{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:53:58Z","timestamp":1760853238059,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.bmc.2006.12.006","type":"journal-article","created":{"date-parts":[[2006,12,10]],"date-time":"2006-12-10T11:57:22Z","timestamp":1165751842000},"page":"1679-1693","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists"],"prefix":"10.1016","volume":"15","author":[{"given":"Jun","family":"Chiba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Iimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Yoneda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumito","family":"Muro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Tsubokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Iigou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gensuke","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Takashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Machinaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2006.12.006_bib1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0092-8674(87)90233-9","volume":"48","author":"Hynes","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.bmc.2006.12.006_bib2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0092-8674(90)90661-W","volume":"60","author":"Elices","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.bmc.2006.12.006_bib3_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0092-8674(90)90715-Q","volume":"60","author":"Guan","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.bmc.2006.12.006_bib3_2","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1083\/jcb.109.3.1321","volume":"109","author":"Wayner","year":"1989","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bmc.2006.12.006_bib4","doi-asserted-by":"crossref","first-page":"27589","DOI":"10.1074\/jbc.C200331200","volume":"277","author":"Cunningham","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2006.12.006_bib5_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pupt.2003.10.004","volume":"17","author":"Vanderslice","year":"2004","journal-title":"Pulmon. Pharmacol. Ther."},{"key":"10.1016\/j.bmc.2006.12.006_bib5_2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/med.10044","volume":"23","author":"Yang","year":"2003","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2006.12.006_bib5_3","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1517\/13543776.12.7.991","volume":"12","author":"Tilley","year":"2002","journal-title":"Expert Opin. Ther. Patents"},{"key":"10.1016\/j.bmc.2006.12.006_bib5_4","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.2174\/1381612023394737","volume":"8","author":"Jackson","year":"2002","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2006.12.006_bib5_5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10001","volume":"22","author":"Yusuf-Makagiansar","year":"2002","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2006.12.006_bib5_6","first-page":"65","volume":"37","author":"Holland","year":"2002"},{"key":"10.1016\/j.bmc.2006.12.006_bib5_7","first-page":"788","volume":"3","author":"Porter","year":"2000","journal-title":"IDrugs"},{"key":"10.1016\/j.bmc.2006.12.006_bib6","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1021\/jm980673g","volume":"42","author":"Lin","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2006.12.006_bib7_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/356063a0","volume":"356","author":"Yednock","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2006.12.006_bib7_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0165-5728(02)00273-4","volume":"131","author":"Piraino","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bmc.2006.12.006_bib8","first-page":"2086","volume":"23","author":"Seiffge","year":"1996","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.bmc.2006.12.006_bib9_1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1056\/NEJM199109263251306","volume":"325","author":"Podolsky","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bmc.2006.12.006_bib9_2","first-page":"115","volume":"2","author":"Powrie","year":"1995","journal-title":"Ther. Immunol."},{"key":"10.1016\/j.bmc.2006.12.006_bib10_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1056\/NEJMoa020696","volume":"348","author":"Miller","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bmc.2006.12.006_bib10_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa020732","volume":"348","author":"Ghosh","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bmc.2006.12.006_bib10_3","unstructured":"Elan-Biogen official home page: http:\/\/www.tysabri.com\/."},{"key":"10.1016\/j.bmc.2006.12.006_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bmcl.2004.10.041","volume":"15","author":"Chiba","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2006.12.006_bib12_1","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1016\/j.bmc.2005.11.058","volume":"14","author":"Chiba","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2006.12.006_bib12b","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1248\/cpb.54.1515","volume":"54","author":"Chiba","year":"2006","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.bmc.2006.12.006_bib13","unstructured":"Castro, A. C.; Lin, K.-C. 213th ACS National Meeting (Apr. 13\u201317, San Francisco), 1997; Abstraction MEDI 077."},{"key":"10.1016\/j.bmc.2006.12.006_bib14","doi-asserted-by":"crossref","first-page":"5538","DOI":"10.1016\/j.bmcl.2006.08.044","volume":"16","author":"Witherington","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"year":"1980","series-title":"The Basic of Medicinal Chemistry\/Burger\u2019s Medicinal Chemistry","author":"Chu","key":"10.1016\/j.bmc.2006.12.006_bib15"},{"key":"10.1016\/j.bmc.2006.12.006_bib16","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/cber.19270600616","volume":"60","author":"Eistert","year":"1927","journal-title":"Chem. Ber."},{"key":"10.1016\/j.bmc.2006.12.006_bib17_1","doi-asserted-by":"crossref","first-page":"6389","DOI":"10.1021\/jo00125a026","volume":"60","author":"Zhu","year":"1995","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2006.12.006_bib17_2","doi-asserted-by":"crossref","first-page":"14735","DOI":"10.1016\/0040-4020(96)00937-4","volume":"52","author":"Radau","year":"1996","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2006.12.006_bib18","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1021\/jo00360a014","volume":"51","author":"RajanBabu","year":"1986","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2006.12.006_bib19","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1016\/S0040-4039(00)91094-3","volume":"16","author":"Sonogashira","year":"1975","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2006.12.006_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-328X(93)80265-D","volume":"447","author":"Bentrey","year":"1993","journal-title":"J. Organomet. Chem."},{"key":"10.1016\/j.bmc.2006.12.006_bib21","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1159\/000235174","volume":"92","author":"Martins","year":"1990","journal-title":"Int. Arch. Allergy Appl. Immunol."},{"key":"10.1016\/j.bmc.2006.12.006_bib22","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.3109\/00498258909043190","volume":"19","author":"Manners","year":"1989","journal-title":"Xenobiotica"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089606009941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089606009941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:07:12Z","timestamp":1760828832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089606009941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0968089606009941"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2006.12.006","relation":{},"ISSN":["0968-0896"],"issn-type":[{"type":"print","value":"0968-0896"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2006.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}