{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T02:02:10Z","timestamp":1774663330100,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.bmc.2005.07.024","type":"journal-article","created":{"date-parts":[[2005,8,16]],"date-time":"2005-08-16T07:12:58Z","timestamp":1124176378000},"page":"6718-6726","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Dicationic near-linear biphenyl benzimidazole derivatives as DNA-targeted antiprotozoal agents"],"prefix":"10.1016","volume":"13","author":[{"given":"Mohamed A.","family":"Ismail","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adalgisa","family":"Batista-Parra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. David","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Wenzler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reto","family":"Brun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Boykin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2005.07.024_bib1_1","first-page":"414","article-title":"Dicationic DNA Minor Groove Binders as Antimicrobial Agents","volume":"Vol. 2","author":"Tidwell","year":"2003"},{"key":"10.1016\/j.bmc.2005.07.024_bib1b","first-page":"389","article-title":"Dications that target the DNA minor groove: Compound design and preparation, DNA interactions, cellular distribution and biological activity","volume":"5","author":"Wilson","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2005.07.024_bib2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1039\/jr9420000103","author":"Ashley","year":"1942","journal-title":"J. Chem. Soc."},{"key":"10.1016\/j.bmc.2005.07.024_bib3","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.pt.2003.09.002","volume":"19","author":"Fairlamb","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.bmc.2005.07.024_bib4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1046\/j.1472-8206.2003.00167.x","volume":"17","author":"Bouteille","year":"2003","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.bmc.2005.07.024_bib5","unstructured":"Yeramian, P. D.; Castagnini, L. A.; Allen, J. A.; Umesh, L.; Gotuzzo, E. Efficacy and Safety of DB289, A new oral drug for treatment of Pneumocystis carinii pneumonia (PCP) in AIDS patients. Presented at the 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy Meeting, September 14\u201317, 2003, Chicago, IL."},{"key":"10.1016\/j.bmc.2005.07.024_bib6","unstructured":"Yeramian, P.; Krudsood, S.; Chalermrut, K.; Silachamroon, U.; Allen, J.; Brun, R.; Meshnick, S.; Tidwell, R.; Looareesuwan, S. Efficacy of DB289 in acute uncomplicated P. falciparum\/P. vivax malaria. Presented at the 52nd Annual Meeting of the American Society of Tropical Medicine and Hygiene, December 3\u20137, 2003, Philadelphia, PA."},{"key":"10.1016\/j.bmc.2005.07.024_bib7","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1128\/AAC.38.9.1890","volume":"38","author":"Dykstra","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2005.07.024_bib8","first-page":"47","volume":"14","author":"Bailly","year":"1999","journal-title":"Anti-Cancer Drug Des."},{"key":"10.1016\/j.bmc.2005.07.024_bib9","doi-asserted-by":"crossref","first-page":"27128","DOI":"10.1074\/jbc.274.38.27128","volume":"274","author":"Fitzgerald","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2005.07.024_bib10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nm0695-525","volume":"1","author":"Henderson","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.bmc.2005.07.024_bib11","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1128\/EC.2.5.1003-1008.2003","volume":"2","author":"Matovu","year":"2003","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.bmc.2005.07.024_bib12_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1021\/jm00155a023","volume":"29","author":"Goodsell","year":"1986","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2005.07.024_bib12_2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1021\/jm00081a003","volume":"35","author":"Cory","year":"1992","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2005.07.024_bib13","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1021\/ja00121a034","volume":"117","author":"Czarny","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2005.07.024_bib14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/jmbi.2000.3869","volume":"300","author":"Mazur","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmc.2005.07.024_bib15","doi-asserted-by":"crossref","first-page":"10310","DOI":"10.1021\/ja981212n","volume":"120","author":"Wilson","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2005.07.024_bib16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.abb.2004.05.019","volume":"429","author":"Shaikh","year":"2004","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bmc.2005.07.024_bib17","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1021\/jm970570i","volume":"41","author":"Boykin","year":"1998","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2005.07.024_bib18","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1021\/jm00006a009","volume":"38","author":"Boykin","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2005.07.024_bib19","doi-asserted-by":"crossref","first-page":"5405","DOI":"10.1016\/j.bmc.2004.07.056","volume":"12","author":"Ismail","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2005.07.024_bib20","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1128\/AAC.40.6.1442","volume":"40","author":"Brun","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2005.07.024_bib21","doi-asserted-by":"crossref","first-page":"13680","DOI":"10.1021\/ja027953c","volume":"124","author":"Nguyen","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2005.07.024_bib22","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0006-3495(04)74178-8","volume":"86","author":"Nguyen","year":"2004","journal-title":"Biophys. J."},{"key":"10.1016\/j.bmc.2005.07.024_bib23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0223-5234(96)88214-6","volume":"30","author":"Kumar","year":"1995","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2005.07.024_bib24","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1021\/jm0302602","volume":"46","author":"Ismail","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2005.07.024_bib25","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0001-706X(97)00079-X","volume":"68","author":"Raz","year":"1997","journal-title":"Acta Trop."},{"key":"10.1016\/j.bmc.2005.07.024_bib26","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1081\/SCC-120028347","volume":"34","author":"Ismail","year":"2004","journal-title":"Synth. Commun."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089605006863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089605006863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T22:56:35Z","timestamp":1760828195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089605006863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":28,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S0968089605006863"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2005.07.024","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dicationic near-linear biphenyl benzimidazole derivatives as DNA-targeted antiprotozoal agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2005.07.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}