{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:17:29Z","timestamp":1791141449739,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.bmc.2012.01.052","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T19:28:49Z","timestamp":1328815729000},"page":"2392-2404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases"],"prefix":"10.1016","volume":"20","author":[{"given":"Janina","family":"Moeker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanae","family":"Teruya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Rossit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan L.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent F.","family":"Bornaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Innocenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally-Ann","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2012.01.052_b0005","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1021\/cr050262p","volume":"108","author":"Krishnamurthy","year":"2008","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmc.2012.01.052_b0010","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discovery"},{"key":"10.1016\/j.bmc.2012.01.052_b0015","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1517\/13543776.2010.484803","volume":"20","author":"Poulsen","year":"2010","journal-title":"Expert Opin. Ther. Patents"},{"key":"10.1016\/j.bmc.2012.01.052_b0020","first-page":"7075","volume":"60","author":"Wykoff","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmc.2012.01.052_b0025","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/sj.bjc.6600936","volume":"89","author":"Potter","year":"2003","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bmc.2012.01.052_b0030","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1158\/0008-5472.CAN-08-2470","volume":"69","author":"Chiche","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmc.2012.01.052_b0035","doi-asserted-by":"crossref","first-page":"6905","DOI":"10.1021\/jm200892s","volume":"54","author":"Morris","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.01.052_b0040","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","volume":"10","author":"Neri","year":"2011","journal-title":"Nat. Rev. Drug Discovery"},{"key":"10.1016\/j.bmc.2012.01.052_b0045","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1200\/JCO.1993.11.4.738","volume":"11","author":"Oosterwijk","year":"1993","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bmc.2012.01.052_b0050","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/(SICI)1097-0215(20000315)85:6<865::AID-IJC21>3.0.CO;2-Q","volume":"85","author":"Grabmaier","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bmc.2012.01.052_b0055","doi-asserted-by":"crossref","first-page":"893","DOI":"10.2174\/156802607780636672","volume":"7","author":"Hilvo","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2012.01.052_b0060","doi-asserted-by":"crossref","first-page":"8514","DOI":"10.1073\/pnas.0702899104","volume":"104","author":"Ogilvie","year":"2007","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2012.01.052_b0065","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.bmcl.2006.11.046","volume":"17","author":"Wilkinson","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.01.052_b0070","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1016\/j.bmcl.2005.06.055","volume":"15","author":"Nishimori","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.01.052_b0075","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.ejmech.2010.02.020","volume":"45","author":"Brzozowski","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.01.052_b0080","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1021\/jm9900523","volume":"42","author":"Scozzafava","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.01.052_b0085","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/med.20141","volume":"29","author":"Winum","year":"2009","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2012.01.052_b0090","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1021\/jm901888x","volume":"53","author":"Lopez","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.01.052_b0095","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.1021\/jm060967z","volume":"49","author":"Wilkinson","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.01.052_b0100","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/j.bmcl.2009.02.086","volume":"19","author":"Singer","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.01.052_b0105","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1016\/j.bmcl.2011.08.066","volume":"21","author":"Salmon","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.01.052_b0110","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1021\/jm061320h","volume":"50","author":"Wilkinson","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.01.052_b0115","first-page":"51","volume":"2008","author":"Wilkinson","year":"1945","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.01.052_b0120","doi-asserted-by":"crossref","first-page":"8329","DOI":"10.1021\/ja061574s","volume":"128","author":"Alterio","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2012.01.052_b0125","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1021\/jm001051+","volume":"43","author":"Casini","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.01.052_b0130","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/1475636021000010950","volume":"17","author":"Casini","year":"2002","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2012.01.052_b0135","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1016\/j.bmcl.2008.05.051","volume":"18","author":"Cecchi","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.01.052_b0140","first-page":"15","volume":"2005","author":"Di Fiore","year":"1937","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.01.052_b0145","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1021\/jm049692i","volume":"47","author":"Innocenti","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.01.052_b0150","unstructured":"Lu, G.; Hillier, S. M.; Maresca, K. P.; Zimmerman, C. N.; Wang, J.; Shay, C.; Marquis, J. C.; Eckelman, W. C.; Joyal, J. L.; Babich, J. W, Abstracts of Papers, 238th ACS National Meeting, Washington, DC, United States, August 16\u201320, 2009."},{"key":"10.1016\/j.bmc.2012.01.052_b0155","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1016\/j.bmcl.2005.02.087","volume":"15","author":"Puccetti","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.01.052_b0160","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1016\/j.bmcl.2011.03.055","volume":"21","author":"Rami","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.01.052_b0165","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3109\/14756369809035830","volume":"13","author":"Scozzafava","year":"1998","journal-title":"J. Enzyme Inhib."},{"key":"10.1016\/j.bmc.2012.01.052_b0170","unstructured":"Smith-Jones, P. M.; Zhang, H.; Carlin, S. D. WO2010147666A1; 2010."},{"key":"10.1016\/j.bmc.2012.01.052_b0175","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0223-5234(98)80033-0","volume":"33","author":"Supuran","year":"1998","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.01.052_b0180","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1021\/jm0494826","volume":"48","author":"Winum","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.01.052_b0185","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.jasms.2006.03.017","volume":"17","author":"Poulsen","year":"2006","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.bmc.2012.01.052_b0190","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1055\/s-1984-30885","volume":"6","author":"Camarasa","year":"1984","journal-title":"Synthesis"},{"key":"10.1016\/j.bmc.2012.01.052_b0195","first-page":"949","volume":"6","author":"K\u00fchne","year":"2006","journal-title":"Synthesis"},{"key":"10.1016\/j.bmc.2012.01.052_b0200","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/cber.19260590626","volume":"59","author":"Zempl\u00e9n","year":"1926","journal-title":"Ber. Deutsch. Chem. Ges."},{"key":"10.1016\/j.bmc.2012.01.052_b0205","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.bmcl.2004.12.053","volume":"15","author":"Vullo","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.01.052_b0210","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0960-894X(03)00091-X","volume":"13","author":"Vullo","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.01.052_b0215","series-title":"Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization","author":"Kerns","year":"2008"},{"key":"10.1016\/j.bmc.2012.01.052_b0220","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1021\/cb800065s","volume":"3","author":"Lavis","year":"2008","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bmc.2012.01.052_b0225","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijpharm.2005.03.022","volume":"297","author":"Di","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bmc.2012.01.052_b0230","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961200082X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961200082X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:00:52Z","timestamp":1760832052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096808961200082X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S096808961200082X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2012.01.052","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2012.01.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}