{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:15:26Z","timestamp":1777493726094,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.bmc.2012.08.057","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T04:02:28Z","timestamp":1346990548000},"page":"1511-1515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors"],"prefix":"10.1016","volume":"21","author":[{"given":"Tiziano","family":"Tuccinardi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Bertini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlotta","family":"Granchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Ortore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Macchia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Minutolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2012.08.057_b0005","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug. Disc."},{"key":"10.1016\/j.bmc.2012.08.057_b0010","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.bmcl.2010.05.009","volume":"20","author":"Supuran","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.08.057_b0015","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.4155\/fmc.11.69","volume":"3","author":"Supuran","year":"2011","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bmc.2012.08.057_b0020","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1517\/13543776.16.12.1627","volume":"16","author":"Scozzafava","year":"2006","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmc.2012.08.057_b0025","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1002\/cmdc.201000200","volume":"5","author":"Schulze Wischeler","year":"2010","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2012.08.057_b0030","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.bmc.2011.01.016","volume":"19","author":"Durdagi","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2012.08.057_b0035","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1021\/jm1003667","volume":"53","author":"Carta","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.08.057_b0040","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/med.20186","volume":"31","author":"Minutolo","year":"2011","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2012.08.057_b0045","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1021\/jm060560u","volume":"49","author":"Tuccinardi","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.08.057_b0050","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1021\/jm701396g","volume":"51","author":"Minutolo","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.08.057_b0055","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1021\/jm801458t","volume":"52","author":"Minutolo","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.08.057_b0060","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1016\/j.ejmech.2011.03.030","volume":"46","author":"Bertini","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.08.057_b0065","doi-asserted-by":"crossref","first-page":"7968","DOI":"10.1021\/jm800964f","volume":"51","author":"Marques","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.08.057_b0070","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1021\/ci600469w","volume":"47","author":"Tuccinardi","year":"2007","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmc.2012.08.057_b0075","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1021\/ci700214j","volume":"47","author":"Tuccinardi","year":"2007","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmc.2012.08.057_b0080","author":"Gitto","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.08.057_b0085","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/jcc.10156","volume":"24","author":"Vreven","year":"2003","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bmc.2012.08.057_b0090","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1021\/ja807814x","volume":"131","author":"Yonezawa","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2012.08.057_b0095","doi-asserted-by":"crossref","first-page":"8289","DOI":"10.1021\/jm200593b","volume":"54","author":"Marques","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.08.057_b0100","unstructured":"Case, D. A.; Darden, T. A.; III, T. E. C.; Simmerling, C. L.; Wang, J.; Duke, R. E.; Luo, R.; Walker, R. C.; Zhang, W.; Merz, K. M.; Roberts, B.; Wang, B.; Hayik, S.; Roitberg, A.; Seabra, G.; Kolossv\u00e1ry, I.; Wong, K. F.; Paesani, F.; Vanicek, J.; Liu, J.; Wu, X.; Brozell, S. R.; Steinbrecher, T.; Gohlke, H.; Cai, Q.; Ye, X.; Wang, J.; Hsieh, M.-J.; Cui, G.; Roe, D. R.; Mathews, D. H.; Seetin, M. G.; Sagui, C.; Babin, V.; Luchko, T.; Gusarov, S.; Kovalenko, A.; Kollman, P. A.: AMBER, version 11; University of California: San Francisco, CA, 2010."},{"key":"10.1016\/j.bmc.2012.08.057_b0105","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/(SICI)1097-461X(1996)58:2<185::AID-QUA7>3.0.CO;2-U","volume":"58","author":"Seifert","year":"1996","journal-title":"Int. J. Quantum Chem."},{"key":"10.1016\/j.bmc.2012.08.057_b0110","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2012.08.057_b0115","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/ja809683v","volume":"131","author":"Maresca","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2012.08.057_b0120","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/jm901524f","volume":"53","author":"Temperini","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.08.057_b0125","doi-asserted-by":"crossref","first-page":"16233","DOI":"10.1073\/pnas.0908301106","volume":"106","author":"Alterio","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2012.08.057_b0130","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.bmcl.2004.12.053","volume":"15","author":"Vullo","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.08.057_b0135","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1021\/jm031079w","volume":"47","author":"Casey","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.08.057_b0140","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1021\/jm001051+","volume":"43","author":"Casini","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.08.057_b0145","unstructured":"Maestro, version 9.0: Schr\u00f6dinger Inc: Portland, OR, 2009."},{"key":"10.1016\/j.bmc.2012.08.057_b0150","unstructured":"Macromodel, version 9.7: Schr\u00f6dinger Inc: Portland, OR, 2009."},{"key":"10.1016\/j.bmc.2012.08.057_b0155","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmc.2012.08.057_b0160","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/prot.10465","volume":"52","author":"Verdonk","year":"2003","journal-title":"Proteins"},{"key":"10.1016\/j.bmc.2012.08.057_b0165","unstructured":"Frisch, M. J.; Trucks, G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Scalmani, G.; Barone, V.; Mennucci, B.; Petersson, G. A.; Nakatsuji, H.; Caricato, M.; Li, X.; Hratchian, H. P.; Izmaylov, A. F.; Bloino, J.; Zheng, G.; Sonnenberg, J. L.; Hada, M.; Ehara, M.; Toyota, K.; Fukuda, R.; Hasegawa, J.; Ishida, M.; Nakajima, T.; Honda, Y.; Kitao, O.; Nakai, H.; Vreven, T.; Jr., J. A. M.; Peralta, J. E.; Ogliaro, F.; Bearpark, M.; Heyd, J. J.; Brothers, E.; Kudin, K. N.; Staroverov, V. N.; Kobayashi, R.; Normand, J.; Raghavachari, K.; Rendell, A.; Burant, J. C.; Iyengar, S. S.; Tomasi, J.; Cossi, M.; Rega, N.; Millam, J. M.; Klene, M.; Knox, J. E.; Cross, J. B.; Bakken, V.; Adamo, C.; Jaramillo, J.; Gomperts, R.; Stratmann, R. E.; Yazyev, O.; Austin, A. J.; Cammi, R.; Pomelli, C.; Ochterski, J. W.; Martin, R. L.; Morokuma, K.; Zakrzewski, V. G.; Voth, G. A.; Salvador, P.; Dannenberg, J. J.; Dapprich, S.; Daniels, A. D.; Farkas, \u00d6.; Foresman, J. B.; Ortiz, J. V.; Cioslowski, J.; Fox, D. J.: Gaussian 09 Revision A.1, Gaussian, Inc., Wallingford CT, 2009."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089612006943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089612006943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:09:05Z","timestamp":1760832545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089612006943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0968089612006943"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2012.08.057","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2012.08.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}