{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:35:00Z","timestamp":1760852100530,"version":"build-2065373602"},"reference-count":66,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.bmc.2004.12.028","type":"journal-article","created":{"date-parts":[[2005,1,15]],"date-time":"2005-01-15T07:30:36Z","timestamp":1105774236000},"page":"1523-1530","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["3D QSAR Markov model for drug-induced eosinophilia\u2014theoretical prediction and preliminary experimental assay of the antimicrobial drug G1"],"prefix":"10.1016","volume":"13","author":[{"given":"Humberto","family":"Gonz\u00e1lez-D\u00edaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esvieta","family":"Tenorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilo","family":"Casta\u00f1edo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Santana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Uriarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2004.12.028_bib1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0167-7799(94)90035-3","volume":"12","author":"Maneyo","year":"1994","journal-title":"TIBTECH"},{"year":"1996","series-title":"Goodman and Gilman\u2019s The Pharmacological Basis of Therapeutics","key":"10.1016\/j.bmc.2004.12.028_bib2"},{"issue":"2","key":"10.1016\/j.bmc.2004.12.028_bib3","first-page":"86","volume":"43","author":"Purchase","year":"1998","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bmc.2004.12.028_bib4","first-page":"271","volume":"5","author":"Purchase","year":"1995","journal-title":"Comment. Toxicol."},{"key":"10.1016\/j.bmc.2004.12.028_bib5","first-page":"207","volume":"6","author":"Fentem","year":"1992","journal-title":"Chem. Ind."},{"key":"10.1016\/j.bmc.2004.12.028_bib6","first-page":"459","volume":"106","author":"Barratt","year":"1998","journal-title":"Environ. Health Persp. Suppl."},{"key":"10.1016\/j.bmc.2004.12.028_bib7","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1021\/tx015502k","volume":"14","author":"Cronin","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bmc.2004.12.028_bib8","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1021\/tx0340504","volume":"16","author":"Schueuermann","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bmc.2004.12.028_bib9","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1021\/tx9900627","volume":"13","author":"Burden","year":"2000","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bmc.2004.12.028_bib10","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1021\/ci010011r","volume":"41","author":"Katritzky","year":"2001","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.bmc.2004.12.028_bib11","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1021\/tx0155045","volume":"14","author":"Todd","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bmc.2004.12.028_bib12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1021\/ci010329j","volume":"42","author":"Espinosa","year":"2002","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.bmc.2004.12.028_bib13","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1021\/ci000450a","volume":"40","author":"Burden","year":"2000","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.bmc.2004.12.028_bib14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s002440010107","volume":"39","author":"Niculescu","year":"2000","journal-title":"Arch. Environm. Contam. Toxicol."},{"key":"10.1016\/j.bmc.2004.12.028_bib15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0887-2333(87)90015-4","volume":"3","author":"Turner","year":"1987","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.bmc.2004.12.028_bib16","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1021\/tx010101q","volume":"14","author":"Serra","year":"2001","journal-title":"Chem. Res. Toxicol."},{"year":"1990","series-title":"Quantitative Drug Design: Comprehensive Medicinal Chemistry","author":"Kubinyi","key":"10.1016\/j.bmc.2004.12.028_bib17"},{"key":"10.1016\/j.bmc.2004.12.028_bib18","unstructured":"Stochastic Processes in Physics, Chemistry, and Biology (Lecture Notes in Physics, 557); Freund, J. A.; Poschel, T., Eds.; Springer: Berlin, 2000"},{"key":"10.1016\/j.bmc.2004.12.028_bib19","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1093\/bioinformatics\/btg285","volume":"19","author":"Gonz\u00e1lez-D\u00edaz","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bmc.2004.12.028_bib20","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1016\/j.polymer.2004.03.071","volume":"45","author":"Gonz\u00e1lez-D\u00edaz","year":"2004","journal-title":"Polymer"},{"key":"10.1016\/j.bmc.2004.12.028_bib21","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1016\/j.bmcl.2004.06.100","volume":"14","author":"Gonz\u00e1lez-D\u00edaz","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2004.12.028_bib22","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/prot.20159","volume":"56","author":"de Armas","year":"2004","journal-title":"Proteins: Struct. Func. Bioinf."},{"key":"10.1016\/j.bmc.2004.12.028_bib23","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.bulm.2003.12.003","volume":"66","author":"G\u00f3nzalez-D\u00edaz","year":"2004","journal-title":"Bull. Math. Biol."},{"key":"10.1016\/j.bmc.2004.12.028_bib24","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1016\/j.bmc.2004.07.017","volume":"12","author":"Ramos de Armas","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2004.12.028_bib25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00894-002-0088-7","volume":"8","author":"Gonz\u00e1lez-D\u00edaz","year":"2002","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.bmc.2004.12.028_bib26","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00894-003-0148-7","volume":"9","author":"Gonz\u00e1les-D\u00edaz","year":"2003","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.bmc.2004.12.028_bib27","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0097-8485(02)00053-0","volume":"27","author":"Gonz\u00e1lez D\u00edaz","year":"2003","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.bmc.2004.12.028_bib28","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0092-8240(03)00064-8","volume":"65","author":"Gonz\u00e1lez-D\u00edaz","year":"2003","journal-title":"Bull. Math. Biol."},{"key":"10.1016\/j.bmc.2004.12.028_bib29","first-page":"83","volume":"1","author":"D\u00edaz","year":"2002","journal-title":"Online J. Bioinf."},{"key":"10.1016\/j.bmc.2004.12.028_bib30","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1021\/tx0256432","volume":"16","author":"Gonz\u00e1lez-D\u00edaz","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bmc.2004.12.028_bib31","first-page":"1663","volume":"11","author":"Blondeau","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"year":"1939","series-title":"The Nature of Chemical Bond","author":"Pauling","key":"10.1016\/j.bmc.2004.12.028_bib32"},{"key":"10.1016\/j.bmc.2004.12.028_bib33","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/jps.2600690717","volume":"69","author":"Kier","year":"1980","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bmc.2004.12.028_bib34","unstructured":"Gonz\u00e1lez-D\u00edaz, H; Hern\u00e1ndez, I. MARCH-INSIDE \u00ae 2002 version 1.0 This is a preliminary experimental version\u2014a future professional version will be available to the public (contact the corresponding author at: humbertogd@vodafone.es or humbertogd@usc.es)"},{"key":"10.1016\/j.bmc.2004.12.028_bib35","series-title":"Chemometric methods in molecular design","first-page":"295","article-title":"Cluster Significance Analysis","volume":"Vol. 2","author":"Mc Farland","year":"1995"},{"key":"10.1016\/j.bmc.2004.12.028_bib36","series-title":"Handbook of Statistics","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0169-7161(82)02034-3","article-title":"Pattern Recognition in Chemistry","author":"Kowalski","year":"1982"},{"key":"10.1016\/j.bmc.2004.12.028_bib37","series-title":"Chemometric Methods in Molecular Design","first-page":"265","article-title":"Discriminant Analysis for Activity Prediction","volume":"Vol. 2","author":"Van Waterbeemd","year":"1995"},{"key":"10.1016\/j.bmc.2004.12.028_bib38","unstructured":"STATISTICA 6.0 Statsoft, Inc. 1999 version 6.0"},{"key":"10.1016\/j.bmc.2004.12.028_bib39","volume":"1","author":"Gonz\u00e1lez-D\u00edaz","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2004.12.028_bib40","series-title":"Applied Therapeutics: The Clinical Use of Drugs","first-page":"1","article-title":"Drug-Induced Blood Disorders","author":"Sasich","year":"2001"},{"year":"1997","series-title":"Intercon","author":"Garc\u00eda","key":"10.1016\/j.bmc.2004.12.028_bib41"},{"year":"2000","series-title":"Meyler\u2019s Side Effect of Drugs","author":"Dukes","key":"10.1016\/j.bmc.2004.12.028_bib42"},{"key":"10.1016\/j.bmc.2004.12.028_bib43","series-title":"Principles and Methods of Toxicology","article-title":"Acute Toxicity, and Eye Irritancy","author":"DiPascuale","year":"1994"},{"year":"2001","series-title":"Pharmaceutical Substances","author":"Kleeman","key":"10.1016\/j.bmc.2004.12.028_bib44"},{"year":"1987","series-title":"Organic Chemical Drugs and Their Synonyms","author":"Negwer","key":"10.1016\/j.bmc.2004.12.028_bib45"},{"year":"1999","series-title":"Clinical Chemistry of Laboratory Animals","author":"Loeb","key":"10.1016\/j.bmc.2004.12.028_bib46"},{"key":"10.1016\/j.bmc.2004.12.028_bib47","first-page":"257","volume":"33","author":"Benichou","year":"1991","journal-title":"Nouv. Rev. Fr. Hematol."},{"key":"10.1016\/j.bmc.2004.12.028_bib48","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3390\/i4080512","volume":"4","author":"Marrero Ponce","year":"2003","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bmc.2004.12.028_bib49","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S1093-3263(98)00013-8","volume":"16","author":"De Juli\u00e1n-Ortiz","year":"1998","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.bmc.2004.12.028_bib50","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1021\/ci034039+","volume":"43","author":"Perez Gonz\u00e1lez","year":"2003","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.bmc.2004.12.028_bib51","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1021\/ci0342019","volume":"44","author":"Molina","year":"2004","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.bmc.2004.12.028_bib52","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/10629369908039165","volume":"10","author":"Gozalbes","year":"1999","journal-title":"SAR QSAR Environ. Res."},{"key":"10.1016\/j.bmc.2004.12.028_bib53","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0166-1280(91)85053-A","volume":"79","author":"Randi\u010d","year":"1991","journal-title":"J. Mol. Struct. (TEOCHEM)"},{"key":"10.1016\/j.bmc.2004.12.028_bib54","first-page":"517","volume":"15","author":"Randi\u010d","year":"1991","journal-title":"New. J. Chem."},{"key":"10.1016\/j.bmc.2004.12.028_bib55","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1021\/ci00002a018","volume":"31","author":"Randi\u010d","year":"1991","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.bmc.2004.12.028_bib56","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/jcc.540140311","volume":"14","author":"Randi\u010d","year":"1993","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bmc.2004.12.028_bib57","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/0002-9343(80)90443-X","volume":"69","author":"Holmberg","year":"1980","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bmc.2004.12.028_bib58","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0939-6411(02)00013-9","volume":"53","author":"Cabrera","year":"2002","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bmc.2004.12.028_bib59","doi-asserted-by":"crossref","DOI":"10.1002\/9783527613106","article-title":"Handbook of Molecular Descriptors","author":"Todeschini","year":"2000"},{"key":"10.1016\/j.bmc.2004.12.028_bib60","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1021\/ci0102923","volume":"42","author":"Graham","year":"2002","journal-title":"J. Chem. Inf. Comput. Sci."},{"year":"1994","series-title":"Stereochemistry of Organic Compounds","author":"Eliel","key":"10.1016\/j.bmc.2004.12.028_bib61"},{"key":"10.1016\/j.bmc.2004.12.028_bib62","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1021\/ci000082a","volume":"41","author":"Golbraikh","year":"2001","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.bmc.2004.12.028_bib63","doi-asserted-by":"crossref","first-page":"63699","DOI":"10.1021\/jm0009134","volume":"43","author":"Benigni","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2004.12.028_bib64","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3390\/80900687","volume":"8","author":"Marrero Ponce","year":"2003","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2004.12.028_bib65","doi-asserted-by":"crossref","first-page":"6351","DOI":"10.1016\/j.bmc.2004.09.034","volume":"12","author":"Marrero-Ponce","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2004.12.028_bib66","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1016\/j.bmc.2004.07.051","volume":"12","author":"Marrero-Ponce","year":"2004","journal-title":"Bioorg. Med. Chem."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089604010120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089604010120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T22:49:37Z","timestamp":1760827777000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089604010120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0968089604010120"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2004.12.028","relation":{},"ISSN":["0968-0896"],"issn-type":[{"type":"print","value":"0968-0896"}],"subject":[],"published":{"date-parts":[[2005,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"3D QSAR Markov model for drug-induced eosinophilia\u2014theoretical prediction and preliminary experimental assay of the antimicrobial drug G1","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2004.12.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}