{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:35:31Z","timestamp":1772130931535,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.bmc.2009.07.069","type":"journal-article","created":{"date-parts":[[2009,8,7]],"date-time":"2009-08-07T05:51:52Z","timestamp":1249624312000},"page":"6671-6681","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation"],"prefix":"10.1016","volume":"17","author":[{"given":"Senait","family":"Ghirmai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc R.","family":"Azar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Cashman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2009.07.069_bib1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1360-0443.2004.00763.x","volume":"99","author":"Bouza","year":"2004","journal-title":"Addiction"},{"key":"10.1016\/j.bmc.2009.07.069_bib2","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1176\/ajp.156.11.1758","volume":"156","author":"Anton","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bmc.2009.07.069_bib3","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1001\/archpsyc.1997.01830240090013","volume":"54","author":"Croop","year":"1997","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bmc.2009.07.069_bib4","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1001\/archpsyc.56.8.719","volume":"56","author":"Mason","year":"1999","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bmc.2009.07.069_bib5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0024-3205(83)90031-0","volume":"32","author":"Tabakoff","year":"1983","journal-title":"Life Sci."},{"key":"10.1016\/j.bmc.2009.07.069_bib6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1369-1600.2006.00036.x","volume":"11","author":"Oslin","year":"2006","journal-title":"Addict. Biol."},{"key":"10.1016\/j.bmc.2009.07.069_bib7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.euroneuro.2005.11.001","volume":"16","author":"Roozen","year":"2006","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.bmc.2009.07.069_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0006-8993(93)90309-B","volume":"621","author":"Benjamin","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.bmc.2009.07.069_bib9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0741-8329(00)00137-3","volume":"23","author":"Stromberg","year":"2001","journal-title":"Alcohol"},{"key":"10.1016\/j.bmc.2009.07.069_bib10","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/sj.npp.1300928","volume":"31","author":"Pastor","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bmc.2009.07.069_bib11","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1093\/ajcn\/42.5.1099","volume":"42","author":"Reid","year":"1985","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bmc.2009.07.069_bib12","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0149-7634(02)00041-6","volume":"26","author":"Yeomans","year":"2002","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bmc.2009.07.069_bib13","first-page":"1699","volume":"21","author":"Grisel","year":"1995","journal-title":"Soc. Neurosci. Abstr."},{"key":"10.1016\/j.bmc.2009.07.069_bib14","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1001\/archpsyc.1996.01830030072011","volume":"53","author":"Gianoulakis","year":"1996","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bmc.2009.07.069_bib15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s002130050169","volume":"129","author":"Herz","year":"1997","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bmc.2009.07.069_bib16","first-page":"5","volume":"56","author":"Ulm","year":"1995","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.bmc.2009.07.069_bib17","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1021\/jm801272c","volume":"52","author":"Li","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2009.07.069_bib18","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1021\/jm701060e","volume":"51","author":"Ghirmai","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2009.07.069_bib19","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1021\/jo00351a025","volume":"51","author":"Mohamed","year":"1986","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2009.07.069_bib20","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S0026-895X(25)08634-1","volume":"47","author":"Traynor","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bmc.2009.07.069_bib21","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.3109\/03602538409033560","volume":"15","author":"Tullman","year":"1984","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.bmc.2009.07.069_bib22","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/S0021-9258(18)94132-3","volume":"264","author":"Bondon","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2009.07.069_bib23","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.bcp.2003.10.022","volume":"67","author":"Denton","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bmc.2009.07.069_bib24","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.1021\/jm049554t","volume":"47","author":"MacDougall","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2009.07.069_bib25","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/j.1530-0277.1997.tb03840.x","volume":"21","author":"Heyser","year":"1997","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.bmc.2009.07.069_bib26","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1111\/j.1530-0277.1999.tb04669.x","volume":"23","author":"Heyser","year":"1999","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.bmc.2009.07.069_bib27","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/sj.npp.1300175","volume":"28","author":"Heyser","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bmc.2009.07.069_bib28","first-page":"2174","volume":"22","author":"June","year":"1998","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.bmc.2009.07.069_bib29","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S0022-3565(24)39326-7","volume":"293","author":"Roberts","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2009.07.069_bib30","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s002130051069","volume":"145","author":"Holter","year":"1999","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bmc.2009.07.069_bib31","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/sj.npp.1301438","volume":"33","author":"Walker","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bmc.2009.07.069_bib32","series-title":"Mechanism and Theory in Organic Chemistry","author":"Lowry","year":"1987"},{"key":"10.1016\/j.bmc.2009.07.069_bib33","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2174\/1568026054367647","volume":"5","author":"Cashman","year":"2005","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2009.07.069_bib34","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1021\/jm0000665","volume":"43","author":"Stevens","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2009.07.069_bib35","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/03602530600959466","volume":"38","author":"Doss","year":"2006","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.bmc.2009.07.069_bib36","first-page":"1001","volume":"25","author":"Brunelle","year":"1997","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bmc.2009.07.069_bib37","first-page":"10017","volume":"256","author":"Roth","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2009.07.069_bib38","doi-asserted-by":"crossref","first-page":"6987","DOI":"10.1021\/jm060519r","volume":"49","author":"Yano","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2009.07.069_bib39","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0741-8329(93)90091-2","volume":"10","author":"Rassnick","year":"1993","journal-title":"Alcohol"},{"key":"10.1016\/j.bmc.2009.07.069_bib40","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1016\/0006-2952(73)90196-2","volume":"22","author":"Cheng","year":"1973","journal-title":"Biochem. Pharmacol."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089609007287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089609007287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:38:18Z","timestamp":1760830698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089609007287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":40,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0968089609007287"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2009.07.069","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and pharmacological evaluation of 6-naltrexamine analogs for alcohol cessation","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2009.07.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}