{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T01:24:44Z","timestamp":1767144284536,"version":"build-2238731810"},"reference-count":80,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2004,5]]},"DOI":"10.1016\/j.bmc.2004.03.024","type":"journal-article","created":{"date-parts":[[2004,4,13]],"date-time":"2004-04-13T05:30:59Z","timestamp":1081834259000},"page":"2571-2587","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["S1 subsite in snake venom thrombin-like enzymes: can S1 subsite lipophilicity be used to sort binding affinities of trypsin-like enzymes to small-molecule inhibitors?"],"prefix":"10.1016","volume":"12","author":[{"suffix":"Jr.","given":"Floriano P.","family":"Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore G.","family":"De-Simone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2004.03.024_BIB1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/nar\/30.1.343","volume":"30","author":"Rawlings","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmc.2004.03.024_BIB2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1006\/jmbi.1996.0264","volume":"258","author":"Lesk","year":"1996","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmc.2004.03.024_BIB3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0304-4165(66)90258-3","volume":"130","author":"Meloun","year":"1966","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmc.2004.03.024_BIB4","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1021\/cr000033x","volume":"102","author":"Hedstrom","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmc.2004.03.024_BIB5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0006-291X(67)80055-X","volume":"27","author":"Schecter","year":"1967","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmc.2004.03.024_BIB6","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1046\/j.1432-1327.1999.00160.x","volume":"260","author":"Czapinska","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0005-2744(78)90213-9","volume":"525","author":"Colomb","year":"1978","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmc.2004.03.024_BIB8","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/pro.5560040301","volume":"4","author":"Perona","year":"1995","journal-title":"Protein Sci."},{"key":"10.1016\/j.bmc.2004.03.024_BIB9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0968-0004(00)88945-8","volume":"20","author":"Stubbs","year":"1995","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bmc.2004.03.024_BIB10","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0041-0101(98)00126-3","volume":"36","author":"Markland","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.bmc.2004.03.024_BIB11","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0167-4838(99)00268-X","volume":"1477","author":"Matsui","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmc.2004.03.024_BIB12","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0041-0101(95)00159-X","volume":"34","author":"Aguiar","year":"1996","journal-title":"Toxicon"},{"key":"10.1016\/j.bmc.2004.03.024_BIB13","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0041-0101(89)90043-3","volume":"27","author":"Silva","year":"1989","journal-title":"Toxicon"},{"key":"10.1016\/j.bmc.2004.03.024_BIB14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0014-5793(93)80205-9","volume":"329","author":"Magalh\u00e3es","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmc.2004.03.024_BIB15","doi-asserted-by":"crossref","first-page":"10377","DOI":"10.1093\/nar\/16.21.10377","volume":"16","author":"Itoh","year":"1988","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmc.2004.03.024_BIB16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0014-5793(92)80559-Y","volume":"297","author":"Burkhart","year":"1992","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmc.2004.03.024_BIB17","doi-asserted-by":"crossref","first-page":"10246","DOI":"10.1074\/jbc.270.17.10246","volume":"270","author":"Zhang","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB18","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/S0969-2126(98)00119-1","volume":"6","author":"Parry","year":"1998","journal-title":"Structure"},{"key":"10.1016\/j.bmc.2004.03.024_BIB19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0167-4838(01)00177-7","volume":"1547","author":"Castro","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmc.2004.03.024_BIB20","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0041-0101(97)00003-2","volume":"35","author":"Magalh\u00e3es","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.bmc.2004.03.024_BIB21","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1016\/S0960-894X(97)10168-8","volume":"7","author":"Massova","year":"1997","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2004.03.024_BIB22","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/0022-2836(89)90110-1","volume":"210","author":"Bartunik","year":"1989","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmc.2004.03.024_BIB23","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S1074-5521(01)00084-9","volume":"8","author":"Katz","year":"2001","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bmc.2004.03.024_BIB24","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1021\/bi00173a030","volume":"33","author":"Nishida","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2004.03.024_BIB25","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/oxfordjournals.jbchem.a021319","volume":"119","author":"Hahn","year":"1996","journal-title":"J. Biochem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/abbi.1995.1208","volume":"318","author":"Nikai","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bmc.2004.03.024_BIB27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0076-6879(94)44004-2","volume":"244","author":"Rawlings","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bmc.2004.03.024_BIB28","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/(SICI)1098-1128(199903)19:2<179::AID-MED4>3.0.CO;2-5","volume":"19","author":"Sanderson","year":"1999","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2004.03.024_BIB29","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0021-9258(18)97474-0","volume":"240","author":"Mares-Guia","year":"1965","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB30","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1021\/bi00818a015","volume":"9","author":"Mares-Guia","year":"1970","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2004.03.024_BIB31","doi-asserted-by":"crossref","first-page":"5777","DOI":"10.1016\/S0021-9258(18)99368-3","volume":"242","author":"Mares-Guia","year":"1967","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB32","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0022-2836(75)80005-2","volume":"98","author":"Bode","year":"1975","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmc.2004.03.024_BIB33","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1021\/ja00449a051","volume":"99","author":"Mares-Guia","year":"1977","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2004.03.024_BIB34","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0026-895X(25)10270-8","volume":"29","author":"Recantini","year":"1986","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bmc.2004.03.024_BIB35","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1021\/jm00014a020","volume":"38","author":"Ortiz","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB36","doi-asserted-by":"crossref","first-page":"9663","DOI":"10.1021\/jp971990m","volume":"101","author":"Essex","year":"1997","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bmc.2004.03.024_BIB37","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1046\/j.1432-1327.2001.01991.x","volume":"268","author":"Talhout","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB38","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1006\/jmbi.2001.5062","volume":"313","author":"Dullweber","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmc.2004.03.024_BIB39","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1021\/jp013563l","volume":"106","author":"Guimar\u00e3es","year":"2002","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bmc.2004.03.024_BIB40","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1021\/cr60056a010","volume":"17","author":"Hammett","year":"1935","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmc.2004.03.024_BIB41","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1021\/jp9702457","volume":"101","author":"Sharp","year":"1997","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bmc.2004.03.024_BIB42","first-page":"1177","volume":"22","author":"Rogana","year":"1989","journal-title":"Brazilian J. Med. Biol. Res."},{"key":"10.1016\/j.bmc.2004.03.024_BIB43","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1021\/jm970245v","volume":"40","author":"Checa","year":"1997","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB44","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/0165-6147(93)90095-2","volume":"14","author":"Tapparelli","year":"1993","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bmc.2004.03.024_BIB45","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0263-7855(98)80001-5","volume":"6","author":"Furet","year":"1988","journal-title":"J. Mol. Graphics"},{"key":"10.1016\/j.bmc.2004.03.024_BIB46","doi-asserted-by":"crossref","first-page":"22089","DOI":"10.1074\/jbc.270.38.22089","volume":"270","author":"Di Cera","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB47","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0301-4622(96)02227-2","volume":"63","author":"Zhang","year":"1997","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB48","doi-asserted-by":"crossref","first-page":"10653","DOI":"10.1073\/pnas.93.20.10653","volume":"93","author":"Dang","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2004.03.024_BIB49","doi-asserted-by":"crossref","first-page":"11721","DOI":"10.1021\/bi00162a008","volume":"31","author":"Wells","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2004.03.024_BIB50","doi-asserted-by":"crossref","first-page":"11185","DOI":"10.1073\/pnas.92.24.11185","volume":"92","author":"Guinto","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2004.03.024_BIB51","doi-asserted-by":"crossref","first-page":"30275","DOI":"10.1074\/jbc.272.48.30275","volume":"272","author":"Lai","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB52","doi-asserted-by":"crossref","first-page":"40177","DOI":"10.1074\/jbc.C200465200","volume":"277","author":"Pineda","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB53","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0969-2126(03)00049-2","volume":"11","author":"Huntington","year":"2003","journal-title":"Structure"},{"key":"10.1016\/j.bmc.2004.03.024_BIB54","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmc.2004.03.024_BIB55","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/jmbi.1999.3091","volume":"292","author":"Jones","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmc.2004.03.024_BIB56","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1042\/bst0240274","volume":"24","author":"Peitsch","year":"1996","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bmc.2004.03.024_BIB57","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1006\/jmbi.1993.1210","volume":"230","author":"Perona","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmc.2004.03.024_BIB58","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1006\/jmbi.2001.4872","volume":"311","author":"Skordalakes","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmc.2004.03.024_BIB59","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/elps.1150181505","volume":"18","author":"Guex","year":"1997","journal-title":"Electrophoresis"},{"key":"10.1016\/j.bmc.2004.03.024_BIB60","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Cryst."},{"key":"10.1016\/j.bmc.2004.03.024_BIB61","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/anie.199009921","volume":"29","author":"van Gunsteren","year":"1990","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"10.1016\/j.bmc.2004.03.024_BIB62","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/381272a0","volume":"381","author":"Hooft","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2004.03.024_BIB63","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1021\/ja00299a024","volume":"107","author":"Dewar","year":"1985","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2004.03.024_BIB64","doi-asserted-by":"crossref","first-page":"16385","DOI":"10.1021\/jp9610776","volume":"100","author":"Chambers","year":"1996","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB65","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.257.5073.1078","volume":"257","author":"Kuntz","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.bmc.2004.03.024_BIB66","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1021\/ja00315a051","volume":"106","author":"Weiner","year":"1984","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2004.03.024_BIB67","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1006\/jmbi.1994.1334","volume":"238","author":"McDonald","year":"1994","journal-title":"Mol. Biol."},{"key":"10.1016\/j.bmc.2004.03.024_BIB68","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/protein\/8.2.127","volume":"8","author":"Wallace","year":"1995","journal-title":"Prot. Eng."},{"key":"10.1016\/j.bmc.2004.03.024_BIB69","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1074\/jbc.272.2.701","volume":"272","author":"Dill","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB70","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1021\/jm00026a001","volume":"38","author":"Ajay Murko","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB71","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0169-7439(01)00155-1","volume":"58","author":"Wold","year":"2001","journal-title":"Chemom. Intell. Lab. Syst."},{"key":"10.1016\/j.bmc.2004.03.024_BIB72","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1021\/cr00020a001","volume":"93","author":"Leo","year":"1993","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmc.2004.03.024_BIB73","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1021\/jm00196a017","volume":"21","author":"Topliss","year":"1979","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB74","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1021\/ar9500675","volume":"29","author":"Kollman","year":"1996","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bmc.2004.03.024_BIB75","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1021\/ja9539002","volume":"118","author":"Head","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2004.03.024_BIB76","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/qsar.19880070105","volume":"7","author":"Cramer","year":"1988","journal-title":"Quant. Struct.-Act. Relat."},{"key":"10.1016\/j.bmc.2004.03.024_BIB77","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/jcc.540070419","volume":"7","author":"Ghose","year":"1986","journal-title":"J. Comp. Chem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB78","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2307\/2344237","volume":"A134","author":"Cormarck","year":"1971","journal-title":"J. Royal Stat. Soc."},{"key":"10.1016\/j.bmc.2004.03.024_BIB79","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1021\/jm00210a006","volume":"21","author":"Andrews","year":"1978","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2004.03.024_BIB80","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1021\/jm00268a008","volume":"16","author":"Coats","year":"1973","journal-title":"J. Med. Chem."}],"updated-by":[{"DOI":"10.1016\/j.bmc.2004.05.001","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000}}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089604002093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089604002093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T22:44:48Z","timestamp":1760827488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089604002093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":80,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S0968089604002093"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2004.03.024","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"S1 subsite in snake venom thrombin-like enzymes: can S1 subsite lipophilicity be used to sort binding affinities of trypsin-like enzymes to small-molecule inhibitors?","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2004.03.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}