{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:36:32Z","timestamp":1790901392638,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.bmc.2006.07.024","type":"journal-article","created":{"date-parts":[[2006,8,3]],"date-time":"2006-08-03T08:29:27Z","timestamp":1154593767000},"page":"7434-7445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Dicationic DNA-targeted antiprotozoal agents: Naphthalene replacement of benzimidazole"],"prefix":"10.1016","volume":"14","author":[{"given":"Sarah","family":"Chackal-Catoen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. David","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Wenzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Brun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Boykin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2006.07.024_bib1_1","first-page":"416","article-title":"Dicationic DNA Minor Groove Binders as Antimicrobial Agents","volume":"Vol. 2","author":"Tidwell","year":"2003"},{"key":"10.1016\/j.bmc.2006.07.024_bib1b","first-page":"389","volume":"5","author":"Wilson","year":"2005","journal-title":"Curr. Med. Chem.: Anti-Cancer Agents"},{"key":"10.1016\/j.bmc.2006.07.024_bib1_3","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1517\/13543784.14.8.957","volume":"14","author":"Soeiro","year":"2005","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.bmc.2006.07.024_bib2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1039\/jr9420000103","author":"Ashley","year":"1942","journal-title":"J. Chem. Soc."},{"key":"10.1016\/j.bmc.2006.07.024_bib3","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.pt.2003.09.002","volume":"19","author":"Fairlamb","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.bmc.2006.07.024_bib4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1046\/j.1472-8206.2003.00167.x","volume":"17","author":"Bouteille","year":"2003","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.bmc.2006.07.024_bib5","unstructured":"Yeramian, P. D.; Castagnini, L. A.; Allen, J. A.; Umesh, L.; Gotuzzo, E. Efficacy and Safety of DB289, a New Oral Drug for Treatment of Pneumocystis carinii pneumonia (PCP) in AIDS Patients. In 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy Meeting, September 14\u201317, 2003, Chicago, IL."},{"key":"10.1016\/j.bmc.2006.07.024_bib6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1086\/430928","volume":"192","author":"Yeramian","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bmc.2006.07.024_bib7","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1128\/AAC.38.9.1890","volume":"38","author":"Dykstra","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2006.07.024_bib8","first-page":"47","volume":"14","author":"Bailly","year":"1999","journal-title":"Anti-Cancer Drug Des."},{"key":"10.1016\/j.bmc.2006.07.024_bib9","doi-asserted-by":"crossref","first-page":"27128","DOI":"10.1074\/jbc.274.38.27128","volume":"274","author":"Fitzgerald","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2006.07.024_bib10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nm0695-525","volume":"1","author":"Henderson","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.bmc.2006.07.024_bib11","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1128\/EC.2.5.1003-1008.2003","volume":"2","author":"Matovu","year":"2003","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.bmc.2006.07.024_bib12_1","doi-asserted-by":"crossref","first-page":"5405","DOI":"10.1016\/j.bmc.2004.07.056","volume":"12","author":"Ismail","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2006.07.024_bib12_2","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.1016\/j.bmc.2005.07.024","volume":"13","author":"Ismail","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2006.07.024_bib13_1","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1021\/jm030604o","volume":"47","author":"Ansede","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2006.07.024_bib13b","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1021\/jm0302602","volume":"46","author":"Ismail","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2006.07.024_bib14","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1128\/AAC.42.3.666","volume":"42","author":"Hall","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2006.07.024_bib15","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1021\/ja004279v","volume":"123","author":"Sommer","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2006.07.024_bib16","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1246\/bcsj.52.3033","volume":"52","author":"Tsuno","year":"1979","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"10.1016\/j.bmc.2006.07.024_bib17_1","first-page":"116","volume":"3\u20134","author":"Verbel","year":"1982","journal-title":"Bull. Chem. Soc. Fr."},{"key":"10.1016\/j.bmc.2006.07.024_bib17_2","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1021\/ja00267a036","volume":"108","author":"Miyashi","year":"1986","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2006.07.024_bib17_3","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/0040-4039(93)89034-N","volume":"34","author":"Murphy","year":"1993","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2006.07.024_bib17_4","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1021\/jm9906264","volume":"43","author":"Shiraishi","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2006.07.024_bib18","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1016\/S0040-4020(01)00421-5","volume":"57","author":"Hattori","year":"2001","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2006.07.024_bib19","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/hlca.19970800322","volume":"80","author":"Kehr","year":"1997","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.bmc.2006.07.024_bib20","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1016\/S0040-4039(98)00414-6","volume":"39","author":"Kubota","year":"1998","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2006.07.024_bib21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0022-328X(87)80017-7","volume":"331","author":"Boer\u00e9","year":"1987","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.bmc.2006.07.024_bib22","doi-asserted-by":"crossref","first-page":"8014","DOI":"10.1021\/jo990035l","volume":"64","author":"Chakraborti","year":"1999","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2006.07.024_bib23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0001-706X(97)00079-X","volume":"68","author":"Raz","year":"1997","journal-title":"Acta Trop."},{"key":"10.1016\/j.bmc.2006.07.024_bib24","doi-asserted-by":"crossref","first-page":"14701","DOI":"10.1021\/bi051791q","volume":"44","author":"Miao","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2006.07.024_bib25","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1021\/jm060295c","volume":"49","author":"Dardonville","year":"2006","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089606005773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089606005773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:02:20Z","timestamp":1760828540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089606005773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":32,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0968089606005773"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2006.07.024","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dicationic DNA-targeted antiprotozoal agents: Naphthalene replacement of benzimidazole","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2006.07.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}