{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T02:42:24Z","timestamp":1768272144310,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.bmc.2010.03.058","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T13:47:13Z","timestamp":1269956833000},"page":"3551-3558","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles"],"prefix":"10.1016","volume":"18","author":[{"given":"Danuta","family":"Branowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelbasset A.","family":"Farahat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Wenzler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reto","family":"Brun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. David","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Boykin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2010.03.058_bib1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.pt.2003.09.010","volume":"19","author":"Watkins","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.bmc.2010.03.058_bib2","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/415686a","volume":"414","author":"Ridley","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2010.03.058_bib3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/ardp.200700184","volume":"341","author":"Schlitzer","year":"2008","journal-title":"Arch. Pharm. Chem. Life Sci."},{"key":"10.1016\/j.bmc.2010.03.058_bib4","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/sj.bjp.0707354","volume":"152","author":"Barrett","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bmc.2010.03.058_bib5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0065-308X(06)63002-9","volume":"63","author":"Barrett","year":"2006","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.bmc.2010.03.058_bib6a","first-page":"414","article-title":"Dicationic DNA Minor Groove Binders as Antimicrobial Agents","volume":"Vol. 2","author":"Tidwell","year":"2003"},{"key":"10.1016\/j.bmc.2010.03.058_bib6b","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2174\/1568011054222319","volume":"5","author":"Wilson","year":"2005","journal-title":"Curr. Med. Chem. Anticancer Agents"},{"key":"10.1016\/j.bmc.2010.03.058_bib6c","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1517\/13543784.14.8.957","volume":"14","author":"Soeiro","year":"2005","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.bmc.2010.03.058_bib6d","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1517\/13543776.15.9.1241","volume":"15","author":"Dardonville","year":"2005","journal-title":"Expert Ther. Patents"},{"key":"10.1016\/j.bmc.2010.03.058_bib6e","first-page":"147","volume":"7","author":"Werbovetz","year":"2006","journal-title":"Curr. Opin. Invest. Drugs"},{"key":"10.1016\/j.bmc.2010.03.058_bib7a","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.pt.2003.09.002","volume":"19","author":"Fairlamb","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.bmc.2010.03.058_bib7b","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1046\/j.1472-8206.2003.00167.x","volume":"17","author":"Bouteille","year":"2003","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.bmc.2010.03.058_bib7_3","unstructured":"Yeramian, P. D.; Castagnini, L. A.; Allen, J. A.; Umesh, L.; Gotuzzo, E. Efficacy and Safety of DB289, a New Oral Drug for Treatment of Pneumocystis carinii pneumonia (PCP) in AIDS Patients. Presented at the 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy Meeting, September 14\u201317, 2003, Chicago, IL."},{"key":"10.1016\/j.bmc.2010.03.058_bib7d","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1128\/AAC.00225-09","volume":"53","author":"Wenzler","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2010.03.058_bib8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1086\/430928","volume":"192","author":"Yeramian","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bmc.2010.03.058_bib9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/00498250500087671","volume":"35","author":"Ansede","year":"2005","journal-title":"Xenobiotica"},{"key":"10.1016\/j.bmc.2010.03.058_bib10","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1021\/jm0302602","volume":"46","author":"Ismail","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.058_bib11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/jlac.197519750115","author":"Dann","year":"1975","journal-title":"Liebigs Ann. Chem."},{"key":"10.1016\/j.bmc.2010.03.058_bib12","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1021\/jm00219a023","volume":"20","author":"Das","year":"1977","journal-title":"J. Med.Chem."},{"key":"10.1016\/j.bmc.2010.03.058_bib13","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1021\/jm00179a022","volume":"23","author":"Das","year":"1980","journal-title":"J. Med.Chem."},{"key":"10.1016\/j.bmc.2010.03.058_bib14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0223-5234(96)88214-6","volume":"30","author":"Kumar","year":"1995","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.058_bib15a","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/0223-5234(96)83970-5","volume":"31","author":"Kumar","year":"1996","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.058_bib15b","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0223-5234(97)89640-7","volume":"32","author":"Boykin","year":"1997","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.058_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0000440","volume":"3","author":"Nwaka","year":"2009","journal-title":"PLOS Neg. Trop. Dis."},{"key":"10.1016\/j.bmc.2010.03.058_bib17","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1016\/S0960-894X(96)00557-4","volume":"6","author":"Boykin","year":"1996","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2010.03.058_bib18","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.2174\/138161208784139675","volume":"14","author":"Fylaktaidou","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2010.03.058_bib19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1515\/HC.1999.5.4.301","volume":"5","author":"Kumar","year":"1999","journal-title":"Heterocycl. Commun."},{"key":"10.1016\/j.bmc.2010.03.058_bib20","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.3987\/COM-03-9747","volume":"60","author":"Batistia-Parra","year":"2003","journal-title":"Heterocycles"},{"key":"10.1016\/j.bmc.2010.03.058_bib21","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.1021\/jm060470p","volume":"49","author":"Ismail","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.058_bib22","doi-asserted-by":"crossref","first-page":"7434","DOI":"10.1016\/j.bmc.2006.07.024","volume":"14","author":"Chackal-Catoen","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.058_bib23","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1055\/s-1986-31766","author":"Dondoni","year":"1986","journal-title":"Synthesis"},{"key":"10.1016\/j.bmc.2010.03.058_bib24","doi-asserted-by":"crossref","first-page":"13659","DOI":"10.1021\/ja048175m","volume":"126","author":"Mallena","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2010.03.058_bib25","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1021\/ja00121a034","volume":"117","author":"Czarny","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2010.03.058_bib26","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.biochi.2008.02.017","volume":"90","author":"Wilson","year":"2008","journal-title":"Biochimie"},{"key":"10.1016\/j.bmc.2010.03.058_bib27_1","series-title":"Circular Dichroism and Linear Dichroism","author":"Rodger","year":"1997"},{"key":"10.1016\/j.bmc.2010.03.058_bib27b","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/bip.360320910","volume":"32","author":"Lyng","year":"1992","journal-title":"Biopolymers"},{"key":"10.1016\/j.bmc.2010.03.058_bib28","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1021\/jm7013088","volume":"51","author":"Rodriguez","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.03.058_bib29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.actatropica.2008.07.006","volume":"108","author":"Thuita","year":"2008","journal-title":"Acta Trop."},{"key":"10.1016\/j.bmc.2010.03.058_bib30","doi-asserted-by":"crossref","unstructured":"W.D. Wilson, F.A. Tanious, M. Fernandez-Saiz, C.T. Rigl, Evaluation of Drug\u2013Nucleic Acid Interactions by Thermal Melting Curves, in: K. Fox (Ed.), Methods in Mol. Biol., Drug\u2013DNA Interaction Protocols, 1997, 90, 219.","DOI":"10.1385\/0-89603-447-X:219"},{"key":"10.1016\/j.bmc.2010.03.058_bib31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0014-5793(95)01537-X","volume":"380","author":"McCoubrey","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmc.2010.03.058_bib32","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1248\/cpb.45.1169","volume":"45","author":"Akihiko","year":"1997","journal-title":"Chem. Pharm. Bull."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089610002725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089610002725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:45:28Z","timestamp":1760831128000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089610002725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0968089610002725"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2010.03.058","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2010.03.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}