{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:16:37Z","timestamp":1791152197888,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.bmc.2008.12.023","type":"journal-article","created":{"date-parts":[[2008,12,25]],"date-time":"2008-12-25T05:39:54Z","timestamp":1230183594000},"page":"1214-1221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference"],"prefix":"10.1016","volume":"17","author":[{"given":"Claudia","family":"Temperini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cecchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2008.12.023_bib1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2174\/138161208783877947","volume":"14","author":"Supuran","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2008.12.023_bib2a","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0140-6736(07)61303-8","volume":"370","author":"Patel","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2008.12.023_bib2b","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000103279","volume":"30","author":"Piecha","year":"2007","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.bmc.2008.12.023_bib2c","doi-asserted-by":"crossref","first-page":"9S","DOI":"10.1016\/j.amjhyper.2007.04.014","volume":"20","author":"Zannad","year":"2007","journal-title":"Am. J. Hepertension"},{"key":"10.1016\/j.bmc.2008.12.023_bib2d","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1161\/01.HYP.0000203147.75714.ba","volume":"47","author":"Sica","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.bmc.2008.12.023_bib3a","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.HYP.33.4.1043","volume":"33","author":"Pickkers","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.bmc.2008.12.023_bib3b","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/01.pap.0000249938.05382.d0","volume":"14","author":"Padilla","year":"2007","journal-title":"Am. J. Ther."},{"key":"10.1016\/j.bmc.2008.12.023_bib3c","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrd2354","volume":"6","author":"Smith","year":"2007","journal-title":"Nat. Rev. Drug Discovery"},{"key":"10.1016\/j.bmc.2008.12.023_bib4a","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/107424840501000406","volume":"10","author":"Dell\u2019Omo","year":"2005","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.bmc.2008.12.023_bib4b","doi-asserted-by":"crossref","first-page":"15S","DOI":"10.1016\/j.amjhyper.2007.04.013","volume":"20","author":"Struijker-Boudier","year":"2007","journal-title":"Am. J. Hepertension"},{"key":"10.1016\/j.bmc.2008.12.023_bib5a","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1254\/jphs.SC0060222","volume":"103","author":"Nishioku","year":"2007","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bmc.2008.12.023_bib5b","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2165\/00129784-200707060-00004","volume":"7","author":"Smith","year":"2007","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"10.1016\/j.bmc.2008.12.023_bib6a","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2337\/dc07-1452","volume":"31","author":"Black","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bmc.2008.12.023_bib6b","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0378-4347(00)00103-1","volume":"740","author":"Herraez-Fernandez","year":"2000","journal-title":"J. Chromatogr., B"},{"key":"10.1016\/j.bmc.2008.12.023_bib7","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discovery"},{"key":"10.1016\/j.bmc.2008.12.023_bib8a","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1016\/j.bmcl.2008.03.051","volume":"18","author":"Temperini","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2008.12.023_bib8b","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1039\/b800767e","volume":"6","author":"Temperini","year":"2008","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bmc.2008.12.023_bib9","unstructured":"Temperini, C.; Cecchi, A.; Scozzafava, A.; Supuran, C.T. J. Med. Chem. 2009, in press."},{"key":"10.1016\/j.bmc.2008.12.023_bib10a","series-title":"Carbonic Anhydrase \u2013 Its Inhibitors and Activators","first-page":"1","author":"Supuran","year":"2004"},{"key":"10.1016\/j.bmc.2008.12.023_bib10b","doi-asserted-by":"crossref","first-page":"7697","DOI":"10.1002\/anie.200701189","volume":"46","author":"K\u00f6hler","year":"2007","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bmc.2008.12.023_bib11a","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/14756360410001689540","volume":"19","author":"Pastorekova","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2008.12.023_bib11b","series-title":"Carbonic anhydrase \u2013 Its inhibitors and activators","first-page":"67","author":"Supuran","year":"2004"},{"key":"10.1016\/j.bmc.2008.12.023_bib11c","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.tips.2006.09.002","volume":"27","author":"Thiry","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bmc.2008.12.023_bib12a","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2008.12.023_bib12b","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1517\/13543776.14.5.667","volume":"14","author":"Scozzafava","year":"2004","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmc.2008.12.023_bib12c","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2174\/138955706777934946","volume":"6","author":"Winum","year":"2006","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.bmc.2008.12.023_bib12d","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1517\/13543776.13.10.1545","volume":"13","author":"Supuran","year":"2003","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmc.2008.12.023_bib13","doi-asserted-by":"crossref","first-page":"6942","DOI":"10.1021\/ja802214x","volume":"130","author":"Aaron","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2008.12.023_bib14","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2174\/138161208783877956","volume":"14","author":"Thiry","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2008.12.023_bib15a","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1517\/14728214.13.2.383","volume":"13","author":"Supuran","year":"2008","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"10.1016\/j.bmc.2008.12.023_bib15b","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2174\/138161208783877820","volume":"14","author":"De Simone","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2008.12.023_bib16a","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.radonc.2007.04.018","volume":"83","author":"Dubois","year":"2007","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.bmc.2008.12.023_bib16b","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1021\/jm800121c","volume":"51","author":"D\u2019Ambrosio","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2008.12.023_bib16c","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1021\/jm701526d","volume":"51","author":"Thiry","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2008.12.023_bib17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bmcl.2007.10.110","volume":"18","author":"G\u00fczel","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2008.12.023_bib18","doi-asserted-by":"crossref","first-page":"7229","DOI":"10.1016\/j.bmc.2007.08.037","volume":"15","author":"Nishimori","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2008.12.023_bib19a","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1021\/jm031057+","volume":"47","author":"Vullo","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2008.12.023_bib19b","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1021\/jm050483n","volume":"48","author":"Nishimori","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2008.12.023_bib20","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.bmcl.2004.12.052","volume":"15","author":"Vullo","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2008.12.023_bib21a","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1016\/j.bmcl.2005.06.055","volume":"15","author":"Nishimori","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2008.12.023_bib21b","doi-asserted-by":"crossref","first-page":"6089","DOI":"10.1016\/j.bmc.2005.06.022","volume":"13","author":"Ozensoy","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2008.12.023_bib22","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.bmcl.2004.12.053","volume":"15","author":"Vullo","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2008.12.023_bib23","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2008.12.023_bib24","unstructured":"Leslie, A.G.W. MOSFLM users guide, MRC-LMB, 1994, Cambridge, UK."},{"key":"10.1016\/j.bmc.2008.12.023_bib25","doi-asserted-by":"crossref","unstructured":"Collaborative Computational Project, Number 4. The CCP4 Suite: Programs for Protein Crystallography. Acta Crystallogr., Sect. D. 1994, 50, 760.","DOI":"10.1107\/S0907444994003112"},{"key":"10.1016\/j.bmc.2008.12.023_bib26","doi-asserted-by":"crossref","unstructured":"Brunger, A. T.; Adams, P. D.; Clore, G. M.; Delano, W. L.; Gros, P.; Grosse-Kunsteleve, R. W.; Fiang, J.; Kuszewsky, J.; Niles, M.; Pannu, N. S.; Read, R. J.; Rice, L. M.; Simmonson T.; Warren, G. L. Acta Crystallogr., Sect. D. 1998, 54, 905.","DOI":"10.1107\/S0907444998003254"},{"key":"10.1016\/j.bmc.2008.12.023_bib27","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","volume":"47","author":"Jones","year":"1991","journal-title":"Acta Crystallogr., Sect. A"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089608011917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089608011917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:30:33Z","timestamp":1760830233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089608011917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0968089608011917"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2008.12.023","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2008.12.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}