{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:44:47Z","timestamp":1790502287775,"version":"4.1.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Reviews"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.blre.2020.100745","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T11:29:34Z","timestamp":1598268574000},"page":"100745","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":157,"special_numbering":"C","title":["Coagulation dysfunction in COVID-19: The interplay between inflammation, viral infection and the coagulation system"],"prefix":"10.1016","volume":"46","author":[{"given":"Maria Grazia","family":"Lazzaroni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Piantoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Masneri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emirena","family":"Garrafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Martini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Tincani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Andreoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Franceschini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.blre.2020.100745_bb0005","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0140-6736(20)30627-9","article-title":"COVID-19 and Italy: what next?","volume":"395","author":"Remuzzi","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.blre.2020.100745_bb0010","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1001\/jama.2020.2648","article-title":"Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the chinese center for disease control and prevention","volume":"323","author":"Wu","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.blre.2020.100745_bb0015","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.blre.2020.100745_bb0020","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/CCM.0b013e3181c98d21","article-title":"Inflammation and coagulation","volume":"38","author":"Levi","year":"2010","journal-title":"Crit Care Med"},{"key":"10.1016\/j.blre.2020.100745_bb0025","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.blre.2020.100745_bb0030","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/jth.14768","article-title":"Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia","author":"Tang","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.blre.2020.100745_bb0035","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1515\/cclm-2020-0188","article-title":"Prominent changes in blood coagulation of patients with SARS-CoV-2 infection","volume":"58","author":"Han","year":"2020","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.blre.2020.100745_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/jamainternmed.2020.0994","article-title":"Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China","volume":"180","author":"Wu","year":"2020","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.blre.2020.100745_bb0045","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/jth.14810","article-title":"ISTH interim guidance on recognition and management of coagulopathy in COVID-19","volume":"18","author":"Thachil","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.blre.2020.100745_bb0050","doi-asserted-by":"crossref","DOI":"10.1111\/jth.14975","article-title":"Coagulopathy in COVID-19","author":"Iba","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.blre.2020.100745_bb0055","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1056\/NEJMoa030685","article-title":"A major outbreak of severe acute respiratory syndrome in Hong Kong","volume":"348","author":"Lee","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.blre.2020.100745_bb0060","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cca.2020.03.022","article-title":"Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis","volume":"506","author":"Lippi","year":"2020","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.blre.2020.100745_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.25767","article-title":"Platelet-to-lymphocyte ratio is associated with prognosis in patients with coronavirus disease-19","author":"Qu","year":"2020","journal-title":"J Med Virol"},{"key":"10.1016\/j.blre.2020.100745_bb0070","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.blre.2020.100745_bb0075","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1378\/chest.126.4.1087","article-title":"Plasma d-dimer levels correlate with outcomes in patients with community-acquired pneumonia","volume":"126","author":"Querol-Ribelles","year":"2004","journal-title":"Chest"},{"issue":"S213","key":"10.1016\/j.blre.2020.100745_bb0080","first-page":"S20","article-title":"Coagulation, fibrinolysis, and fibrin deposition in acute lung injury","volume":"31","author":"Idell","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.blre.2020.100745_bb0085","first-page":"1821","article-title":"Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury\/acute respiratory distress syndrome","volume":"35","author":"Ware","year":"2007","journal-title":"Crit Care Med"},{"key":"10.1016\/j.blre.2020.100745_bb0090","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.blre.2020.100745_bb0095","first-page":"185","article-title":"Characteristics, causes, diagnosis and treatment of coagulation dysfunction in patients with COVID-19","volume":"41","author":"Mei","year":"2020","journal-title":"Zhonghua xueyexue zazhi"},{"key":"10.1016\/j.blre.2020.100745_bb0100","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/jth.14817","article-title":"Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy","volume":"18","author":"Tang","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.blre.2020.100745_bb0105","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-2334-4-34","article-title":"A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection","volume":"4","author":"Ng","year":"2004","journal-title":"BMC Infect Dis"},{"issue":"20","key":"10.1016\/j.blre.2020.100745_bb0110","first-page":"30400","article-title":"Fibrinolysis shutdown correlation with thromboembolic events in severe COVID-19 infection","volume":"S1072\u20137515","author":"Wright","year":"2020","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.blre.2020.100745_bb0115","first-page":"1","article-title":"Evaluation of coagulation function by rotation thromboelastometry in critically ill patients with severe COVID-19 pneumonia","author":"Pavoni","year":"2020","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.blre.2020.100745_bb0120","doi-asserted-by":"crossref","first-page":"195","DOI":"10.5858\/2004-128-195-AODDTS","article-title":"Analysis of deaths during the severe acute respiratory syndrome (SARS) epidemic in Singapore: challenges in determining a SARS diagnosis","volume":"128","author":"Chong","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.blre.2020.100745_bb0125","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s00415-004-0519-8","article-title":"Large artery ischaemic stroke in severe acute respiratory syndrome (SARS)","volume":"251","author":"Umapathi","year":"2004","journal-title":"J Neurol"},{"key":"10.1016\/j.blre.2020.100745_bb0130","series-title":"Findings of acute pulmonary embolism in COVID-19 patients. available at SSRN 3548771","author":"Chen","year":"2020"},{"key":"10.1016\/j.blre.2020.100745_bb0135","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.thromres.2020.04.013","article-title":"Incidence of thrombotic complications in critically ill ICU patients with COVID-19","volume":"191","author":"Klok","year":"2020","journal-title":"Thromb Res"},{"key":"10.1016\/j.blre.2020.100745_bb0140","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/jth.14830","article-title":"Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia","volume":"18","author":"Cui","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.blre.2020.100745_bb0145","doi-asserted-by":"crossref","first-page":"e362","DOI":"10.1016\/S2352-3026(20)30109-5","article-title":"Attention should be paid to venous thromboembolism prophylaxis in the management of COVID-19","volume":"7","author":"Wang","year":"2020","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.blre.2020.100745_bb0150","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s00134-020-06062-x","article-title":"High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study","volume":"4","author":"Helms","year":"2020","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.blre.2020.100745_bb0155","article-title":"Clinical characteristics of 20,662 patients with COVID-19 in mainland China: A systemic review and meta-analysis","author":"Tang","year":"2020","journal-title":"medRxiv preprint"},{"key":"10.1016\/j.blre.2020.100745_bb0160","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"W-j","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.blre.2020.100745_bb0165","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glaa146","article-title":"Clinical characteristics of hospitalized individuals dying with COVID-19 by age group in Italy","author":"Palmieri","year":"2020","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.blre.2020.100745_bb0170","doi-asserted-by":"crossref","DOI":"10.1001\/jamacardio.2020.1286","article-title":"Potential effects of coronaviruses on the cardiovascular system: a review","author":"Madjid","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.blre.2020.100745_bb0175","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1016\/j.jacc.2020.03.031","article-title":"Cardiovascular considerations for patients, health care workers, and health systems during the COVID-19 pandemic","volume":"75","author":"Driggin","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.blre.2020.100745_bb0180","doi-asserted-by":"crossref","first-page":"E1583","DOI":"10.3390\/cells9071583","article-title":"Vasculopathy and coagulopathy associated with SARS-CoV-2 infection","volume":"9","author":"Lab\u00f2","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.blre.2020.100745_bb0185","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/00003246-200204000-00008","article-title":"Deep vein thrombosis during prolonged mechanical ventilation despite prophylaxis","volume":"30","author":"Ibrahim","year":"2002","journal-title":"Crit Care Med"},{"key":"10.1016\/j.blre.2020.100745_bb0190","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41581-020-0279-4","article-title":"Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic","volume":"16","author":"South","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.blre.2020.100745_bb0195","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nm1267","article-title":"Crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury","volume":"11","author":"Kuba","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.blre.2020.100745_bb0200","doi-asserted-by":"crossref","first-page":"10970","DOI":"10.1073\/pnas.2005615117","article-title":"Effective treatment of severe COVID-19 patients with tocilizumab","volume":"117","author":"Xu","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.blre.2020.100745_bb0205","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.thromres.2016.11.007","article-title":"Coagulation and sepsis","volume":"149","author":"Levi","year":"2017","journal-title":"Thromb Res"},{"key":"10.1016\/j.blre.2020.100745_bb0210","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1055\/s-0037-1613944","article-title":"Platelets release thrombopoietin (Tpo) upon activation: another regulatory loop in thrombocytopoiesis?","volume":"83","author":"Folman","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.blre.2020.100745_bb0215","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00281-011-0283-7","article-title":"Systemic versus localized coagulation activation contributing to organ failure in critically ill patients","volume":"34","author":"Levi","year":"2012","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.blre.2020.100745_bb0220","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1055\/s-0038-1650653","article-title":"Interleukin-6 stimulates coagulation, not fibrinolysis, in humans","volume":"76","author":"Stouthard","year":"1996","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.blre.2020.100745_bb0225","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1055\/s-0037-1614223","article-title":"Transcriptional activation of the factor VIII gene in liver cell lines by interleukin-6","volume":"79","author":"Stirling","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.blre.2020.100745_bb0230","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1074\/jbc.271.2.736","article-title":"Interleukin 6 induces the expression of vascular endothelial growth factor","volume":"271","author":"Cohen","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.blre.2020.100745_bb0235","first-page":"2059","article-title":"The shedding protease ADAM17: physiology and pathophysiology","volume":"2017","author":"Zunke","year":"1864","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.blre.2020.100745_bb0240","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.acvd.2012.02.010","article-title":"Three key proteases\u2013angiotensin-I-converting enzyme (ACE), ACE2 and renin\u2013within and beyond the renin-angiotensin system","volume":"105","author":"Guang","year":"2012","journal-title":"Arch Cardiovasc Dis"},{"key":"10.1016\/j.blre.2020.100745_bb0245","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2174\/1381612033455431","article-title":"The pulmonary renin-angiotensin system","volume":"9","author":"Marshall","year":"2003","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.blre.2020.100745_bb0250","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0002-9149(01)01509-0","article-title":"Angiotensin, fibrinolysis, and vascular homeostasis","volume":"87","author":"Vaughan","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.blre.2020.100745_bb0255","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nm1267","article-title":"A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus\u2013induced lung injury","volume":"11","author":"Kuba","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.blre.2020.100745_bb0260","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1160\/TH05-12-0827","article-title":"Analysis of thrombotic factors in severe acute respiratory syndrome (SARS) patients","volume":"96","author":"Wu","year":"2006","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.blre.2020.100745_bb0265","doi-asserted-by":"crossref","first-page":"6180","DOI":"10.1128\/JVI.79.10.6180-6193.2005","article-title":"Comparative host gene transcription by microarray analysis early after infection of the Huh7 cell line by severe acute respiratory syndrome coronavirus and human coronavirus 229E","volume":"79","author":"Tang","year":"2005","journal-title":"J Virol"},{"issue":"e00271","key":"10.1016\/j.blre.2020.100745_bb0270","first-page":"13","article-title":"Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury","volume":"4","author":"Gralinski","year":"2013","journal-title":"MBio"},{"key":"10.1016\/j.blre.2020.100745_bb0275","doi-asserted-by":"crossref","first-page":"e1003229","DOI":"10.1371\/journal.ppat.1003229","article-title":"Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis","volume":"9","author":"Berri","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.blre.2020.100745_bb0280","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/j.1538-7836.2005.01217.x","article-title":"Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation","volume":"3","author":"Reheman","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.blre.2020.100745_bb0285","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.cell.2020.04.004","article-title":"Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2","volume":"181","author":"Monteil","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.blre.2020.100745_bb0290","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(20)30937-5","article-title":"Endothelial cell infection and endotheliitis in COVID-19","volume":"395","author":"Varga","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.blre.2020.100745_bb0295","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1073\/pnas.82.8.2523","article-title":"An endothelial cell-dependent pathway of coagulation","volume":"82","author":"Stern","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.blre.2020.100745_bb0300","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1002\/jmv.23354","article-title":"Viral infections and mechanisms of thrombosis and bleeding","volume":"84","author":"Goeijenbier","year":"2012","journal-title":"J Med Virol"},{"key":"10.1016\/j.blre.2020.100745_bb0305","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/art.10130","article-title":"Antiphospholipid antibodies induced in mice by immunization with a cytomegalovirus-derived peptide cause thrombosis and activation of endothelial cells in vivo","volume":"46","author":"Gharavi","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.blre.2020.100745_bb0310","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1203\/00006450-200109000-00009","article-title":"The varicella-autoantibody syndrome","volume":"50","author":"Josephson","year":"2001","journal-title":"Pediatr Res"},{"key":"10.1016\/j.blre.2020.100745_bb0315","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1365-2141.1995.tb05324.x","article-title":"The use of an anti-\u03b22-glycoprotein-I assay for discrimination between anticardiolipin antibodies associated with infection and increased risk of thrombosis","volume":"91","author":"McNally","year":"1995","journal-title":"Br J Haematol"},{"key":"10.1016\/j.blre.2020.100745_bb0320","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1046\/j.1365-2249.2002.01722.x","article-title":"High prevalence of co-factor independent anticardiolipin antibodies in malaria exposed individuals","volume":"127","author":"Consigny","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.blre.2020.100745_bb0325","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1056\/NEJMc2007575","article-title":"Coagulopathy and antiphospholipid antibodies in patients with Covid-19","volume":"382","author":"Zhang","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.blre.2020.100745_bb0330","article-title":"Lupus anticoagulant is frequent in patients with Covid-19","author":"Harzallah","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.blre.2020.100745_bb0335","article-title":"Anti-phospholipid antibodies in COVID-19 are different from those detectable in the anti-phospholipid syndrome","author":"Borghi","year":"2020","journal-title":"medRxiv and bioRxiv"},{"key":"10.1016\/j.blre.2020.100745_bb0340","article-title":"The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 receptor binding domain undergoes conformational change upon heparin binding","author":"Mycroft-West","year":"2020","journal-title":"BioRxiv"},{"key":"10.1016\/j.blre.2020.100745_bb0345","doi-asserted-by":"crossref","first-page":"13221","DOI":"10.1128\/JVI.02078-14","article-title":"Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells","volume":"88","author":"Milewska","year":"2014","journal-title":"J Virol"},{"key":"10.1016\/j.blre.2020.100745_bb0350","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3201\/eid1003.030683","article-title":"Coronaviridae and SARS-associated coronavirus strain HSR1","volume":"10","author":"Vicenzi","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.blre.2020.100745_bb0355","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.4049\/jimmunol.165.10.5671","article-title":"Characterization of the heparin-binding properties of IL-6","volume":"165","author":"Mummery","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.blre.2020.100745_bb0360","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/j.1365-2125.2011.04034.x","article-title":"Anti-platelet therapy: phosphodiesterase inhibitors","volume":"72","author":"Gresele","year":"2011","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.blre.2020.100745_bb0365","doi-asserted-by":"crossref","first-page":"11062","DOI":"10.1128\/JVI.79.17.11062-11070.2005","article-title":"Dipyridamole reversibly inhibits mengovirus RNA replication","volume":"79","author":"Fata-Hartley","year":"2005","journal-title":"J Virol"},{"issue":"e24","key":"10.1016\/j.blre.2020.100745_bb0370","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.cell.2019.10.027","article-title":"Mucosal profiling of pediatric-onset colitis and IBD reveals common pathogenics and therapeutic pathways","volume":"179","author":"Huang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.blre.2020.100745_bb0375","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1476-5381.2012.01847.x","article-title":"cAMP and Epac in the regulation of tissue fibrosis","volume":"166","author":"Insel","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.blre.2020.100745_bb0380","article-title":"Therapeutic effects of dipyridamole on COVID-19 patients with coagulation dysfunction","author":"Liu","year":"2020","journal-title":"MedRxiv"}],"container-title":["Blood Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0268960X20300953?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0268960X20300953?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T20:27:14Z","timestamp":1759436834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0268960X20300953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":76,"alternative-id":["S0268960X20300953"],"URL":"https:\/\/doi.org\/10.1016\/j.blre.2020.100745","relation":{},"ISSN":["0268-960X"],"issn-type":[{"value":"0268-960X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coagulation dysfunction in COVID-19: The interplay between inflammation, viral infection and the coagulation system","name":"articletitle","label":"Article Title"},{"value":"Blood Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.blre.2020.100745","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100745"}}