{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:18:51Z","timestamp":1787239131356,"version":"build-2736575974"},"reference-count":23,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.bmc.2009.08.061","type":"journal-article","created":{"date-parts":[[2009,9,5]],"date-time":"2009-09-05T05:11:43Z","timestamp":1252127503000},"page":"7126-7130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Natural product leads for drug discovery: Isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents"],"prefix":"10.1016","volume":"17","author":[{"given":"Songpo","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh K.","family":"Tipparaju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Pegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojie","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunyan","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Orjala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Mesecar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott G.","family":"Franzblau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan P.","family":"Kozikowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2009.08.061_bib1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.7164\/antibiotics.30.275","volume":"30","author":"Omura","year":"1977","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bmc.2009.08.061_bib2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/anie.198004591","volume":"19","author":"Steglich","year":"1980","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"10.1016\/j.bmc.2009.08.061_bib3","doi-asserted-by":"crossref","first-page":"668","DOI":"10.7164\/antibiotics.40.668","volume":"40","author":"Bush","year":"1987","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bmc.2009.08.061_bib4","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1039\/B601930G","volume":"23","author":"Sanchez","year":"2006","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bmc.2009.08.061_bib5","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.7164\/antibiotics.43.1236","volume":"43","author":"Knubel","year":"1990","journal-title":"J. Antibiot."},{"key":"10.1016\/j.bmc.2009.08.061_bib6a","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1002\/cmdc.200800047","volume":"3","author":"Tipparaju","year":"2008","journal-title":"Chem. Med. Chem."},{"key":"10.1016\/j.bmc.2009.08.061_bib6b","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1016\/j.bmcl.2008.05.004","volume":"18","author":"Tipparaju","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2009.08.061_bib7","doi-asserted-by":"crossref","first-page":"7344","DOI":"10.1021\/jm801241n","volume":"51","author":"Tipparaju","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2009.08.061_bib8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1124\/mol.55.2.377","volume":"55","author":"Bailly","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bmc.2009.08.061_bib9","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1021\/jm0493764","volume":"48","author":"Zhang","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2009.08.061_bib10","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1021\/cr020059j","volume":"102","author":"Knolker","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmc.2009.08.061_bib11","doi-asserted-by":"crossref","first-page":"9159","DOI":"10.1016\/j.tet.2008.06.101","volume":"64","author":"Janosik","year":"2008","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2009.08.061_bib12a","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3987\/COM-04-S(P)29","volume":"64","author":"Somei","year":"2004","journal-title":"Heterocycles"},{"key":"10.1016\/j.bmc.2009.08.061_bib12b","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3987\/COM-99-8531","volume":"51","author":"Hayashi","year":"1999","journal-title":"Heterocycles"},{"key":"10.1016\/j.bmc.2009.08.061_bib12c","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.3987\/COM-97-7848","volume":"45","author":"Hayashi","year":"1997","journal-title":"Heterocycles"},{"key":"10.1016\/j.bmc.2009.08.061_bib12d","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3987\/COM-95-S4","volume":"44","author":"Somei","year":"1997","journal-title":"Heterocycles"},{"key":"10.1016\/j.bmc.2009.08.061_bib12e","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.3987\/COM-95-7192","volume":"41","author":"Somei","year":"1995","journal-title":"Heterocycles"},{"key":"10.1016\/j.bmc.2009.08.061_bib13","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1021\/ol049780x","volume":"6","author":"Cai","year":"2004","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmc.2009.08.061_bib14a","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/cber.19240570212","volume":"57","author":"Madelung","year":"1924","journal-title":"Ber. Dtsch. Chem. Ges."},{"key":"10.1016\/j.bmc.2009.08.061_bib14b","first-page":"193","volume":"19","author":"Bergman","year":"1982","journal-title":"Chemica Scripta"},{"key":"10.1016\/j.bmc.2009.08.061_bib14c","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1021\/ar00173a006","volume":"23","author":"McGovern","year":"1990","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bmc.2009.08.061_bib15","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1021\/jo062184r","volume":"72","author":"Wada","year":"2007","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2009.08.061_bib16","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1128\/AAC.41.5.1004","volume":"41","author":"Collins","year":"1997","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089609008359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089609008359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:39:45Z","timestamp":1760830785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089609008359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":23,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0968089609008359"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2009.08.061","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural product leads for drug discovery: Isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2009.08.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}