{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:02:02Z","timestamp":1781776922487,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1016\/j.bmc.2004.06.034","type":"journal-article","created":{"date-parts":[[2004,7,21]],"date-time":"2004-07-21T14:22:43Z","timestamp":1090419763000},"page":"4625-4631","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Analogues of tetramethylrosamine as transport molecules for and inhibitors of P-glycoprotein-mediated multidrug resistance"],"prefix":"10.1016","volume":"12","author":[{"given":"Scott L.","family":"Gibson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Hilf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Detty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2004.06.034_bib1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrc706","volume":"2","author":"Gottesman","year":"2002","journal-title":"Nature Rev.\/Cancer"},{"issue":"Suppl. 3","key":"10.1016\/j.bmc.2004.06.034_bib2","first-page":"523","volume":"89","author":"Vasey","year":"2003","journal-title":"Brit. J. Cancer"},{"key":"10.1016\/j.bmc.2004.06.034_bib3","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/0959-8049(96)00069-X","volume":"32A","author":"Lehnert","year":"1996","journal-title":"Euro. J. Cancer"},{"key":"10.1016\/j.bmc.2004.06.034_bib4","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1056\/NEJM199511233332103","volume":"333","author":"Baldini","year":"1995","journal-title":"New Eng. J. Med."},{"key":"10.1016\/j.bmc.2004.06.034_bib5","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/bjc.1998.192","volume":"77","author":"Lehnert","year":"1998","journal-title":"Brit. J. Cancer"},{"key":"10.1016\/j.bmc.2004.06.034_bib6","first-page":"827","volume":"9","author":"Burger","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bmc.2004.06.034_bib7","doi-asserted-by":"crossref","first-page":"7496","DOI":"10.1038\/sj.onc.1206950","volume":"22","author":"Scotto","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.bmc.2004.06.034_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0014-4827(03)00342-2","volume":"290","author":"Baker","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bmc.2004.06.034_bib9","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/00001813-199607000-00012","volume":"7","author":"Tiberghien","year":"1996","journal-title":"Anti-Cancer Drugs"},{"key":"10.1016\/j.bmc.2004.06.034_bib10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0300-483X(01)00457-7","volume":"167","author":"Hirsch-Ernst","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.bmc.2004.06.034_bib11","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1021\/jm0109863","volume":"45","author":"Loor","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2004.06.034_bib12","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/0959-8049(96)00111-6","volume":"32A","author":"Fisher","year":"1996","journal-title":"Euro. J. Cancer"},{"key":"10.1016\/j.bmc.2004.06.034_bib13","doi-asserted-by":"crossref","first-page":"7512","DOI":"10.1038\/sj.onc.1206951","volume":"22","author":"Fojo","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.bmc.2004.06.034_bib14","first-page":"145","volume":"1","author":"Kessel","year":"1989","journal-title":"Cancer Commun."},{"key":"10.1016\/j.bmc.2004.06.034_bib15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1432-1033.1997.00104.x","volume":"248","author":"Eytan","year":"1997","journal-title":"Euro. J. Biochem."},{"key":"10.1016\/j.bmc.2004.06.034_bib16","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1046\/j.1432-1033.2003.03403.x","volume":"270","author":"Loetchutinat","year":"2003","journal-title":"Euro. J. Biochem."},{"key":"10.1016\/j.bmc.2004.06.034_bib17","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1182\/blood.V93.1.306","volume":"93","author":"Robey","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.bmc.2004.06.034_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1046\/j.1432-1327.1998.2540189.x","volume":"254","author":"Shapiro","year":"1998","journal-title":"Euro. J. Biochem."},{"key":"10.1016\/j.bmc.2004.06.034_bib19","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.bmc.2004.03.029","volume":"12","author":"Detty","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2004.06.034_bib20","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1016\/S0021-9258(18)53597-3","volume":"268","author":"Al-Shawi","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2004.06.034_bib21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/jcp.1040830114","volume":"83","author":"Ling","year":"1974","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.bmc.2004.06.034_bib22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0092-8674(74)90091-9","volume":"2","author":"McBurney","year":"1974","journal-title":"Cell"},{"key":"10.1016\/j.bmc.2004.06.034_bib23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1042\/bj20020957","volume":"376","author":"Borges-Walmsley","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmc.2004.06.034_bib24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.bi.58.070189.001033","volume":"58","author":"Endicott","year":"1989","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bmc.2004.06.034_bib25","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0889-8588(18)30099-6","volume":"9","author":"Fisher","year":"1995","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"10.1016\/j.bmc.2004.06.034_bib26","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/0959-8049(96)00111-6","volume":"32A","author":"Fisher","year":"1996","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bmc.2004.06.034_bib27","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1200\/JCO.1998.16.11.3674","volume":"18","author":"Bradshaw","year":"1998","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bmc.2004.06.034_bib28","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/00001813-199909000-00005","volume":"10","author":"Sparreboom","year":"1999","journal-title":"Anti-Cancer Drugs"},{"key":"10.1016\/j.bmc.2004.06.034_bib29","first-page":"2964","volume":"60","author":"Newman","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmc.2004.06.034_bib30","first-page":"4186","volume":"6","author":"Stewart","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bmc.2004.06.034_bib31","first-page":"505","volume":"23","author":"Vrouenraets","year":"2003","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bmc.2004.06.034_bib32","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1023\/A:1007612905378","volume":"17","author":"De Rosa","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.bmc.2004.06.034_bib33","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00055735-200306000-00010","volume":"14","author":"Landy","year":"2003","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.bmc.2004.06.034_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/104454702753474931","volume":"20","author":"Dougherty","year":"2002","journal-title":"J. Clin. Laser Med. Surg."},{"key":"10.1016\/j.bmc.2004.06.034_bib35","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/jnci\/80.10.739","volume":"80","author":"Nahabedian","year":"1988","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bmc.2004.06.034_bib36","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/lsm.1900080413","volume":"8","author":"Edell","year":"1988","journal-title":"Lasers Surg. Med."},{"key":"10.1016\/j.bmc.2004.06.034_bib37","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/bjs.1800790209","volume":"79","author":"Purkiss","year":"1992","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.bmc.2004.06.034_bib38","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1751-1097.1992.tb04253.x","volume":"55","author":"Kessel","year":"1992","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.bmc.2004.06.034_bib39","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0304-3835(95)03818-H","volume":"93","author":"Canti","year":"1995","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bmc.2004.06.034_bib40","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1751-1097.1995.tb08628.x","volume":"61","author":"Gibson","year":"1995","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.bmc.2004.06.034_bib41","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1021\/jm030136i","volume":"46","author":"You","year":"2003","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089604004791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089604004791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T22:46:36Z","timestamp":1760827596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089604004791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":41,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0968089604004791"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2004.06.034","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analogues of tetramethylrosamine as transport molecules for and inhibitors of P-glycoprotein-mediated multidrug resistance","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2004.06.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}