{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:00:21Z","timestamp":1792594821152,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Reviews"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.blre.2018.04.005","type":"journal-article","created":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T20:55:18Z","timestamp":1523652918000},"page":"480-489","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":190,"title":["Blocking \u201cdon't eat me\u201d signal of CD47-SIRP\u03b1 in hematological malignancies, an in-depth review"],"prefix":"10.1016","volume":"32","author":[{"given":"Atlantis","family":"Russ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh B.","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Montfort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irbaz Bin","family":"Riaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Umar","family":"Khalid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Carew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffan T.","family":"Nawrocki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Persky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6914-7439","authenticated-orcid":false,"given":"Faiz","family":"Anwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.blre.2018.04.005_bb0005","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1242\/jcs.108.11.3419","article-title":"In vivo expression of alternatively spliced forms of integrin-associated protein (CD47)","volume":"108","author":"Reinhold","year":"1995","journal-title":"J Cell Sci"},{"key":"10.1016\/j.blre.2018.04.005_bb0010","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1074\/jbc.274.2.559","article-title":"Integrin-associated protein is a ligand for the P84 neural adhesion molecule","volume":"274","author":"Jiang","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.blre.2018.04.005_bb0015","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1182\/blood.V94.11.3633","article-title":"Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47","volume":"94","author":"Seiffert","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.blre.2018.04.005_bb0020","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1242\/jcs.00119","article-title":"Thrombospondin-1 differentially induces chemotaxis and DNA synthesis of human venous smooth muscle cells at the receptor-binding level","volume":"115","author":"Lymn","year":"2002","journal-title":"J Cell Sci"},{"key":"10.1016\/j.blre.2018.04.005_bb0025","doi-asserted-by":"crossref","first-page":"14740","DOI":"10.1074\/jbc.272.23.14740","article-title":"Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3","volume":"272","author":"Chung","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.blre.2018.04.005_bb0030","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1126\/science.274.5288.795","article-title":"Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice","volume":"274","author":"Lindberg","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.blre.2018.04.005_bb0035","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4049\/jimmunol.158.2.677","article-title":"Integrin-associated protein (CD47) is a comitogenic molecule on CD3-activated human T cells","volume":"158","author":"Ticchioni","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.blre.2018.04.005_bb0040","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.blre.2018.04.005_bb0045","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1126\/science.288.5473.2051","article-title":"Role of CD47 as a marker of self on red blood cells","volume":"288","author":"Oldenborg","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.blre.2018.04.005_bb0050","doi-asserted-by":"crossref","first-page":"6887","DOI":"10.1128\/MCB.16.12.6887","article-title":"A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion","volume":"16","author":"Fujioka","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.blre.2018.04.005_bb0055","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1080\/1042819042000201989","article-title":"Role of CD47 in erythroid cells and in autoimmunity","volume":"45","author":"Oldenborg","year":"2004","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.blre.2018.04.005_bb0060","first-page":"5416","article-title":"An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains","volume":"52","author":"Campbell","year":"1992","journal-title":"Cancer Res"},{"key":"10.1016\/j.blre.2018.04.005_bb0065","first-page":"781","article-title":"Monoclonal antibody against human ovarian tumor-associated antigens","volume":"76","author":"Poels","year":"1986","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.blre.2018.04.005_bb0070","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2009.05.046","article-title":"CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis","volume":"138","author":"Jaiswal","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.blre.2018.04.005_bb0075","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.cell.2009.05.045","article-title":"CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells","volume":"138","author":"Majeti","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.blre.2018.04.005_bb0080","doi-asserted-by":"crossref","first-page":"6662","DOI":"10.1073\/pnas.1121623109","article-title":"The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors","volume":"109","author":"Willingham","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.blre.2018.04.005_bb0085","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1158\/0008-5472.CAN-10-2238","article-title":"Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia","volume":"71","author":"Chao","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.blre.2018.04.005_bb0090","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1038\/leu.2012.141","article-title":"Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells","volume":"26","author":"Kim","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.blre.2018.04.005_bb0095","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1182\/blood.V99.5.1745","article-title":"Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells","volume":"99","author":"Zhan","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.blre.2018.04.005_bb0100","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1016\/j.ejca.2014.03.004","article-title":"Efficacy of anti-CD47 antibody-mediated phagocytosis with macrophages against primary effusion lymphoma","volume":"50","author":"Goto","year":"2014","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.blre.2018.04.005_bb0105","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.cell.2010.07.044","article-title":"Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma","volume":"142","author":"Chao","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.blre.2018.04.005_bb0110","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJMra0708875","article-title":"Monoclonal antibody therapy for B-cell non-Hodgkin's lymphoma","volume":"359","author":"Cheson","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.blre.2018.04.005_bb0115","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.cell.2005.08.032","article-title":"Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte","volume":"123","author":"Gardai","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.blre.2018.04.005_bb0120","first-page":"2","article-title":"Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47","author":"Chao","year":"2010","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.blre.2018.04.005_bb0125","doi-asserted-by":"crossref","first-page":"10133","DOI":"10.18632\/oncotarget.7100","article-title":"A function-blocking CD47 antibody suppresses stem cell and EGF signaling in triple-negative breast cancer","volume":"7","author":"Kaur","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.blre.2018.04.005_bb0130","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.biocel.2016.05.005","article-title":"Divergent modulation of normal and neoplastic stem cells by thrombospondin-1 and CD47 signaling","volume":"81","author":"Kaur","year":"2016","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.blre.2018.04.005_bb0135","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/srep01038","article-title":"Blockade of CD47 increases survival of mice exposed to lethal total body irradiation","volume":"3","author":"Soto-Pantoja","year":"2013","journal-title":"Sci Rep"},{"key":"10.1016\/j.blre.2018.04.005_bb0140","doi-asserted-by":"crossref","first-page":"24858","DOI":"10.1074\/jbc.M115.665752","article-title":"CD47 receptor globally regulates metabolic pathways that control resistance to ionizing radiation","volume":"290","author":"Miller","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.blre.2018.04.005_bb0145","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/15233","article-title":"CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia","volume":"5","author":"Mateo","year":"1999","journal-title":"Nat Med"},{"key":"10.1016\/j.blre.2018.04.005_bb0150","first-page":"1189","article-title":"Antitumor activity of a monoclonal antibody against CD47 in xenograft models of human leukemia","volume":"17","author":"Uno","year":"2007","journal-title":"Oncol Rep"},{"key":"10.1016\/j.blre.2018.04.005_bb0155","doi-asserted-by":"crossref","first-page":"7073","DOI":"10.1128\/MCB.02116-06","article-title":"Drp1 mediates caspase-independent type III cell death in normal and leukemic cells","volume":"27","author":"Bras","year":"2007","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.blre.2018.04.005_bb0160","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3324\/haematol.13690","article-title":"Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton","volume":"94","author":"Barbier","year":"2009","journal-title":"Haematologica"},{"key":"10.1016\/j.blre.2018.04.005_bb0165","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/j.1349-7006.2011.01925.x","article-title":"A new disulfide-linked dimer of a single-chain antibody fragment against human CD47 induces apoptosis in lymphoid malignant cells via the hypoxia inducible factor-1alpha pathway","volume":"102","author":"Sagawa","year":"2011","journal-title":"Cancer Sci"},{"key":"10.1016\/j.blre.2018.04.005_bb0170","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.bbrc.2004.01.128","article-title":"A bivalent single-chain Fv fragment against CD47 induces apoptosis for leukemic cells","volume":"315","author":"Kikuchi","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.blre.2018.04.005_bb0175","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.leukres.2004.09.005","article-title":"Apoptosis inducing bivalent single-chain antibody fragments against CD47 showed antitumor potency for multiple myeloma","volume":"29","author":"Kikuchi","year":"2005","journal-title":"Leuk Res"},{"key":"10.1016\/j.blre.2018.04.005_bb0180","doi-asserted-by":"crossref","first-page":"60892","DOI":"10.18632\/oncotarget.18492","article-title":"Anti-CD47 antibodies induce phagocytosis of live, malignant B cells by macrophages via the Fc domain, resulting in cell death by phagoptosis","volume":"8","author":"Metayer","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.blre.2018.04.005_bb0185","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1084\/jem.20120502","article-title":"Disruption of SIRP\u03b1 signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts","volume":"209","author":"Theocharides","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.blre.2018.04.005_bb0190","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.4238\/2015.May.25.15","article-title":"Ara-C and anti-CD47 antibody combination therapy eliminates acute monocytic leukemia THP-1 cells in vivo and in vitro","volume":"14","author":"Wang","year":"2015","journal-title":"Genet Mol Res"},{"key":"10.1016\/j.blre.2018.04.005_bb0195","doi-asserted-by":"crossref","DOI":"10.1145\/2818302","article-title":"Pre-clinical development of a humanized anti-CD47 antibody with anti-cancer therapeutic potential","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.blre.2018.04.005_bb0200","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1038\/sj.cdd.4402201","article-title":"Calreticulin exposure is required for the immunogenicity of gamma-irradiation and UVC light-induced apoptosis","volume":"14","author":"Obeid","year":"2007","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.blre.2018.04.005_bb0205","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1080\/19420862.2015.1062192","article-title":"A bispecific antibody targeting CD47 and CD20 selectively binds and eliminates dual antigen expressing lymphoma cells","volume":"7","author":"Piccione","year":"2015","journal-title":"MAbs"},{"key":"10.1016\/j.blre.2018.04.005_bb0210","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1182\/blood-2011-02-338020","article-title":"Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy","volume":"118","author":"Chao","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.blre.2018.04.005_bb0215","doi-asserted-by":"crossref","first-page":"11103","DOI":"10.1073\/pnas.1305569110","article-title":"Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response","volume":"110","author":"Tseng","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.blre.2018.04.005_bb0220","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/nm.3931","article-title":"CD47 blockade triggers T cell-mediated destruction of immunogenic tumors","volume":"21","author":"Liu","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.blre.2018.04.005_bb0225","first-page":"70","article-title":"CD47 is a prognostic factor and an antibody target that synergizes with rituximab to eradicate non-Hodgkin lymphoma","author":"Chao","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.blre.2018.04.005_bb0230","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1182\/blood.V128.22.1812.1812","article-title":"A phase 1 study of TTI-621, a novel immune checkpoint inhibitor targeting CD47, in patients with relapsed or refractory hematologic malignancies","volume":"128","author":"Ansell","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.blre.2018.04.005_bb0235","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1126\/science.1238856","article-title":"Engineered SIRP alpha variants as immunotherapeutic adjuvants to anticancer antibodies","volume":"341","author":"Weiskopf","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.blre.2018.04.005_bb0240","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/19420862.2015.1011450","article-title":"Macrophages are critical effectors of antibody therapies for cancer","volume":"7","author":"Weiskopf","year":"2015","journal-title":"MAbs"},{"key":"10.1016\/j.blre.2018.04.005_bb0245","doi-asserted-by":"crossref","first-page":"21024","DOI":"10.1074\/jbc.M302306200","article-title":"Calreticulin is at the surface of circulating neutrophils and uses CD59 as an adaptor molecule","volume":"278","author":"Ghiran","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.blre.2018.04.005_bb0250","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nm1523","article-title":"Calreticulin exposure dictates the immunogenicity of cancer cell death","volume":"13","author":"Obeid","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.blre.2018.04.005_bb0255","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ejca.2017.02.013","article-title":"Cancer immunotherapy targeting the CD47\/SIRPalpha axis","volume":"76","author":"Weiskopf","year":"2017","journal-title":"Eur J Cancer"}],"container-title":["Blood Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0268960X17300930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0268960X17300930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T23:34:56Z","timestamp":1693611296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0268960X17300930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0268960X17300930"],"URL":"https:\/\/doi.org\/10.1016\/j.blre.2018.04.005","relation":{},"ISSN":["0268-960X"],"issn-type":[{"value":"0268-960X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blocking \u201cdon't eat me\u201d signal of CD47-SIRP\u03b1 in hematological malignancies, an in-depth review","name":"articletitle","label":"Article Title"},{"value":"Blood Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.blre.2018.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}