Transfusion"},{"key":"10.1016\/j.blre.2013.10.001_bb0275","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1111\/j.1537-2995.2012.03655.x","article-title":"Development and validation of a prediction model for low hemoglobin deferral in a large cohort of whole blood donors","volume":"52","author":"Baart","year":"2012","journal-title":"Transfusion"},{"key":"10.1016\/j.blre.2013.10.001_bb0280","doi-asserted-by":"crossref","DOI":"10.1111\/j.1537-2995.2012.03957.x","article-title":"External validation and updating of a Dutch prediction model for low hemoglobin deferral in Irish whole blood donors","author":"Baart","year":"2013","journal-title":"Transfusion"},{"key":"10.1016\/j.blre.2013.10.001_bb0285","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1517\/17530059.2013.763794","article-title":"Molecular diagnosis of hemochromatosis","volume":"7","author":"Piperno","year":"2013","journal-title":"Expert Opin Med Diagn"},{"key":"10.1016\/j.blre.2013.10.001_bb0290","doi-asserted-by":"crossref","first-page":"311","DOI":"10.5581\/1516-8484.20120079","article-title":"Non-HFE hemochromatosis","volume":"34","author":"Santos","year":"2012","journal-title":"Rev Bras Hematol Hemoter"},{"key":"10.1016\/j.blre.2013.10.001_bb0295","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1515\/CCLM.2011.654","article-title":"Genotyping of the hemochromatosis HFE p.H63D and p.C282Y mutations by high-resolution melting with the Rotor-Gene 6000(R) instrument","volume":"49","author":"Santos","year":"2011","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.blre.2013.10.001_bb0300","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.bcmd.2011.02.008","article-title":"Hereditary hemochromatosis: mutations in genes involved in iron homeostasis in Brazilian patients","volume":"46","author":"Santos","year":"2011","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.blre.2013.10.001_bb0305","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000321493","article-title":"HJV hemochromatosis, iron overload, and hypogonadism in a Brazilian man: treatment with phlebotomy and deferasirox","volume":"124","author":"Santos","year":"2010","journal-title":"Acta Haematol"},{"key":"10.1016\/j.blre.2013.10.001_bb0310","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.3324\/haematol.2012.062661","article-title":"CYBRD1 as a modifier gene that modulates iron phenotype in HFE p.C282Y homozygous patients","volume":"97","author":"Pelucchi","year":"2012","journal-title":"Haematologica"},{"key":"10.1016\/j.blre.2013.10.001_bb0315","first-page":"183","article-title":"Hereditary hemochromatosis","volume":"87","author":"Crownover","year":"2013","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.blre.2013.10.001_bb0320","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jhep.2013.04.004","article-title":"Monogenic diseases that can be cured by liver transplantation","volume":"59","author":"Fagiuoli","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.blre.2013.10.001_bb0325","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1532-429X-15-24","article-title":"On myocardial siderosis and left ventricular dysfunction in hemochromatosis","volume":"15","author":"Carpenter","year":"2013","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.blre.2013.10.001_bb0330","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1615\/CritRevOncog.2013007759","article-title":"Iron and hepatic carcinogenesis","volume":"18","author":"Tirnitz-Parker","year":"2013","journal-title":"Crit Rev Oncog"},{"key":"10.1016\/j.blre.2013.10.001_bb0335","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1365-2036.2012.05051.x","article-title":"Review article: the iron overload syndromes","volume":"35","author":"Siddique","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.blre.2013.10.001_bb0340","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.2337\/diabetes.51.8.2348","article-title":"Cross-talk between iron metabolism and diabetes","volume":"51","author":"Fernandez-Real","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.blre.2013.10.001_bb0345","first-page":"890","article-title":"Excess iron storage in patients with type 2 diabetes unrelated to primary hemochromatosis","volume":"343","author":"Perez de Nanclares","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.blre.2013.10.001_bb0350","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cmet.2013.02.007","article-title":"Iron and diabetes risk","volume":"17","author":"Simcox","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/j.blre.2013.10.001_bb0355","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s00125-006-0200-0","article-title":"High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary haemochromatosis","volume":"49","author":"McClain","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.blre.2013.10.001_bb0360","doi-asserted-by":"crossref","first-page":"E1236","DOI":"10.1152\/ajpendo.00022.2010","article-title":"Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob\/ob lep\u2212\/\u2212) mouse","volume":"298","author":"Cooksey","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.blre.2013.10.001_bb0365","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.metabol.2009.08.006","article-title":"Effect of iron overload on glucose metabolism in patients with hereditary hemochromatosis","volume":"59","author":"Hatunic","year":"2010","journal-title":"Metab Clin Exp"},{"key":"10.1016\/j.blre.2013.10.001_bb0370","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1007\/s00125-006-0445-7","article-title":"Increased insulin secretory capacity but decreased insulin sensitivity after correction of iron overload by phlebotomy in hereditary haemochromatosis","volume":"49","author":"Abraham","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.blre.2013.10.001_bb0375","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/jim-52-01-22","article-title":"Role of oxidative stress in the etiology of type 2 diabetes and the effect of antioxidant supplementation on glycemic control","volume":"52","author":"Opara","year":"2004","journal-title":"J Invest Med"},{"key":"10.1016\/j.blre.2013.10.001_bb0380","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2119\/2007-00114.Jouihan","article-title":"Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis","volume":"14","author":"Jouihan","year":"2008","journal-title":"Mol Med"},{"key":"10.1016\/j.blre.2013.10.001_bb0385","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/er.2001-0039","article-title":"Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes","volume":"23","author":"Evans","year":"2002","journal-title":"Endocr Rev"},{"key":"10.1016\/j.blre.2013.10.001_bb0390","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1741-7015-10-119","article-title":"Dietary iron intake, body iron stores, and the risk of type 2 diabetes: a systematic review and meta-analysis","volume":"10","author":"Bao","year":"2012","journal-title":"BMC Med"},{"key":"10.1016\/j.blre.2013.10.001_bb0395","doi-asserted-by":"crossref","first-page":"e41641","DOI":"10.1371\/journal.pone.0041641","article-title":"Body iron stores and heme-iron intake in relation to risk of type 2 diabetes: a systematic review and meta-analysis","volume":"7","author":"Zhao","year":"2012","journal-title":"PloS one"},{"key":"10.1016\/j.blre.2013.10.001_bb0400","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00125-007-0604-5","article-title":"Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study","volume":"50","author":"Forouhi","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.blre.2013.10.001_bb0405","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.2337\/dc06-0093","article-title":"Ferritin and transferrin are both predictive of the onset of hyperglycemia in men and women over 3years: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study","volume":"29","author":"Fumeron","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.blre.2013.10.001_bb0410","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1001\/jama.291.6.711","article-title":"Body iron stores in relation to risk of type 2 diabetes in apparently healthy women","volume":"291","author":"Jiang","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.blre.2013.10.001_bb0415","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/dmrr.2394","article-title":"Ferritin levels and risk of type 2 diabetes mellitus: an updated systematic review and meta-analysis of prospective evidence","volume":"29","author":"Kunutsor","year":"2013","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.blre.2013.10.001_bb0420","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1182\/blood-2009-07-232496","article-title":"A genome-wide association analysis of serum iron concentrations","volume":"115","author":"Tanaka","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.blre.2013.10.001_bb0425","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3945\/ajcn.111.025684","article-title":"Association of TMPRSS6 polymorphisms with ferritin, hemoglobin, and type 2 diabetes risk in a Chinese Han population","volume":"95","author":"Gan","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.blre.2013.10.001_bb0430","doi-asserted-by":"crossref","first-page":"E1140","DOI":"10.1152\/ajpendo.00620.2009","article-title":"Iron restriction improves type 2 diabetes mellitus in Otsuka Long\u2013Evans Tokushima fatty rats","volume":"298","author":"Minamiyama","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.blre.2013.10.001_bb0435","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1373\/clinchem.2004.046847","article-title":"Iron stores, blood donation, and insulin sensitivity and secretion","volume":"51","author":"Fernandez-Real","year":"2005","journal-title":"Clin Chem"},{"key":"10.1016\/j.blre.2013.10.001_bb0440","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.metabol.2010.06.005","article-title":"Glucose metabolism after normalization of markers of iron overload by venesection in subjects with hereditary hemochromatosis","volume":"59","author":"Hatunic","year":"2010","journal-title":"Metab Clin Exp"},{"key":"10.1016\/j.blre.2013.10.001_bb0445","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.2337\/diab.38.10.1207","article-title":"Deferoxamine therapy in high-ferritin diabetes","volume":"38","author":"Cutler","year":"1989","journal-title":"Diabetes"},{"key":"10.1016\/j.blre.2013.10.001_bb0450","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.2337\/diabetes.51.4.1000","article-title":"Blood letting in high-ferritin type 2 diabetes: effects on insulin sensitivity and beta-cell function","volume":"51","author":"Fernandez-Real","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.blre.2013.10.001_bb0455","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.2337\/diacare.21.12.2190a","article-title":"Effect of phlebotomy on plasma glucose and insulin concentrations","volume":"21","author":"Facchini","year":"1998","journal-title":"Diabetes Care"},{"key":"10.1016\/j.blre.2013.10.001_bb0460","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.2337\/diacare.25.12.2249","article-title":"Blood letting in high-ferritin type 2 diabetes: effects on vascular reactivity","volume":"25","author":"Fernandez-Real","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1016\/j.blre.2013.10.001_bb0465","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1053\/gast.2002.32403","article-title":"Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease","volume":"122","author":"Facchini","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.blre.2013.10.001_bb0470","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jama.297.6.603","article-title":"Reduction of iron stores and cardiovascular outcomes in patients with peripheral arterial disease: a randomized controlled trial","volume":"297","author":"Zacharski","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.blre.2013.10.001_bb0475","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nrm2295","article-title":"Regulation of iron acquisition and storage: consequences for iron-linked disorders","volume":"9","author":"De Domenico","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.blre.2013.10.001_bb0480","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12185-010-0760-0","article-title":"The molecular basis of iron overload disorders and iron-linked anemias","volume":"93","author":"Kaplan","year":"2011","journal-title":"Int J Hematol"},{"key":"10.1016\/j.blre.2013.10.001_bb0485","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.1021\/bi300752r","article-title":"Mechanisms of mammalian iron homeostasis","volume":"51","author":"Pantopoulos","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.blre.2013.10.001_bb0490","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1093\/hmg\/ddp315","article-title":"Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms","volume":"18","author":"Ramsay","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.blre.2013.10.001_bb0495","doi-asserted-by":"crossref","first-page":"840","DOI":"10.3324\/haematol.2008.001867","article-title":"Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis","volume":"94","author":"Ramsay","year":"2009","journal-title":"Haematologica"},{"key":"10.1016\/j.blre.2013.10.001_bb0500","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1079\/PHN2001139","article-title":"Iron deficiency in Europe","volume":"4","author":"Hercberg","year":"2001","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.blre.2013.10.001_bb0505","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/bcmd.2002.0586","article-title":"Seeking candidate mutations that affect iron homeostasis","volume":"29","author":"Lee","year":"2002","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.blre.2013.10.001_bb0510","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00439-005-0094-9","article-title":"Evaluating HapMap SNP data transferability in a large-scale genotyping project involving 175 cancer-associated genes","volume":"118","author":"Ribas","year":"2006","journal-title":"Hum Genet"},{"key":"10.1016\/j.blre.2013.10.001_bb0515","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/gepi.20326","article-title":"Enhanced detection of genetic association of hypertensive heart disease by analysis of latent phenotypes","volume":"32","author":"Gu","year":"2008","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.blre.2013.10.001_bb0520","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00041433-199704000-00007","article-title":"How to tackle genetic loci predisposing to atherosclerosis?","volume":"8","author":"Pajukanta","year":"1997","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.blre.2013.10.001_bb0525","first-page":"257","article-title":"Application of molecular biology to mental illness. Analysis of genomic DNA and brain mRNA","volume":"3","author":"Gurling","year":"1985","journal-title":"Psychiatr Dev"},{"key":"10.1016\/j.blre.2013.10.001_bb0530","first-page":"164","article-title":"The candidate gene approach","volume":"24","author":"Kwon","year":"2000","journal-title":"Alcohol Res Health"},{"key":"10.1016\/j.blre.2013.10.001_bb0535","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1093\/nar\/23.16.3126","article-title":"Matrix-assisted laser desorption\/ionization mass spectrometry of immobilized duplex DNA probes","volume":"23","author":"Tang","year":"1995","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.blre.2013.10.001_bb0540","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1073\/pnas.0630494100","article-title":"A high-throughput gene expression analysis technique using competitive PCR and matrix-assisted laser desorption ionization time-of-flight MS","volume":"100","author":"Ding","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.blre.2013.10.001_bb0545","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ymeth.2010.06.017","article-title":"DNA methylation profiling using bisulfite-based epityping of pooled genomic DNA","volume":"52","author":"Docherty","year":"2010","journal-title":"Methods"},{"key":"10.1016\/j.blre.2013.10.001_bb0550","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1471-2407-10-101","article-title":"A rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes","volume":"10","author":"Fumagalli","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.blre.2013.10.001_bb0555","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-385855-9.00001-1","article-title":"Use of matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry for multiplex genotyping","volume":"53","author":"Meyer","year":"2011","journal-title":"Adv Clin Chem"},{"key":"10.1016\/j.blre.2013.10.001_bb0560","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-1-61737-954-3_5","article-title":"Medium-throughput SNP, genotyping using mass spectrometry: multiplex SNP genotyping using the iPLEX(R) Gold assay","volume":"700","author":"Millis","year":"2011","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.blre.2013.10.001_bb0565","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/978-1-60327-411-1_20","article-title":"Qualitative and quantitative genotyping using single base primer extension coupled with matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry (MassARRAY)","volume":"578","author":"Oeth","year":"2009","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.blre.2013.10.001_bb0570","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.tmrv.2012.10.001","article-title":"Matrix-assisted laser desorption\/ionisation, time-of-flight mass spectrometry-based blood group genotyping\u2014the alternative approach","volume":"27","author":"Gassner","year":"2013","journal-title":"Transfus Med Rev"},{"key":"10.1016\/j.blre.2013.10.001_bb0575","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrg2579","article-title":"Detecting gene\u2013gene interactions that underlie human diseases","volume":"10","author":"Cordell","year":"2009","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.blre.2013.10.001_bb0580","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ajhg.2010.07.021","article-title":"BOOST: a fast approach to detecting gene\u2013gene interactions in genome-wide case\u2013control studies","volume":"87","author":"Wan","year":"2010","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.blre.2013.10.001_bb0585","doi-asserted-by":"crossref","first-page":"e61943","DOI":"10.1371\/journal.pone.0061943","article-title":"Development of GMDR-GPU for gene\u2013gene interaction analysis and its application to WTCCC GWAS data for type 2 diabetes","volume":"8","author":"Zhu","year":"2013","journal-title":"PloS one"}],"container-title":["Blood Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0268960X13000581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0268960X13000581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T15:25:42Z","timestamp":1716045942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0268960X13000581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":117,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0268960X13000581"],"URL":"https:\/\/doi.org\/10.1016\/j.blre.2013.10.001","relation":{},"ISSN":["0268-960X"],"issn-type":[{"value":"0268-960X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iron and transfusion medicine","name":"articletitle","label":"Article Title"},{"value":"Blood Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.blre.2013.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}