{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:43:55Z","timestamp":1791168235727,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.bmc.2012.10.045","type":"journal-article","created":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T22:54:21Z","timestamp":1352242461000},"page":"146-152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase"],"prefix":"10.1016","volume":"21","author":[{"given":"Marco","family":"Catto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Pisani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Leonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orazio","family":"Nicolotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pesce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Stefanachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Cellamare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Carotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2012.10.045_b0005","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","volume":"362","author":"Querfurth","year":"2010","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.bmc.2012.10.045_b0010","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1586\/ern.12.43","volume":"12","author":"Corbett","year":"2012","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.bmc.2012.10.045_b0015","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1755-5949.2010.00175.x","volume":"16","author":"Martorana","year":"2010","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bmc.2012.10.045_b0020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.pharmthera.2011.12.002","volume":"134","author":"Tayeb","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bmc.2012.10.045_b0025","doi-asserted-by":"crossref","first-page":"836","DOI":"10.2174\/138955711796575434","volume":"11","author":"Orhan","year":"2011","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.045_b0030","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/00000542-199210000-00025","volume":"77","author":"Bevan","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bmc.2012.10.045_b0035","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S1474-4422(09)70063-8","volume":"8","author":"Meriggioli","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2012.10.045_b0040","first-page":"S20","volume":"14","author":"McKinnon","year":"2008","journal-title":"Am. J. Manag. Care"},{"key":"10.1016\/j.bmc.2012.10.045_b0045","unstructured":"http:\/\/www.rcsb.org\/pdb\/home\/home.do."},{"key":"10.1016\/j.bmc.2012.10.045_b0055","doi-asserted-by":"crossref","first-page":"7450","DOI":"10.1016\/j.bmc.2008.06.022","volume":"16","author":"Leonetti","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.045_b0060","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0968-0896(98)00213-2","volume":"7","author":"Carlier","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.045_b0065","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2174\/1389557013406972","volume":"1","author":"Camps","year":"2001","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.045_b0070","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1021\/jm060257t","volume":"49","author":"Gemma","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.045_b0080","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cbpa.2009.04.619","volume":"13","author":"Bolognesi","year":"2009","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.bmc.2012.10.045_b0085","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2174\/138161209787315585","volume":"15","author":"Bolognesi","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2012.10.045_b0090","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.2174\/092986711797379302","volume":"18","author":"Pisani","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.045_b0095","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.2174\/092986712801215883","volume":"19","author":"Costantino","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.045_b0100","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1002\/cmdc.201000210","volume":"5","author":"Pisani","year":"2010","journal-title":"Chem. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.045_b0110","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.1021\/jm001028o","volume":"43","author":"Gnerre","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.045_b0115","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1021\/jm060183l","volume":"49","author":"Catto","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.045_b0120","doi-asserted-by":"crossref","first-page":"6685","DOI":"10.1021\/jm9010127","volume":"52","author":"Pisani","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.045_b0125","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1021\/jm010894d","volume":"44","author":"Br\u00fchlmann","year":"2001","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.045_b0130","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.bmc.2011.12.042","volume":"20","author":"Anand","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.045_b0135","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bmc.2012.10.045_b0140","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1039\/jr9500000895","author":"Dean","year":"1950","journal-title":"J. Chem. Soc."},{"key":"10.1016\/j.bmc.2012.10.045_b0145","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/jhet.5570230118","volume":"23","author":"Kokotos","year":"1986","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.bmc.2012.10.045_b0150","first-page":"9","volume":"1995","author":"Jackson","year":"1979","journal-title":"Heterocycles"},{"key":"10.1016\/j.bmc.2012.10.045_b0155","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1021\/jo01112a001","volume":"21","author":"Shaw","year":"1956","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2012.10.045_b0160","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/cber.19470800517","volume":"80","author":"Offe","year":"1947","journal-title":"Chem. Ber."},{"key":"10.1016\/j.bmc.2012.10.045_b0165","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1021\/jm00024a009","volume":"38","author":"Sugimoto","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.045_b0170","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0896-6273(00)80108-7","volume":"16","author":"Inestrosa","year":"1996","journal-title":"Neuron"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089612008693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089612008693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:07:42Z","timestamp":1760832462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089612008693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0968089612008693"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2012.10.045","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2012.10.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}