{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:56:38Z","timestamp":1782698198254,"version":"3.54.5"},"reference-count":28,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.bmc.2006.09.018","type":"journal-article","created":{"date-parts":[[2006,9,29]],"date-time":"2006-09-29T10:09:46Z","timestamp":1159524586000},"page":"8249-8258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Synthesis of some substituted pyrazinopyridoindoles and 3D QSAR studies along with related compounds: Piperazines, piperidines, pyrazinoisoquinolines, and diphenhydramine, and its semi-rigid analogs as antihistamines (H1)"],"prefix":"10.1016","volume":"14","author":[{"given":"Mridula","family":"Saxena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuti","family":"Gaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Prathipati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2006.09.018_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1113\/jphysiol.1910.sp001392","volume":"41","author":"Barger","year":"1910","journal-title":"J. Physiol."},{"key":"10.1016\/j.bmc.2006.09.018_bib2","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1124\/jpet.102.046581","volume":"305","author":"Hofstra","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2006.09.018_bib3","first-page":"495","volume":"vol. 5","author":"Zhang","year":"1997"},{"key":"10.1016\/j.bmc.2006.09.018_bib4","first-page":"1224","volume":"22B","author":"Saxena","year":"1983","journal-title":"Indian J. Chem."},{"key":"10.1016\/j.bmc.2006.09.018_bib5","first-page":"144","volume":"30","author":"Patnaik","year":"1992","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.bmc.2006.09.018_bib6","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1021\/jm00173a011","volume":"33","author":"Saxena","year":"1990","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2006.09.018_bib7_1","first-page":"201","volume":"3","author":"Saxena","year":"1993","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bmc.2006.09.018_bib7_2","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/s00044-004-0114-7","volume":"13","author":"Gaur","year":"2004","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bmc.2006.09.018_bib8","first-page":"1261","volume":"B","author":"Ram","year":"1984","journal-title":"Indian J. Chem."},{"key":"10.1016\/j.bmc.2006.09.018_bib9","unstructured":"Patnaik, G. K.; Saxena, A. K.; Dhawan, B. N. In Aspects of Allergy and Applied Immunol; Agarwal, M. K., Ed., 1984; Vol. 17, 75."},{"key":"10.1016\/j.bmc.2006.09.018_bib10","unstructured":"Hypotheses in Catalyst, Biosym-MSI, San Diego, CA, 1992."},{"key":"10.1016\/j.bmc.2006.09.018_bib11","unstructured":"Apex-3D, BIOSYM Technologies, Inc. San Diego, CA, USA."},{"key":"10.1016\/j.bmc.2006.09.018_bib12","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1016\/S0968-0896(02)00313-9","volume":"10","author":"Arokia Babu","year":"2002","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2006.09.018_bib13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0968-0896(00)00243-1","volume":"2","author":"Pandya","year":"2001","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2006.09.018_bib14","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/10629360108039834","volume":"6","author":"Pandey","year":"2001","journal-title":"SAR QSAR Environ. Res."},{"key":"10.1016\/j.bmc.2006.09.018_bib15","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1016\/S0960-894X(03)00491-8","volume":"15","author":"Kashaw","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2006.09.018_bib16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bmc.2003.10.032","volume":"1","author":"Rathi","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2006.09.018_bib17","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1021\/jm00263a036","volume":"16","author":"Saxena","year":"1973","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2006.09.018_bib18","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1021\/jm00317a013","volume":"10","author":"Jain","year":"1967","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2006.09.018_bib19","first-page":"172","volume":"34","author":"Srimal","year":"1972","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.bmc.2006.09.018_bib20","first-page":"1087","volume":"28","author":"Singh","year":"1978","journal-title":"Arzneim.-Forsch"},{"key":"10.1016\/j.bmc.2006.09.018_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcc.540040211","volume":"4","author":"Brooks","year":"1983","journal-title":"J. Comp. Chem."},{"key":"10.1016\/j.bmc.2006.09.018_bib22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jcc.540160205","volume":"16","author":"Smellie","year":"1995","journal-title":"J. Comp. Chem."},{"key":"10.1016\/j.bmc.2006.09.018_bib23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00128336","volume":"4","author":"Stewart","year":"1990","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"10.1016\/j.bmc.2006.09.018_bib24","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1021\/jm00017a019","volume":"38","author":"Terlaak","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2006.09.018_bib25","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/BF00125173","volume":"9","author":"Terlaak","year":"1995","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"10.1016\/j.bmc.2006.09.018_bib26","first-page":"22994","volume":"42","author":"Wieland","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2006.09.018_bib27","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1021\/jm980428x","volume":"42","author":"Ehren","year":"1999","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089606007498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089606007498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:09:00Z","timestamp":1760828940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089606007498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":28,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0968089606007498"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2006.09.018","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of some substituted pyrazinopyridoindoles and 3D QSAR studies along with related compounds: Piperazines, piperidines, pyrazinoisoquinolines, and diphenhydramine, and its semi-rigid analogs as antihistamines (H1)","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2006.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}