{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:53:29Z","timestamp":1765806809582,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,9,24]],"date-time":"2011-09-24T00:00:00Z","timestamp":1316822400000},"content-version":"vor","delay-in-days":692,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.bmc.2009.09.031","type":"journal-article","created":{"date-parts":[[2009,9,25]],"date-time":"2009-09-25T12:43:37Z","timestamp":1253882617000},"page":"7429-7434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Synthesis, biological, and theoretical evaluations of new 1,2,3-triazoles against the hemolytic profile of the Lachesis muta snake venom"],"prefix":"10.1016","volume":"17","author":[{"given":"Vin\u00edcius R.","family":"Campos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula A.","family":"Abreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena C.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos R.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro K.","family":"Jord\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitor F.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.B.V.","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda da C.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura A.","family":"Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaisa S.","family":"Domingos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u00e1dio F.","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 L.","family":"Fuly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna C.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2009.09.031_bib1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.toxicon.2007.04.008","volume":"50","author":"Fuly","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.bmc.2009.09.031_bib2","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0041-0101(99)00208-1","volume":"38","author":"Fuly","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.bmc.2009.09.031_bib3","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0041-0101(00)00201-4","volume":"39","author":"Colombini","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.bmc.2009.09.031_bib4","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.toxicon.2004.12.006","volume":"45","author":"Stephano","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.bmc.2009.09.031_bib5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.toxicon.2008.10.016","volume":"53","author":"Ferreira","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.bmc.2009.09.031_bib6","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.biochi.2008.05.009","volume":"90","author":"Oliveira","year":"2008","journal-title":"Biochimie"},{"key":"10.1016\/j.bmc.2009.09.031_bib7","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1016\/j.bmcl.2004.05.012","volume":"14","author":"Basappa","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2009.09.031_bib8","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.toxicon.2007.07.025","volume":"50","author":"Punger\u010dar","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.bmc.2009.09.031_bib9","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.toxicon.2006.11.014","volume":"49","author":"Damico","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.bmc.2009.09.031_bib10","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.toxicon.2005.02.030","volume":"45","author":"White","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.bmc.2009.09.031_bib11","first-page":"315","volume":"86","author":"Cardoso","year":"1993","journal-title":"Quart. J. Med."},{"key":"10.1016\/j.bmc.2009.09.031_bib12","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.bmcl.2003.10.044","volume":"14","author":"da Silva","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2009.09.031_bib13","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0031-9422(00)00229-6","volume":"55","author":"Mors","year":"2000","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2009.09.031_bib14","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1080\/08923970802279019","volume":"30","author":"S\u00e1nchez","year":"2008","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.bmc.2009.09.031_bib15","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.toxicon.2007.09.009","volume":"51","author":"Souza","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.bmc.2009.09.031_bib16","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.toxicon.2005.04.023","volume":"46","author":"Ticli","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.bmc.2009.09.031_bib17","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jmb.2005.04.072","volume":"350","author":"Murakami","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmc.2009.09.031_bib18","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.toxicon.2007.01.002","volume":"49","author":"Fernandes","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.bmc.2009.09.031_bib19","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bbapap.2004.08.009","volume":"1703","author":"Murakami","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmc.2009.09.031_bib20","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1016\/j.bmcl.2005.06.012","volume":"15","author":"Khanum","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2009.09.031_bib21","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/S0968-0896(03)00055-5","volume":"11","author":"Cunha","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2009.09.031_bib22","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1016\/S0968-0896(03)00487-5","volume":"11","author":"Menegatti","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2009.09.031_bib23","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.ejmech.2007.10.015","volume":"43","author":"Da Silva","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2009.09.031_bib24","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1590\/S0103-50532007000600027","volume":"18","author":"Gallardo","year":"2007","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.bmc.2009.09.031_bib25","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.ejmech.2007.02.020","volume":"42","author":"Ferreira","year":"2007","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2009.09.031_bib26","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1016\/j.bmc.2009.03.053","volume":"17","author":"Jord\u00e3o","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2009.09.031_bib27","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1021\/jo00293a053","volume":"55","author":"Danheiser","year":"1990","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2009.09.031_bib28","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1021\/jo01110a013","volume":"21","author":"Audrieth","year":"1956","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2009.09.031_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","volume":"23","author":"Lipinski","year":"1997","journal-title":"Adv. Drug Delivery Rev."},{"key":"10.1016\/j.bmc.2009.09.031_bib30","first-page":"459","volume":"26","author":"Fuly","year":"1993","journal-title":"Braz. J. Med. Biol Res."},{"key":"10.1016\/j.bmc.2009.09.031_bib31","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/S0006-2952(02)00873-0","volume":"63","author":"Fuly","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bmc.2009.09.031_bib32","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/(SICI)1096-987X(199905)20:7<720::AID-JCC7>3.0.CO;2-X","volume":"20","author":"Halgren","year":"1999","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bmc.2009.09.031_bib33","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/jcc.20425","volume":"27","author":"Rocha","year":"2006","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bmc.2009.09.031_bib34","first-page":"661","volume":"86","author":"Davidson","year":"1988","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmc.2009.09.031_bib35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ejmech.2008.02.047","volume":"44","author":"Da Silva","year":"2009","journal-title":"Eur. J. Med. Chem."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089609008839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089609008839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:37:51Z","timestamp":1760830671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089609008839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":35,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0968089609008839"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2009.09.031","relation":{},"ISSN":["0968-0896"],"issn-type":[{"type":"print","value":"0968-0896"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis, biological, and theoretical evaluations of new 1,2,3-triazoles against the hemolytic profile of the Lachesis muta snake venom","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2009.09.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}