{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:08:59Z","timestamp":1787832539734,"version":"build-2784847793"},"reference-count":70,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","bloodreviews.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Reviews"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.blre.2015.07.005","type":"journal-article","created":{"date-parts":[[2015,7,18]],"date-time":"2015-07-18T10:09:32Z","timestamp":1437214172000},"page":"49-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Acute megakaryocytic leukemia: What have we learned"],"prefix":"10.1016","volume":"30","author":[{"given":"Andrew W.","family":"Hahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Prouet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smith","family":"Giri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjan","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike G.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.blre.2015.07.005_bb0005","first-page":"679","article-title":"Uber einen fall von akuter megakaryocyblasten-leukamie, zugleich einige bemerkungen zum Problem der akuten leukemie","volume":"118","author":"JKA","year":"1931","journal-title":"Z Klin Med"},{"key":"10.1016\/j.blre.2015.07.005_bb0010","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1182\/blood.V51.1.45.45","article-title":"Megakaryoblastic acute leukemia: identification by the ultrastructural demonstration of platelet peroxidase","volume":"51","author":"Breton-Gorius","year":"1978","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0015","doi-asserted-by":"crossref","first-page":"460","DOI":"10.7326\/0003-4819-103-3-460","article-title":"Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7). a report of the French\u2013American\u2013British Cooperative Group","volume":"103","author":"Bennett","year":"1985","journal-title":"Ann Intern Med"},{"issue":"Suppl. 1","key":"10.1016\/j.blre.2015.07.005_bb0020","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/10428199509075307","article-title":"Acute megakaryoblastic leukemia","volume":"18","author":"Gassmann","year":"1995","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.blre.2015.07.005_bb0025","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1182\/blood.V97.12.3727","article-title":"Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience","volume":"97","author":"Athale","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0030","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3109\/10428199309148552","article-title":"Acute megakaryoblastic leukemia in children and adolescents: a retrospective analysis of 24 cases","volume":"10","author":"Ribeiro","year":"1993","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.blre.2015.07.005_bb0035","first-page":"608","article-title":"Distinctive demography, biology, and outcome of acute myeloid leukemia and myelodysplastic syndrome in children with Down syndrome: Children's Cancer Group Studies 2861 and 2891","volume":"91","author":"Lange","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0040","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1182\/blood.V80.9.2210.2210","article-title":"Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: experience on Pediatric Oncology Group AML Study 8498","volume":"80","author":"Ravindranath","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0045","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0146-0005(97)80025-0","article-title":"Leukemia and\/or myeloproliferative syndrome in neonates with Down syndrome","volume":"21","author":"Zipursky","year":"1997","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.blre.2015.07.005_bb0050","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0145-2126(98)00016-2","article-title":"Acute myelogenous leukemia in Down's syndrome: report of a single pediatric institution using a BFM treatment strategy","volume":"22","author":"Zubizarreta","year":"1998","journal-title":"Leuk Res"},{"key":"10.1016\/j.blre.2015.07.005_bb0055","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3109\/08880018709141272","article-title":"Megakaryoblastic leukemia and Down's syndrome: a review","volume":"4","author":"Zipursky","year":"1987","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.blre.2015.07.005_bb0060","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1182\/blood-2014-09-603415","article-title":"Acute megakaryocytic leukemia is associated with worse outcomes than other types of acute myeloid leukemia","volume":"124","author":"Giri","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0065","first-page":"2405","article-title":"Acute megakaryocytic leukemia: the Eastern Cooperative Oncology Group experience","volume":"96","author":"Tallman","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0070","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1182\/blood-2005-06-2450","article-title":"Adult acute megakaryocytic leukemia: an analysis of 37 patients treated at M.D. Anderson Cancer Center","volume":"107","author":"Oki","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0075","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1038\/sj.leu.2402618","article-title":"Acute megakaryoblastic leukemia: experience of GIMEMA trials","volume":"16","author":"Pagano","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.blre.2015.07.005_bb0080","first-page":"248","article-title":"Testicular granulocytic sarcoma as a form of relapse in a patient with acute megakaryoblastic leukemia","volume":"43","author":"Sastre","year":"1998","journal-title":"Sangre (Barc)"},{"key":"10.1016\/j.blre.2015.07.005_bb0085","doi-asserted-by":"crossref","first-page":"805","DOI":"10.2298\/SARH1112805C","article-title":"Granulocytic sarcoma of the femur in a patient with acute megakaryoblastic leukaemia","volume":"139","author":"Colovic","year":"2011","journal-title":"Srp Arh Celok Lek"},{"key":"10.1016\/j.blre.2015.07.005_bb0090","first-page":"1186","article-title":"Relapse of acute myelogenous leukemia as a cerebellar myeloblastoma showing megakaryoblastic differentiation","volume":"12","author":"Lorsbach","year":"1999","journal-title":"Mod Pathol"},{"key":"10.1016\/j.blre.2015.07.005_bb0095","doi-asserted-by":"crossref","first-page":"603","DOI":"10.7326\/0003-4819-102-5-603","article-title":"Hematologic malignancies associated with primary mediastinal germ-cell tumors","volume":"102","author":"Nichols","year":"1985","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.blre.2015.07.005_bb0100","first-page":"347","article-title":"Malignant disorders of megakaryocytes associated with primary mediastinal germ cell tumors","volume":"215","author":"Nichols","year":"1986","journal-title":"Prog Clin Biol Res"},{"key":"10.1016\/j.blre.2015.07.005_bb0105","doi-asserted-by":"crossref","first-page":"539","DOI":"10.7326\/0003-4819-111-6-539","article-title":"Mediastinal germ cell tumor and acute megakaryoblastic leukemia","volume":"111","author":"Domingo","year":"1989","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.blre.2015.07.005_bb0110","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1182\/blood.V72.2.402.402","article-title":"Leukemias with megakaryoblastic involvement: clinical, hematologic, and immunologic characteristics","volume":"72","author":"San Miguel","year":"1988","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0115","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1002\/1097-0142(19871201)60:11<2654::AID-CNCR2820601114>3.0.CO;2-Q","article-title":"Myeloproliferative disorders terminating in acute megakaryoblastic leukemia with chromosome 3q26 abnormality","volume":"60","author":"Akahoshi","year":"1987","journal-title":"Cancer"},{"key":"10.1016\/j.blre.2015.07.005_bb0120","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1034\/j.1600-0609.2002.02734.x","article-title":"Acute megakaryocytic leukemia in essential thrombocythemia: an unusual evolution?","volume":"69","author":"Radaelli","year":"2002","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.blre.2015.07.005_bb0125","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1182\/blood-2004-07-2864","article-title":"Leukemic transformation in myelofibrosis with myeloid metaplasia: a single-institution experience with 91 cases","volume":"105","author":"Mesa","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0130","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1182\/blood-2001-12-0241","article-title":"Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Francais de Cytogenetique Hematologique (GFCH)","volume":"100","author":"Dastugue","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0135","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1365-2141.1979.tb03693.x","article-title":"Megakaryoblastic leukaemia (acute myelofibrosis): a report of three cases","volume":"42","author":"den Ottolander","year":"1979","journal-title":"Br J Haematol"},{"key":"10.1016\/j.blre.2015.07.005_bb0140","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/1097-0142(197904)43:4<1211::AID-CNCR2820430408>3.0.CO;2-X","article-title":"Malignant myelosclerosis (acute myelofibrosis): report of two cases following cytotoxic chemotherapy","volume":"43","author":"Ali","year":"1979","journal-title":"Cancer"},{"key":"10.1016\/j.blre.2015.07.005_bb0145","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ajcp\/67.6.512","article-title":"Malignant myelosclerosis. Myeloproliferative disorder or leukemia?","volume":"67","author":"Bird","year":"1977","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.blre.2015.07.005_bb0150","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1182\/blood.V57.4.781.781","article-title":"Human megakaryocyte stimulation of proliferation of bone marrow fibroblasts","volume":"57","author":"Castro-Malaspina","year":"1981","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0155","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/modpathol.3800348","article-title":"Acute panmyelosis with myelofibrosis: an entity distinct from acute megakaryoblastic leukemia","volume":"18","author":"Orazi","year":"2005","journal-title":"Mod Pathol"},{"key":"10.1016\/j.blre.2015.07.005_bb0160","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/ajcp\/77.1.107","article-title":"Megakaryocytic leukemia; identification utilizing anti-factor VIII immunoperoxidase","volume":"77","author":"Innes","year":"1982","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.blre.2015.07.005_bb0165","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1182\/blood.V79.2.347.347","article-title":"Characterization of glycoprotein IIb\/IIIa-positive cells in human umbilical cord blood: their potential usefulness as megakaryocyte progenitors","volume":"79","author":"Zucker-Franklin","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0170","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/sj.leu.2400648","article-title":"CD34+ megakaryoblastic leukaemic cells are CD38\u2212, but CD61+ and glycophorin A+: improved criteria for diagnosis of AML-M7?","volume":"11","author":"Helleberg","year":"1997","journal-title":"Leukemia"},{"key":"10.1016\/j.blre.2015.07.005_bb0175","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1365-2141.2007.06971.x","article-title":"Acute megakaryoblastic leukaemia (AMKL) in children: a comparison of AMKL with and without Down syndrome","volume":"140","author":"Hama","year":"2008","journal-title":"Br J Haematol"},{"key":"10.1016\/j.blre.2015.07.005_bb0180","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/cyto.b.21198","article-title":"Acute megakaryoblastic leukemia associated with trisomy 21 demonstrates a distinct immunophenotype","volume":"88","author":"Wang","year":"2015","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1016\/j.blre.2015.07.005_bb0185","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0165-4608(93)90157-H","article-title":"Review of the cytogenetic changes in acute megakaryoblastic leukemia: one disease or several?","volume":"67","author":"Lu","year":"1993","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.blre.2015.07.005_bb0190","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1182\/blood.V78.3.748.748","article-title":"The t(1;22) (p13;q13) is nonrandom and restricted to infants with acute megakaryoblastic leukemia: a Pediatric Oncology Group Study","volume":"78","author":"Carroll","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0195","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1182\/blood.V79.12.3325.bloodjournal79123325","article-title":"The translocation t(1;22)(p13;q13) is a nonrandom marker specifically associated with acute megakaryocytic leukemia in young children","volume":"79","author":"Lion","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0200","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/90054","article-title":"Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia","volume":"28","author":"Ma","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.blre.2015.07.005_bb0205","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.bcmd.2013.07.008","article-title":"The impact of trisomy 21 on foetal haematopoiesis","volume":"51","author":"Roberts","year":"2013","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.blre.2015.07.005_bb0210","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2141.2009.07789.x","article-title":"Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis","volume":"147","author":"Roy","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1016\/j.blre.2015.07.005_bb0215","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1182\/blood-2005-06-2448","article-title":"A prospective study of the natural history of transient leukemia (TL) in neonates with Down syndrome (DS): Children's Oncology Group (COG) study POG-9481","volume":"107","author":"Massey","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0220","doi-asserted-by":"crossref","first-page":"299","DOI":"10.5483\/BMBRep.2014.47.6.092","article-title":"Cohesin gene mutations in tumorigenesis: from discovery to clinical significance","volume":"47","author":"Solomon","year":"2014","journal-title":"BMB Rep"},{"key":"10.1016\/j.blre.2015.07.005_bb0225","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ng955","article-title":"Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome","volume":"32","author":"Wechsler","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.blre.2015.07.005_bb0230","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1182\/blood-2003-10-3383","article-title":"Natural history of GATA1 mutations in Down syndrome","volume":"103","author":"Ahmed","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0235","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/ng.2759","article-title":"The landscape of somatic mutations in Down syndrome-related myeloid disorders","volume":"45","author":"Yoshida","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.blre.2015.07.005_bb0240","first-page":"1318","article-title":"Correlation of cytogenetic findings with clinical features in 18 patients with inv(3)(q21q26) or t(3;3)(q21;q26)","volume":"8","author":"Fonatsch","year":"1994","journal-title":"Leukemia"},{"key":"10.1016\/j.blre.2015.07.005_bb0245","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1182\/blood-2010-04-279794","volume":"116","author":"Miesner","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0250","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1056\/NEJM199005173222004","article-title":"Hematologic neoplasia associated with primary mediastinal germ-cell tumors","volume":"322","author":"Nichols","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.blre.2015.07.005_bb0255","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cancergen.2014.03.009","article-title":"Acquired isochromosome 12p, somatic TP53 and PTEN mutations, and a germline ATM variant in an adolescent male with concurrent acute megakaryoblastic leukemia and mediastinal germ cell tumor","volume":"207","author":"Oshrine","year":"2014","journal-title":"Cancer Genet"},{"key":"10.1016\/j.blre.2015.07.005_bb0260","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1365-2141.1992.tb06942.x","article-title":"Long-term treatment results for acute megakaryoblastic leukaemia patients: a multicentre study","volume":"82","author":"Ruiz-Arguelles","year":"1992","journal-title":"Br J Haematol"},{"key":"10.1016\/j.blre.2015.07.005_bb0265","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1182\/blood-2011-04-347229","article-title":"How I treat extramedullary acute myeloid leukemia","volume":"118","author":"Bakst","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0270","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.3324\/haematol.2011.045047","article-title":"(1)(8)F-FDG-PET\/CT for detection of extramedullary acute myeloid leukemia","volume":"96","author":"Stolzel","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.blre.2015.07.005_bb0275","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/ejh.12085","article-title":"Extramedullary disease in patients with acute myeloid leukemia assessed by 18F-FDG PET","volume":"90","author":"Cribe","year":"2013","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.blre.2015.07.005_bb0280","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/1042819021000040279","article-title":"Acute megakaryoblastic leukaemia: a national clinical and biological study of 53 adult and childhood cases by the Groupe Francais d'Hematologie Cellulaire (GFHC)","volume":"44","author":"Duchayne","year":"2003","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.blre.2015.07.005_bb0285","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/leu.2012.223","article-title":"Prognostic features in acute megakaryoblastic leukemia in children without Down syndrome: a report from the AML02 multicenter trial and the Children's Oncology Group Study POG 9421","volume":"27","author":"O'Brien","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.blre.2015.07.005_bb0290","article-title":"Extramedullary tumor of cerebral falx: an unusual presentation of acute megakaryocytic leukemia","author":"Hatakeyama","year":"2014","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.blre.2015.07.005_bb0295","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.leukres.2015.02.003","article-title":"Early mortality in acute myeloid leukemia","volume":"39","author":"Hahn","year":"2015","journal-title":"Leuk Res"},{"key":"10.1016\/j.blre.2015.07.005_bb0300","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1365-2141.1983.tb02045.x","article-title":"Reversal of marrow fibrosis in acute megakaryoblastic leukaemia after remission-induction and consolidation chemotherapy followed by bone marrow transplantation","volume":"53","author":"Mehta","year":"1983","journal-title":"Br J Haematol"},{"key":"10.1016\/j.blre.2015.07.005_bb0305","first-page":"449","article-title":"Acute megakaryoblastic leukemia with massive myelofibrosis: complete remission and reversal of marrow fibrosis with allogeneic bone marrow transplantation as the only treatment","volume":"6","author":"Bullorsky","year":"1990","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.blre.2015.07.005_bb0310","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1182\/blood-2004-03-1103","article-title":"Hematopoietic stem cell transplantation for de novo acute megakaryocytic leukemia in first complete remission: a retrospective study of the European Group for Blood and Marrow Transplantation (EBMT)","volume":"105","author":"Garderet","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0315","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/S0301-472X(99)00076-4","article-title":"Stromal damage as consequence of high-dose chemo\/radiotherapy in bone marrow transplant recipients","volume":"27","author":"Galotto","year":"1999","journal-title":"Exp Hematol"},{"issue":"Suppl. 1","key":"10.1016\/j.blre.2015.07.005_bb0320","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1538-7836.2009.03398.x","article-title":"Regulation of megakaryocyte maturation and platelet formation","volume":"7","author":"Bluteau","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.blre.2015.07.005_bb0325","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.cell.2012.06.032","article-title":"Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL","volume":"150","author":"Wen","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.blre.2015.07.005_bb0330","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1158\/1078-0432.CCR-12-2604","article-title":"Molecular pathways: induction of polyploidy as a novel differentiation therapy for leukemia","volume":"19","author":"Krause","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.blre.2015.07.005_bb0335","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1073\/pnas.0511150103","article-title":"Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling","volume":"103","author":"Bourquin","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.blre.2015.07.005_bb0340","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1182\/blood-2008-09-179812","article-title":"RUNX1 regulates phosphoinositide 3-kinase\/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia","volume":"114","author":"Edwards","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.blre.2015.07.005_bb0345","doi-asserted-by":"crossref","first-page":"e68601","DOI":"10.1371\/journal.pone.0068601","article-title":"Overexpression of GATA1 confers resistance to chemotherapy in acute megakaryocytic leukemia","volume":"8","author":"Caldwell","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.blre.2015.07.005_bb0350","doi-asserted-by":"crossref","first-page":"e27486","DOI":"10.1371\/journal.pone.0027486","article-title":"A unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy","volume":"6","author":"Xavier","year":"2011","journal-title":"PLoS One"}],"container-title":["Blood Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0268960X15000600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0268960X15000600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T05:58:08Z","timestamp":1599285488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0268960X15000600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0268960X15000600"],"URL":"https:\/\/doi.org\/10.1016\/j.blre.2015.07.005","relation":{},"ISSN":["0268-960X"],"issn-type":[{"value":"0268-960X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute megakaryocytic leukemia: What have we learned","name":"articletitle","label":"Article Title"},{"value":"Blood Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.blre.2015.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}