{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:38:35Z","timestamp":1789799915366,"version":"4.0.1"},"reference-count":156,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.bmc.2007.04.031","type":"journal-article","created":{"date-parts":[[2007,4,26]],"date-time":"2007-04-26T09:03:24Z","timestamp":1177578204000},"page":"4674-4699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":187,"title":["The biology and chemistry of hyperlipidemia"],"prefix":"10.1016","volume":"15","author":[{"given":"Kishor S.","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.K.","family":"Kathiravan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul S.","family":"Somani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chamanlal J.","family":"Shishoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2007.04.031_bib1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJM199809243391301","volume":"339","author":"Rosmund","year":"1998","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.bmc.2007.04.031_bib2","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0140-6736(96)07493-4","volume":"349","author":"Murray","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2007.04.031_bib3","series-title":"Geographical Pathology of Atheroslclerosis","author":"McGill","year":"1985"},{"key":"10.1016\/j.bmc.2007.04.031_bib7","first-page":"14","volume":"27","author":"Ghatak","year":"1995","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.bmc.2007.04.031_bib8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0025-7125(16)30174-2","volume":"78","author":"Ginsberg","year":"1994","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.bmc.2007.04.031_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-74-1-1","volume":"74","author":"Kannel","year":"1971","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bmc.2007.04.031_bib15","first-page":"A20","volume":"19","author":"Beisiegel","year":"1998","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bmc.2007.04.031_bib16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/ajcn\/75.2.191","volume":"75","author":"Schaefer","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bmc.2007.04.031_bib17","series-title":"Lipoprotein Lipase","first-page":"15","author":"Olivecrona","year":"1987"},{"key":"10.1016\/j.bmc.2007.04.031_bib18","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/oxfordjournals.jbchem.a134000","volume":"92","author":"Kubo","year":"1982","journal-title":"J. Biochem."},{"key":"10.1016\/j.bmc.2007.04.031_bib19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00041433-200004000-00008","volume":"11","author":"Peelman","year":"2000","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.bmc.2007.04.031_bib20","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1161\/01.ATV.0000121505.88326.d2","volume":"24","author":"Brewer","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bmc.2007.04.031_bib21","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/00041433-199908000-00008","volume":"10","author":"Olofsson","year":"1999","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.bmc.2007.04.031_bib22","doi-asserted-by":"crossref","first-page":"20747","DOI":"10.1016\/S0021-9258(19)36846-2","volume":"268","author":"Chang","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib23","unstructured":"Jackson, R. L. In Antihyperlipidemic drugs: medicinal, chemical and biochemical aspects, Witiak, D. T., Newman, H. A. I., Feller, D. R., Eds.; Elsevier: Amsterdam, 1991; 17, 2."},{"key":"10.1016\/j.bmc.2007.04.031_bib24","first-page":"328","volume":"997","author":"Kostner","year":"2002","journal-title":"J. Kardiol."},{"key":"10.1016\/j.bmc.2007.04.031_bib25","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1161\/01.CIR.31.3.321","volume":"31","author":"Frederickson","year":"1965","journal-title":"Circulation"},{"key":"10.1016\/j.bmc.2007.04.031_bib26","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1365-2362.1993.tb00776.x","volume":"23","author":"Kleinveld","year":"1993","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.bmc.2007.04.031_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0002-9459(24)08821-1","volume":"69","author":"Roche","year":"2005","journal-title":"Am. J. Pharm. Educ."},{"key":"10.1016\/j.bmc.2007.04.031_bib28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1567-5688(03)00003-5","volume":"4","author":"Istvan","year":"2003","journal-title":"Atherosclerosis Suppl."},{"key":"10.1016\/j.bmc.2007.04.031_bib29","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1016\/j.bmcl.2004.08.015","volume":"14","author":"Sharma","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.04.031_bib30","first-page":"304","volume":"34","author":"Gebahardt","year":"1996","journal-title":"Lipids"},{"key":"10.1016\/j.bmc.2007.04.031_bib31","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1056\/NEJM198005293022202","volume":"302","author":"Shepherd","year":"1980","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.bmc.2007.04.031_bib32","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1023\/A:1007831418308","volume":"14","author":"Donovan","year":"2000","journal-title":"Cardiovasc. Drug Ther."},{"key":"10.1016\/j.bmc.2007.04.031_bib33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/eurheartj\/16.1.5","volume":"16","author":"Shepherd","year":"1995","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bmc.2007.04.031_bib34","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/S0021-9150(97)00313-4","volume":"137","author":"Steals","year":"1998","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bmc.2007.04.031_bib35","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/0003-9861(55)90070-9","volume":"54","author":"Aithul","year":"1955","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bmc.2007.04.031_bib36","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/0026-0495(85)90092-7","volume":"34","author":"Knopp","year":"1985","journal-title":"Metabolism"},{"key":"10.1016\/j.bmc.2007.04.031_bib37","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0021-9150(00)00456-1","volume":"151","author":"Ros","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bmc.2007.04.031_bib38","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0149-2918(01)80102-8","volume":"23","author":"Bays","year":"2001","journal-title":"Clin. Ther."},{"key":"10.1016\/j.bmc.2007.04.031_bib39","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1021\/jm050422p","volume":"48","author":"Kvaerno","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib40","unstructured":"Mewshaw, R. A.; Commons, J.; Strike, D. P. EP 428385A, 1991."},{"key":"10.1016\/j.bmc.2007.04.031_bib41","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s11745-998-0232-8","volume":"33","author":"Krause","year":"1998","journal-title":"Lipids"},{"key":"10.1016\/j.bmc.2007.04.031_bib42","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.bmcl.2004.01.091","volume":"14","author":"Ninomiya","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.04.031_bib43","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1126\/science.294.5548.1866","volume":"294","author":"Chawla","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bmc.2007.04.031_bib44","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.med.53.082901.104018","volume":"53","author":"Berger","year":"2002","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bmc.2007.04.031_bib45","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/01.ATV.0000015598.86369.04","volume":"22","author":"Barbier","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bmc.2007.04.031_bib46","doi-asserted-by":"crossref","first-page":"48051","DOI":"10.1074\/jbc.M206966200","author":"Duez","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib47","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1172\/JCI10370","volume":"106","author":"Li","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bmc.2007.04.031_bib48","first-page":"136","volume":"4","author":"Shah","year":"2003","journal-title":"Rev. Cardiovasc. Med."},{"key":"10.1016\/j.bmc.2007.04.031_bib49","unstructured":"Roberts, S.; McDonald, I. M. In Burger\u2019s Medicinal Chemistry and Drug Discovery, 6th ed.; Abraham, D. J. Ed.; John Wiley: New Jersey, 1998; Vol. 3, pp 339."},{"key":"10.1016\/j.bmc.2007.04.031_bib50","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1021\/jm00087a016","volume":"35","author":"Roth","year":"1992","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib51","unstructured":"Yamada K.; Oda, S.; Shirakura, S.; Ohishi, E.; Ohnuma, H.; Yanase, M.; Kumazawa, T.; Kubo, K. In Abstracts XI International Symposium on Drugs Affecting Lipid Metabolism, Florence, May 13\u201316, 1992; p 89."},{"key":"10.1016\/j.bmc.2007.04.031_bib52","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0022-2275(20)38328-0","volume":"30","author":"Largis","year":"1989","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bmc.2007.04.031_bib53","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0021-9258(17)43530-7","volume":"259","author":"Ross","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib54","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0960-894X(00)80149-3","volume":"2","author":"Ashton","year":"1992","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.04.031_bib55","unstructured":"Arrowsmith, R. J.; Dann, J. G.; Harris, C. J.; Honey, A. C.; O\u2019Connor, K. J. In Abstract, IX International Symposium on Atherosclerosis, Resemont, October 6\u201311 1991; 185, pp A99."},{"key":"10.1016\/j.bmc.2007.04.031_bib56","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0022-5193(76)90124-7","volume":"62","author":"Mitchell","year":"1976","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.bmc.2007.04.031_bib57","series-title":"Highlights in Ubiquinone Research","author":"Mitchell","year":"1990"},{"key":"10.1016\/j.bmc.2007.04.031_bib58","series-title":"Biomedical and Clinical Aspects of Coenzyme Q 6","author":"Lenaz","year":"1991"},{"key":"10.1016\/j.bmc.2007.04.031_bib59","unstructured":"Mellstedt, H.; Osterborg, A.; Nylander, M.; Morita, M.; Folkers, K. A deficiency of coenzyme Q10 (CoQ10) in conventional cancer therapy and blood levels of CoQ10 in cancer patients in Sweden. In Eighth International Symposium on Biomedical and Clinical Aspects of Coenzyme Q, 1994."},{"key":"10.1016\/j.bmc.2007.04.031_bib60","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1074\/jbc.270.11.5756","volume":"270","author":"Bowry","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib61","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1073\/pnas.90.1.45","volume":"90","author":"Ingold","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2007.04.031_bib62","doi-asserted-by":"crossref","first-page":"S265","DOI":"10.1016\/0098-2997(94)90037-X","volume":"15","author":"Langsjoen","year":"1994","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.bmc.2007.04.031_bib63","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0891-5849(00)00311-7","volume":"29","author":"Witting","year":"2000","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.bmc.2007.04.031_bib64","first-page":"16","volume":"4","author":"Kogan","year":"1999","journal-title":"Patol Fiziol Eksp Ter."},{"key":"10.1016\/j.bmc.2007.04.031_bib65","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/biof.5520090225","volume":"9","author":"Munkhlom","year":"1999","journal-title":"BioFactors"},{"key":"10.1016\/j.bmc.2007.04.031_bib66","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0003-9861(69)90532-3","volume":"135","author":"Watson","year":"1969","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bmc.2007.04.031_bib67","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1432-1033.1973.tb03038.x","volume":"38","author":"Cheema Dhadli","year":"1973","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bmc.2007.04.031_bib68","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0076-6879(81)72038-X","volume":"72","author":"Lowestein","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bmc.2007.04.031_bib69","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/S0021-9258(19)40033-1","volume":"265","author":"Elshourbagy","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib70","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/0003-9861(72)90054-9","volume":"150","author":"Brunengraber","year":"1972","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bmc.2007.04.031_bib71","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0014-5793(72)80266-7","volume":"22","author":"Barth","year":"1972","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmc.2007.04.031_bib72","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0021-9258(18)62460-3","volume":"246","author":"Lowenstein","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib73","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0003-9861(72)90025-2","volume":"150","author":"Sullivan","year":"1972","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bmc.2007.04.031_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02532964","volume":"12","author":"Sullivan","year":"1977","journal-title":"Lipids"},{"key":"10.1016\/j.bmc.2007.04.031_bib75","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1042\/bj2720181","volume":"272","author":"Berknout","year":"1990","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmc.2007.04.031_bib76","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1042\/bj3340113","volume":"334","author":"Pearce","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmc.2007.04.031_bib77","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1021\/jm960167w","volume":"39","author":"Gribble","year":"1996","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib78","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2174\/1568013033483357","volume":"3","author":"Grppt","year":"2003","journal-title":"Curr. Med. Chem. Immunol. Endocrinol. Metab. Agents"},{"key":"10.1016\/j.bmc.2007.04.031_bib79","doi-asserted-by":"crossref","first-page":"770","DOI":"10.2337\/diabetes.47.5.770","volume":"47","author":"Russel","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.bmc.2007.04.031_bib80","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1136\/bmj.282.6278.1741","volume":"282","author":"Miller","year":"1981","journal-title":"Br. Med. J."},{"key":"10.1016\/j.bmc.2007.04.031_bib81","first-page":"434","volume":"6","author":"Picardo","year":"1986","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bmc.2007.04.031_bib82","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0022-2275(20)43114-1","volume":"9","author":"Glomset","year":"1968","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bmc.2007.04.031_bib83","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0960-894X(00)00668-5","volume":"11","author":"Elokdah","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.04.031_bib84","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1006\/bbrc.2001.5001","volume":"284","author":"Lee","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmc.2007.04.031_bib85","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1016\/j.bmcl.2003.09.009","volume":"13","author":"Lee","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.04.031_bib86","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1016\/S0960-894X(03)00549-3","volume":"13","author":"Lee","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.04.031_bib87","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0167-5273(02)00562-4","volume":"90","author":"Weirzbicki","year":"2003","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bmc.2007.04.031_bib88","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/S0022-2275(20)32526-8","volume":"39","author":"Jamil","year":"1998","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bmc.2007.04.031_bib89","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/0005-2760(86)90084-6","volume":"875","author":"Wetterau","year":"1986","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1016\/j.bmc.2007.04.031_bib90","first-page":"187","volume":"5","author":"Wetterau","year":"1991","journal-title":"Adv. Vasc. Biol."},{"key":"10.1016\/j.bmc.2007.04.031_bib91","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1126\/science.282.5389.751","volume":"282","author":"Wetterau","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.bmc.2007.04.031_bib92","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1126\/science.282.5389.751","volume":"282","author":"Wetterau","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.bmc.2007.04.031_bib93","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S0960-894X(03)00116-1","volume":"13","author":"Magnin","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.04.031_bib94","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1161\/01.ATV.0000054658.91146.64","volume":"23","author":"Barter","year":"2003","journal-title":"Atheroscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bmc.2007.04.031_bib95","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1161\/01.CIR.0000015857.31889.7B","volume":"105","author":"Grooth","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.bmc.2007.04.031_bib96","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0009-9120(97)00098-2","volume":"30","author":"Hill","year":"1997","journal-title":"Clin. Biochem"},{"key":"10.1016\/j.bmc.2007.04.031_bib97","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/35018119","volume":"406","author":"Okamoto","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2007.04.031_bib98","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/BF02536247","volume":"29","author":"Bisgaier","year":"1994","journal-title":"Lipids"},{"key":"10.1016\/j.bmc.2007.04.031_bib99","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1021\/jm000337b","volume":"43","author":"Durley","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib100","doi-asserted-by":"crossref","first-page":"13870","DOI":"10.1021\/bi001356q","volume":"39","author":"Connolly","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2007.04.031_bib101","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.2337\/diacare.28.9.2312","volume":"28","author":"Bloomgarden","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bmc.2007.04.031_bib102","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1161\/01.CIR.100.11.1148","volume":"100","author":"Libby","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.bmc.2007.04.031_bib103","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1161\/01.CIR.102.18.2165","volume":"102","author":"Pasceri","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.bmc.2007.04.031_bib104","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1161\/01.CIR.0000029802.88087.5E","volume":"106","author":"Verma","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.bmc.2007.04.031_bib105","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1161\/01.CIR.0000052617.91920.FD","volume":"107","author":"Devaraj","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.bmc.2007.04.031_bib106","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1042\/cs0980531","volume":"98","author":"Cleland","year":"2000","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bmc.2007.04.031_bib107","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1161\/01.CIR.0000114526.50618.24","volume":"109","author":"Paul","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.bmc.2007.04.031_bib108","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1161\/01.CIR.0000136819.93989.E1","volume":"110","author":"Lewis","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.bmc.2007.04.031_bib109","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1042\/bst0320134","volume":"32","author":"Jessup","year":"2004","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bmc.2007.04.031_bib110","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/S0891-5849(00)00344-0","volume":"28","author":"Chisolm","year":"2000","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.bmc.2007.04.031_bib111","doi-asserted-by":"crossref","first-page":"17852","DOI":"10.1074\/jbc.271.30.17852","volume":"271","author":"Gelissen","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib112","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.ATV.11.1.15","volume":"11","author":"Biorkhem","year":"1991","journal-title":"Arterioscler. Thromb."},{"key":"10.1016\/j.bmc.2007.04.031_bib113","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1021\/jm00028a017","volume":"37","author":"Paul","year":"1994","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib114","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1016\/j.bmcl.2004.03.072","volume":"14","author":"Jeong","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.04.031_bib115","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1021\/jm010143b","volume":"44","author":"Lohray","year":"2001","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib116","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1016\/S0960-894X(03)00490-6","volume":"13","author":"Madhavan","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.04.031_bib117","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1021\/jm991039l","volume":"43","author":"Chrysselis","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib118","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/75651","volume":"25","author":"Smith","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bmc.2007.04.031_bib119","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1034\/j.1399-0004.2002.620109.x","volume":"62","author":"Ludwig","year":"2002","journal-title":"Clin. Genet."},{"key":"10.1016\/j.bmc.2007.04.031_bib120","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1021\/jm00055a012","volume":"36","author":"Frye","year":"1993","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib121","first-page":"12383","volume":"259","author":"Taylor","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib122","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/jcp.1041170117","volume":"117","author":"Chen","year":"1983","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bmc.2007.04.031_bib123","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0021-9258(19)86186-0","volume":"255","author":"Gibbons","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib124","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1126\/science.663671","volume":"201","author":"Kandutsch","year":"1978","journal-title":"Science"},{"key":"10.1016\/j.bmc.2007.04.031_bib125","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0006-2952(95)00152-P","volume":"50","author":"Burton","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bmc.2007.04.031_bib126","unstructured":"Adams, J. L.; Bossard, M. J.; Mayer, R. J.; Gallagher, T. F.; Tomaszek, T. A.; Metcalf, B. W. In Abstracts, 199th ACS Meeting MEDi (Boston), 1990; pp 10."},{"key":"10.1016\/j.bmc.2007.04.031_bib127","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1021\/jo00003a059","volume":"56","author":"Tuck","year":"1991","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib128","unstructured":"Gaylor, J. L.; Johnson, P. R.; Ko, S. S.; Magolda, R. L.; Stam, S. H.; Trzaskos, J. M. US 5041432, 1991. Chem. Abstr. 1989, 110, 115192."},{"key":"10.1016\/j.bmc.2007.04.031_bib129","doi-asserted-by":"crossref","first-page":"20070","DOI":"10.1016\/S0021-9258(18)54892-4","volume":"266","author":"Mayer","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib130","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1042\/bj3340113","volume":"334","author":"Carazo","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmc.2007.04.031_bib131","unstructured":"Yang, S. S.; Chiang, Y.-C. P.; Heck, J. V.; Chang, M. N. US 4983597, 1991. Chem. Abstr. 1992, 116, 20923."},{"key":"10.1016\/j.bmc.2007.04.031_bib132","unstructured":"Garrity, G. M.; Hennet, O. D.; Glacobbe, R. A.; Joshua, H.; Greenspan, M. D.; Milligan, J. A.; Onishi, J. O.; Diez Matas, M. T.; Rozdilsky, W.; Del Val, S. M.; Martin, I.; Liesch, J. M. EP411703A1, 1991. Chem. Abstr. 1991, 115, 181508."},{"key":"10.1016\/j.bmc.2007.04.031_bib133","unstructured":"Harrity, T. W.; George, R. J.; Ciosek, C. P., Jr.; Biller, S. A.; Chen, Y.; Dickson, J. K., Jr.; Fryszman, O. M.; Jolibois, K. J.; Kunselman, L. K.; Lawrence, R. M.; Logan, J. V. H.; Magnin, D. R.; Rich, L. C.; Slusarchyk, D. A.; Sulsky, R. B.; Gregg, R. E. In XII International Symposium on Drugs Affecting Lipid Metabolism (Houston, TX, November 7\u201310), 1995; pp 54."},{"key":"10.1016\/j.bmc.2007.04.031_bib134","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1177\/009127009803801205","volume":"38","author":"Sharma","year":"1998","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.bmc.2007.04.031_bib135","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/S0022-3565(24)36653-4","volume":"281","author":"Amin","year":"1997","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"10.1016\/j.bmc.2007.04.031_bib136","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/S0022-2275(20)32020-4","volume":"41","author":"Hiyoshi","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bmc.2007.04.031_bib137","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1194\/jlr.M200316-JLR200","volume":"44","author":"Hiyoshi","year":"2003","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bmc.2007.04.031_bib138","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/sj.bjp.0703545","volume":"131","author":"Ugawa","year":"2000","journal-title":"Brit. J. Pharmacol."},{"key":"10.1016\/j.bmc.2007.04.031_bib139","unstructured":"Jarvi, E. T.; Edwards, M. L.; McCarthy, J. R. US 5011859, 1991. Chem. Abstr. 1991, 115, 136448."},{"key":"10.1016\/j.bmc.2007.04.031_bib140","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF02536171","volume":"27","author":"Van Sickle","year":"1992","journal-title":"Lipids"},{"key":"10.1016\/j.bmc.2007.04.031_bib141","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0021-9150(91)90080-M","volume":"88","author":"Horie","year":"1991","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bmc.2007.04.031_bib142","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1021\/jm960483a","volume":"40","author":"Stach","year":"1997","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.04.031_bib143","unstructured":"Wannamaker, M. W.; Van Sickle, W. A.; Moore, W. R. US 5084461, 1992. Chem. Abstr. 1993, 118, 191562."},{"key":"10.1016\/j.bmc.2007.04.031_bib144","doi-asserted-by":"crossref","first-page":"7892","DOI":"10.1021\/bi00149a021","volume":"31","author":"Taton","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2007.04.031_bib145","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0022-2275(20)37449-6","volume":"38","author":"Morland","year":"1997","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bmc.2007.04.031_bib146","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1126\/science.1072891","volume":"296","author":"Urizar","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bmc.2007.04.031_bib147","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/nm1201-1332","volume":"7","author":"Grand-Perret","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.bmc.2007.04.031_bib148","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/nm1201-1282","volume":"7","author":"Rader","year":"2001","journal-title":"Nat. Med"},{"key":"10.1016\/j.bmc.2007.04.031_bib149","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0022-2275(20)31620-5","volume":"42","author":"Datta","year":"2001","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bmc.2007.04.031_bib150","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0002-9149(00)00976-0","volume":"86","author":"Blair","year":"2000","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.bmc.2007.04.031_bib151","doi-asserted-by":"crossref","unstructured":"Parker, R. A. US Pat., 3714191, 1973. Chem. Abstr. 1973, 78, 11139.","DOI":"10.2307\/1861254"},{"key":"10.1016\/j.bmc.2007.04.031_bib152","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1210\/jcem-12-10-1287","volume":"12","author":"Reseman","year":"1952","journal-title":"J. Clin. Endocrinol."},{"key":"10.1016\/j.bmc.2007.04.031_bib153","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/j.1552-4604.1978.tb01559.x","volume":"18","author":"Melmendir","year":"1978","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.bmc.2007.04.031_bib154","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0005-2760(84)90078-X","volume":"795","author":"Albers","year":"1984","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmc.2007.04.031_bib155","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1172\/JCI104846","volume":"42","author":"Bhatathiry","year":"1963","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bmc.2007.04.031_bib156","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1172\/JCI104323","volume":"40","author":"Steinberg","year":"1961","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bmc.2007.04.031_bib157","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1016\/S0960-894X(02)00799-0","volume":"12","author":"Kumar","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.04.031_bib158","doi-asserted-by":"crossref","unstructured":"Shiroki, M. Japan Kokai., 7643796(1976). Chem. Abstr., 1976, 85, 94398.","DOI":"10.2208\/jscej1969.1976.250_85"},{"key":"10.1016\/j.bmc.2007.04.031_bib159","unstructured":"Sauter, F. Ger. Offen., 221003 (1972). Chem. Abstr., 1972, 77, 164752."},{"key":"10.1016\/j.bmc.2007.04.031_bib160","first-page":"567","volume":"40","author":"Shishoo","year":"1990","journal-title":"Arzneim.-Forsch.\/Drug Res."},{"key":"10.1016\/j.bmc.2007.04.031_bib161","unstructured":"Shishoo, C. J.; Devani, M. B.; Bhadti, V. S.; Indian Pat., 151,496(1981). Chem. Abstr., 1981, 100, 209858."},{"key":"10.1016\/j.bmc.2007.04.031_bib162","first-page":"1125","volume":"47","author":"Shishoo","year":"1997","journal-title":"Arzneim.-Forsch.\/Drug Res."},{"key":"10.1016\/j.bmc.2007.04.031_bib163","first-page":"273","volume":"46","author":"Shishoo","year":"1996","journal-title":"Arzneim.-Forsch.\/Drug Res."},{"key":"10.1016\/j.bmc.2007.04.031_bib164","volume":"9","author":"Kathiravan","year":"2007","journal-title":"Arzneim.-Forsch.\/Drug Res."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089607003471?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089607003471?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:11:22Z","timestamp":1760829082000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089607003471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":156,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0968089607003471"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2007.04.031","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The biology and chemistry of hyperlipidemia","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2007.04.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}