{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:41:20Z","timestamp":1760830880044,"version":"build-2065373602"},"reference-count":41,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1016\/j.bmc.2007.08.025","type":"journal-article","created":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T07:16:05Z","timestamp":1187853365000},"page":"6882-6892","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["5\u2032-O-Masked 2\u2032-deoxyadenosine analogues as lead compounds for hepatitis C virus (HCV) therapeutic agents"],"prefix":"10.1016","volume":"15","author":[{"given":"Masahiro","family":"Ikejiri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keizo","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunitada","family":"Shimotohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokumi","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2007.08.025_bib1","series-title":"Classification and Nomenclature of Viruses: Sixth Report of the Internal Committee on Taxonomy of Viruses","first-page":"424","author":"Murphy","year":"1995"},{"key":"10.1016\/j.bmc.2007.08.025_bib2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.2523562","volume":"244","author":"Choo","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.bmc.2007.08.025_bib3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1055\/s-2007-1007264","volume":"15","author":"Goodman","year":"1995","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.bmc.2007.08.025_bib4_1","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S0140-6736(01)06102-5","volume":"358","author":"Manns","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2007.08.025_bib4_2","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1056\/NEJMoa020047","volume":"347","author":"Fried","year":"2002","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.bmc.2007.08.025_bib5a","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/jm0400101","volume":"48","author":"Gordon","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.08.025_bib5_2","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nature04080","volume":"436","author":"De Francesco","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2007.08.025_bib6a","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1128\/JVI.77.19.10689-10694.2003","volume":"77","author":"Stuyver","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.bmc.2007.08.025_bib6_2","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1021\/jm030424e","volume":"47","author":"Eldrup","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.08.025_bib6_3","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.1021\/jm040068f","volume":"47","author":"Eldrup","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.08.025_bib6b","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1128\/AAC.48.2.651-654.2004","volume":"48","author":"Stuyver","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2007.08.025_bib6_5","doi-asserted-by":"crossref","first-page":"5504","DOI":"10.1021\/jm0502788","volume":"48","author":"Clark","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.08.025_bib6c","doi-asserted-by":"crossref","first-page":"11979","DOI":"10.1074\/jbc.M210914200","volume":"278","author":"Carroll","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2007.08.025_bib6d","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1016\/j.bmcl.2007.02.004","volume":"17","author":"Smith","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.08.025_bib7_1","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1016\/j.bmcl.2004.04.067","volume":"14","author":"Smith","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.08.025_bib7_2","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1021\/jm058223t","volume":"48","author":"Wang","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.08.025_bib7_3","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.bmc.2004.12.011","volume":"13","author":"Shi","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2007.08.025_bib7_4","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.bbrc.2005.03.062","volume":"330","author":"Naka","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmc.2007.08.025_bib7_5","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/j.bmcl.2005.12.002","volume":"16","author":"Clark","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.08.025_bib7_6","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1016\/j.bmcl.2006.05.089","volume":"16","author":"Yoo","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.08.025_bib7_7","doi-asserted-by":"crossref","first-page":"5290","DOI":"10.1016\/j.bmcl.2006.07.092","volume":"16","author":"Hocek","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.08.025_bib7_8","doi-asserted-by":"crossref","first-page":"5081","DOI":"10.1021\/ol061959f","volume":"8","author":"Lee","year":"2006","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmc.2007.08.025_bib7_9","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1016\/j.bmc.2007.05.020","volume":"15","author":"Butora","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2007.08.025_bib8_1","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1021\/jm0603623","volume":"49","author":"Pierra","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.08.025_bib8_2","doi-asserted-by":"crossref","first-page":"726A","DOI":"10.1016\/S0168-8278(04)00080-7","volume":"40","author":"Afdhal","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.bmc.2007.08.025_bib9","first-page":"69","volume":"Vol. 3","author":"Arimilli","year":"1999"},{"key":"10.1016\/j.bmc.2007.08.025_bib10_1","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1021\/jm0495172","volume":"48","author":"Prakash","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.08.025_bib10_2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.bmcl.2004.11.020","volume":"15","author":"Ding","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.08.025_bib10_3","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1016\/j.bmcl.2007.02.029","volume":"17","author":"Gunic","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.08.025_bib10_4","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1021\/jm0613370","volume":"50","author":"Perrone","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2007.08.025_bib11","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1016\/j.bmcl.2007.02.026","volume":"17","author":"Ikejiri","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2007.08.025_bib12_1","unstructured":"Ref. 11 and references therein. A racemic mixture of 14 was employed."},{"key":"10.1016\/j.bmc.2007.08.025_bib12_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/07328318808070199","volume":"7","author":"Webb","year":"1988","journal-title":"Nucleosides Nucleotides"},{"key":"10.1016\/j.bmc.2007.08.025_bib12c","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0040-4020(01)85111-5","volume":"44","author":"Liguori","year":"1988","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2007.08.025_bib13","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1016\/S0040-4020(02)00186-2","volume":"58","author":"\u010cesnek","year":"2002","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2007.08.025_bib14","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1248\/cpb.33.3263","volume":"33","author":"Ueda","year":"1985","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.bmc.2007.08.025_bib15","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1016\/S0040-4020(00)00222-2","volume":"56","author":"Ciuffreda","year":"2000","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2007.08.025_bib16_1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1053\/jhep.2003.50449","volume":"38","author":"Watashi","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.bmc.2007.08.025_bib16_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.virol.2005.06.015","volume":"340","author":"Murata","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.bmc.2007.08.025_bib16_3","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.bbrc.2006.03.059","volume":"343","author":"Goto","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmc.2007.08.025_bib18","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1080\/07328319808004216","volume":"17","author":"Parang","year":"1998","journal-title":"Nucleosides Nucleotides"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089607007195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089607007195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:16:03Z","timestamp":1760829363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089607007195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":41,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0968089607007195"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2007.08.025","relation":{},"ISSN":["0968-0896"],"issn-type":[{"type":"print","value":"0968-0896"}],"subject":[],"published":{"date-parts":[[2007,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"5\u2032-O-Masked 2\u2032-deoxyadenosine analogues as lead compounds for hepatitis C virus (HCV) therapeutic agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2007.08.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}