{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T03:36:22Z","timestamp":1772508982476,"version":"3.50.1"},"reference-count":65,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.bmc.2010.03.026","type":"journal-article","created":{"date-parts":[[2010,3,16]],"date-time":"2010-03-16T04:38:48Z","timestamp":1268714328000},"page":"2822-2828","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Nanoscale enzyme inhibitors: Fullerenes inhibit carbonic anhydrase by occluding the active site entrance"],"prefix":"10.1016","volume":"18","author":[{"given":"Alessio","family":"Innocenti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"Durdagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadjmeh","family":"Doostdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Amanda Strom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew R.","family":"Barron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2010.03.026_bib1a","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.ejmech.2003.09.005","volume":"38","author":"Bosi","year":"2003","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.026_bib1b","first-page":"805","volume":"4","author":"Pantarotto","year":"2004","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.026_bib1c","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1021\/cr800441b","volume":"109","author":"S\u00e1nchez","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmc.2010.03.026_bib2a","doi-asserted-by":"crossref","first-page":"6506","DOI":"10.1021\/ja00068a005","volume":"115","author":"Sijbesma","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2010.03.026_bib2b","doi-asserted-by":"crossref","first-page":"6510","DOI":"10.1021\/ja00068a006","volume":"115","author":"Sijbesma","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2010.03.026_bib2c","first-page":"41","volume":"54","author":"Nosik","year":"2009","journal-title":"Vopr. Virusol."},{"key":"10.1016\/j.bmc.2010.03.026_bib3a","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1021\/ci900047s","volume":"49","author":"Durdagi","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmc.2010.03.026_bib3b","doi-asserted-by":"crossref","first-page":"9957","DOI":"10.1016\/j.bmc.2008.10.039","volume":"16","author":"Durdagi","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.026_bib4a","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1002\/smll.200801820","volume":"5","author":"Kang","year":"2009","journal-title":"Small"},{"key":"10.1016\/j.bmc.2010.03.026_bib4b","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1021\/nn900318y","volume":"3","author":"Chaudhuri","year":"2009","journal-title":"ACS Nano"},{"key":"10.1016\/j.bmc.2010.03.026_bib4c","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1039\/b711141j","volume":"6","author":"Mroz","year":"2007","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.bmc.2010.03.026_bib5a","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1016\/j.bmcl.2009.07.149","volume":"19","author":"Kato","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2010.03.026_bib5b","doi-asserted-by":"crossref","first-page":"5902","DOI":"10.1016\/j.bmcl.2009.08.067","volume":"19","author":"Horie","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2010.03.026_bib6a","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2147\/IJN.S7653","volume":"4","author":"Yudoh","year":"2009","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bmc.2010.03.026_bib6b","first-page":"261","volume":"4","author":"Partha","year":"2009","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bmc.2010.03.026_bib6c","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1002\/art.22917","volume":"56","author":"Yudoh","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bmc.2010.03.026_bib7","first-page":"4107","volume":"29","author":"Ting","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bmc.2010.03.026_bib8","doi-asserted-by":"crossref","first-page":"074001","DOI":"10.1115\/1.3156800","volume":"131","author":"Day","year":"2009","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.bmc.2010.03.026_bib9","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1039\/b806051g","volume":"38","author":"Boisselier","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bmc.2010.03.026_bib10","first-page":"229","volume":"1","author":"Green","year":"2006","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bmc.2010.03.026_bib11a","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.2174\/138161209788923886","volume":"15","author":"Wadhwa","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2010.03.026_bib11b","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1517\/17425240903300857","volume":"6","author":"Losic","year":"2009","journal-title":"Expert Opin. Drug Delivery."},{"key":"10.1016\/j.bmc.2010.03.026_bib12a","first-page":"1949","volume":"6","author":"Goren","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bmc.2010.03.026_bib12b","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2165\/00003495-199700544-00006","volume":"54","author":"Muggia","year":"1997","journal-title":"Drugs"},{"key":"10.1016\/j.bmc.2010.03.026_bib13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2010.03.026_bib14_1","series-title":"Drug Design of Zinc\u2013Enzyme Inhibitors: Functional, Structural, and Disease Applications","first-page":"15","article-title":"Carbonic Anhydrases as Drug Targets\u2014General Presentation","author":"Supuran","year":"2009"},{"key":"10.1016\/j.bmc.2010.03.026_bib14b","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/med.20112","volume":"28","author":"Winum","year":"2008","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2010.03.026_bib14c","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2010.03.026_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14756360902784425","volume":"24","author":"Ebbesen","year":"2009","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.026_bib16a","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2174\/138161208783877947","volume":"14","author":"Supuran","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2010.03.026_bib16b","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1517\/14728214.13.2.383","volume":"13","author":"Supuran","year":"2008","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"10.1016\/j.bmc.2010.03.026_bib16c","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2174\/138161208783877820","volume":"14","author":"De Simone","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2010.03.026_bib16_4","series-title":"Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications","first-page":"139","article-title":"Antiglaucoma Carbonic Anhydrase Inhibitors as Ophthalomologic Drugs","author":"Mincione","year":"2009"},{"key":"10.1016\/j.bmc.2010.03.026_bib17a","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.tips.2006.09.002","volume":"27","author":"Thiry","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bmc.2010.03.026_bib17b","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.febslet.2004.10.043","volume":"577","author":"Svastova","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmc.2010.03.026_bib18a","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/14756360410001689540","volume":"19","author":"Pastorekova","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.026_bib18b","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1021\/jm801267c","volume":"52","author":"Hilvo","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.026_bib19_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s004180000181","volume":"114","author":"Kivel\u00e4","year":"2000","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.bmc.2010.03.026_bib19b","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1042\/bse0430165","volume":"43","author":"Brahimi-Horn","year":"2007","journal-title":"Essays Biochem."},{"key":"10.1016\/j.bmc.2010.03.026_bib19c","doi-asserted-by":"crossref","first-page":"20473","DOI":"10.1074\/jbc.M801330200","volume":"283","author":"Swietach","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2010.03.026_bib20","doi-asserted-by":"crossref","first-page":"16130","DOI":"10.1021\/ja805558k","volume":"130","author":"Stiti","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2010.03.026_bib21_1","series-title":"Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications","first-page":"73","article-title":"X-ray Crystallography of CA Inhibitors and its Importance in Drug Design","author":"Alterio","year":"2009"},{"key":"10.1016\/j.bmc.2010.03.026_bib21b","doi-asserted-by":"crossref","first-page":"8329","DOI":"10.1021\/ja061574s","volume":"128","author":"Alterio","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2010.03.026_bib22a","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/ja809683v","volume":"131","author":"Maresca","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2010.03.026_bib22b","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/jm901287j","volume":"53","author":"Maresca","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.026_bib23","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1021\/bc050299g","volume":"17","author":"Benyamini","year":"2006","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.bmc.2010.03.026_bib24a","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1039\/b411118d","author":"Yang","year":"2004","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bmc.2010.03.026_bib24b","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1002\/chem.200601186","volume":"13","author":"Yang","year":"2007","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.bmc.2010.03.026_bib24c","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1039\/B614298B","volume":"5","author":"Yang","year":"2007","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bmc.2010.03.026_bib25","doi-asserted-by":"crossref","first-page":"16233","DOI":"10.1073\/pnas.0908301106","volume":"106","author":"Alterio","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2010.03.026_bib26a","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1016\/j.bmcl.2008.03.051","volume":"18","author":"Temperini","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2010.03.026_bib26b","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1021\/jm050333c","volume":"48","author":"Menchise","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.026_bib26_3","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1021\/jm800121c","volume":"51","author":"D\u2019Ambrosio","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.026_bib26d","doi-asserted-by":"crossref","first-page":"13998","DOI":"10.1021\/jp906593c","volume":"113","author":"Ciani","year":"2009","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.bmc.2010.03.026_bib27a","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/jps.2600830603","volume":"83","author":"Clare","year":"1994","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bmc.2010.03.026_bib27b","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1021\/jm0603320","volume":"49","author":"Temperini","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.026_bib28a","doi-asserted-by":"crossref","first-page":"10384","DOI":"10.1021\/bi970760v","volume":"36","author":"Briganti","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2010.03.026_bib28b","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1016\/j.bmcl.2005.08.069","volume":"15","author":"Temperini","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2010.03.026_bib28c","doi-asserted-by":"crossref","first-page":"7057","DOI":"10.1002\/chem.200600159","volume":"12","author":"Temperini","year":"2006","journal-title":"Chemistry"},{"key":"10.1016\/j.bmc.2010.03.026_bib28d","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.bmcl.2006.11.027","volume":"17","author":"Temperini","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2010.03.026_bib28e","doi-asserted-by":"crossref","first-page":"8373","DOI":"10.1016\/j.bmc.2008.08.043","volume":"16","author":"Temperini","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.026_bib29","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2010.03.026_bib30","unstructured":"Schrodinger Suite, Schrodinger, LLC, New York, USA, 2007, (web page: www.schrodinger.com)."},{"key":"10.1016\/j.bmc.2010.03.026_bib31a","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1021\/jm050540c","volume":"49","author":"Sherman","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.026_bib31b","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jm051256o","volume":"49","author":"Friesner","year":"2006","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089610002300?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089610002300?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:42:15Z","timestamp":1760830935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089610002300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":65,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0968089610002300"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2010.03.026","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanoscale enzyme inhibitors: Fullerenes inhibit carbonic anhydrase by occluding the active site entrance","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2010.03.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}