{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:40:14Z","timestamp":1791081614682,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.bmc.2011.01.025","type":"journal-article","created":{"date-parts":[[2011,1,20]],"date-time":"2011-01-20T04:31:33Z","timestamp":1295497893000},"page":"3659-3668","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: Coumarin- and pyrimidine-based SIRT1\/2 inhibitors with different selectivity profile"],"prefix":"10.1016","volume":"19","author":[{"given":"Dante","family":"Rotili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Carafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Tarantino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Botta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Nebbioso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Altucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2011.01.025_b0005","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cbpa.2005.08.010","volume":"9","author":"Denu","year":"2005","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.bmc.2011.01.025_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20070140","volume":"404","author":"Michan","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmc.2011.01.025_b0015","doi-asserted-by":"crossref","first-page":"4000","DOI":"10.1007\/s00018-008-8357-y","volume":"65","author":"Taylor","year":"2008","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.bmc.2011.01.025_b0020","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cbpa.2008.01.019","volume":"12","author":"Milne","year":"2008","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.bmc.2011.01.025_b0025","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/j.1365-2958.2004.04209.x","volume":"53","author":"Lamming","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.bmc.2011.01.025_b0030","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.biochem.73.011303.073651","volume":"73","author":"Blander","year":"2004","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bmc.2011.01.025_b0035","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0047-6374(80)90028-7","volume":"12","author":"Muller","year":"1980","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bmc.2011.01.025_b0040","doi-asserted-by":"crossref","first-page":"13091","DOI":"10.1073\/pnas.95.22.13091","volume":"95","author":"Lakowski","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2011.01.025_b0045","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/jn\/116.4.641","volume":"116","author":"Weindruch","year":"1986","journal-title":"J. Nutr."},{"key":"10.1016\/j.bmc.2011.01.025_b0050","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/j.1532-5415.1999.tb03851.x","volume":"47","author":"Roth","year":"1999","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.bmc.2011.01.025_b0055","doi-asserted-by":"crossref","first-page":"156","DOI":"10.2174\/157489008786263989","volume":"3","author":"Pillarisetti","year":"2008","journal-title":"Recent Patents Cardiovasc. Drug Disc."},{"key":"10.1016\/j.bmc.2011.01.025_b0060","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nrd2665","volume":"7","author":"Lavu","year":"2008","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2011.01.025_b0065","doi-asserted-by":"crossref","first-page":"5489","DOI":"10.1038\/sj.onc.1210616","volume":"26","author":"Saunders","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.bmc.2011.01.025_b0070","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1196\/annals.1395.005","volume":"1100","author":"Fraga","year":"2007","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.bmc.2011.01.025_b0075","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nature06515","volume":"451","author":"Zhao","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2011.01.025_b0080","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1126\/science.1143780","volume":"317","author":"Outeiro","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.bmc.2011.01.025_b0085","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.bbapap.2009.11.010","volume":"1804","author":"Cen","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmc.2011.01.025_b0090","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1002\/anie.200461346","volume":"44","author":"Biel","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bmc.2011.01.025_b0095","doi-asserted-by":"crossref","first-page":"7239","DOI":"10.1021\/jm060686r","volume":"49","author":"Tervo","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.01.025_b0100","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.1021\/jm049933m","volume":"47","author":"Tervo","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.01.025_b0105","doi-asserted-by":"crossref","first-page":"7307","DOI":"10.1021\/jm060118b","volume":"49","author":"Trapp","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.01.025_b0110","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1002\/cmdc.200700003","volume":"2","author":"Trapp","year":"2007","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2011.01.025_b0115","doi-asserted-by":"crossref","first-page":"8045","DOI":"10.1021\/jm050522v","volume":"48","author":"Napper","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.01.025_b0120","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1002\/anie.200605207","volume":"46","author":"Gey","year":"2007","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bmc.2011.01.025_b0125","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1021\/jo900578j","volume":"74","author":"Guti\u00e9rrez","year":"2009","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2011.01.025_b0130","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1124\/mol.110.065961","volume":"78","author":"Oh","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bmc.2011.01.025_b0135","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1158\/0008-5472.CAN-05-3617","volume":"66","author":"Heltweg","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmc.2011.01.025_b0140","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.ccr.2008.03.004","volume":"13","author":"Lain","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bmc.2011.01.025_b0145","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/onc.2008.436","volume":"28","author":"Lara","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.bmc.2011.01.025_b0150","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1021\/jm049002a","volume":"48","author":"Mai","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.01.025_b0155","doi-asserted-by":"crossref","first-page":"6897","DOI":"10.1021\/jm060601m","volume":"49","author":"Mai","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.01.025_b0160","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1124\/mol.107.036772","volume":"72","author":"Mai","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bmc.2011.01.025_b0165","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.bmcl.2006.12.028","volume":"17","author":"Mai","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2011.01.025_b0170","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1016\/j.bmcl.2008.04.017","volume":"18","author":"Sbardella","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2011.01.025_b0175","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.bmcl.2008.12.097","volume":"19","author":"Mai","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2011.01.025_b0180","doi-asserted-by":"crossref","first-page":"7789","DOI":"10.1021\/jm050100l","volume":"48","author":"Mai","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.01.025_b0185","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1021\/jm9008289","volume":"52","author":"Mai","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.01.025_b0190","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1021\/jm9013345","volume":"53","author":"Pasco","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.01.025_b0195","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/cmdc.201000030","volume":"5","author":"Rotili","year":"2010","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2011.01.025_b0200","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1021\/jm700972e","volume":"51","author":"Neugebauer","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.01.025_b0205","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1371\/journal.pbio.0030041","volume":"3","author":"Pagans","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bmc.2011.01.025_b0210","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1021\/jm8014298","volume":"52","author":"Medda","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.01.025_b0215","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1021\/jm800340w","volume":"51","author":"Nawrozkij","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.01.025_b0220","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1039\/JR9570002593","author":"Buu-Hoi","year":"1957","journal-title":"J. Chem. Soc."},{"key":"10.1016\/j.bmc.2011.01.025_b0225","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nm1161","volume":"11","author":"Nebbioso","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.bmc.2011.01.025_b0230","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/89050","volume":"7","author":"Altucci","year":"2001","journal-title":"Nat. Med."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089611000411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089611000411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:54:23Z","timestamp":1760831663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089611000411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0968089611000411"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2011.01.025","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: Coumarin- and pyrimidine-based SIRT1\/2 inhibitors with different selectivity profile","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2011.01.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}