{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:11:55Z","timestamp":1777471915754,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.bmc.2010.06.064","type":"journal-article","created":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T05:03:16Z","timestamp":1277960596000},"page":"6134-6142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Design, synthesis, and anticonvulsant activity of new N-Mannich bases derived from spirosuccinimides and spirohydantoins"],"prefix":"10.1016","volume":"18","author":[{"given":"Jolanta","family":"Obniska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Byrtus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Kami\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Paw\u0142owski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Szczesio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janina","family":"Karolak-Wojciechowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2010.06.064_bib1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1021\/jm00154a022","volume":"29","author":"Wong","year":"1986","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.06.064_bib2","series-title":"Antiepileptic Drugs: Mechanisms of Action","first-page":"223","author":"Camerman","year":"1980"},{"key":"10.1016\/j.bmc.2010.06.064_bib3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0166-1280(00)00364-X","volume":"504","author":"Tasso","year":"2000","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bmc.2010.06.064_bib4","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1021\/jm030913e","volume":"47","author":"Kenda","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.06.064_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2006.10.008","volume":"73","author":"Bialer","year":"2007","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.bmc.2010.06.064_bib6","first-page":"740","volume":"6","author":"Malawska","year":"2005","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.bmc.2010.06.064_bib7","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.eplepsyres.2006.02.004","volume":"69","author":"Rogawski","year":"2006","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.bmc.2010.06.064_bib8","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrn1430","volume":"5","author":"Rogawski","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bmc.2010.06.064_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0306-4522(03)00168-4","volume":"119","author":"Ellerkmann","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.bmc.2010.06.064_bib10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jfluchem.2006.01.009","volume":"127","author":"Obniska","year":"2006","journal-title":"J. Fluorine Chem."},{"key":"10.1016\/j.bmc.2010.06.064_bib11","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1016\/j.bmc.2008.03.037","volume":"16","author":"Kami\u0144ski","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2010.06.064_bib12","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.ejmech.2008.05.020","volume":"44","author":"Obniska","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.06.064_bib13","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.ejmech.2006.03.001","volume":"41","author":"Obniska","year":"2006","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.06.064_bib14","first-page":"207","volume":"58","author":"Obniska","year":"2006","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.bmc.2010.06.064_bib15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1021\/jm00367a015","volume":"27","author":"Poupaert","year":"1984","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.06.064_bib16","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1021\/jm00044a003","volume":"37","author":"Sun","year":"1994","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.06.064_bib17","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1021\/jm030450c","volume":"47","author":"Thenmozhiyal","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.06.064_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0014-827X(01)01198-3","volume":"57","author":"Naydenova","year":"2002","journal-title":"Il Farmaco"},{"key":"10.1016\/j.bmc.2010.06.064_bib19","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1016\/j.bmcl.2006.05.102","volume":"16","author":"Patel","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2010.06.064_bib20","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ejmech.2008.02.024","volume":"44","author":"Zhu","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.06.064_bib21","first-page":"21","volume":"40","author":"Faust","year":"1957","journal-title":"J. Am. Pharm. Assoc."},{"key":"10.1016\/j.bmc.2010.06.064_bib22","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1021\/jo01081a024","volume":"25","author":"Goodson","year":"1960","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2010.06.064_bib23","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.molstruc.2005.07.032","volume":"783","author":"Dzier\u017cawska-Majewska","year":"2006","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bmc.2010.06.064_bib24","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.molstruc.2007.07.004","volume":"876","author":"Karolak-Wojciechowska","year":"2008","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bmc.2010.06.064_bib25","first-page":"931","volume":"62","author":"Karolak-Wojciechowska","year":"2006","journal-title":"Acta Crystallogr., Sect. E"},{"key":"10.1016\/j.bmc.2010.06.064_bib26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molstruc.2007.11.016","volume":"888","author":"Karolak-Wojciechowska","year":"2008","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bmc.2010.06.064_bib27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1046\/j.1528-1157.44.s7.10.x","volume":"44","author":"White","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.bmc.2010.06.064_bib28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0920-1211(01)00302-3","volume":"47","author":"Barton","year":"2001","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.bmc.2010.06.064_bib29","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.bmc.2010.06.064_bib30","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1528-1157.1978.tb04507.x","volume":"19","author":"Krall","year":"1978","journal-title":"Epilepsia"},{"key":"10.1016\/j.bmc.2010.06.064_bib31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1528-1157.1989.tb05815.x","volume":"30","author":"Kupferberg","year":"1989","journal-title":"Epilepsia"},{"key":"10.1016\/j.bmc.2010.06.064_bib32","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jps.3030460322","volume":"46","author":"Dunham","year":"1957","journal-title":"J. Am. Pharm. Assoc. Sci."},{"key":"10.1016\/j.bmc.2010.06.064_bib33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0022-3565(25)05160-2","volume":"107","author":"Brown","year":"1953","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2010.06.064_bib34","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1111\/j.0013-9580.2004.04504.x","volume":"45","author":"Kaminski","year":"2004","journal-title":"Epilepsia"},{"key":"10.1016\/j.bmc.2010.06.064_bib35","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2174\/1568007054546108","volume":"4","author":"Noraberg","year":"2005","journal-title":"Curr. Drug Targets CNS Neurol. Disord."},{"key":"10.1016\/j.bmc.2010.06.064_bib36","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/026119290403200403","volume":"32","author":"Noraberg","year":"2004","journal-title":"Altern. Lab. Anim."},{"key":"10.1016\/j.bmc.2010.06.064_bib37","doi-asserted-by":"crossref","first-page":"4944","DOI":"10.1073\/pnas.040577097","volume":"97","author":"Carter","year":"2000","journal-title":"PNAS"},{"key":"10.1016\/j.bmc.2010.06.064_bib38","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1107\/S0108767307043930","volume":"64","author":"Sheldrick","year":"2008","journal-title":"Acta Crystallogr., Sect. A"},{"key":"10.1016\/j.bmc.2010.06.064_bib39","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1016\/j.bmc.2005.12.041","volume":"14","author":"Thirumurugan","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2010.06.064_bib40","doi-asserted-by":"crossref","first-page":"6202","DOI":"10.1021\/jm050283b","volume":"48","author":"Yogeeswari","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2010.06.064_bib41","series-title":"Antiepileptic Drugs","first-page":"43","author":"White","year":"2002"},{"key":"10.1016\/j.bmc.2010.06.064_bib42","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0026-895X(25)15168-7","volume":"22","author":"Willow","year":"1982","journal-title":"Mol. Pharmacol."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089610005924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089610005924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:45:59Z","timestamp":1760831159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089610005924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":42,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0968089610005924"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2010.06.064","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and anticonvulsant activity of new N-Mannich bases derived from spirosuccinimides and spirohydantoins","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2010.06.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}