{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:19:43Z","timestamp":1791231583669,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.bmc.2008.07.080","type":"journal-article","created":{"date-parts":[[2008,8,4]],"date-time":"2008-08-04T10:19:44Z","timestamp":1217845184000},"page":"8697-8705","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":140,"title":["Oleanolic acid and its derivatives: New inhibitor of protein tyrosine phosphatase 1B with cellular activities"],"prefix":"10.1016","volume":"16","author":[{"given":"Yi-Nan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Ya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2008.07.080_bib1","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1126\/science.8128219","volume":"263","author":"Barford","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.bmc.2008.07.080_bib2","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1126\/science.283.5407.1544","volume":"283","author":"Elchebly","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bmc.2008.07.080_bib3","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1128\/MCB.20.15.5479-5489.2000","volume":"20","author":"Klaman","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bmc.2008.07.080_bib4","doi-asserted-by":"crossref","first-page":"13420","DOI":"10.1073\/pnas.94.25.13420","volume":"94","author":"Puius","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bmc.2008.07.080_bib5","doi-asserted-by":"crossref","first-page":"10300","DOI":"10.1074\/jbc.275.14.10300","volume":"275","author":"Iversen","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2008.07.080_bib6","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nsmb803","volume":"11","author":"Wiesmann","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bmc.2008.07.080_bib7","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/nrd895","volume":"1","author":"Johnson","year":"2002","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2008.07.080_bib8","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.2174\/0929867033457296","volume":"10","author":"Liu","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2008.07.080_bib9","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.1002\/anie.200461517","volume":"44","author":"Bialy","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bmc.2008.07.080_bib10","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.drudis.2007.03.011","volume":"12","author":"Zhang","year":"2007","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.bmc.2008.07.080_bib11","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1056\/NEJM200104053441409","volume":"344","author":"Goldman","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bmc.2008.07.080_bib12","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nrd2130","volume":"5","author":"Wilhelm","year":"2006","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2008.07.080_bib13","doi-asserted-by":"crossref","first-page":"19982","DOI":"10.1074\/jbc.M200567200","volume":"277","author":"Iverson","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2008.07.080_bib14","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1021\/jm0600904","volume":"49","author":"Combs","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2008.07.080_bib15","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1021\/jm061146x","volume":"50","author":"Boutselis","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2008.07.080_bib16","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1021\/jm0702478","volume":"50","author":"Wilson","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2008.07.080_bib17","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.bmcl.2005.11.071","volume":"16","author":"Cui","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2008.07.080_bib18","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1021\/np0601861","volume":"69","author":"Na","year":"2006","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bmc.2008.07.080_bib19","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1021\/np060476h","volume":"70","author":"Wang","year":"2007","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bmc.2008.07.080_bib20","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1021\/np060477+","volume":"70","author":"Cui","year":"2007","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bmc.2008.07.080_bib21","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1021\/ol0703783","volume":"9","author":"Gong","year":"2007","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmc.2008.07.080_bib22","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1016\/S0960-894X(02)00757-6","volume":"12","author":"Chen","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2008.07.080_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/10286020310001596033","volume":"7","author":"Li","year":"2005","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.bmc.2008.07.080_bib24","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/cbdv.200790086","volume":"4","author":"Li","year":"2007","journal-title":"Chem. Biodiv."},{"key":"10.1016\/j.bmc.2008.07.080_bib25","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.bbagen.2006.05.009","volume":"1760","author":"Zhang","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmc.2008.07.080_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejphar.2008.01.020","volume":"584","author":"Shi","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmc.2008.07.080_bib27","first-page":"52","volume":"50","author":"Chung","year":"2007","journal-title":"J. Appl. Biol. Chem."},{"key":"10.1016\/j.bmc.2008.07.080_bib28","unstructured":"Lihong, Hu et al. PCT CN2005\/000172, 2005."},{"key":"10.1016\/j.bmc.2008.07.080_bib29","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0031-9422(88)83136-4","volume":"27","author":"Matsunaga","year":"1988","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2008.07.080_bib30","first-page":"176","volume":"16B","author":"Pardhy","year":"1978","journal-title":"Ind. J. Chem."},{"key":"10.1016\/j.bmc.2008.07.080_bib31","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1055\/s-2000-11109","volume":"66","author":"Shim","year":"2000","journal-title":"Planta Medica"},{"key":"10.1016\/j.bmc.2008.07.080_bib32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1055\/s-2006-959434","volume":"60","author":"Bonte","year":"1994","journal-title":"Planta Medica"},{"key":"10.1016\/j.bmc.2008.07.080_bib33","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1016\/S0040-4039(01)91563-1","volume":"19","author":"O\u2019Donnell","year":"1978","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2008.07.080_bib34","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1021\/jo00247a044","volume":"53","author":"Corey","year":"1988","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2008.07.080_bib35","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1021\/jo01344a063","volume":"31","author":"Karliner","year":"1966","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2008.07.080_bib36","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1021\/jm020093q","volume":"45","author":"Chen","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2008.07.080_bib37","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S0022-3565(25)12127-7","volume":"275","author":"Liu","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2008.07.080_bib38","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ceb.2005.02.001","volume":"17","author":"Bourdeau","year":"2005","journal-title":"Curr. Opin. Cel. Biol."},{"key":"10.1016\/j.bmc.2008.07.080_bib39","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1046\/j.0014-2956.2002.02756.x","volume":"269","author":"Cheng","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bmc.2008.07.080_bib40","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.2337\/diab.30.12.1000","volume":"30","author":"DeFronzo","year":"1981","journal-title":"Diabetes"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089608007062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089608007062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:25:56Z","timestamp":1760829956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089608007062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":40,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0968089608007062"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2008.07.080","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oleanolic acid and its derivatives: New inhibitor of protein tyrosine phosphatase 1B with cellular activities","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2008.07.080","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}