{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:20:16Z","timestamp":1792693216824,"version":"4.5.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.bmc.2012.01.024","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T19:48:59Z","timestamp":1328039339000},"page":"2131-2140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Design and synthesis of novel bone-targeting dual-action pro-drugs for the treatment and reversal of osteoporosis"],"prefix":"10.1016","volume":"20","author":[{"given":"Steve","family":"Arns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romelo","family":"Gibe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Monzur Morshed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2012.01.024_b0005","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.bmcl.2007.12.047","volume":"18","author":"Gauthier","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.01.024_b0010","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1080\/01926230490462138","volume":"32","author":"Vahle","year":"2004","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.bmc.2012.01.024_b0015_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/8756-3282(85)90311-4","volume":"6","author":"Ueno","year":"1985","journal-title":"Bone"},{"key":"10.1016\/j.bmc.2012.01.024_b0015_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0169-6009(91)90109-D","volume":"15","author":"Jee","year":"1991","journal-title":"J. Bone Mineral."},{"key":"10.1016\/j.bmc.2012.01.024_b0015_3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0952-3278(90)90081-U","volume":"41","author":"Norrdin","year":"1990","journal-title":"Prost. Leuk. Essent Fatty Acids"},{"key":"10.1016\/j.bmc.2012.01.024_b0020","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0968-0896(99)00045-0","volume":"7","author":"Gil","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.01.024_b0025","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0026-895X(24)23047-9","volume":"60","author":"Machwate","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bmc.2012.01.024_b0030","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.2174\/1381612023393585","volume":"8","author":"Uludag","year":"2002","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2012.01.024_b0035_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.molmed.2004.05.007","volume":"10","author":"Heymann","year":"2004","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bmc.2012.01.024_b0035_2","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.bmcl.2007.11.029","volume":"18","author":"Ebner","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.01.024_b0040","unstructured":"X. Billot, R. N. Young, H. Han. 1,5-Disubstituted Pyrrolid-2-one Derivatives For Use As EP4 Receptor Agonists In The Treatment of Eye Diseases Such As Glaucoma. US Patent WO 03\/103772. December 18, 2003."},{"key":"10.1016\/j.bmc.2012.01.024_b0045","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3987\/COM-04-S(P)47","volume":"54","author":"Young","year":"2004","journal-title":"Heterocycles"},{"key":"10.1016\/j.bmc.2012.01.024_b0050_1","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1016\/S0968-0896(02)00031-7","volume":"10","author":"Maruyama","year":"2002","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2012.01.024_b0050_2","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.bone.2004.01.002","volume":"34","author":"Tanaka","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.bmc.2012.01.024_b0055","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0960-894X(03)00042-8","volume":"13","author":"Billot","year":"2003","journal-title":"Bioorg. Med Chem Lett."},{"key":"10.1016\/j.bmc.2012.01.024_b0060","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1021\/jm8001839","volume":"51","author":"Gediya","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.01.024_b0065","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/jlcr.1753","volume":"53","author":"Arns","year":"2010","journal-title":"J. Labelled Comp. Rad."},{"key":"10.1016\/j.bmc.2012.01.024_b0070","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1039\/b008065i","volume":"4","author":"Br\u00fcmmer","year":"2001","journal-title":"Chem. Comm."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089612000533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089612000533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:03:54Z","timestamp":1760832234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089612000533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0968089612000533"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2012.01.024","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and synthesis of novel bone-targeting dual-action pro-drugs for the treatment and reversal of osteoporosis","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2012.01.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}