{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T03:09:17Z","timestamp":1771988957607,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.bmc.2004.08.039","type":"journal-article","created":{"date-parts":[[2004,9,24]],"date-time":"2004-09-24T18:56:37Z","timestamp":1096052197000},"page":"5807-5817","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Novel imidazole substituted 6-methylidene-penems as broad-spectrum \u03b2-lactamase inhibitors"],"prefix":"10.1016","volume":"12","author":[{"given":"Aranapakam M.","family":"Venkatesan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ushirogochi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itsuki","family":"Yamamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Kumagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Lenoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Shlaes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek S.","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2004.08.039_bib1_1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.2174\/0929867023370031","volume":"9","author":"Sandanayaka","year":"2002","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2004.08.039_bib1_2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2174\/1568012023354901","volume":"9","author":"Micetich","year":"2002","journal-title":"Curr. Med. Chem. Anti-Infect. Agents"},{"key":"10.1016\/j.bmc.2004.08.039_bib1_3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1517\/13543784.9.2.247","volume":"9","author":"Payne","year":"2000","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.bmc.2004.08.039_bib1d","doi-asserted-by":"crossref","first-page":"839","DOI":"10.2174\/1381612805666230112183102","volume":"5","author":"Bush","year":"1999","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2004.08.039_bib2","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1128\/AAC.39.6.1211","volume":"39","author":"Bush","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2004.08.039_bib3a","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1042\/bj1990779","volume":"199","author":"Reading","year":"1981","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmc.2004.08.039_bib3b","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1128\/AAC.14.3.414","volume":"14","author":"English","year":"1978","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2004.08.039_bib3c","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1021\/jm00391a032","volume":"30","author":"Micetich","year":"1987","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2004.08.039_bib3_4","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1021\/jm034056q","volume":"46","author":"Sandanayaka","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2004.08.039_bib4","doi-asserted-by":"crossref","first-page":"26674","DOI":"10.1016\/S0021-9258(19)61429-8","volume":"275","author":"Yang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2004.08.039_bib5","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1021\/ja00122a009","volume":"117","author":"Bulychev","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2004.08.039_bib6_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S1074-5521(01)00034-5","volume":"8","author":"Tondi","year":"2001","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bmc.2004.08.039_bib6_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1042\/bj2090229","volume":"209","author":"Beesley","year":"1983","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmc.2004.08.039_bib7_1","doi-asserted-by":"crossref","first-page":"10436","DOI":"10.1021\/ja011094v","volume":"123","author":"Kaur","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2004.08.039_bib7_2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.7164\/antibiotics.43.114","volume":"43","author":"Nishimura","year":"1990","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bmc.2004.08.039_bib8","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1021\/jm049903j","volume":"47","author":"Tabei","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2004.08.039_bib9_1","doi-asserted-by":"crossref","first-page":"13152","DOI":"10.1021\/bi034986b","volume":"42","author":"Nukaga","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2004.08.039_bib9_2","unstructured":"Venkatesan, A. M.; Gu, Y.; Dos Santos, O.; Abe, T.; Agarwal, A.; Yang, Y.; Petersen, P. J.; Weiss, W. J.; Mansour, T. S.; Nukaga, M.; Hujer, A. M.; Bonomo, R. A.; Knox, J. R., J. Med. Chem., in press"},{"key":"10.1016\/j.bmc.2004.08.039_bib10","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1039\/C39920001663","author":"Broom","year":"1992","journal-title":"J. Chem. Soc., Chem. Commun."},{"key":"10.1016\/j.bmc.2004.08.039_bib11","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1128\/AAC.39.1.227","volume":"30","author":"Matagne","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2004.08.039_bib12_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.7164\/antibiotics.44.331","volume":"44","author":"Bennett","year":"1991","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bmc.2004.08.039_bib12_2","doi-asserted-by":"crossref","first-page":"969","DOI":"10.7164\/antibiotics.44.969","volume":"44","author":"Bennett","year":"1991","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bmc.2004.08.039_bib13_1","first-page":"929","volume":"11","author":"Massova","year":"1999","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2004.08.039_bib13_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-1-4615-4897-3_5","volume":"456","author":"Bush","year":"1998","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bmc.2004.08.039_bib13c","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/prot.340160406","volume":"16","author":"Jelsch","year":"1993","journal-title":"Proteins Struct. Funct."},{"key":"10.1016\/j.bmc.2004.08.039_bib13d","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1074-5521(00)00052-1","volume":"8","author":"Caselli","year":"2001","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bmc.2004.08.039_bib14","doi-asserted-by":"crossref","first-page":"350","DOI":"10.7164\/antibiotics.50.350","volume":"50","author":"Philips","year":"1997","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bmc.2004.08.039_bib15_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1039\/P19940000179","author":"Osborne","year":"1994","journal-title":"J. Chem. Soc., Perkin. Trans. 1"},{"key":"10.1016\/j.bmc.2004.08.039_bib15_2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1039\/C39890000371","author":"Osborne","year":"1989","journal-title":"J. Chem. Soc., Chem. Commun."},{"key":"10.1016\/j.bmc.2004.08.039_bib15_3","unstructured":"Abe, T.; Matsunaga, H.; Mihira, A.; Sato, C.; Ushirogochi, H.; Takasaki, T.; Venkatesan, A. M.; Mansour., T. S., WO-2003093277, 2003"},{"key":"10.1016\/j.bmc.2004.08.039_bib16_1","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1021\/jo01294a042","volume":"45","author":"Bouffard","year":"1980","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2004.08.039_bib16_2","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1021\/ja00526a045","volume":"102","author":"Pfaendlet","year":"1980","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2004.08.039_bib16_3","doi-asserted-by":"crossref","first-page":"6285","DOI":"10.1016\/S0040-4039(01)84578-0","volume":"26","author":"Bouffard","year":"1985","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2004.08.039_bib16_4","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1021\/jo00324a002","volume":"46","author":"Aileen","year":"1981","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2004.08.039_bib16_5","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1021\/jo00438a003","volume":"42","author":"DiNinno","year":"1977","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2004.08.039_bib17_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1080\/00397918908050713","volume":"19","author":"Mansour","year":"1989","journal-title":"Synth. Commun."},{"key":"10.1016\/j.bmc.2004.08.039_bib17_2","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.3987\/COM-93-6398","volume":"36","author":"Kumagai","year":"1993","journal-title":"Heterocycles"},{"key":"10.1016\/j.bmc.2004.08.039_bib18_1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1021\/ja01534a046","volume":"80","author":"House","year":"1958","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2004.08.039_bib18_2","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1021\/ja01516a022","volume":"81","author":"Cristol","year":"1959","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2004.08.039_bib19","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1021\/jm00149a029","volume":"28","author":"Paul","year":"1985","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2004.08.039_bib20_1","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1128\/AAC.43.12.2904","volume":"43","author":"Yang","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2004.08.039_bib20_2","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1128\/AAC.37.4.851","volume":"37","author":"Bush","year":"1993","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2004.08.039_bib20_3","first-page":"565","volume":"12","author":"Bush","year":"1986","journal-title":"Drugs Expt. Clin. Res."},{"key":"10.1016\/j.bmc.2004.08.039_bib21","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1128\/AAC.47.3.1062-1067.2003","volume":"47","author":"Majiduddin","year":"2003","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089604006637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089604006637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T22:48:17Z","timestamp":1760827697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089604006637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":44,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0968089604006637"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2004.08.039","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel imidazole substituted 6-methylidene-penems as broad-spectrum \u03b2-lactamase inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2004.08.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}