{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:19:54Z","timestamp":1780377594319,"version":"3.54.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.bmc.2009.11.021","type":"journal-article","created":{"date-parts":[[2009,11,21]],"date-time":"2009-11-21T07:19:54Z","timestamp":1258787994000},"page":"14-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library"],"prefix":"10.1016","volume":"18","author":[{"given":"Rohan A.","family":"Davis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Innocenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally-Ann","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2009.11.021_bib1a","series-title":"Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications","first-page":"15","article-title":"Carbonic Anhydrases as Drug Targets\u2014General Presentation","author":"Supuran","year":"2009"},{"key":"10.1016\/j.bmc.2009.11.021_bib1b","series-title":"Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications","first-page":"73","article-title":"X-ray Crystallography of CA Inhibitors and its Importance in Drug Design","author":"Alterio","year":"2009"},{"key":"10.1016\/j.bmc.2009.11.021_bib2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2009.11.021_bib3a","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/med.20112","volume":"28","author":"Winum","year":"2008","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2009.11.021_bib3b","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2009.11.021_bib4a","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.1523\/JNEUROSCI.0036-09.2009","volume":"29","author":"Svichar","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bmc.2009.11.021_bib4b","doi-asserted-by":"crossref","first-page":"16771","DOI":"10.1073\/pnas.0508449102","volume":"102","author":"Shah","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2009.11.021_bib5a","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2174\/138161208783877893","volume":"14","author":"Pastorekova","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2009.11.021_bib5b","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.tips.2006.09.002","volume":"27","author":"Thiry","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bmc.2009.11.021_bib5c","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.febslet.2004.10.043","volume":"577","author":"Svastova","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmc.2009.11.021_bib5d","doi-asserted-by":"crossref","first-page":"8329","DOI":"10.1021\/ja061574s","volume":"128","author":"Alterio","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2009.11.021_bib5e","doi-asserted-by":"crossref","first-page":"16130","DOI":"10.1021\/ja805558k","volume":"130","author":"Stiti","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2009.11.021_bib6a","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/1087057108315739","volume":"13","author":"Vu","year":"2008","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.bmc.2009.11.021_bib6b","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/ja809683v","volume":"131","author":"Maresca","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2009.11.021_bib7","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1021\/ja00087a086","volume":"116","author":"Nair","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2009.11.021_bib8a","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.bmcl.2008.01.077","volume":"18","author":"Innocenti","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2009.11.021_bib8b","doi-asserted-by":"crossref","first-page":"7424","DOI":"10.1016\/j.bmc.2008.06.013","volume":"16","author":"Innocenti","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2009.11.021_bib8c","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1016\/j.bmcl.2008.04.077","volume":"18","author":"Innocenti","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2009.11.021_bib8d","doi-asserted-by":"crossref","first-page":"9101","DOI":"10.1016\/j.bmc.2008.09.028","volume":"16","author":"Bayram","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2009.11.021_bib8e","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1016\/j.bmc.2009.01.067","volume":"17","author":"\u015eent\u00fcrk","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2009.11.021_bib9a","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s11745-004-1351-y","volume":"39","author":"Wahle","year":"2004","journal-title":"Lipids"},{"key":"10.1016\/j.bmc.2009.11.021_bib9b","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.2174\/092986708785908996","volume":"15","author":"Fu","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2009.11.021_bib10","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.tetlet.2004.12.057","volume":"46","author":"Davis","year":"2005","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2009.11.021_bib11","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.bmc.2005.08.030","volume":"14","author":"Poulsen","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2009.11.021_bib12","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1021\/np050025h","volume":"68","author":"Davis","year":"2005","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bmc.2009.11.021_bib13","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.tetlet.2008.12.010","volume":"50","author":"Davis","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2009.11.021_bib14","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1016\/j.phytochem.2004.07.019","volume":"65","author":"Healy","year":"2004","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2009.11.021_bib15","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1021\/np070073x","volume":"70","author":"Davis","year":"2007","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.bmc.2009.11.021_bib16","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.bmc.2008.12.030","volume":"17","author":"Davis","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2009.11.021_bib17","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/mrc.1984","volume":"45","author":"Davis","year":"2007","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.bmc.2009.11.021_bib18a","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1002\/anie.200803437","volume":"48","author":"Kumar","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bmc.2009.11.021_bib18b","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1016\/j.bmc.2008.11.001","volume":"17","author":"Wilk","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2009.11.021_bib18c","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1039\/b704729k","volume":"37","author":"H\u00fcbel","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bmc.2009.11.021_bib19a","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1517\/13543776.13.10.1545","volume":"13","author":"Supuran","year":"2003","journal-title":"Expert Opin. Ther. Patents"},{"key":"10.1016\/j.bmc.2009.11.021_bib19b","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2174\/156802607780636762","volume":"7","author":"De Simone","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2009.11.021_bib19c","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2174\/138161208783877820","volume":"14","author":"De Simone","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2009.11.021_bib20a","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1042\/bj3100197","volume":"310","author":"Lynch","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmc.2009.11.021_bib20b","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1096\/fasebj.10.4.8647347","volume":"10","author":"Hazen","year":"1996","journal-title":"FASEB J."},{"key":"10.1016\/j.bmc.2009.11.021_bib21","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2009.11.021_bib22","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1021\/jm050483n","volume":"48","author":"Nishimori","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2009.11.021_bib23","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0960-894X(03)00029-5","volume":"13","author":"Casini","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2009.11.021_bib24","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.bmcl.2005.03.032","volume":"15","author":"De Simone","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2009.11.021_bib25","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1016\/j.bmc.2007.04.020","volume":"15","author":"Supuran","year":"2007","journal-title":"Bioorg. Med. Chem."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089609010293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089609010293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:41:38Z","timestamp":1760830898000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089609010293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0968089609010293"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2009.11.021","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2009.11.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}