{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:46:27Z","timestamp":1790945187025,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.bmc.2005.01.025","type":"journal-article","created":{"date-parts":[[2005,2,15]],"date-time":"2005-02-15T12:08:56Z","timestamp":1108469336000},"page":"2637-2649","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase"],"prefix":"10.1016","volume":"13","author":[{"given":"Soghra","family":"Khabnadideh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Musso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Brun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M. Ruiz","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Gonz\u00e1lez-Pacanowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2005.01.025_bib1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0925-4439(02)00088-1","volume":"1587","author":"Gilbert","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmc.2005.01.025_bib2","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1021\/jm981130+","volume":"42","author":"Chowdhury","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2005.01.025_bib3","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/S0960-894X(99)00213-9","volume":"9","author":"Zuccotto","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2005.01.025_bib4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1023\/A:1016085005275","volume":"12","author":"Zuccotto","year":"1998","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"10.1016\/j.bmc.2005.01.025_bib5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0223-5234(01)01235-1","volume":"36","author":"Zuccotto","year":"2001","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2005.01.025_bib6","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0960-894X(01)00089-0","volume":"11","author":"Chowdhury","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2005.01.025_bib7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/1475636021000059083","volume":"17","author":"Chowdhury","year":"2002","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2005.01.025_bib8","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1016\/j.bmc.2003.08.012","volume":"11","author":"Pez","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2005.01.025_bib9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0166-6851(88)90147-8","volume":"31","author":"Sirawaraporn","year":"1988","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.bmc.2005.01.025_bib10","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1021\/jm00145a002","volume":"28","author":"Goodford","year":"1985","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2005.01.025_bib11","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1128\/AAC.33.11.1860","volume":"33","author":"Berman","year":"1989","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2005.01.025_bib12","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1021\/jm00278a007","volume":"15","author":"Davoll","year":"1972","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2005.01.025_bib13","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1021\/jm00281a012","volume":"15","author":"Elslager","year":"1972","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2005.01.025_bib14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0014-4894(69)90050-2","volume":"25","author":"Thompson","year":"1969","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.bmc.2005.01.025_bib15","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1016\/j.bmc.2003.08.012","volume":"11","author":"Pez","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2005.01.025_bib16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0169-409X(02)00003-0","volume":"54","author":"Walters","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bmc.2005.01.025_bib17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","volume":"23","author":"Lipinski","year":"1997","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bmc.2005.01.025_bib18","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1055\/s-1990-21170","author":"Harris","year":"1990","journal-title":"Synlett"},{"key":"10.1016\/j.bmc.2005.01.025_bib19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0223-5234(92)90054-5","volume":"27","author":"Harris","year":"1992","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2005.01.025_bib20","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1016\/S0040-4039(00)91094-3","volume":"16","author":"Sonogashira","year":"1975","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2005.01.025_bib21","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1021\/jm010856u","volume":"44","author":"Graffner-Nordberg","year":"2001","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2005.01.025_bib22","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1021\/jo00115a023","volume":"60","author":"Cativiela","year":"1995","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2005.01.025_bib23","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0021-9258(18)70678-9","volume":"28","author":"Futterman","year":"1957","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2005.01.025_bib24","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/j.1460-2075.1985.tb03772.x","volume":"4","author":"Baltz","year":"1985","journal-title":"EMBO J."},{"key":"10.1016\/j.bmc.2005.01.025_bib25","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0001-706X(97)00079-X","volume":"68","author":"Raz","year":"1997","journal-title":"Acta Trop."},{"key":"10.1016\/j.bmc.2005.01.025_bib26","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1550-7408.1977.tb00987.x","volume":"24","author":"Cunningham","year":"1977","journal-title":"J. Protozool."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089605000519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089605000519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T22:49:43Z","timestamp":1760827783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089605000519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0968089605000519"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2005.01.025","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2005.01.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}