{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:24:53Z","timestamp":1784895893341,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.bmc.2011.10.015","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T12:53:10Z","timestamp":1318855990000},"page":"7003-7007","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors"],"prefix":"10.1016","volume":"19","author":[{"given":"Rosaria","family":"Gitto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Maria","family":"Damiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Vullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Chimirri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2011.10.015_b0005","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2011.10.015_b0010","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1021\/jm701526d","volume":"51","author":"Thiry","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.10.015_b0015","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2174\/138161208783877866","volume":"14","author":"Mincione","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2011.10.015_b0020","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2174\/156802607780636762","volume":"7","author":"De Simone","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2011.10.015_b0025","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2174\/156802607780636726","volume":"7","author":"Thiry","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2011.10.015_b0030","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.bmcl.2010.05.009","volume":"20","author":"Supuran","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2011.10.015_b0035","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2011.10.015_b0040","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/med.20068","volume":"26","author":"Winum","year":"2006","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2011.10.015_b0045","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.2174\/138161210793429841","volume":"16","author":"Supuran","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2011.10.015_b0050","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1021\/jm200209n","volume":"54","author":"Hen","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.10.015_b0055","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.1016\/j.bmcl.2010.07.051","volume":"20","author":"Di Fiore","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2011.10.015_b0060","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1021\/jm801386n","volume":"52","author":"Temperini","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.10.015_b0065","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/prot.22144","volume":"74","author":"Di Fiore","year":"2009","journal-title":"Proteins"},{"key":"10.1016\/j.bmc.2011.10.015_b0070","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.1021\/ja068359w","volume":"129","author":"Srivastava","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2011.10.015_b0075","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1016\/j.bmc.2011.04.005","volume":"19","author":"Carta","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2011.10.015_b0080","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bbapap.2009.07.027","volume":"1804","author":"De Simone","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmc.2011.10.015_b0085","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.2174\/092986710790979999","volume":"17","author":"Guler","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2011.10.015_b0090","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1158\/0008-5472.CAN-10-4261","volume":"71","author":"Lou","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmc.2011.10.015_b0095","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1158\/0008-5472.CAN-08-2470","volume":"69","author":"Chiche","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmc.2011.10.015_b0100","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1016\/j.bmcl.2009.06.022","volume":"19","author":"Ahlskog","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2011.10.015_b0105","doi-asserted-by":"crossref","first-page":"893","DOI":"10.2174\/156802607780636672","volume":"7","author":"Hilvo","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2011.10.015_b0110","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1016\/j.bmc.2009.03.066","volume":"17","author":"Gitto","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2011.10.015_b0115","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1021\/jm9014026","volume":"53","author":"Gitto","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.10.015_b0120","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/cmdc.201000044","volume":"5","author":"Gitto","year":"2010","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2011.10.015_b0125","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1021\/jm2000213","volume":"54","author":"Mader","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.10.015_b0130","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/ardp.200600022","volume":"339","author":"De Luca","year":"2006","journal-title":"Arch. Pharm. (Weinheim)"},{"key":"10.1016\/j.bmc.2011.10.015_b0135","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1016\/j.bmcl.2005.06.055","volume":"15","author":"Nishimori","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2011.10.015_b0140","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1021\/jm050483n","volume":"48","author":"Nishimori","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.10.015_b0145","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1021\/jm0612057","volume":"50","author":"Nishimori","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2011.10.015_b0150","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1021\/jm0512600","volume":"49","author":"Nishimori","year":"2006","journal-title":"J. Med. Chem."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089611008236?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089611008236?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T23:56:31Z","timestamp":1760831791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089611008236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":30,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0968089611008236"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2011.10.015","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2011.10.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}